Application for the Reassessment of a Hazardous Substance under ...

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7.31 Estimated exposures to children after public space applications (Scenario 30)indicate very high risk (RQs of >>1) could result from contact with contaminatedsurfaces (i.e. from playing on sprayed turf). While, the calculated exposures willhave been over-estimated in these models, because no dissipation of dichlorvoshas been factored in [see Table XXII], the risk levels are unacceptably high.Dichlorvos reassessment – application Page 348 of 436
REFERENCES:APVMA, 2008a. ―DICHLORVOS - Toxicology Assessment: The reconsideration ofapprovals of the active constituent, registrations of products containing dichlorvos andapprovals of their associated labels.‖ Australian Pesticides & Veterinary MedicinesAuthority, KINGSTON ACT 2604; 2008.APVMA, 2008b. ―DICHLORVOS - OCCUPATIONAL HEALTH AND SAFETYASSESSMENT: The reconsideration of approvals of the active constituent, registrationsof products containing dichlorvos and approvals of their associated labels.‖ AustralianPesticides & Veterinary Medicines Authority, KINGSTON ACT 2604; 2008.ATSDR, 1997. ―TOXICOLOGICAL PROFILE FOR DICHLORVOS‖ Agency forToxic Substances and Disease Registry, Atlanta, Georgia 30333; 1997.CalDPR, 1996. ―DICHLORVOS (DDVP): RISK CHARACTERIZATIONDOCUMENT.‖ Medical Toxicology and Worker Health and Safety Branches,Department of Pesticide Regulation, California Environmental Protection Agency.Franklin, C. & Worgan, J.P., 2005. ―Occupational and Residential ExposureAssessment for Pesticides.‖ John Wiley and Sons; ISBN 0471489891, 9780471489894.[Abstract only]UK CRD, 1992. ―Uniform Principles for Safeguarding the Health of Applicators ofPlant Protection Products.‖ Biologische Bundesanstalt für Land- und Forstwirtschaft,Bundesgesundheitsamt, und Industrieverband Agrar e.V. ISBN 3489-27700-7. 1992;http://www.pesticides.gov.uk/uploadedfiles/Web_Assets/PSD/German_Model_PSD1.xls [professional mixer/loader/applicator models]UK CRD, 2006; [Amateur: Aerosol Surface Treatment Model]http://www.pesticides.gov.uk/uploadedfiles/Web_Assets/PSD/Amateur%20use%20model2.xlsUK CRD, 2007; [Revised UK Predictive Operator Exposure Model (UK POEM): homegarden model]http://www.pesticides.gov.uk/uploadedfiles/Web_Assets/PSD/UK_POEM_07.xlsUK CRD, 2008a. ―GUIDANCE FOR POST-APPLICATION (RE-ENTRY WORKER)EXPOSURE ASSESSMENT.‖http://www.pesticides.gov.uk/approvals.asp?id=2422&link=%2Fuploadedfiles%2FWeb%5FAssets%2FPSD%2FRe%2Dentry%2520worker%2520guidance%5Ffinal%2520version%2EpdfUK CRD, 2008b. ―BYSTANDER EXPOSURE GUIDANCE.‖http://www.pesticides.gov.uk/approvals.asp?id=2428&link=%2Fuploadedfiles%2FWeb%5FAssets%2FPSD%2FBystander%2520exposure%2520guidance%5Ffinal%2520version%2EpdfDichlorvos reassessment – application Page 349 of 436
Page 1 and 2:
Application for the Reassessment of
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6.1 Evaluation of options to streng
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EXECUTIVE SUMMARYIn briefERMA New Z
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Aerosol containing 50 g/kgdichlorvo
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ERMA New Zealand‘s recommendation
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26 - 29Outdoor public space usage30
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Substance details1-8,11-16,20-25,30
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1.2.3 In 2008, the Environmental Ri
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Table 1. Dichlorvos-containing subs
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public environments and use for bio
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available to it. In preparing this
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3.3 International regulatory positi
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3.6 Classification3.6.1 The HSNO cl
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Hazard Class /SubclassClassificatio
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Hazard Class /SubclassClassificatio
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Rates:Fogging: 13 ml / litre (water
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BV2 SurfaceInsecticideBV2 SurfaceIn
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Table 7.Dichlorvos outdoor and indo
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Scenario Crop/Use Method Rate Appli
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humidity conditions. The higher res
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4.3 EnvironmentIdentification of ad
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4.3.9.3 Aquatic environment - Groun
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is considered to be highly improbab
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RiskGroupRQ range Level of risk Use
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RiskGroupRQ range Level of risk Use
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assessment, as the Use Scenario inc
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Nonnegligible1 < RQ < 10Nonnegligib
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Table 12.LifecycleStageImport,manuf
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LifecycleStageUse -bystanderUseScen
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Table 13.Identification of benefici
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value that can be attributed to dic
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outbreak, MAF‘s ability to demons
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the duty of the Crown is not merely
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5.1.7.1 J. Hicking stated that dich
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Table 14. Comparative of hazard cla
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Crop Pest Active ingredient Preharv
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Crop Pest Active ingredient Preharv
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SECTION 6- PROPOSALS TO MANAGE RISK
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Assessment was carried out with spe
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6.1.11 Controls to protect bystande
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Table 16Effect of additional contro
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Use Scenario Receptor Level of Risk
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have, and notes the following as ar
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Table 18Summary of benefits associa
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UseScenariosAssessment ofEffectOutc
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Substance detailsHSR000126DDVPInsec
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Table 22.there are no practicable r
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7.4 Preliminary Recommendations7.4.
