universiti putra malaysia protective effect of phenobarbitone and ...

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with zinc in the rumen of sheep, perhaps in a way similar to the binding of zinc to saponin (Price et al., 1987). Chemoprotection or chemoprevention is an emerging strategy for disease prevention and treatment (Eaton and Groopman, 1994). Chemoprotection is now known as an effective approach for cancer prevention in human, particularly against aflatoxin induced liver cancer (Hong et al., 1990; Eaton and Groopman, 1994). For instance, administration of oltipraz, a schistosomicidal drug, was found to induce the activity of glutathione-S transferase and several other drug-metabolizing enzymes, which are involved, either directly or indirectly, in the detoxification of carcinogens (Roebuck et al., 1991). The possibility that increases in these enzymes may lead to enhanced detoxification of carcinogens and other toxic substances provided the evidence to predict excellent chemoprotection following the use of drug-metabolizing enzymes inducers. Many studies showed that phenobarbitone (Cook and Wilson, 1970; Shetty et al., 1972; Ford et aI., 1976 and Swick et al., 1983) and griseofulvin (Olantunde et al., 1999) have a potential to induce drug metabolizing enzymes and can increase the effectiveness of xenobiotic detoxification in human and animal. 2
The objectives of this study were to investigate the following:- 1. To determine the protective effect of phenobarbitone and griseofulvin in B. decumbens toxicity by inducing drug metabolizing enzyme activities in sheep. 2. To compare the effectiveness of phenobarbitone and griseofulvin in inducing drug metabolizing enzymes activities for the protection of B. decumbens toxicity in sheep. 3
Page 1 and 2: UNIVERSITI PUTRA MALAYSIA PROTECTIV
Page 3 and 4: "To my beloved family and all those
Page 5 and 6: concentration of formaldehyde and p
Page 7 and 8: glucuronyltransferase dengan mengan
Page 9 and 10: I certify that an Examination Commi
Page 11 and 12: DECLARATION I hereby declare that t
Page 13 and 14: 3 GENERAL MATERIALS AND METHODS 36
Page 15 and 16: Table 2 3 4 LIST OF TABLES Protein
Page 17 and 18: Plate 2 3 4 LIST OF PLATES Signal g
Page 19: CHAPTERl INTRODUCTION The rearing o
Page 23 and 24: 03 APR 2008 High productivity, tole
Page 25: lood urea nitrogen (BUN) creatinine

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