Supplementary Information Rank Prob (t-test ... - UCLA-DOE

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description91 0.00089 2.09 down Mm.143527 2500002L14Rik 101971_at AW061255 RIKEN cDNA 2500002L14 gene92 0.00092 1.75 up Mm.6419 BC004044 100949_at AI461767 hypothetical protein, BC00404493 0.00092 1.93 down Mm.22596 Tstap35b 102113_f_at AI324061 tissue specific transplantation antigen P35B94 0.00095 2.93 down Mm.606 Gata3 100924_at X55123 GATA binding protein 395 0.00096 2.91 down Mm.30028 Vps28 96847_at AI845393 vacuolar protein sorting 28 (yeast)96 0.00097 1.99 up Mm.1583 Ly6c 93077_s_at D86232 lymphocyte antigen 6 complex, locus C97 0.00099 10.79 up Mm.6433 SWAM2 161317_r_at AV088715 elafin-like protein II98 0.00103 2.45 down Mm.18643 Tctex3 103387_at AB011550 t-complex testis-expressed 399 0.00106 1.93 down Mm.18688 1110014C03Rik 93336_at AW121539 RIKEN cDNA 1110014C03 gene100 0.00108 4.37 down Mm.10753 Pnliprp1 92601_at AA674409 pancreatic lipase related protein 1101 0.00108 2.18 down Mm.88645 Tes 101551_s_at X78989 testis derived transcript102 0.00111 6.67 down Mm.182959 1700015E05Rik 94209_g_at AW045202 RIKEN cDNA 1700015E05 gene103 0.00112 2.41 down Mm.4582 Mer 92698_at U21301 c-mer proto-oncogene104 0.00113 2.19 down Mm.26833 AW047992 104015_at AW047992 expressed sequence AW047992105 0.00114 1.79 down Mm.30017 0610012F20Rik 96840_at AI851243 RIKEN cDNA 0610012F20 gene106 0.00115 2.68 down Mm.27943 Slc7a5 104221_at AB017189 solute carrier family 7 (cationic amino acid transporter, y+ system), member107 0.00115 1.99 up Mm.24794 2410001E19Rik 104758_at AA895984 RIKEN cDNA 2410001E19 gene108 0.00116 1.71 down Mm.14253 5730525G14Rik 102812_i_at AW210346 RIKEN cDNA 5730525G14 gene109 0.00117 2.20 down Mm.4808 Hivep1 92908_at L36829 human immunodeficiency virus type I enhancer binding protein 1110 0.00118 1.50 down Mm.2491 Hadhsc 95485_at D29639 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain111 0.00119 2.71 down Mm.117294 Man1a 160580_at U04299 mannosidase 1, alpha112 0.00120 1.58 down Mm.25321 AI427847 96001_at AW122293 expressed sequence AI427847113 0.00123 1.93 up Mm.2322 Pim1 104533_at AA764261 proviral integration site 1114 0.00125 2.24 down Mm.22130 Rpn2 94076_i_at D31717 ribophorin II115 0.00125 4.27 up Mm.42093 Rbig1 102081_at AF060570 retinoblastoma inhibiting gene 1116 0.00128 3.02 down Mm.27154 Vnn1 104165_at AJ132098 vanin 1117 0.00129 2.06 up Mm.21764 Snrpg 93999_at AW060597 small nuclear ribonucleoprotein polypeptide G118 0.00132 2.90 up Mm.11827 1810030M08Rik 160590_r_at AI853323 RIKEN cDNA 1810030M08 gene119 0.00133 15.46 down Mm.6587 Prdx5 100332_s_at AF093853 peroxiredoxin 5120 0.00139 1.73 down Mm.29023 C76256 96771_at AI006228 expressed sequence C76256121 0.00142 3.14 down Mm.182227 4931406C07Rik 96089_at AI255972 RIKEN cDNA 4931406C07 gene122 0.00143 3.72 up Mm.4525 Cdh11 100006_at D21253 cadherin 11123 0.00143 3.66 up Mm.5038 Scg2 92981_at X68837 secretogranin II124 0.00144 1.61 down Mm.196239 4922501H04Rik 97447_at AI836718 RIKEN cDNA 4922501H04 gene125 0.00144 1.53 down Mm.30012 1110005P14Rik 96359_at AI836554 RIKEN cDNA 1110005P14 gene126 0.00145 3.31 up Mm.87857 Bcl2a1d 93869_s_at U23781 B-cell leukemia/lymphoma 2 related protein A1d127 0.00145 1.85 down Mm.24174 AI316495 94918_at AI839392 expressed sequence AI316495128 0.00147 4.24 down Mm.6772 C78582 93451_at AW047919 EST C78582129 0.00149 2.33 down Mm.135837 Mm.135837 160683_at AW049969 Mus musculus, Similar to hypothetical protein FLJ10618, clone IMAGE:3594130 0.00151 1.94 down Mm.22596 Tstap35b 94298_at X53619 tissue specific transplantation antigen P35B131 0.00151 1.62 down Mm.196630 AI046681 96240_at AI851309 expressed sequence AI046681132 0.00154 2.31 down Mm.27578 Maged1 96703_at AB029448 melanoma antigen, family D, 1133 0.00154 1.72 down Mm.35680 2310004K06Rik 160434_at AW122426 RIKEN cDNA 2310004K06 gene134 0.00154 2.90 down Mm.28357 Map1lc3 160288_at AI841311 microtubule-associated protein 1 light chain 3135 0.00155 1.92 down Mm.25848 Bckdha 96035_at L47335 branched chain ketoacid dehydrogenase E1, alpha polypeptide136 0.00156 1.88 down Mm.29455 1810045K07Rik 95146_at AI839280 RIKEN cDNA 1810045K07 gene137 0.00158 3.77 down Mm.28524 D6Wsu116e 98880_at AW124955 DNA segment, Chr 6, Wayne State University 116, expressed138 0.00160 2.32 down Mm.22681 Pon2 104378_at L48514 paraoxonase 2139 0.00161 2.65 down Mm.22682 Pip5k2c 160693_at AI849873 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma140 0.00163 3.87 up Mm.17510 Msln 102953_at D86370 mesothelin141 0.00167 2.61 up Mm.35844 Gas5 98530_at AI849615 growth arrest specific 5142 0.00167 1.57 down Mm.29694 4633402N23Rik 97370_at AI552922 RIKEN cDNA 4633402N23 gene143 0.00175 7.00 up Mm.27498 Usp18 95024_at AW047653 ubiquitin specific protease 18144 0.00176 2.13 up Mm.18789 Sox4 101430_at AW124153 SRY-box containing gene 4145 0.00176 2.68 down Mm.34064 Stat5b 100422_i_at AJ237939 signal transducer and activator of transcription 5B146 0.00176 2.82 down Mm.8457 Cd59a 101516_at U60473 CD59a antigen147 0.00177 3.44 up Mm.1550 Stat4 102994_at U06923 signal transducer and activator of transcription 4148 0.00179 3.05 down Mm.2621 Aldh2 96057_at AI647493 aldehyde dehydrogenase 2, mitochondrial149 0.00179 3.18 down Mm.29192 Nars 95070_at AW125874 asparaginyl-tRNA synthetase150 0.00182 2.39 down Mm.44240 Mm.44240 100042_at AI837921 Mus musculus, Similar to hydroxyacyl glutathione hydrolase, clone MGC:669151 0.00186 1.57 down Mm.10406 3110001M13Rik 92574_at AI851046 RIKEN cDNA 