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method and LOQ)Water (principle ofm
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Appendix B: Environmental Fate of d
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Bioconcentration factor Gnathopogon
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Table C.2:Scenarios used in exposur
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Scenario 3: Vegetables - 1 applicat
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FIELD AND STANDARD POND HALFLIFE VA
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insectivorous bird7 Passionfruit Sm
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4 Leafyvegetables(BBCH ≥50)4 Leaf
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summer)7 passionfruit(BBCH 10-19)7
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Ground (lowboom)0.03 0.03 1.07 1.07
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Appendix D: Ecotoxicity of dichlorv
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ioaccumulationClearance timeLevel o
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Table D.5:Toxicity to terrestrial i
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Appendix E: Risk Assessment: Enviro
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Aquatic organsimsTable E.3:Environm
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12345Crop type Table I.1 (Annex 1)
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7 passionfruit(BBCH 20-39)7 passion
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Fruit (tree) 2052 70759 >50Passionf
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Appendix F: Human Toxicity of dichl
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CONTENTS:Title Page 11 Purpose 2Con
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2 SUBSTANCE IDENTIFICATIONIUPAC nam
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However, dichlorvos has genotoxic p
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4 ABSORPTION, DISTRIBUTION, METABOL
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aerosol cans (230-330 g dichlorvos)
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4.3 Metabolism:found in tissues of
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dose of 1.0 mg/kg bw, a single gava
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eports. LD 50 = 46.4 mg/kg b.w. is
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6 ACUTE DERMAL 6.1HSNO Classificati
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7 ACUTE INHALATION 6.1HSNO Classifi
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measured and it was not possible to
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8 SKIN IRRITATION 6.3 & CORROSION 8
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9 EYE IRRITATION 6.4 & CORROSION 8.
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10 RESPIRATORY SENSITISATION 6.5AHS
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Justification for Classification: U
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12 MUTAGENICITY 6.6HSNO Classificat
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ERMA New Zealand CONFIDENTIAL Repor
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The ATSDR (1997) reported:“Dichlo
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•ATSDR (1997): http://www.atsdr.c
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13 CARCINOGENICITY 6.7HSNO Classifi
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fibroadenomas were observed in 6 (1
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• Sex/Numbers:• Test material:
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The NTP Peer Review concluded that:
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concurrent studies for comparison w
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The APVMA (2008a) reported a chroni
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was exposed. The estimated daily in
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14 REPRODUCTIVE TOXICITY 6.8HSNO Cl
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ppm during premating days, signific
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Toxicology, Chemistry and Life Scie
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addition, there was an increase in
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• Maternal toxicity NOAEL =• Ma
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Research Triangle Park, North Carol
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16 REPRODUCTIVE OR DEVELOPMENTAL TO
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17 SPECIFIC TARGET ORGAN TOXICITY 6
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There was a significant dose-relate
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KEY STUDY:• Type of study:• Spe
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BACKGROUND:The APVMA (2008a) also r
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cholinesterases can only be estimat
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Ltd, Sittingbourne Research Center,
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23 OTHER POTENTIAL TOXIC ENDPOINTS2
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―Results“Mortalities and clinic
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1984). QA study. Study conducted ac
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“No information was located on im
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“Comment: These incidents clearly
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25 ACCEPTABLE OPERATOR EXPOSURE LEV
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to pretreatment activity). When the
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cholinesterase inhibition in health
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protect agricultural workers who ha
