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In view of procuring highly potent biodynamic agents and after reviewingrecent literature survey on oxo/thio/amino pyrimidines for their variousmethods of synthesis and different pharmacological activities, synthesis ofpyrimidines have been undertaken which can be summarized in the followingsections as follows:SECTION - I :Synthesis and therapeutic evaluation of 6-(2-(4-chlorophenyl)- 8-methyl-1H-imidazo[1,2-a]pyridine-3-yl)-4-aryl pyrimidine-2(H)-one.SECTION - II :Synthesis and therapeutic evaluation of 6-(2-(4-chlorophenyl)- 8-methyl-1H-imidazo[1,2-a]pyridine- 3-yl)- 4-aryl pyrimidine-2(H)-thione.SECTION – III :Synthesis and therapeutic evaluation of 4-(2-(4-chlorophenyl)- 8-methyl-1H-imidazo[1,2-a]pyridine-3-yl)- 6-aryl pyrimidine-2-amine.62Pyrimidine…..