3110001M13 gene152 0.00188 2.80 down Mm.5023 Pcp4 160899_at X17320 Purkinje cell protein 4153 0.00189 5.06 up Mm.88200 Cd72 101878_at J04170 CD72 antigen154 0.00190 1.97 down Mm.28704 Sec23b 98944_at AI848343 SEC23B (S. cerevisiae)155 0.00190 2.12 up Mm.34537 Cebpa 98447_at M62362 CCAAT/enhancer binding protein (C/EBP), alpha156 0.00192 2.50 up Mm.29581 Hey1 161451_r_at AV292193 hairy/enhancer-of-split related with YRPW motif 1157 0.00201 2.93 up Mm.27337 A030007L17Rik 94995_at AI854331 RIKEN cDNA A030007L17 gene158 0.00210 2.41 up Mm.4071 Lamr1 97750_at X06406 laminin receptor 1 (67kD, ribosomal protein SA)159 0.00210 1.66 down Mm.23836 Grs2-pending 94876_f_at AI849207 golgi reassembly stacking protein 2160 0.00211 1.83 up Mm.19127 Prdx4 93495_at U96746 peroxiredoxin 4161 0.00214 1.68 down Mm.24209 Mesdc2 95405_at AW045534 mesoderm development candiate 2162 0.00215 1.83 up Mm.218317 4930553M18Rik 104640_f_at AI464596 RIKEN cDNA 4930553M18 gene163 0.00216 1.84 down Mm.28357 Map1lc3 160287_at AI852557 microtubule-associated protein 1 light chain 3164 0.00218 2.71 down Mm.22479 Krt1-18 94270_at M22832 keratin complex 1, acidic, gene 18165 0.00220 2.30 down Mm.18800 Rab24 93347_at Z22819 RAB24, member RAS oncogene family166 0.00223 8.62 up Mm.24547 Aadac 95439_at AI047508 arylacetamide deacetylase (esterase)167 0.00225 4.08 up Mm.2970 Lgals3 95706_at X16834 lectin, galactose binding, soluble 3168 0.00229 2.87 up Mm.4132 Cish2 99475_at U88327 cytokine inducible SH2-containing protein 2169 0.00232 1.90 up Mm.1815 Ctps 103341_at U49350 cytidine 5'-triphosphate synthase170 0.00234 2.31 down Mm.3679 Ttc3 98555_at AB008516 tetratricopeptide repeat domain171 0.00239 1.91 down Mm.7504 Gss 101425_at U35456 glutathione synthetase172 0.00241 3.11 up Mm.2718 Eef1b2 96625_at AW123132 eukaryotic translation elongation factor 1 beta 2173 0.00244 1.53 down Mm.22635 AA415817 160163_at AI843518 expressed sequence AA415817174 0.00257 3.32 up Mm.46701 Tm4sf6 92555_at AF053454 transmembrane 4 superfamily member 6175 0.00258 1.52 down Mm.201455 AW122395 162426_f_at AV292472 expressed sequence AW122395176 0.00261 2.19 up Mm.193099 Fn1 92852_at M18194 fibronectin 1177 0.00263 1.71 down Mm.4025 Nfib 99440_at Y07686 nuclear factor I/B178 0.00263 1.97 down Mm.24670 9130410M22Rik 104739_at AW045650 RIKEN cDNA 9130410M22 gene179 0.00265 1.56 up Mm.380 Snk 92310_at M96163 serum-inducible kinase180 0.00265 2.07 up Mm.3090 Mm.3090 104513_at AA688938 ESTsPage 2 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description361 0.00791 1.76 down Mm.24397 4933436C10Rik 160188_at AI854103 RIKEN cDNA 4933436C10 gene362 0.00795 1.71 up Mm.372 Rps26 98564_f_at U67770 ribosomal protein S26363 0.00798 2.91 up Mm.30502 2210039B01Rik 98524_f_at AI848479 RIKEN cDNA 2210039B01 gene364 0.00801 1.87 down Mm.2283 Nucb 94839_at M96823 nucleobindin365 0.00801 1.54 down Mm.98 Psmb6 101992_at U13393 proteasome (prosome, macropain) subunit, beta type 6366 0.00803 3.59 up Mm.1347 Hlx 102657_at X58250 H2.0-like homeo box gene367 0.00806 1.72 down Mm.22473 Rabac1 94269_at L40934 Rab acceptor 1 (prenylated)368 0.00807 3.22 down Mm.20934 Hipk2 103833_at AF077659 homeodomain interacting protein kinase 2369 0.00808 2.02 down Mm.34525 4930406E12Rik 98445_at AW125311 RIKEN cDNA 4930406E12 gene370 0.00809 1.40 down Mm.1024 Mm.1024 94106_at AI853048 ESTs371 0.00810 2.62 down Mm.182434 1700066C05Rik 102348_at AI551087 RIKEN cDNA 1700066C05 gene372 0.00813 1.90 down Mm.10727 Atp6b2 92598_at AI843029 ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa373 0.00818 1.49 up Mm.2845 Tcfubf 97901_at X60831 transcription factor UBF374 0.00819 4.06 up Mm.101230 Mm.101230 99425_at X07888 Mus musculus, Similar to 3-hydroxy-3-methylglutaryl-Coenzyme A reductase375 0.00823 6.34 up Mm.219138 Mm.219138 95352_at C75967 ESTs376 0.00823 1.67 up Mm.2443 Bak1 104710_at Y13231 BCL2-antagonist/killer 1377 0.00826 2.52 up Mm.25029 C79329 95981_at C79329 expressed sequence C79329378 0.00829 3.74 down Mm.7114 2210008A03Rik 101384_at AI852933 RIKEN cDNA 2210008A03 gene379 0.00831 2.39 down Mm.1779 Scp2 93278_at M91458 sterol carrier protein 2, liver380 0.00833 3.72 up Mm.31041 Gstm6 104637_at AI326397 glutathione S-transferase, mu 6381 0.00836 1.84 down Mm.21771 Cul1 94002_at AI849838 cullin 1382 0.00840 5.04 up Mm.38260 Mm.38260 92319_i_at AA675031 ESTs383 0.00846 2.45 up Mm.21146 Gata6 104698_at U51335 GATA binding protein 6384 0.00846 1.44 down Mm.41853 Dnase2a 99184_at AW120896 deoxyribonuclease II alpha385 0.00856 1.43 down Mm.34789 1200014P03Rik 98461_at AI987835 RIKEN cDNA 1200014P03 gene386 0.00858 1.97 down Mm.21069 0610007A03Rik 93743_at AI838388 RIKEN cDNA 0610007A03 gene387 0.00860 2.56 up Mm.1585 Tm7sf1 103017_at AI060729 transmembrane 7 superfamily member 1388 0.00868 1.89 down Mm.201455 AW122395 160795_at AW123662 expressed sequence AW122395389 0.00879 3.20 up Mm.2786 Proc 161656_r_at AV103587 protein C390 0.00882 2.12 down Mm.21830 Ril-pending 104094_at Y08361 reversion induced LIM gene391 0.00885 1.84 down Mm.18516 H3f3b 100708_at X13605 H3 histone, family 3B392 0.00886 2.18 up Mm.139720 2610318G08Rik 102385_at AA980618 RIKEN cDNA 2610318G08 gene393 0.00886 2.28 down Mm.29812 Sep15-pending 96249_at AW122105 15-kDa selenoprotein394 0.00890 1.75 down Mm.45465 4921506I22Rik 100547_at AI836977 RIKEN cDNA 4921506I22 gene395 0.00893 1.81 down Mm.171115 Mm.171115 160403_at AW122690 ESTs396 0.00894 3.70 up Mm.3076 Scn8a 104504_at U26707 sodium channel, voltage-gated, type VIII, alpha polypeptide397 