Flotte Terry CV - American Society of Gene & Cell Therapy

Curriculum Vitae: Terence R. FlotteMoss RB, Gardner P. A phase II, double-blind, randomized, placebo-controlled clinical trial oftgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Hum GeneTher. 2002 Jul 20;13(11):1349-59. PubMed PMID: 12162817.126. Mah C, Fraites TJ Jr, Zolotukhin I, Song S, Flotte TR, Dobson J, Batich C, Byrne BJ. Improvedmethod of recombinant AAV2 delivery for systemic targeted gene therapy. Mol Ther. 2002Jul;6(1):106-12. PubMed PMID: 12095310.127. Flotte TR, Virella-Lowell I, Chesnut KA. Adeno-associated viral vectors for CF gene therapy.Methods Mol Med. 2002;70:599-608. PubMed PMID: 11917554.128. Kapturczak MH, Flotte T, Atkinson MA. Adeno-associated virus (AAV) as a vehicle fortherapeutic gene delivery: improvements in vector design and viral production enhance potential toprolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes. CurrMol Med. 2001 May;1(2):245-58. Review. PubMed PMID: 11899074.129. Flotte TR. Recombinant adeno-associated virus gene therapy for cystic fibrosis and alpha(1)-antitrypsin deficiency. Chest. 2002 Mar;121(3 Suppl):98S-102S. PubMed PMID: 11893723.130. Potter M, Chesnut K, Muzyczka N, Flotte T, Zolotukhin S. Streamlined large-scale production ofrecombinant adeno-associated virus (rAAV) vectors. Methods Enzymol. 2002;346:413-30. PubMedPMID: 11883083.131. Kapturczak M, Zolotukhin S, Cross J, Pileggi A, Molano RD, Jorgensen M, Byrne B, Flotte TR,Ellis T, Inverardi L, Ricordi C, Nick H, Atkinson M, Agarwal A. Transduction of human and mousepancreatic islet cells using a bicistronic recombinant adeno-associated viral vector. Mol Ther. 2002Feb;5(2):154-60. PubMed PMID: 11829522.132. Goudy K, Song S, Wasserfall C, Zhang YC, Kapturczak M, Muir A, Powers M, Scott-JorgensenM, Campbell-Thompson M, Crawford JM, Ellis TM, Flotte TR, Atkinson MA. Adeno-associatedvirus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice. Proc Natl Acad SciU S A. 2001 Nov 20;98(24):13913-8. PubMed PMID: 11717448; PubMed Central PMCID:PMC61141.133. Flotte TR. Gene therapy for cystic fibrosis. Curr Opin Mol Ther. 1999 Aug;1(4):510-6. Review.PubMed PMID: 11713767.134. Flotte TR. Recombinant adeno-associated virus vectors for cystic fibrosis gene therapy. CurrOpin Mol Ther. 2001 Oct;3(5):497-502. Review. PubMed PMID:11699895.135. Flotte TR. Size does matter: overcoming the adeno-associated virus packaging limit. Respir Res.2000;1(1):16-8. Epub 2000 Jul 5. Review. PubMed PMID:11667959; PubMed Central PMCID:PMC59536.136. Donsante A, Vogler C, Muzyczka N, Crawford JM, Barker J, Flotte T, Campbell-Thompson M,Daly T, Sands MS. Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.Gene Ther. 2001 Sep;8(17):1343-6. PubMed PMID: 11571571.Page 22 of 29