Referat Dr. med. C. Caflisch

Schedule 10. Withdrawal from oxazepam (Serax) 20mg three times daily (60mg) with diazepam(Valium) substitution (20mg oxazepam is approximately equivalent to 10mg diazepam)MorningMiddayEvening/NightDaily DiazepamEquivalentStarting dosage oxazepam 20mg oxazepam 20mg oxazepam 20mg30mgStage 1(1 week)oxazepam 20mgoxazepam 20mgoxazepam 10mgdiazepam 5mg30mgStage 2(1 week)oxazepam 10mgdiazepam 5mgoxazepam 20mgoxazepam 10mgdiazepam 5mg30mgStage 3(1 week)oxazepam 10mgdiazepam 5mgoxazepam 10mgdiazepam 5mgoxazepam 10mgdiazepam 5mg30mgStage 4(1-2 weeks)oxazepam 10mgdiazepam 5mgoxazepam 10mgdiazepam 5mgStop oxazepamdiazepam 8mg28mgStage 5(1-2 weeks)Stop oxazepamdiazepam 8mgoxazepam 10mgdiazepam 5mgdiazepam 8mg26mgStage 6(1-2 weeks)diazepam 8mgStop oxazepamdiazepam 8mgdiazepam 8mg24mgStage 7(1-2 weeks)diazepam 10mgdiazepam 2mgdiazepam 10mg22mgStage 8(1-2 weeks)diazepam 10mgStop diazepamdiazepam 10mg20mgStage 9(1-2 weeks)diazepam 8mg--diazepam 10mg18mgContinue as on Schedule 2 from Stage 12Schedule 10 Notes:1.Oxazepam is short-acting (half-life 4-15 hrs) so substitution to diazepam (long-acting) is recommended.2.Diazepam need only be taken twice a day.3.A change from 5mg to 2mg diazepam tablets is necessary from Stage 4 onwards.