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EXPERIMENTALSynthesis and therapeutic evaluation of 2-(4-chlorophenyl)-3-(3-(4-methoxyphenyl)isoxazole-5-yl)-8-methyl-1H-imidazo[1,2-a]pyridine.[A]Preparation of 2-chloro-1- (p-chlorophenyl)ethanone.See on Page No. 37 Part-I (A)[B]Preparation of 2-(p-chlorophenyl)- 8-methyl imidazo[1,2-a]pyridineSee on Page No. 37 Part-I (B)[C] Preparation of 2-(p-chlorophenyl)- 8- methyl imidazo[1,2-a]pyridine- 3-carbaldehyde.See on Page No. 37 Part-I (C)[D]Preparation of (2Z)-3-[2-(p-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one.See on Page No.38 Part-I (D)[E] Preparation of 2-(4-chlorophenyl)-3-(3-(4-methoxyphenyl)isoxazole-5-yl)-8-methyl-1H-imidazo[1,2-a]pyridine.A mixture (2z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl] arylprop-2-en-1-one. (4.02gm,0.01m) and hydroxylamine hydrochloride (0.7gm, 0.01m)was refluxed in ethanol for 11 hrs. NaOH is used as catalyst. The contents werepoured on to crushed ice and product isolated was crystallized from dichloromethane.Yield 63% (3.0gm); m.p.165 °C ; (C 24 H 18 ClN 3 O 2 ; Found : C,69.15%;H,4.24%; N,9.87%; Required : C,69.31%:H,4.36%;N,10.10%)TLC solvent system : Ethyl acetate : Hexane ( 4:6)Similarly, other Isoxazole derivatives have been obtained. The physical dataare recorded in Table No.- 5(B).144Isoxazole…..