0.00898 2.84 up Mm.132399 Galnt6 96998_at AJ133523 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra398 0.00904 1.43 down Mm.34750 Nudt9 98099_at AW045760 nudix (nucleoside diphosphate linked moiety X)-type motif 9399 0.00907 4.90 up Mm.7226 Tcf2 162159_i_at AV026659 transcription factor 2400 0.00911 2.10 up Mm.1260 Nme1 161161_r_at AV216468 expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphospha401 0.00913 2.01 up Mm.68157 Mm.68157 98800_at U25739 ESTs, Weakly similar to JC7182 Na+-dependent vitamin C [H.sapiens]402 0.00913 3.70 up Mm.27503 5730408K05Rik 104195_at AA939440 RIKEN cDNA 5730408K05 gene403 0.00918 2.57 up Mm.7622 Akap2 101435_at AF033275 A kinase anchor protein 2404 0.00923 5.31 up Mm.200446 AW540062 162183_at AV013237 expressed sequence AW540062405 0.00925 3.93 up Mm.4032 Resp18 99442_at L34214 regulated endocrine-specific protein 18406 0.00926 1.83 down Mm.2462 Psmc2 95448_at AI839371 proteasome (prosome, macropain) 26S subunit, ATPase 2407 0.00928 2.03 up Mm.41923 Rpl18 160476_f_at AI839717 ribosomal protein L18408 0.00930 1.23 down Mm.28466 Slc25a11 160295_at AW049350 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member409 0.00934 1.58 down Mm.35098 0610011F06Rik 98124_at AI875453 RIKEN cDNA 0610011F06 gene410 0.00937 2.11 down Mm.29910 Rps6ka1 97405_at M28489 ribosomal protein S6 kinase polypeptide 1411 0.00941 2.44 up Mm.26859 Gjb5 104016_at M91236 gap junction membrane channel protein beta 5412 0.00942 2.05 down Mm.6988 Alad 101044_at X13752 aminolevulinate, delta-, dehydratase413 0.00943 3.07 up Mm.189129 Mm.189129 161693_r_at AV230283 EST414 0.00943 2.35 down Mm.595 Bmp7 93243_at X56906 bone morphogenetic protein 7415 0.00946 2.64 up Mm.665 Psmc5 161921_f_at AV139898 protease (prosome, macropain) 26S subunit, ATPase 5416 0.00949 1.62 down Mm.30085 Akr1a4 96888_at AI839814 aldo-keto reductase family 1, member A4 (aldehyde reductase)417 0.00953 1.76 down Mm.73251 2210402G22Rik 97484_at AI852704 RIKEN cDNA 2210402G22 gene418 0.00953 7.96 up Mm.42124 Slfn2 92471_i_at AF099973 schlafen 2419 0.00955 1.78 up Mm.1972 Rac2 103579_at X53247 RAS-related C3 botulinum substrate 2420 0.00962 3.22 up Mm.2724 Folr2 104172_at M64817 folate receptor 2 (fetal)421 0.00963 1.27 up Mm.22193 2310004N11Rik 104152_at AA960466 RIKEN cDNA 2310004N11 gene422 0.00968 1.98 down Mm.14101 H1f4 94288_at J03482 H1 histone family, member 4423 0.00971 2.10 down 96755_at AA638002424 0.00973 1.57 down Mm.5248 Tsnax 100534_at AI183109 translin-associated factor X425 0.00977 1.65 up Mm.2814 Mpp1 97803_at U38196 membrane protein, palmitoylated (55 kDa)426 0.00980 1.73 down Mm.28794 1810046J19Rik 94453_at AI852571 RIKEN cDNA 1810046J19 gene427 0.00982 1.74 up Mm.29646 0610010E05Rik 162081_f_at AV312736 RIKEN cDNA 0610010E05 gene428 0.00988 3.09 down Mm.212992 Mm.212992 161900_f_at AV373835 ESTs, Moderately similar to B3AR MOUSE BETA-3 ADRENERGIC RECEPT429 0.00991 1.88 up Mm.30205 Scya19 96950_at AW120505 small inducible cytokine A19430 0.00993 1.54 down Mm.208 1110060D06Rik 103260_at AI838553 RIKEN cDNA 1110060D06 gene431 0.00993 3.32 up Mm.42157 Hivep2 92484_at Y15907 human immunodeficiency virus type I enhancer binding protein 2432 0.00995 2.41 up Mm.4974 Ncam1 161750_f_at AV324706 neural cell adhesion molecule 1433 0.01008 3.41 up Mm.154045 Tacstd2 160651_at AI563854 tumor-associated calcium signal transducer 2434 0.01009 2.73 down Mm.9590 Nakap95-pending 101947_at AB028921 neighbor of A-kinase anchoring protein 95435 0.01011 2.10 up Mm.16533 Rpo2-1 103055_r_at M12130 RNA polymerase II 1436 0.01014 1.65 down Mm.1304 Slc11a2 102642_at L33415 solute carrier family 11 (proton-coupled divalent metal ion transporters), mem437 0.01020 1.92 down Mm.15868 Vdp-pending 103018_at AF096868 vesicle docking protein, 115 kDa438 0.01021 4.63 up Mm.15793 Tgtp 102906_at L38444 T-cell specific GTPase439 0.01023 2.64 up Mm.22712 1700017B05Rik 104389_at AW049360 RIKEN cDNA 1700017B05 gene440 0.01030 1.90 down Mm.21580 0610006A03Rik 93835_at AI843222 RIKEN cDNA 0610006A03 gene441 0.01033 1.67 up Mm.28983 1110007M04Rik 96756_at AA693236 RIKEN cDNA 1110007M04 gene442 0.01046 2.71 down Mm.104540 Napa 98887_at AW125607 N-ethylmaleimide sensitive fusion protein attachment protein alpha443 0.01046 1.50 down Mm.177990 1700008C22Rik 160123_at AI835524 RIKEN cDNA 1700008C22 gene444 0.01046 1.56 down Mm.178947 Becn1 160380_at AI846699 beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)445 0.01046 2.25 up Mm.1196 AW536703 102090_f_at AI841710 expressed sequence AW536703446 0.01054 2.82 down Mm.3982 Gas6 99067_at X59846 growth arrest specific 6447 0.01056 1.59 down Mm.148348 1500005G05Rik 103922_f_at AI839690 RIKEN cDNA 1500005G05 gene448 0.01058 1.86 down Mm.22522 Mbd1 104340_at AF072240 methyl-CpG binding domain protein 1449 0.01059 2.73 up Mm.20246 2410004D18Rik 160122_at AW061161 RIKEN cDNA 2410004D18 gene450 0.01063 2.61 up Mm.136604 Nfil3 101805_f_at U89411 nuclear factor, interleukin 3, regulatedPage 5 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description451 0.01076 3.20 up Mm.2095 Zfp64 103841_at U49046 zinc finger protein 64452 0.01092 2.34 up Mm.30375 Klk5 161637_f_at AV053185 kallikrein 5453 0.01092 1.45 down Mm.200125 Sqstm1 101995_at U40930 sequestosome 1454 0.01096 2.32 up Mm.2900 Fmo3 104421_at U87147 flavin containing monooxygenase 3455 0.01101 3.19 up Mm.172 Lox 161177_f_at AV232133 lysyl oxidase456 0.01105 1.77 up Mm.38261 Ubce8 97171_f_at AI060627 ubiquitin-conjugating enzyme 8457 0.01111 1.97 down Mm.29161 Slc16a7 