Encyclopedia of Traditional Chinese Medicines

xxii22270 Ursolic acidβ-Ursolic acid [77-52-1] C 30 H 48 O 3 (456.72).White solid powder (chloroform–methanol), mp 298~294ºC, 265~267ºC.HOHHOHHOPharm: (27 items)Cytotoxic (KB, ED 50 > 25μg/mL, control Doxorubicin, ED 50 = 0.12μg/mL; Hep3B, ED 50 >25μg/mL, control Doxorubicin, ED 50 = 0.14μg/mL; Colon205, ED 50 > 25μg/mL,control Doxorubicin, ED 50 = 0.10μg/mL; HeLa, ED 50 > 25μg/mL, control Doxorubicin,ED [4369] 50 = 0.11μg/mL) ;cytotoxic (in vitro, HONE-1 cell, IC 50 = (8.8±1.5)μmol/L, control Etoposide, IC 50 =(0.5±0.2)μmol/L, cis-Platin, IC 50 = (3.2±0.5)μmol/L; KB cell, IC 50 = (8.2±2.7)μmol/L,Etoposide, IC 50 = (0.9±0.3)μmol/L, cis-Platin, IC 50 = (4.4±0.9)μmol/L; HT29 cell, IC 50= (4.7±1.5)μmol/L, Etoposide, IC 50 = (2.4±0.5)μmol/L, cis-Platin, IC 50 =(5.7±1.1)μmol/L) [5254] ;antineoplastic (liver cancer cells in vitro, mus ascites carcinoma in vivo, life wasprolonged);antibacterial (Escherichia coli, IZD = 13~15mm, control Chloramphenicol, IZD =16~20mm, control DMSO (4%), IZD < 10mm; Staphylococcus aureus, IZD =10~12mm, control Chloramphenicol, IZD = 16~20mm, control DMSO (4%), IZD