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Furthermore, Alcaraz M.J, et al. 138 have described the role of nuclear factorkappaβ and heme oxygenase-1 in the mechanism of action of anti-inflammatorychalcone derivative in RAW 264.7 cells. Nerya O et al. 139 have prepared some newChalcones as potent tryosinase inhibitors.OCH 3OOOHOCH 3Type-VSabzevari O. et al. 140 have constructed some new chalcone derivatives asMolecular cytotoxic mechanism of anticancer hydroxy chalcones (Type-V).Recently, Ban H.S. et al. 141 synthesized some novel chalcones as inhibitionof lipopolysaccharide-induced expression of inducible nitric oxide synthesis andtumor necrosis factor-alpha by 2’-hydroxychalcone derivatives in RAW 264.7 cells.Hollosy F.et al. 142 have prepared some new chalcones as Plant-derived proteintyrosine kinase inhibitors as anticancer agents.Chalcone beaing a very good synthon variety of novel heterocycles with goodpharmacological profile can be designed. These valid observation led us to explorechalcone chemistry by synthesising several derivatives like pyrazolines,cyanopyridines, cyanopyridones, cyclohexenones, indazoles and aminopyrimidinesbearing different heterocyclic ring systems for medicinal value, in order to achievingbetter therapeutic agents, this study described as under.28Chalcone…..