Application for the Reassessment of a Hazardous Substance under ...

With overalls and gloves (protection factors applied to the body areas covered):[1 x {0.184 + (26.8 x 0.2) + (2.55 x 0.1)} x 0.3] / 70 = (5.799 x 0.3) / 70 =1.7397 / 70 = 0.0249 mg/kg b.w.With full-body chemical resistant clothes and gloves:[1 x {(0.184 x 0.05) + (26.8 x 0.05) + (2.55 x 0.1)} x 0.3] / 70 = (1.6042 x 0.3) / 70 =0.4813 / 70 = 0.0069 mg/kg b.w.Inhalation exposures:PHED model 19 predicted the inhalation exposure rate was 0.174 mg a.i./kg handled.= amount active handled [kg] x inhalation exposure [mg/kg handled]1 x 0.174 = 0.174 mg a.i./personThen accepting the inhalation absorption factor of 100%, and dividing by 70 kg b.w.,the systemic dose will be:(0.174 x 1.00) / 70 = 0.0025 mg/kg b.w.If RPE is considered to mitigate exposures, APVMA used 10% penetration of half-facerespirators; 2% penetration of full-face respirators; and, no penetration of air-hoserespirators or SCBA (Thongsinthusak et al., 1993; Original not sighted):With half-face (protection factor applied):((1 x 0.174) x 0.10) / 70 = 0.0174 / 70 = 0.0003 mg/kg b.w.With full-face (protection factor applied):((1 x 0.174) x 0.02) / 70 = 0.0035 / 70 = 0.00005 mg/kg b.w.Dichlorvos reassessment – application Page 365 of 436