95060_at AF058054 solute carrier family 16 (monocarboxylic acid transporters), member 7458 0.01111 2.64 up Mm.29055 Cbx1 96775_at X56690 chromobox homolog 1 (Drosophila HP1 beta)459 0.01112 1.42 down Mm.4352 Col15a1 99638_at D17546 procollagen, type XV460 0.01118 2.43 up Mm.968 Nr1h2 101981_at U09419 nuclear receptor subfamily 1, group H, member 2461 0.01119 3.31 up Mm.1181 Retn 102366_at AA718169 resistin462 0.01120 2.75 up Mm.214642 Mm.214642 100769_at AU045946 Mus musculus zinc finger protein 352 mRNA, complete cds463 0.01120 2.26 down Mm.22543 AI429776 104348_at AI835152 expressed sequence AI429776464 0.01126 2.92 up Mm.11738 Stk6 92639_at U80932 serine/threonine kinase 6465 0.01126 1.80 down Mm.182913 Csnk1d 97262_at AW050305 casein kinase 1, delta466 0.01127 4.44 down Mm.25351 AV067083 94370_at AA615075 expressed sequence AV067083467 0.01132 3.96 up 95366_at L35599468 0.01134 1.88 down Mm.13694 Oat 92848_at X64837 ornithine aminotransferase469 0.01138 2.07 up Mm.30212 C76483 96954_at AW122567 EST C76483470 0.01144 1.74 down Mm.25709 Ing1 94396_at AA647507 inhibitor of growth family, member 1471 0.01146 2.18 up Mm.3146 Tcf20 97090_at U20282 transcription factor 20472 0.01147 3.66 up Mm.56895 D17H6S56E-3 93197_at AF109905 DNA segment, Chr 17, human D6S56E 3473 0.01148 1.83 down Mm.29812 Sep15-pending 160360_at AI838205 15-kDa selenoprotein474 0.01150 2.32 up Mm.6224 Stx1bl-pending 101643_at D45207 syntaxin 1 b-like475 0.01153 1.74 down Mm.7418 Ppp2cb 101101_at Z67746 protein phosphatase 2a, catalytic subunit, beta isoform476 0.01153 1.82 down Mm.9392 Golga3 93951_at AB029537 golgi autoantigen, golgin subfamily a, 3477 0.01160 1.55 up Mm.195926 D8Ertd319e 103924_at AW048884 DNA segment, Chr 8, ERATO Doi 319, expressed478 0.01163 1.77 down Mm.3868 Yy1 98767_at AI842603 YY1 transcription factor479 0.01164 1.61 down Mm.23693 2010320M17Rik 94862_i_at AI850000 RIKEN cDNA 2010320M17 gene480 0.01170 9.85 up Mm.80559 Mm.80559 161107_r_at AA529901 ESTs, Weakly similar to W01A11.2.p [Caenorhabditis elegans] [C.elegans]481 0.01171 1.63 down Mm.22333 Rpn1 94237_at AI846708 ribophorin I482 0.01172 2.64 down 103083_at U69543483 0.01174 1.63 down Mm.154581 Aco2 96870_at AI836740 aconitase 2, mitochondrial484 0.01176 2.01 up Mm.154355 2700066J21Rik 104470_at AI957346 RIKEN cDNA 2700066J21 gene485 0.01178 1.56 up Mm.12858 Eif4a1 92816_r_at X03039 eukaryotic translation initiation factor 4A1486 0.01180 1.52 down Mm.2412 Ppib 94915_at X58990 peptidylprolyl isomerase B487 0.01181 1.65 down Mm.18520 5730494M16Rik 103364_f_at AW045256 RIKEN cDNA 5730494M16 gene488 0.01182 2.09 down Mm.25632 9030624B09Rik 94983_at AI851614 RIKEN cDNA 9030624B09 gene489 0.01182 2.01 up Mm.22592 Ccnb2 94294_at X66032 cyclin B2490 0.01183 1.77 down Mm.6417 Cd24a 100600_at M58661 CD24a antigen491 0.01189 2.74 up Mm.18064 G6pc 103333_at U00445 glucose-6-phosphatase, catalytic492 0.01191 1.43 up Mm.29383 Mm.29383 96822_at AA734428 ESTs, Highly similar to E2BE RAT TRANSLATION INITIATION FACTOR EIF493 0.01193 3.54 up Mm.202045 AI173996 95283_at AI173996 expressed sequence AI173996494 0.01197 2.01 down Mm.19981 Dagk1 103596_at AF085219 diacylglycerol kinase, alpha (80 kDa)495 0.01207 4.36 up Mm.1401 Cmkar4 102794_at Z80112 chemokine (C-X-C) receptor 4496 0.01207 2.32 up Mm.219665 Mm.219665 161480_i_at AV055186 Mus musculus, Similar to KIAA1089 protein, clone MGC:30464 IMAGE:3992497 0.01211 1.68 down Mm.6250 Prom 93390_g_at AF039663 prominin498 0.01213 2.14 down Mm.4270 Atbf1 92521_at D26046 AT motif binding factor 1499 0.01216 2.36 down Mm.39038 Mm.39038 99033_at AI837130 Mus musculus, Similar to inositol 1,3,4-triphosphate 5/6 kinase, clone IMAGE500 0.01216 2.21 up Mm.193432 ORF18 161667_r_at AV139526 open reading frame 18501 0.01225 2.12 down Mm.709 Grp58 101060_at M73329 glucose regulated protein, 58 kDa502 0.01227 1.83 down Mm.21507 1810020N21Rik 93819_at AI847269 RIKEN cDNA 1810020N21 gene503 0.01228 1.90 down Mm.193395 6330580J24Rik 160346_at AI841825 RIKEN cDNA 6330580J24 gene504 0.01235 1.41 down Mm.340 Hmgb3 98038_at AF022465 high mobility group box 3505 0.01239 2.43 up Mm.25248 AA960558 162252_f_at AV335799 expressed sequence AA960558506 0.01242 1.46 down Mm.157042 AA408125 101943_at AA960259 expressed sequence AA408125507 0.01246 2.71 up Mm.21880 Prss25 104102_at AW047978 protease, serine, 25508 0.01250 1.72 down Mm.20169 2310005K03Rik 103225_at AW018420 RIKEN cDNA 2310005K03 gene509 0.01257 2.35 up Mm.2241 Arhgdib 94258_at L07918 rho, GDP dissociation inhibitor (GDI) beta510 0.01259 1.46 down Mm.23030 AI447437 92243_at AA117417 expressed sequence AI447437511 0.01261 1.68 up Mm.6161 Pcyt1a 161074_at AW107428 phosphate cytidylyltransferase 1, choline, alpha isoform512 0.01262 2.66 up Mm.4411 Gcnt1 92655_at U19265 glucosaminyl (N-acetyl) transferase 1, core 2513 0.01264 2.21 up Mm.218317 4930553M18Rik 104639_i_at AI464596 RIKEN cDNA 4930553M18 gene514 0.01270 1.64 up Mm.140380 Rpl23 161498_at AV099015 ribosomal protein L23515 0.01270 2.31 down Mm.201898 AU018122 94413_at AW121487 expressed sequence AU018122516 0.01277 2.03 down Mm.200358 Tcf7 97994_at AI019193 transcription factor 7, T-cell specific517 0.01280 1.77 down Mm.200319 D2Abb2e 104501_at AI849048 DNA segment, Chr 2, Abbott 2 expressed518 0.01281 5.67 up Mm.26006 AU014713 103992_f_at AA636966 expressed sequence AU014713519 0.01287 3.40 up Mm.203883 AA408556 160974_at AW108045 expressed sequence AA408556520 0.01290 2.48 down Mm.21596 EDEM 104065_at AW212878 ER alpha-mannosidase like521 0.01290 4.90 up