เนืองอก (Neoplasm)
เนืองอก (Neoplasm) เนืองอก (Neoplasm)
22/11/55• Benign tumor :Macroscopic Features– Sharply demarcated– Encapsulated– Homogenous– Easy to remove• Malignant tumor :– Lack a capsule– Invade the surrounding tissue– Heterogeneous with hemorrhage and necrosis– Difficult to totally removeMicroscopic FeaturesWellDifferentiated• Benign tumor :– Well differentiated (resemble tissue of origin)– No anaplasia• Malignant tumor :– Poorly differentiated or undifferentiated– Prominent anaplasia (different from normaltissue considerably)http://www.grin.com/object/external_document.237742/03859758dd392bf614e1ff70bcd4a902_LARGE.pngPoorlyDifferentiated(Anaplasia)2
22/11/55• Benign tumor :Cell Growth– Uniform cell population with regular shape nuclei– Slower growth rate• Malignant tumor :– Heterogeneous cell population– Nuclear pleomorphism (variable in size, shape,and staining properties)– High N/C ratio with prominent nuclei– Faster growth ratehttp://upload.wikimedia.org/wikipedia/commons/5/5b/Uterine_leiomyoma_(2).jpgLeiomyomaLocal Invasion and Metastasis• Benign tumor :– Expansive growth and compress adjacentnormal tissue– Remain localized• Malignant tumor :– Invasion to the surrounding tissue– Capable of distant metastasisLeiomyosarcomahttp://www.uaz.edu.mx/histo/pathology/ed/ch_18/c18_leiomyosarc.jpg3
- Page 1: 22/11/55http://www.clipartreview.co
- Page 5 and 6: 22/11/55Mesenchymal tumors• Benig
- Page 7 and 8: 22/11/55Physical carcinogens• Rad
- Page 9 and 10: 22/11/55Invasion and Metastasis•
- Page 11: 22/11/55References• Damjanov I.,
22/11/55• Benign tumor :Macroscopic Features– Sharply demarcated– Encapsulated– Homogenous– Easy to remove• Malignant tumor :– Lack a capsule– Invade the surrounding tissue– Heterogeneous with hemorrhage and necrosis– Difficult to totally removeMicroscopic FeaturesWellDifferentiated• Benign tumor :– Well differentiated (resemble tissue of origin)– No anaplasia• Malignant tumor :– Poorly differentiated or undifferentiated– Prominent anaplasia (different from normaltissue considerably)http://www.grin.com/object/external_document.237742/03859758dd392bf614e1ff70bcd4a902_LARGE.pngPoorlyDifferentiated(Anaplasia)2
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