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Download (3100Kb) - Etheses - Saurashtra University

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“STUDIES ON SOME HETEROCYCLICENTITIES OF MEDICINAL INTEREST”A brief summary of the work to be incorporated in the thesis entitled,“STUDIES ON SOME HETEROCYCLIC ENTITIES OF MEDICINAL INTEREST”has been summarized as under.A. Studies on imidazo pyridine derivativesThe aza-indolizine contains a phenyl ring fused to a imidazole ring asindicated in the structure, hence it is also known as imidazo[1,2-a]pyridine.Theconstitution of imidazo[1,2-a]pyridine was represented by W.L.Mosby.78692N31N45The group of compound containing imidazo[1,2-a]pyridine moiety areprominent structural feature in a variety of natural products as well as in othercompounds of medicinal interest and have attracted attention for their biologicalactivities.PART-I :SYNTHESIS OF (2Z)-3-[2-(4-CHLOROPHENYL)-8-METHYL IMIDAZO[1,2-a]PYRIDINE-3-YL]-1-ARYL PROP-2-EN-1-ONE.Chalcone derivatives have been found to be associated with variouspharmacological activities. These finding encouraged as to synthesize some newnovel synthesis.1Synopsis…..

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