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S<strong>in</strong>ce open<strong>in</strong>g <strong>in</strong> 1987, the Strelitz Diabetes Center has become one of thelead<strong>in</strong>g diabetes research and patient care facilities <strong>in</strong> the Mid-Atlantic.Jenna Kaln<strong>in</strong>s26 years liv<strong>in</strong>g with diabetesgenetic work with Dr. V<strong>in</strong>ik’s INGAP therapyto possibly elim<strong>in</strong>ate the need for <strong>in</strong>jections <strong>in</strong>diabetics.There’s a honeymoon period after someone isdiagnosed with Type 1 (also known as juvenileonset) diabetes before they require <strong>in</strong>sul<strong>in</strong>. In thisperiod, the body’s immune system hasn’t completelydestroyed the pancreas’ own <strong>in</strong>sul<strong>in</strong>-secret<strong>in</strong>g cells.While at the University of Virg<strong>in</strong>ia,Dr. Nadler founded a company,DiaK<strong>in</strong>e Therapeutics, Inc., todevelop a medication called lisofyll<strong>in</strong>efor diabetes treatments. He discoveredthat the anti-<strong>in</strong>flammatory agentseems able to stop the body fromwip<strong>in</strong>g out its <strong>in</strong>sul<strong>in</strong> production.It modulates the immune system,protect<strong>in</strong>g the <strong>in</strong>sul<strong>in</strong>-secret<strong>in</strong>g cellswithout leav<strong>in</strong>g the patient vulnerableto <strong>in</strong>fection.Lisofyll<strong>in</strong>e as a diabetes treatmenthas been very promis<strong>in</strong>g <strong>in</strong> animalresearch. “Now we’re hop<strong>in</strong>g to moveahead to the patient,” Dr. Nadler says.If lisofyll<strong>in</strong>e can protect the new cells spawnedby Dr. V<strong>in</strong>ik’s INGAP, then they could becomb<strong>in</strong>ed <strong>in</strong>to a cocktail that not only haltsdiabetes damage but reverses the disease.A few months of the therapy could be enoughto help a patient reduce their need for — or evenpermanently elim<strong>in</strong>ate — <strong>in</strong>sul<strong>in</strong> <strong>in</strong>jections, Dr.Nadler says.Dr. V<strong>in</strong>ik is look<strong>in</strong>g at stem cells as anotherway to treat Type 1 diabetes. The EVMS centeris among 20 nationwide participat<strong>in</strong>g <strong>in</strong> anewly-launched two-year study funded by OsirisTherapeutics Inc. exam<strong>in</strong><strong>in</strong>g how its Prochymalstem-cell therapy can arrest disease progressionand promote the regeneration of damaged tissues.(The process uses stem cells harvested from adultbone marrow.)All this work has Dr. Nadler enthused.“I would say, without exaggerat<strong>in</strong>g, that we havenot only the top diabetes research program <strong>in</strong> theCommonwealth of Virg<strong>in</strong>ia, but one of the top <strong>in</strong>the <strong>Eastern</strong> United States. We are also tra<strong>in</strong><strong>in</strong>g thenext generation of diabetes physicians.”Advanc<strong>in</strong>g Cl<strong>in</strong>ical CareSett<strong>in</strong>g the Strelitz Diabetes Center further apartis its expertise <strong>in</strong> treat<strong>in</strong>g the myriad complicationsof the disease.The team is known for tak<strong>in</strong>g lab f<strong>in</strong>d<strong>in</strong>gs,such as discoveries about the nerve damage process,directly <strong>in</strong>to the patient cl<strong>in</strong>ics.26Fall 2009www.eVMS.EDUdiabetes research

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