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have reported the 5-substitutedfuro [2,3-d] pyrimidines (24) for enzymeinhibitoryactivity and antitumor activity.CO-L-GluNH 2(CH 2 )nNN H 2NO(24) n = 4PYRIMIDINES AS ANTITUMOUR AGENTSA number of other pyrimidine antagonists displaying antitumour activity,in which the base is conjugated to a modified suger ring have been reported.Although D-Arabinofuranosyl uridine (ara-uridine) shows no useful acitivity and5-bromo- and 5-iodo-D-arabinofuranosyl uridine inhibit the growth ofsarcoma 180 and L1210 cells in culture. 271 Other thymidine analogues withsimilar activity include 5-azidomethyl-,5-aminomethyl and 5-hydroxymethyl-2’-deoxyuridine 272 . 3’-Amino-3’-deoxy thymidine 273 and 3’-amino-2’,3’-dideoxycytidine 274 also posses strong activity against L1210 leukaemia 2’-Deoxy-2’-fluoro-5-methyl-1-B-D-arabinofuranosyluracil (FMAU);(25) is highlyactive against arabinofuranosyl cytidine (ara-C) resistant L1210 and P815 celllines both in vitro and in vivo. 275 2-B-D-Ribofuranosylthiazole-4-carboxamide (Tiazofurin; 26) has aroused much interest recently for its activity againstsolid tumour such as lung carcinoma. It is metabolized to an analogue of NADin which the thiazole-4-carboxamide moiety replaces the nicotinamide ring.55Pyrimidine…..