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Application for the Reassessment of
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6.1 Evaluation of options to streng
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EXECUTIVE SUMMARYIn briefERMA New Z
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Aerosol containing 50 g/kgdichlorvo
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ERMA New Zealand‘s recommendation
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26 - 29Outdoor public space usage30
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Substance details1-8,11-16,20-25,30
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1.2.3 In 2008, the Environmental Ri
- Page 17 and 18: Table 1. Dichlorvos-containing subs
- Page 19 and 20: public environments and use for bio
- Page 21 and 22: available to it. In preparing this
- Page 23 and 24: 3.3 International regulatory positi
- Page 25 and 26: 3.6 Classification3.6.1 The HSNO cl
- Page 27 and 28: Hazard Class /SubclassClassificatio
- Page 29 and 30: Hazard Class /SubclassClassificatio
- Page 31 and 32: Rates:Fogging: 13 ml / litre (water
- Page 33 and 34: BV2 SurfaceInsecticideBV2 SurfaceIn
- Page 35 and 36: Table 7.Dichlorvos outdoor and indo
- Page 37 and 38: Scenario Crop/Use Method Rate Appli
- Page 39 and 40: humidity conditions. The higher res
- Page 41 and 42: 4.3 EnvironmentIdentification of ad
- Page 43 and 44: 4.3.9.3 Aquatic environment - Groun
- Page 45 and 46: is considered to be highly improbab
- Page 47 and 48: RiskGroupRQ range Level of risk Use
- Page 49 and 50: RiskGroupRQ range Level of risk Use
- Page 51 and 52: assessment, as the Use Scenario inc
- Page 53 and 54: Nonnegligible1 < RQ < 10Nonnegligib
- Page 55 and 56: Table 12.LifecycleStageImport,manuf
- Page 57 and 58: LifecycleStageUse -bystanderUseScen
- Page 59 and 60: Table 13.Identification of benefici
- Page 61 and 62: value that can be attributed to dic
- Page 63 and 64: outbreak, MAF‘s ability to demons
- Page 65 and 66: the duty of the Crown is not merely
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- Page 73 and 74: RapidbiodegradationCrop Pest Active
- Page 75 and 76: 5.2.5 ERMA New Zealand identified t
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- Page 79 and 80: 6.1.9.2 Specified PPE/RPE:ERMA New
- Page 81 and 82: 6.1.13.3 Guidance to provide inform
- Page 83 and 84: Use Scenario Receptor Level of Risk
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- Page 87 and 88: Use Scenario Receptor Level of Risk
- Page 89 and 90: Use Scenario Receptor Level of Risk
- Page 91 and 92: Use Scenario Receptor Level of Risk
- Page 93 and 94: Use Scenario Receptor Level of Risk
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- Page 105 and 106: SECTION 7 - OVERALL EVALUATION7.1 E
- Page 107 and 108: 7.2 Overall Evaluation7.2.1 A summa
- Page 109 and 110: Table 19.Overall evaluation - summa
- Page 111 and 112: ApprovalnumberSubstanceDescriptionO
- Page 113 and 114: Substance detailsHSR000212Aerosolco
- Page 115 and 116: 7.3.12 In preparing this applicatio
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Table A.2:Methods of analysisAnalyt
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GC/FPD (cross reference KIIA 4.2.4/
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Degradates, 2,2-dichloroacetic acid
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Appendix C: Environmental Exposure
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Table C.3:Output from GENEEC2 expos
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-----------------------------------
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Terrestrial exposureBirds - food ex
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3 Cereals3 Cereals(BBCH 30-39)(BBCH
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(BBCH 71-89)3 Bush &canefruit(BBCH
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Plants and soil organisms, off-targ
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The vegetation distribution factor
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eastern oyster(Crassostreavirginica
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JapanesequailJapanesequailJapaneseq
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Environmental classificationOn the
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TER= LD 50 / estimated environmenta
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Comparison of levels of concern (Ta
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(BBCH 10-19)3 Leafy + fruitingveget
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Table E.8:Earthworm -TER in-fieldAp
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Restricting application rates or fr
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1 PURPOSE1.1 The purpose of this re
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19 Specific Target Organ Toxicity 6
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3 TOXICOLOGICAL HAZARD PROFILE - IN
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urinary parameters, or on organ wei
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(Casida et al., 1962). Dichlorvos w
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The US EPA (2006) reported that:4.2
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4.4 Elimination:CalDRP (1996) repor
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5 ACUTE ORAL 6.1HSNO Classification
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The ATSDR (1997) reported:“A numb
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in Table 10.1 of the User Guide to
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autopsy: distended lung; oedematous
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Acute inhalation toxicity of dichlo
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Wuppertal-Elberfeld. Report date: 2
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• Reference source:• Reliabilit
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11 CONTACT SENSITISATION 6.5BHSNO C
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persistent vertical, mildly erythem
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In summary, dichlorvos is mutagenic
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The APVMA (2008a) summarised:―Num
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“The lack of dichlorvos genotoxic
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following i.p. administration of si
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historical control range (0-28%). C
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(APVMA, 2008a)• NOAEL < 4 mg/kg b
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FemaleLogisitic Regression Tests P
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BACKGROUND:The ATSDR (1997) summari
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―Dichlorvos has been formulated f
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“Mortalities, Clinical Signs and
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carcinogenicity found in mice follo
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ChE activity: There was a significa
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from Charles River Laboratories (CR
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eceiving dichlorvos by capsule for
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• Endpoint:Appearance, behaviour,
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• Endpoint:Appearance, behaviour,
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live fetuses were weighed and exami
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evidence is insufficiently suggesti
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(p
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June 1992. Report date: 15th Januar
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• Test Guideline:No information;
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surviving animals appeared to behav
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of 2-year treatment period. No effe
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ChE inhibition: There was a clear d
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levels, analytical dichlorvos conce
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21 SPECIFIC TARGET ORGAN TOXICITY 6
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odyweight depressed by 10-13% (only
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― … Total and differential leuc
