Referat Dr. med. C. Caflisch

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AbstractBackground: Opioid maintained patients report high levels of anxiety, but the use ofbenzodiazepines among these patients has been associated with negative outcomessuch as increased risk of overdose and death and poorer retention in programmes.Previous research has used interview or urine analysis to assess benzodiazepine use.In this study a prescription database was applied.Methods: The Norwegian Prescription Database covers all prescriptions for the entirepopulation from 1 January 2004. Benzodiazepine prescriptions to patients receivingmethadone (N= 1364) or buprenorphine (N= 805) in 2004 and 2005 were studied.Type and amount of drugs received were investigated.Results: Overall 40% of the patients received at least one prescription for abenzodiazepine drug. Oxazepam was the most frequently prescribed drug. Femalepatients, methadone-maintained patients and patients in the liberal programmesreceived a prescription more often. Prescribed doses were high and highest in theliberal programmes. Older patients received more hypnotics. Dose of maintenancedrug was positively related to amount of anxiolytics prescribed.Conclusions: This study showed that more benzodiazepines were prescribed to opioidmaintenance treatment patients than previously shown by investigations usinginterview or urine analysis. The doses prescribed were generally high. In light of thenegative outcomes following benzodiazepine use in these patients, Norwegiandoctors need to review their prescription practices.
Australian and New Zealand Journal of Psychiatry 2003; 37:458–463Treatment of benzodiazepine dependence inmethadone maintenance treatment patients:a comparison of two therapeutic modalitiesand the role of psychiatric comorbidityTal Weizman, Marc Gelkopf, Yuval Mela<strong>med</strong>, Miriam Adelson, Avraham Bleich
Page 1 and 2: Zentrum für Abhängigkeitserkranku
Page 4 and 5: Geschichte der PsychopharmakaMorphi
Page 6: Librium wird als erstes Medikament
Page 9: Leavitt et al. 2000When „Enough
Page 12 and 13: The purpose of the study was to ass
Page 14: Drug Alcohol Depend. 1993 May;32(3)
Page 19 and 20: Eine Abhängigkeit von Benzodiazepi
Page 21 and 22: Index · Contents · Introduction
Page 24: Authors’ conclusionsAll included
Page 29 and 30: METHODE (1)Benzodiazepinabhängige
Page 31 and 32: RESULTATE (1)Alle Patienten bis auf
Page 33 and 34: DISKUSSION (1)Die Substitution mit
Page 38 and 39: Der „Seresta-Notstand“Sommer 20
Page 41 and 42: Der „Seresta-Notstand“Sommer 20
Page 43 and 44: SCHLUSSBEMERKUNGENStudien zur Subst

Referat Dr. med. C. Caflisch

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