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280. See, for example, W. H. Prusoff, T. -S. Lin, W. R. Mancini, M. J. Otto, S. A. Siegeland J. J. Lee, In ‘ Topics in Antiviral Chemotherapy‟. ed. R. T. Walkar and E. DeClercq, Plenum Press, New York, 1984, p. 1.281. W. H. Prusoff, M. S. Chen, P. H. Fisher, T-S., Lin, G. T. Shiau, R. F. Schinazi and J.Walker, Pharmacol. Ther. ,1979, 7, 1.282. R. W. Sidwell and J. T. Witkowski, in ‘ Burger‟s Medicinal Chemistry‟, 4th edn., M.E. Wolff, Wiley, New York, 1979, 543.283. T. S. Lin, J. P. Neenan, Y. -C. Cheng, W. H. Prusoff and D. C. Ward, J. Med Chem.,1976, 19 ,495.284. C. K. Chu, Y. Choi, S. Grill, E. Gullen, C S. Lee; J. Med. Chem., 2000, 43, 2538-46.285. E. DeClercq, Trends Pharmacol. Sci.,1987, 8, 339.286. P. A. Furman and D. W. Barry, Am. J. Med.,1988, 85 (2A), 176.287. Y. Cheng, G. E. Dutschman, K. F. bastow, M. G. Sarngadharan and R. Y. C. Ting, J.Biol. Chem.,1987, 262, 2187.288. E. DeClercq, E. balzarini, J. Descamps and F. Eckstein, Biochem. Pharmacol.,1980, 84, 8239.289. H. Mitsuya and S. Broder, Nature (London), 1987, 325 , 773.290. E. DeClercq, in ‘ Antiviral Drug Development, A Multidisciplinary Approach‟, ed.E. DeClercq and R. T. Walker, NATO ASI Series, series A, Plenum Press. NewYork, 1988, 143, 97.291. C. H. Kim, V. E. Marquez, S. Border, H. Mitsuya and J. S. Driscoll, J. Med. Chem.,1987, 30, 862.292. Y. C. Cheng, G. E. Dutschman, K. F. Bastow, and R. Y. C. Ting, J. Biol. Chem.,1987, 262, 2187.293. P. Khalili, E. Naimi, W. Y. Sun, E. E. Knaus and L. I. Wiebe, Eur. J. Pharm. Sci.,2003, 19, 305-313.294. Rostom, S. A., Fahmy, H. T., Saudi, M. N.; Scientia Phatmaceutical, 2003, 71(2),57-74.295. R. A. Nugent, S. T. Schlachter, M. J. Murphy; J. Med. Chem.,1998, 41, 3793-3803.296. F. Manetti, J. A. Este, M. Botta; J. Med. Chem., 2005, 48, 8000-08.297. Aurelio Orjales, Ramon Mosquera, Agustin Berisa, M. Teresa Nunez, Beatriz Lopezand M. Carmen Dieguez; FAES FARMA S. A., Department of Research,Bilbao,Spain, 2004.176References…..

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