Curriculum Vitae: Terence R. <strong>Flotte</strong>PATENTS PENDING(6) "Methods and Compositions for Expressing a Nucleic Acid in a Dendritic <strong>Cell</strong>", Ref: UF# 10851(Womer, et.al.), 2003.(7) "Adeno-associated viral vectors for the treatment and prevention <strong>of</strong> Diabetes", U.S. Patent ApplicationSerial No. 10/340/112, Ref: UF#11223, 2003. Inventor(s): Terence <strong>Flotte</strong>, Sihong Song, Barry Byrne &Michael Morgan.(8) "Treatment for Phenylketonuria", U.S. Patent App. Serial No. 10/427/181. Inventor(s): Phil Laipis,Terence <strong>Flotte</strong>, Leticia Reyes, Bin Yan. UF# 10834.(9) "Improved rAAV Vectors for Enhancing Transduction <strong>of</strong> <strong>Cell</strong>s Expressing Low-Density LipoproteinReceptors". Inventors: Scott A Loiler, Terence R. <strong>Flotte</strong>, Nicholas Muzyczka and Mark A. Atkinson.Ref.#: UF#10708, Submitted 30 October 2003. Serial No. 10/511,914.(10) "Compositions and Methods for Treating Cystic Fibrosis". Inventor: Terence R. <strong>Flotte</strong>, et.al. Filed:September 3, 2004. UFRF Reference No.: 11249 U.S. Provisional Application No. 60/607,324.(11) "Delivery <strong>of</strong> <strong>Gene</strong>s to the Pancreas as a Method for Delivery <strong>of</strong> Therapeutic Molecules for Diabetesand Other Diseases", UF#-11668, 2005.LICENSING/CERTIFICATION/SELECTED MEMBERSHIPSMassachusetts <strong>Society</strong> for Medical Research, Board <strong>of</strong> Directors (2013-to present)Association <strong>of</strong> <strong>American</strong> Physicians (2010- present)Association <strong>of</strong> Medical School Pediatric Department Chairs, Inc. (06/02- 04/07)<strong>American</strong> Board <strong>of</strong> Pediatrics Pulmonary Sub-board Certification (April 1992)<strong>American</strong> Board <strong>of</strong> Pediatrics Certification (1989 – 1999)Alpha Omega Alpha Honor Medical <strong>Society</strong>, Member<strong>Society</strong> for Pediatric Research, Member<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong>, Member<strong>American</strong> <strong>Society</strong> <strong>of</strong> Microbiology, Member<strong>American</strong> Thoracic <strong>Society</strong>, Member<strong>American</strong> Medical Association, MemberMaryland State Medical License (inactive)Florida State Medical License (inactive)Massachusetts Medical License #23395Massachusetts Medical <strong>Society</strong>Massachusetts Medical <strong>Society</strong> House <strong>of</strong> DelegatesCOMMITTEESLiaison Committee on Medical Education <strong>of</strong> the <strong>American</strong> Med. Assn, AMA’s member (July 2012-2015)Advisory Council <strong>of</strong> the <strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> (ASGCT)(2011-present)Massachusetts Medical <strong>Society</strong>, Publications Committee (2011-2012)UMMHC/UMMMC Board <strong>of</strong> Trustees (2007-present)Commonwealth Medico Legal Commission (2007-present)Page 6 <strong>of</strong> 29
Curriculum Vitae: Terence R. <strong>Flotte</strong>Chancellor's Search Committee (2007-2008)Medical Claims Committee (2007-2008)Greater Worcester Community Foundation (2007-present)MDA Steering Committee (2007-present)<strong>Society</strong> for Pediatric Research Young Investigator’s Award Selection Committee (2006-2009)Task Force Committee for UF, Office <strong>of</strong> the Provost & Senior Vice President, Chairman (2006)Biomedical Engineering Endowed Chair Search Committee, UF (2006-2007)UF Department <strong>of</strong> Urology Chair Search Committee, Chairman (2005-2006)Association <strong>of</strong> Medical School Pediatric Department Chairs Executive Committee (2005-2007)The <strong>American</strong> Board <strong>of</strong> Pediatrics, Subboard Credentials Committee (2005-2008)McKnight Brain Institute Director Search Committee (2004)ASGT Clinical and Regulatory Affairs Committee, Chair (effective 06/02 to 6/06)National <strong>Gene</strong> Vector Laboratory Steering Committee (11/01-3/06)<strong>American</strong> Board <strong>of</strong> Pediatrics, Member (2006-present)<strong>American</strong> Board <strong>of</strong> Pediatrics Pulmonary Sub-Board (1/03-12/08)<strong>American</strong> Board <strong>of</strong> Pediatrics, Associate Member (2003-2008)<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> <strong>Therapy</strong> Clinical and Regulatory Affairs Committee (5/99-6/06)Cystic Fibrosis Foundation Research and Training Grant Review Committee (6/95-present)Advisory Council for Partner's in Care-Together for Kids Program (2006)University <strong>of</strong> Florida Institutional Biosafety Committee (IBC) (8/96-6/02)Chairman <strong>of</strong> AAV Working Group <strong>of</strong> FDA Rare Diseases Initiative (7/98-5/99)<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> <strong>Therapy</strong> Program Committee (3/97- 3/01)<strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> <strong>Therapy</strong> Scientific Committee on Cystic Fibrosis & Lung Diseases (3/97- 6/00)<strong>American</strong> Thoracic <strong>Society</strong> National Pediatric Assembly Program Committee (5/95-5/98)Abstract Review Committee for North <strong>American</strong> CF Conference (1993, 1995)Maryland Thoracic <strong>Society</strong> Research Planning Committee (7/93-6/96)Johns Hopkins Pediatric Residency Curriculum Committee (1/94-6/96)University <strong>of</strong> Florida Faculty Research Advisory Board (11/96-10/98)INVITED SYMPOSIUM PRESENTATIONS/MODERATOR DUTIES2012 14th Biennial International Parvovirus Workshop "Persistence <strong>of</strong> Transgene Expression 12 monthsafter Intramuscular Administration <strong>of</strong> a Recombinant Adeno—Associated Virus Alpha-1Antitrypsin Vector in a Phase 2 Clinical Trial". Cornell University, Ithaca NY, June 20, 20122012 <strong>American</strong> <strong>Society</strong> <strong>of</strong> <strong>Gene</strong> & <strong>Cell</strong> <strong>Therapy</strong> (ASGCT) 15th Annual Meeting, “Phase 2 rAAV1-AATTrial: 12-month follow-up”. Philadelphia, PA, May 18, 20122011 International Academy <strong>of</strong> Life Sciences, Advancing In The Life Science And Uniting Universities,Corporate And Government Partners. “The Value Chain – University As Center For Competence &Innovation”. University <strong>of</strong> Massachusetts Boston, Boston, Massachusetts, October 28, 2011.2011 NHLBI <strong>Gene</strong> and <strong>Cell</strong> <strong>Therapy</strong> (GCT) DSMB. “<strong>Gene</strong> <strong>Therapy</strong> for Single <strong>Gene</strong> Disorders Affectingthe Lung - review <strong>of</strong> the field in pulmonary gene therapy, gene/cell therapy trials ongoing and thediseases that should be targeted for gene/cell therapy in the future”. September 22, Rockville, MD2011 Children’s Hospital “Development <strong>of</strong> <strong>Gene</strong> <strong>Therapy</strong> for Single <strong>Gene</strong> Disorders” Boston, MA July 6 22010 Novartis “<strong>Gene</strong> <strong>Therapy</strong> Clinical Trials / Cystic Fibrosis and Alpha-1 antitrypsin Deficiency usingAAV vectors February 2, 20102010 Children’s Hospital “A new outlook on Lung Inflammation in CF” Boston, MA January 11, 20102008 Richard Talamo, M.D. Memorial Lecture, Invited Panelist, Boston, MA, November 19, 20082008 Wenzhou Medical College, Wenzhou, China, “<strong>Gene</strong> <strong>Therapy</strong> on Eye Diseases, November 11, 2008Page 7 <strong>of</strong> 29