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EXPERIMENTALSynthesis and therapeutic evaluation of (3-(2-(4-chlorophenyl)-8-methyl-1Himidazo[1,2-a]pyridine-3-yl)oxirane-2-yl)(4-methoxyphenyl)methanone.[A]Preparation of 2-chloro-1- (p-chlorophenyl)ethanone.See on Page No. 37 Part-I (A)[B]Preparation of 2-(p-chlorophenyl)- 8-methyl imidazo[1,2-a]pyridineSee on Page No. 37 Part-I (B)[C] Preparation of 2-(p-chlorophenyl)- 8- methyl imidazo[1,2-a]pyridine- 3-carbaldehyde.See on Page No. 37 Part-I (C)[D]Preparation of (2Z)-3-[2-(p-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine- 3-yl]-1-aryl prop-2-en-1-one.See on Page No. 38 Part-I (D)[E] Preparation of (3-(2-(4-Chlorophenyl)-8-methyl-1H-imidazo[1,2-a]pyridine-3-yl)oxirane-2-yl)(4-methoxyphenyl)methanone.A mixture (2z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one (4.02gm,0.01m) and 30% H 2 O 2 solution (0.34,0.01m) wasrefluxed in Mixture of methanol and acetone for 1-2 hrs. Aq. NaOH solution is usedas catalyst. The contents were poured on to crushed ice and product isolated wascrystallized from di-chloromethane. Yield 60% (2.55gm); m.p.171 °C;(C 24 H 19 ClN 2 O 3 ;Found: C,68.75%;H,4.55%;N,6.60%; Required : C,68.82%;H,4.57%;N,,6.69%)TLC solvent system : Ethyl acetate : Hexane ( 4:6)Similarly, other Oxirane derivatives have been obtained. The physical dataare recorded in Table No.- 6(B).159Oxirane…..