Mm.26775 Mrpl36 161488_r_at AV080549 mitochondrial ribosomal protein L36522 0.01296 3.78 up Mm.183034 AA617404 162406_f_at AV313012 expressed sequence AA617404523 0.01300 1.68 up Mm.196126 2810025E10Rik 94480_at AW260202 RIKEN cDNA 2810025E10 gene524 0.01303 2.13 up Mm.21826 Timm13a 94012_at AI848685 translocase of inner mitochondrial membrane 13 homolog a (yeast)525 0.01307 2.18 up Mm.9714 Gdf9 160567_at L06444 growth differentiation factor 9526 0.01312 1.46 up Mm.262 Arhc 162468_at AV064502 ras homolog 9 (RhoC)527 0.01315 3.82 up Mm.159237 9130002K18Rik 98577_f_at Y12713 RIKEN cDNA 9130002K18 gene528 0.01322 3.85 up Mm.24506 AA409164 160712_r_at AI837948 expressed sequence AA409164529 0.01322 1.45 up Mm.6712 Des 100997_at L22550 desmin530 0.01325 3.15 up Mm.30142 D15Wsu77e 97920_at AA755126 DNA segment, Chr 15, Wayne State University 77, expressed531 0.01326 1.71 down Mm.219659 Hist2 93067_f_at U62674 histone gene complex 2532 0.01329 3.38 down Mm.155711 Ceacam2 101908_s_at AF101164 CEA-related cell adhesion molecule 2533 0.01333 2.11 up Mm.1235 F9 102291_at M23109 coagulation factor IX534 0.01334 2.06 down Mm.16323 Eif4a2 93089_at X12507 eukaryotic translation initiation factor 4A2535 0.01334 1.80 down Mm.21905 Rab2 94031_at X95403 RAB2, member RAS oncogene family536 0.01349 3.02 up Mm.5781 DXErtd223e 101601_at C79025 DNA segment, Chr X, ERATO Doi 223, expressed537 0.01350 1.71 up Mm.205855 D13Wsu123e 94450_at AI854202 DNA segment, Chr 13, Wayne State University 123, expressed538 0.01356 3.33 up Mm.14768 Rex3 93020_at AF051347 reduced expression 3539 0.01361 1.75 down Mm.206206 Ncdn-pending 104095_at AI843152 neurochondrin540 0.01368 1.42 down Mm.200342 AI787263 103845_at AI839005 expressed sequence AI787263Page 6 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description541 0.01369 1.53 down Mm.2895 D13Wsu50e 94502_at AW125724 DNA segment, Chr 13, Wayne State University 50, expressed542 0.01370 1.78 down Mm.218873 3110054G10Rik 103315_at AW120526 RIKEN cDNA 3110054G10 gene543 0.01373 1.54 down Mm.21520 Mm.21520 104052_at AI840921 Mus musculus, Similar to ribosomal protein L34 pseudogene 1, clone MGC:6544 0.01381 1.98 up Mm.29733 Ldb3 160354_at AJ005621 LIM domain binding 3545 0.01382 1.81 down Mm.35853 Comt 98535_at AF076156 catechol-O-methyltransferase546 0.01382 1.93 up Mm.5289 Gapd 101214_f_at M32599 glyceraldehyde-3-phosphate dehydrogenase547 0.01389 1.87 down Mm.14825 Idh3g 93029_at U68564 isocitrate dehydrogenase 3 (NAD+), gamma548 0.01394 1.86 up Mm.180299 D16Wsu109e 95431_at AA623426 DNA segment, Chr 16, Wayne State University 109, expressed549 0.01396 4.03 up Mm.7956 Rgs7 93645_at AF011360 regulator of G protein signaling 7550 0.01400 2.36 down Mm.255 Hoxb9 103952_at M34857 homeo box B9551 0.01402 1.81 up Mm.7521 Ran 101254_at L32751 RAN, member RAS oncogene family552 0.01403 3.99 up Mm.27757 Bmp1 95557_at L24755 bone morphogenetic protein 1553 0.01405 1.68 up Mm.10734 Aoc3 102327_at AF078705 amine oxidase, copper containing 3554 0.01407 1.88 down Mm.2315 AI447560 103531_f_at AI049144 expressed sequence AI447560555 0.01409 1.53 down Mm.24738 Mm.24738 103767_f_at AA675006 ESTs556 0.01415 1.95 up Mm.103 Hkp1 92568_at M74555 house-keeping protein 1557 0.01416 1.67 up Mm.197601 Hspe1 92829_at U09659 heat shock 10 kDa protein 1 (chaperonin 10)558 0.01421 3.09 down Mm.29151 Herpud1 95057_at AI846938 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-lik559 0.01422 1.76 down Mm.4077 Mm.4077 92397_at AW123016 ESTs560 0.01424 6.50 up Mm.279 1110019N10Rik 162471_i_at AV071208 RIKEN cDNA 1110019N10 gene561 0.01432 4.95 up Mm.27584 AW547774 161000_i_at AA275196 expressed sequence AW547774562 0.01433 1.76 up Mm.153758 0610040H15Rik 162470_at AV070263 RIKEN cDNA 0610040H15 gene563 0.01434 1.88 down Mm.2777 Tpd52 160249_at U44426 tumor protein D52564 0.01439 2.87 down Mm.193097 Mm.193097 98507_at AI834950 Mus musculus, Similar to nuclear receptor subfamily 1, group D, member 1,565 0.01445 1.86 down Mm.29010 Mbc2 96767_at AF098633 membrane bound C2 domain containing protein566 0.01453 2.06 down Mm.35628 Fut8 98143_at AB025198 fucosyltransferase 8567 0.01454 3.05 down Mm.205520 Mm.205520 97826_at AI465965 Mus musculus, clone IMAGE:4988271, mRNA, partial cds568 0.01455 2.44 up Mm.24609 AW495713 104727_at AI836317 expressed sequence AW495713569 0.01458 1.72 down Mm.15571 App 93063_at U82624 amyloid beta (A4) precursor protein570 0.01460 1.39 down Mm.22117 Polr2g 94073_at AI836182 polymerase (RNA) II (DNA directed) polypeptide G571 0.01463 1.38 down Mm.42948 Prdx2 100331_g_at AF032714 peroxiredoxin 2572 0.01466 3.49 up Mm.1805 F8 94799_at L05573 coagulation factor VIII573 0.01467 1.51 up Mm.22687 Nup62 160167_at AW121948 nucleoporin 62574 0.01468 2.47 up Mm.7952 Peg3 96765_at AW120874 paternally expressed 3575 0.01469 6.48 up Mm.19353 LOC56304 100721_f_at U10410 recombinant antineuraminidase single chain Ig VH and VL domains576 0.01469 2.29 up Mm.5244 Crem 100533_s_at M60285 cAMP responsive element modulator577 0.01470 2.24 down Mm.27575 Zfp68 95522_i_at AB024005 Zinc finger protein 68578 0.01470 2.00 up Mm.5980 Mm.5980 99825_at AA881307 ESTs, Weakly similar to NFM MOUSE NEUROFILAMENT TRIPLET M PRO579 0.01473 1.55 down Mm.24025 Stag2 92513_at AJ002636 stromal antigen 2580 0.01473 2.11 down Mm.22776 Eif3s8 94837_at U67328 eukaryotic translation initiation factor 3, subunit 8 (110 kDa)581 0.01473 1.41 down Mm.31979 Nudel-pending 98882_s_at AW047320 nuclear distribution gene E-like582 0.01479 2.54 up Mm.1593 Lcat 161759_r_at