Download (3100Kb) - Etheses - Saurashtra University

(l) Non steroidal anti-inflammatory drugs (NSAID)Drugs, which gives relief from fever, pain and inflammation are called NSAID.Novel NSAID are Pyroxicam, Meloxicam and Nimesulide.Different kind of drugs generally used are designed as anesthetic,antiviral,antibacterials,antifungal,antianxiety,antiinflammatory,analgesic,antipyretic,antiulcerand hypnotics which prompted us to synthesis drugs having Imidazo[1,2-a]pyridinemoieties as a better therapeutic activity.AIMS & OBJECTIVESAims and objectives of the present investigation are:(a) To generate several Chalcone,Pyrimidine,Isoxazole,Pyrazoline,Cyclohexinone,Oxirane derivatives bearing Imidazo[1,2-a]pyridine moiety.(b) To characterize these products for their structural assignment using variousSpectroscopic techniques like IR, 1 H NMR and Mass spectroscopy.(c) To screen these new derivatives for their antimicrobial activity using differentStrains of bacteria and fungi and to compare antimicrobial activity with differentknown drugs at different concentrations for their MIC values.In view of these facts, the research work presented in thesis are as follows.STUDIES ON IMIDAZO[1,2-a]PYRIDINEPart-I : STUDIES ON CHALCONESPart-II : STUDIES ON PYRIMIDINESPart-III : STUDIES ON CYCLOHEXINONESPart-IV : STUDIES ON PYRAZOLINESPart-V : STUDIES ON ISOXAZOLESPart-IV : STUDIES ON OXIRANES14General Introduction …..