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EXPERIMENTALSynthesis and therapeutic evaluation of 4-(2-(4-chlorophenyl)-8-methyl-1Himidazo[1,2-a]pyridine-3-yl)-6-(4-methoxyphenyl)pyrimidine-2-amine.[A]Preparation of 2-chloro-1-(p-chlorophenyl) ethanone.See on Page No. 37 Part-I (A)[B]Preparation of 2-(p-chlorophenyl)-8-methyl imidazo[1,2-a]pyridineSee on Page No. 37 Part-I (B)[C] Preparation of 2-(p-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-carbaldehyde.See on Page No. 37 Part-I (C)[D]Preparation of (2Z)-3-[2-(p-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one.See on Page No. 38 Part-I (D)[E] Preparation of 4-(2-(4-chlorophenyl)-8-methyl-1H-imidazo[1,2-a]pyridine- 3- yl)-6-(4-methoxyphenyl)pyrimidine-2-amine.A mixture (2z)-3-[2-(4-chlorophenyl)-8-methy imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one.(4.02gm,0.01m) and Guanidine hydrochloride (0.59gm,0.01m)was refluxed in methanol for 6-8 hrs. NaOH is used as catalyst. The contents werepoured on to crushed ice and product isolated was crystallized from di-chloromethane. Yield 61% (2.9gm); m.p.165 °C; (C 25 H 20 ClN 5 O; Found:C,67.85%;H,4.55%;N,15.83% ; Required : C,67.95%;H,4.56%;N,15.85%)TLC solvent system : Ethyl acetate : Hexane ( 4:6)Similarly, other Aminopyrimidines derivatives have been obtained. Thephysical data are recorded in Table No.- 2(IIIB).99Aminopyrimidine…..