AV329184 lecithin cholesterol acyltransferase583 0.01479 3.75 up Mm.44238 Kcnj15 99974_at AI314692 potassium inwardly-rectifying channel, subfamily J, member 15584 0.01481 2.01 up Mm.196611 Syn1 93730_at AF085809 synapsin I585 0.01485 1.53 up Mm.2608 Bgn 162347_f_at AV166064 biglycan586 0.01487 1.65 down Mm.31076 0610040B21Rik 97492_at AW121746 RIKEN cDNA 0610040B21 gene587 0.01496 6.07 up Mm.5307 9130016M20Rik 99341_r_at AA087373 RIKEN cDNA 9130016M20 gene588 0.01498 2.30 up Mm.1390 Epha8 102682_at U72207 Eph receptor A8589 0.01500 3.75 up Mm.37811 Pou2f2 92305_s_at X53654 POU domain, class 2, transcription factor 2590 0.01500 1.72 down Mm.5400 Brd7 100543_s_at AA620184 bromodomain-containing 7591 0.01501 1.92 up Mm.103632 Rasl2-9 102821_s_at L32752 RAS-like, family 2, locus 9592 0.01502 2.92 down Mm.10763 Diap2 94127_at Y15910 diaphanous homolog 2 (Drosophila)593 0.01502 3.71 down Mm.1967 Tom1 103578_at AJ006972 target of myb1 homolog (chicken)594 0.01516 1.79 down Mm.28896 Sdccagg28 96735_at AW049732 serologically defined colon cancer antigen 28595 0.01518 2.07 up Mm.116 H2-Oa 98333_at AF100956 histocompatibility 2, O region alpha locus596 0.01525 2.68 up Mm.89123 Emb 162068_r_at AV309223 embigin597 0.01527 1.34 down Mm.21569 2700069E09Rik 93832_at AI854541 RIKEN cDNA 2700069E09 gene598 0.01542 1.58 down Mm.28332 Mm.28332 96158_at AW123477 Mus musculus, clone IMAGE:3708215, mRNA599 0.01548 3.49 up Mm.3266 Evi2 98026_g_at M34896 ecotropic viral integration site 2600 0.01549 1.96 down Mm.4876 Rcn 160896_at D13003 reticulocalbin601 0.01551 2.14 up Mm.29911 3200001M24Rik 96300_f_at AI854238 RIKEN cDNA 3200001M24 gene602 0.01554 2.64 down Mm.195848 Amd2 100323_at Z23077 S-adenosylmethionine decarboxylase 2603 0.01562 2.28 down Mm.27084 C76297 96529_at AW122059 expressed sequence C76297604 0.01570 2.48 up Mm.42099 Roc2-pending 102083_at AF084463 GTP-binding protein Roc2605 0.01578 1.88 down Mm.1391 Gata2 102789_at AB000096 GATA binding protein 2606 0.01584 2.09 down Mm.25044 Fliih 97593_f_at C79694 flightless I homolog (Drosophila)607 0.01584 1.43 up Mm.6424 Itgb5 161786_f_at AV363187 integrin beta 5608 0.01586 2.83 up Mm.42081 Mm.42081 102077_at AF039839 Mus musculus adriamycin-resistant related protein (Arr) mRNA, complete cd609 0.01589 8.34 up Mm.38315 Mm.38315 92321_r_at AA415783 ESTs, Weakly similar to ZF26 MOUSE ZINC FINGER PROTEIN 26 [M.musc610 0.01590 2.39 down Mm.34106 AI467657 92202_g_at AI553024 expressed sequence AI467657611 0.01596 1.78 up Mm.39130 2210402A09Rik 99093_at AI852864 RIKEN cDNA 2210402A09 gene612 0.01597 1.72 down Mm.28626 2410018G23Rik 98921_at AW125612 RIKEN cDNA 2410018G23 gene613 0.01599 1.39 down Mm.2137 Sin3b 93789_s_at AF038848 transcriptional regulator, SIN3B (yeast)614 0.01605 2.56 up Mm.2793 Siat4c 95599_at D28941 sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)615 0.01605 2.28 up Mm.27261 R75501 161193_r_at AV241177 expressed sequence R75501616 0.01605 3.03 up Mm.23898 Mm.23898 95398_at AI447945 ESTs617 0.01612 6.15 up Mm.4668 Mpo 100414_s_at X15313 myeloperoxidase618 0.01615 2.33 up Mm.89843 Spi1-4 93109_f_at M75718 serine protease inhibitor 1-4619 0.01615 1.70 down Mm.29529 C77668 97329_at AW124061 expressed sequence C77668620 0.01619 2.82 up Mm.43677 Apoa2 99648_at X62772 apolipoprotein A-II621 0.01624 3.14 up Mm.45765 2810417H13Rik 93952_r_at AA409629 RIKEN cDNA 2810417H13 gene622 0.01629 3.23 up Mm.12429 Cbfa2t3h 102397_at AF038029 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog623 0.01631 3.02 up Mm.155714 Myh7 98616_f_at AJ223362 myosin, heavy polypeptide 7, cardiac muscle, beta624 0.01631 3.58 up Mm.31099 Art1 104638_at U31510 ADP-ribosyltransferase 1625 0.01632 1.43 down Mm.1800 Mm.1800 94796_at AA710643 ESTs626 0.01636 3.98 up Mm.2766 Pva 96720_f_at X59382 parvalbumin627 0.01637 1.85 down Mm.25836 Cldn8 93146_at AF087826 claudin 8628 0.01641 1.84 up Mm.4113 Rae1 161455_r_at AV295434 RAE1 RNA export 1 homolog (S. pombe)629 0.01643 4.36 up Mm.42203 Knsl1 99541_at AJ223293 kinesin-like 1630 0.01644 3.01 up Mm.99965 D1Lub1 101846_r_at M55219 DNA segment, Chr 1, Lubeck 1Page 7 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description631 0.01647 3.02 up Mm.10091 Pkig 92549_at U97170 protein kinase inhibitor, gamma632 0.01647 1.66 up Mm.18968 AU041772 103427_at AW123223 expressed sequence AU041772633 0.01649 1.66 down Mm.6967 Bcl2l2 160920_at U59746 Bcl2-like 2634 0.01652 3.77 up Mm.121889 Mm.121889 101686_at D18410 ESTs635 0.01654 1.37 down Mm.4859 1110060F11Rik 160518_at AI048434 RIKEN cDNA 1110060F11 gene636 0.01659 1.50 down Mm.30113 Ndufs3 96899_at AW123802 NADH dehydrogenase (ubiquinone) Fe-S protein 3637 0.01660 4.80 down Mm.42012 Lama3 97790_s_at X84014 laminin, alpha 3638 0.01669 2.54 up Mm.7980 Prkcc 93648_at L28035 protein kinase C, gamma639 0.01673 2.13 up Mm.25877 Phtf 94406_at AJ242864 putative homeodomain transcription factor640 0.01674 2.00 down Mm.24790 4933432B13Rik 103774_at AW108350 RIKEN cDNA 4933432B13 gene641 0.01675 2.58 up Mm.5033 Mm.5033 98837_at AI462038 ESTs, Moderately similar to RELX MOUSE PRORELAXIN PRECURSOR [M642 0.01683 2.26 up Mm.142380 Rpl27a 101680_at X05021 ribosomal protein L27a643 0.01689 1.43 down Mm.29118 Mm.29118 95042_at AI839770 Mus musculus, Similar to hypothetical protein, clone MGC:6903 IMAGE:2655644 0.01691 3.91 up Mm.30502 2210039B01Rik 100920_at AA822539 RIKEN cDNA 2210039B01 gene645 0.01694 6.56 up Mm.3404 Meox1 98419_at Z15103 mesenchyme homeobox 1646 0.01694 1.46 down Mm.28212 Sepr 160275_at AI840996 selenoprotein