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EXPERIMENTALSynthesis and therapeutic evaluation of 6-(2-(4-chlorophenyl)-8-methyl-1Himidazo[1,2-a]pyridine-3-yl)-4-(4-methoxyphenyl)pyrimidine-2(H)-thione.[A]Preparation of 2-chloro-1-(p-chlorophenyl) ethanone.See on Page No. 37 Part-I (A)[B]Preparation of 2-(p-chlorophenyl)-8-methyl imidazo[1,2-a]pyridineSee on Page No. 37 Part-I (B)[C] Preparation of 2-(p-chlorophenyl)-8-methyl imidazo[1,2-a]pyridine-3-carbaldehyde.See on Page No. 37 Part-I (C)[D]Preparation of (2Z)-3-[2-(p-chlorophenyl)-8-methylimidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one.See on Page No. 38 Part-I (D)[E] Preparation of 6-(2-(4-chlorophenyl)-8-methyl-1H-imidazo[1,2-a]pyridine- 3- yl)-4-(4-methoxyphenyl)pyrimidine-2(H)-thione.A mixture (2z)-3-[2-(4-chlorophenyl)- 8-methyl imidazo[1,2-a]pyridine-3-yl]-1-aryl prop-2-en-1-one.(4.20gm,0.01m) and Thiourea (0.76gm,0.01m) was refluxed inmethanol for 6 hrs. NaOH is used as catalyst. The contents were poured on tocrushed ice and product isolated was crystallized from di-chloromethane. Yield 63%(3.0gm) ; m.p.187 °C ; (C 25 H 19 ClN 4 OS ; Found : C,65.25%;H,4.10%;N,12.15% ;Required : C,65.42%;H,4.17%;N,12.21%)TLC solvent system : Ethyl acetate : Hexane ( 4:6)Similarly, other Thiopyrimidines derivatives have been obtained. The physicaldata are recorded in Table No.- 2(IIB).86Thiopyrimidine…..