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Muller categorized mutations with respect tochange in gene function relative to wildtypeLoss-of-(wildtype)function (l-o-f) mutant alleles“Gain”-of-(over wildtype)function (g-o-f) mutant alleles
to infer the normal function of a gene:LOF allelesGOF allelessimplest to interpret…to understand what (if anything) they aretelling us about the wildtype gene functionone needs to know the null mutant phenotype.Can use GOF alleles to generate LOF alleles relatively easily:“revert” (suppress) the dominance of a GOF alleleLOF alleleIllustrated by:ovo D1 antimorphovo e8K hypomorphHow would we know if these female-sterile mutant allelesare in the same gene?
Page 1: Mutations (changes in DNA):the life
Page 6 and 7: Muller did not just define the five
Page 8 and 9: See how the phenotype changes when
Page 10 and 11: w apricotpartial lof:hypomorph(ic)I
Page 12 and 13: “Gain”-of-(over wildtype)functi
Page 14 and 15: Categorized with respect to:Mutatio
Page 16: categories of conditional mutations

alleles

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