R647 0.01700 4.57 up Mm.42095 Sfrp4 92469_at AF117709 secreted frizzled-related sequence protein 4648 0.01703 1.78 down Mm.44488 1110031K21Rik 95374_f_at AI413993 RIKEN cDNA 1110031K21 gene649 0.01704 2.66 up Mm.41653 Rlbp1 92435_at AF084642 retinaldehyde binding protein 1650 0.01706 1.87 down Mm.5326 2610022K04Rik 93165_at AW121327 RIKEN cDNA 2610022K04 gene651 0.01719 4.21 up Mm.689 Acvr1 93460_at L15436 activin A receptor, type 1652 0.01722 5.43 up Mm.29008 Iigp-pending 96764_at AJ007971 interferon-inducible GTPase653 0.01727 1.68 down Mm.7050 5730405M13Rik 160922_at AA980810 RIKEN cDNA 5730405M13 gene654 0.01729 1.73 down Mm.4184 Zfp1 92444_f_at X16493 zinc finger protein 1655 0.01731 1.76 down Mm.23827 Mm.23827 104560_at AW125634 Mus musculus, Similar to putative mitochondrial solute carrier, clone MGC:37656 0.01740 1.55 down Mm.29870 Itm3-pending 96283_at AI849180 integral membrane protein 3657 0.01744 1.54 down Mm.18962 Catna1 93364_at X59990 catenin alpha 1658 0.01750 1.49 down Mm.155712 Stx5a 96076_at AW121716 syntaxin 5A659 0.01752 1.64 down Mm.30256 2810422B04Rik 160400_at AI853616 RIKEN cDNA 2810422B04 gene660 0.01753 1.74 down Mm.27647 1110003E01Rik 96716_at AW121102 RIKEN cDNA 1110003E01 gene661 0.01764 2.91 up Mm.46048 Sh3bp5 98766_at AB016835 SH3-domain binding protein 5 (BTK-associated)662 0.01764 1.73 up Mm.29904 Mrpl15 96296_at AI843685 mitochondrial ribosomal protein L15663 0.01765 1.52 down Mm.34497 2510002C21Rik 98440_at AA596710 RIKEN cDNA 2510002C21 gene664 0.01766 2.39 up Mm.41038 Mm.41038 97754_at AI841211 ESTs, Weakly similar to ZINC FINGER PROTEIN MLZ-4 [M.musculus]665 0.01769 2.67 up Mm.22662 Krt1-10 94321_at V00830 keratin complex 1, acidic, gene 10666 0.01779 2.28 down Mm.31392 AI325977 104648_at AI844597 expressed sequence AI325977667 0.01780 3.40 up Mm.4695 Nat2 92746_at U37249 N-acetyltransferase 2 (arylamine N-acetyltransferase)668 0.01798 4.58 up Mm.196591 Spi1-3 100329_at X00945 serine protease inhibitor 1-3669 0.01804 1.78 down Mm.29655 Mm.29655 95692_at AI852514 ESTs, Highly similar to SR68_HUMAN SIGNAL RECOGNITION PARTICLE670 0.01806 1.49 down Mm.22130 Rpn2 94077_f_at D31717 ribophorin II671 0.01810 3.19 up Mm.43330 0610025G13Rik 99627_r_at AA638667 RIKEN cDNA 0610025G13 gene672 0.01823 2.83 up Mm.13824 Vhlh 102676_at U12570 von Hippel-Lindau syndrome homolog673 0.01834 2.55 down Mm.3153 Myh11 97990_at D85923 myosin heavy chain 11, smooth muscle674 0.01835 1.81 down Mm.4097 Rxrip110 99464_at U22015 retinoid X receptor interacting protein 110675 0.01839 1.63 up Mm.28803 1010001J12Rik 94455_at AA795062 RIKEN cDNA 1010001J12 gene676 0.01841 2.10 up Mm.14627 Plscr1 102839_at D78354 phospholipid scramblase 1677 0.01843 2.42 up Mm.2514 Grca 161771_r_at AV341612 gene rich cluster, A gene678 0.01844 3.84 up Mm.88841 Olfr37a 96999_at AJ133424 olfactory receptor 37a679 0.01849 1.55 down Mm.34695 Arpc1a 95144_at AB024984 actin related protein 2/3 complex, subunit 1A (41 kDa)680 0.01853 2.08 up Mm.57153 Soat2 97132_at AA189890 sterol O-acyltransferase 2681 0.01856 1.41 down Mm.14287 Hspa1l 96761_at AF109906 heat shock 70kD protein 1-like682 0.01859 2.00 up Mm.37835 Rpl7 97696_r_at M29015 ribosomal protein L7683 0.01861 2.80 down Mm.29580 Scgn10 95668_at AI840972 superiorcervical ganglia, neural specific 10684 0.01862 2.87 down Mm.10812 Pde9a 102338_at AF031147 phosphodiesterase 9A685 0.01862 1.45 down Mm.44174 Mrpl43 99674_at AW060297 mitochondrial ribosomal protein L43686 0.01864 1.51 down Mm.20290 AW536573 103630_at AI844089 expressed sequence AW536573687 0.01865 1.83 down Mm.28917 1810045K17Rik 92189_at AI846017 RIKEN cDNA 1810045K17 gene688 0.01871 1.55 up Mm.17980 Hmox1 160101_at X56824 heme oxygenase (decycling) 1689 0.01877 1.46 down Mm.2040 Glb1 103647_at M57734 galactosidase, beta 1690 0.01879 1.68 down Mm.10313 Ankhzn 102054_at AB011370 ankyrin repeat hooked to zinc finger motif691 0.01881 2.41 up Mm.29938 Ifi1 97409_at U19119 interferon inducible protein 1692 0.01883 2.42 up Mm.68157 Mm.68157 161149_r_at AV222871 ESTs, Weakly similar to JC7182 Na+-dependent vitamin C [H.sapiens]693 0.01885 1.54 down Mm.29633 1810008O21Rik 97356_at AI839653 RIKEN cDNA 1810008O21 gene694 0.01886 3.77 up Mm.26584 AA960287 94441_at AW061237 expressed sequence AA960287695 0.01887 2.32 up Mm.3177 Ly64 162041_f_at AV374719 lymphocyte antigen 64696 0.01892 1.68 down Mm.972 Uqcrc1 101989_at AW125380 ubiquinol-cytochrome c reductase core protein 1697 0.01894 3.63 up Mm.22248 Igfbp4 101570_at X76066 insulin-like growth factor binding protein 4698 0.01894 1.61 down Mm.29915 Mm.29915 96302_at AA711516 Mus musculus, clone MGC:36924 IMAGE:4945988, mRNA, complete cds699 0.01903 2.83 up Mm.3446 Dck 98071_f_at X77731 deoxycytidine kinase700 0.01910 5.16 up Mm.5715 C78532 101232_at C78532 expressed sequence C78532701 0.01913 1.47 down Mm.30195 R75577 96943_at AW125234 expressed sequence R75577702 0.01915 2.40 up Mm.10081 Gli 103366_at AI117236 GLI-Kruppel family member GLI703 0.01927 1.87 up Mm.180895 3110001K13Rik 104212_at AA607767 RIKEN cDNA 3110001K13 gene704 0.01936 1.98 up Mm.27449 AI853703 104188_at AI853703 expressed sequence AI853703705 0.01936 3.94 up Mm.4861 Tnfsf5 98812_at X65453 tumor necrosis factor (ligand) superfamily, member 5706 0.01937 1.56 down Mm.22072 Noc4 96641_at AW060674 neighbor of Cox4707 0.01940 2.69 up Mm.24816 F2r 92267_at L03529 coagulation factor II (thrombin) receptor708 0.01945 2.12 down Mm.39716 Sec63 99350_at C76102 SEC63 (S. cerevisiae)709 0.01946 1.77 down Mm.39472 Mm.39472 160424_f_at