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[See earlier Sections for Key Studi
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“Conclusions: A single oral dose
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“Necropsy: Macroscopic examinatio
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24 HUMAN EXPOSURE REPORTSThe APVMA
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volunteers. Erythrocyte acetylcholi
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25.1 Key Study:KEY STUDY: Oral• T
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• Species:• Strain:• Sex/Numb
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impairment of visual performance, n
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Absorption factors:[See Section 4 A
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26 SUMMARY & CONCLUSIONSCLASS 6 & 8
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Hazard Class/SubclassHazardclassifi
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Critical NOAEL/LOAEL used for occup
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WHO, 1988. ―INTERNATIONAL PROGRAM
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―It is considered that the most s
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and on a weekly basis for 4 weeks:
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Plasma ChE activity in additional m
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Appendix G: Human Health Risk Asses
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1 PURPOSE1.1 The purpose of this re
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2SUBSTANCE IDENTIFICATIONIUPAC name
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Table I: Dichlorvos Use ScenariosSc
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4OPERATOR EXPOSURE & RISK ASSESSMEN
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14, the mixing/loading component of
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enclosed space applications. Head/n
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handled. The APVMA considered that
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abcdeUK CRD interpretation of the G
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Application: no PPE 57 0.2955 )abcU
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Table V: Occupational Exposure Esti
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Table VI: Occupational Exposure Est
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Table VII: Occupational Exposure Es
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Operation / RPE / PPETable VIII: Oc
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Table IX: Residential Exposure Esti
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Conclusions on operator exposure es
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25, surface spraying of larger spac
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and peas 20 minutes after applicati
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5.18 The Task Specific Factors (TSF
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abcdefgUK CRD Guidance for Post-App
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Table XIII: Re-entry into glasshous
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5.34 No REI for treated glasshouses
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At 72 mg dichlorvos/m 3 (1800g a.i.
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5.46 In this instance, after treatm
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Re-entry into treated mushroom hous
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[Note: P001132 Nuvos label gives a
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Table XVIII: Re-entry into building
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characteristics of different buildi
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5.88 Re-entry for ventilation of in
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in the EPA Exposure Factors Handboo
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determine the Risk Quotient (RQ). T
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Bystander and resident exposure & r
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indicates the likelihood of an unac
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7 SUMMARY AND CONCLUSIONS7.1 TCL es
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7.4 Cymbidium: EC dichlorvos soluti
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7.16 Re-entry into cereals treated
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7.31 Estimated exposures to childre
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UK CRD, 2008c. ―OPERATOR EXPOSURE
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espirator with a dust/mist prefilte
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Appendix 2:Occupational Exposure Es
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B)Operator exposures during manual
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[0.625 x {(0.018 x 0.05) + (2.68 x
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Appendix 3:Occupational Exposure Es
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Then accepting the inhalation absor
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The APVMA considered that the predi
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Appendix 5Re-entry Worker Exposure
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Appendix 6Resident Exposures to Dic
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Object to mouth exposures were calc
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Domestic Indoor Surface Application
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Children‘s total exposure was est
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Last PageDichlorvos reassessment -
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Risk QuotientDichlorvos Mixing Load
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Open SpacePublic SpaceManual Foggin
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MajorMassiveSignificant irreversibl
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Table H4.4Level of riskMagnitude of
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Toxicity and environmental data on
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Endpoint Units * L M N 1N 2 N 3 N 4
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Ecotoxicity mixture calculationsSub
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Appendix J: Current ControlsHSNO Ac
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PackagingcontrolsDisposalcontrolsEm
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Controlsrelating toStationaryContai
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Hazardous Substances (Classes 1 to
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Hazardous Substances (Classes 6, 8,
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Hazardous Substances (Classes 6, 8,
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Hazardous Substances (Personnel Qua
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Hazardous Substances (Identificatio
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y the previous source of manufactur
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Table J.6:Agricultural Compounds an
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Outcome of risk assessment for form
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Product Use Further details ofuseAp
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5. Include in label instructions a
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For each of the US permitted uses,
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Current UsesIn the past dichlorvos
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Appendix M: ACVM and other NZFSA ad
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organismsProviding generalassessmen
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egistration subject to conditions;
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34. The MRLs vary from country to c
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Production Food Safety (APFSWG) whi
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64. Based on a Joint meeting of the
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Appendix N: Plant & Food Research R
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Urban D.J., Cook, N.J. (1986). Haza