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Wash: refers to skin washes; Dressi
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Hazard Class/SubclassHazardclassifi
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Hazard Class/SubclassHazardclassifi
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REFERENCES:APVMA, 2008a. ―DICHLOR
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Appendix 1:APVMA - Summary of bench
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“Inhalational NOEL for Occupation
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activity). In fact, treatment was s
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LAST PAGEDichlorvos reassessment -
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Dichlorvos:Occupational, Bystander,
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CONTENTS:Title Page 11 Purpose 2Con
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3ACTIVITY SCENARIOS3.1 Table (I) su
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access of bystanders to treated are
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can reduce dermal exposures to mixe
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contaminated with, respectively 0.0
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The modelling is based upon dischar
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Table II: Occupational Exposure Est
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Table III: Occupational Exposure Es
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Operation / RPE / PPETable IV: Occu
Page 297 and 298: 1.25L product/ha; work rate, 1.25 h
Page 299 and 300: Application: Air-hose RPE + chem. r
Page 301 and 302: Application: Half-face RPE + overal
Page 303 and 304: P for RPE (% penetration): none, 1
Page 305 and 306: Table X: Occupational Exposure Esti
Page 307 and 308: provided: work day exposure is limi
Page 309 and 310: 5POST-APPLICATION OR RE-ENTRY WORKE
Page 311 and 312: D = DFR x TC x DA x WR x AR x P / B
Page 313 and 314: Re-entry into out-door crops (Scena
Page 315 and 316: Re-entry into treated glasshouses d
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Page 319 and 320: Re-entry into treated glasshouses u
Page 321 and 322: Table XVII: Re-entry into glasshous
Page 323 and 324: lowest use rate (52 mg/m 3 ; 1300g
Page 325 and 326: DA = percentage dermal absorption [
Page 327 and 328: Re-entry into treated enclosed indu
Page 329 and 330: nature of the building itself, not
Page 331 and 332: Conclusions on re-entry worker expo
Page 333 and 334: 6BYSTANDER & RESIDENT EXPOSURE & RI
Page 335 and 336: Children’s incidental ingestion o
Page 337 and 338: Table XX: Spray driftExposure throu
Page 339 and 340: Exposure through contactwithcontami
Page 341 and 342: Conclusions on bystander and reside
Page 343 and 344: Table XXIII: Dichlorvos Use Scenari
Page 345 and 346: mixing/loading. Mixing/loading fogg
Page 347: 7.23 Re-entry for ventilation of in
Page 351 and 352: Appendix 1:Occupational Exposure Es
Page 353 and 354: FactorExposure (μg/kg a.i. handled
Page 355 and 356: Inhalation exposure from cylinder c
Page 357 and 358: [0.01875 x {(0.018 x 0.05) + (2.68
Page 359 and 360: With half-face respirator (protecti
Page 361 and 362: With full-body chemical resistant c
Page 363 and 364: Appendix 4:Occupational Exposure Es
Page 365 and 366: With overalls and gloves (protectio
Page 367 and 368: The Dermal Exposure (D) is 2.06 μg
Page 369 and 370: TTR = turf transferable residues -
Page 371 and 372: F = fraction of residue retained on
Page 373 and 374: TTR = transferable residues - the E
Page 375 and 376: Public Space ApplicationsScenario (
Page 377 and 378: ERMA New Zealand‟s comment on the
Page 379 and 380: Enclosed SpaceAgricultural UseOutdo
Page 381 and 382: Appendix H: Qualitative Descriptors
Page 383 and 384: 1.3. The likelihood applies to the
Page 385 and 386: Appendix I: Data from which classif
Page 387 and 388: Endpoint Units * Dichlorvos Propoxu
Page 389 and 390: Toxicity mixture calculationsSubcla
Page 391 and 392: Subclass 9.3 -Ecotoxicity to terres
Page 393 and 394: Table J.1:Existing controls for dic
Page 395 and 396: TrackingcontrolsIdentification cont
Page 397 and 398: Table J.2:Summary of default contro
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Hazardous Substances (Classes 1 to
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Hazardous Substances (Classes 6, 8,
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Hazardous Substances (Classes 6, 8,
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(a) means piping that—(i) is conn
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Code I29 Regs 51, 52 Signage requir
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Non-HSNO Act controlsAgricultural C
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Appendix K: Overseas regulatory act
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Product Use Further details ofuseSu
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Risk assessment identified concerns
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Current usesFormulations:Methods of
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CanadaStatusPMRA are undertaking a
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Appendix L: Parties consulted durin
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Animal Products Act 19995. The purp
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14. Regulatory control of these pro
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Zealand‘s trade in primary produc
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processed and stored. It employs ve
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may be taken to risk management in
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Appendix A• Agricultural Compound
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Appendix O: ReferencesACVM (2010) h
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