AI846851 Mus musculus farnesyl pyrophosphate synthase (Fpps) mRNA, complete cd710 0.01949 1.85 down Mm.42944 Tceb1l 99607_at Z47088 transcription elongation factor B (SIII), polypeptide 1 (15 kDa),-like711 0.01949 2.09 down Mm.200644 R75096 161006_at AI853978 expressed sequence R75096712 0.01956 2.25 down Mm.13148 AI450991 102646_at AW122284 expressed sequence AI450991713 0.01960 2.97 up Mm.3066 Pax1 96595_at M20978 paired box gene 1714 0.01960 2.29 down Mm.46014 shrm 100024_at AI641895 shroom715 0.01960 2.63 down Mm.8034 Pbsn 94632_at AF005204 probasin716 0.01966 1.89 up Mm.91981 Mm.91981 161842_r_at AV329374 ESTs717 0.01972 1.57 down Mm.29866 Mm.29866 160366_at AI846422 Mus musculus, clone MGC:27590 IMAGE:4501468, mRNA, complete cds718 0.01974 1.79 up Mm.30069 1200003J11Rik 96873_at AI843287 RIKEN cDNA 1200003J11 gene719 0.01980 1.94 up Mm.57249 Dyrk1b 102584_at Y18280 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b720 0.01991 1.76 up Mm.23884 1300011P19Rik 160186_at AI847282 RIKEN cDNA 1300011P19 genePage 8 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description721 0.01996 1.63 down Mm.21451 4933434E20Rik 104038_at AI843511 RIKEN cDNA 4933434E20 gene722 0.01998 1.65 up Mm.28773 0610016J10Rik 98959_at AW120623 RIKEN cDNA 0610016J10 gene723 0.01999 1.58 down Mm.6874 Surf1 101031_at M14689 surfeit gene 1724 0.02000 2.97 down Mm.24179 AW061228 95897_at AW061228 expressed sequence AW061228725 0.02002 1.54 down Mm.28688 Sars1 98936_at AI837395 seryl-aminoacyl-tRNA synthetase 1726 0.02005 2.52 up Mm.11434 5730403J10Rik 102354_at AI049398 RIKEN cDNA 5730403J10 gene727 0.02007 2.58 down Mm.20916 Wfs1 103824_at AF084482 Wolfram syndrome 1 homolog (human)728 0.02009 1.82 down Mm.29473 Copz1 95149_at AW121088 coatomer protein complex, subunit zeta 1729 0.02015 1.52 down Mm.6577 Vti1b-pending 100964_at AF035208 vesicle transport through interaction with t-SNAREs 1b homolog730 0.02028 3.10 up Mm.2183 Lsp1 161914_s_at AV122642 lymphocyte specific 1731 0.02036 2.43 down Mm.116866 LOC170938 100713_at AB020542 zinc finger protein s11-6732 0.02037 2.62 up Mm.195085 Tyms-ps 100756_r_at M30774 thymidylate synthase, pseudogene733 0.02038 2.02 down Mm.92529 Ubqln2 102002_at AI836406 ubiquilin 2734 0.02063 1.42 up Mm.23826 BC003940 104559_at AI848162 phosphotyrosyl phosphatase activator735 0.02067 2.41 down Mm.4317 Pigr 99926_at AB001489 polymeric immunoglobulin receptor736 0.02072 1.51 down Mm.30099 Mm.30099 160386_at AI835981 Mus musculus, Similar to cisplatin resistance related protein CRR9p, clone M737 0.02075 1.70 down Mm.10409 Golga4 102060_at AF051357 golgi autoantigen, golgin subfamily a, 4738 0.02076 2.38 down Mm.153748 5031422I09Rik 96187_at AI837021 RIKEN cDNA 5031422I09 gene739 0.02078 1.78 down Mm.200774 Mgea6 104033_at AI841996 meningioma expressed antigen 6 (coiled-coil proline-rich)740 0.02079 1.59 up Mm.28579 1110066C01Rik 98904_at AW061339 RIKEN cDNA 1110066C01 gene741 0.02082 2.67 up Mm.41552 Mm.41552 96531_at AA153773 Mus musculus, clone MGC:28734 IMAGE:4460615, mRNA, complete cds742 0.02090 3.76 up Mm.25069 Mm.25069 95997_at C79758 ESTs743 0.02091 2.13 up Mm.2408 C3ar1 103707_at U77461 complement component 3a receptor 1744 0.02096 2.12 up Mm.160237 Mm.160237 97680_at M65237 Mouse murinoglobulin (MUG3) mRNA, last 2 exons745 0.02102 1.85 up Mm.15537 Cyp1a2 102998_at X04283 cytochrome P450, 1a2, aromatic compound inducible746 0.02103 3.22 up Mm.4328 AA536748 98345_at AA674593 expressed sequence AA536748747 0.02106 3.24 up Mm.20857 Zfp125 103267_i_at AI154710 zinc finger protein 125748 0.02112 1.75 up Mm.1693 Hmgb2 93250_r_at X67668 high mobility group box 2749 0.02117 2.12 up Mm.202767 AA408257 161092_at AA408501 expressed sequence AA408257750 0.02119 2.80 up Mm.30008 2900055D03Rik 96355_at AI839395 RIKEN cDNA 2900055D03 gene751 0.02129 1.75 down Mm.214958 Srebf1 93264_at AI843895 sterol regulatory element binding factor 1752 0.02129 3.49 up Mm.137 Scya6 92849_at M58004 small inducible cytokine A6753 0.02133 2.03 up Mm.21070 AI504353 103853_at AI845664 expressed sequence AI504353754 0.02136 2.72 down Mm.3903 Rasd1 99032_at AF009246 RAS, dexamethasone-induced 1755 0.02136 3.52 up Mm.12965 Cst7 102638_at AB015224 cystatin F (leukocystatin)756 0.02140 2.59 up Mm.1263 Serpine1 94147_at M33960 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activato757 0.02155 1.86 up Mm.28140 AI447804 161791_r_at AV363719 expressed sequence AI447804758 0.02157 1.76 up Mm.25192 Mm.25192 96493_at AA682091 ESTs759 0.02159 6.99 up Mm.57008 Art2b 99402_at X87612 ADP-ribosyltransferase 2b760 0.02163 1.75 down Mm.45233 2400003B06Rik 100074_at AW046723 RIKEN cDNA 2400003B06 gene761 0.02164 1.99 up Mm.1 S100a10 92539_at M16465 S100 calcium binding protein A10 (calpactin)762 0.02164 1.94 down Mm.8739 Sgce 101861_at AF031919 sarcoglycan, epsilon763 0.02171 1.78 down Mm.27680 AW489456 93482_at AI117835 expressed sequence AW489456764 0.02173 2.32 up Mm.18923 Mcmd7 93356_at D26091 mini chromosome maintenance deficient 7 (S. cerevisiae)765 0.02181 1.90 down Mm.28336 0610010I20Rik 97869_at AI844043 RIKEN cDNA 0610010I20 gene766 0.02183 2.16 down Mm.214583 Prosc 101568_at AW227620 proline synthetase co-transcribed767 0.02185 2.69 up Mm.6279 Rai2 93399_at X76652 retinoic acid induced 2768 0.02189 1.60 up Mm.297 Actb 101578_f_at M12481 actin, beta, cytoplasmic769 0.02192 4.06 up Mm.2627 Xrcc5 161686_i_at AV217007 X-ray repair complementing defective repair in Chinese hamster cells 5770 0.02193 2.30 up Mm.13356 3110079L04Rik 92840_at AA683712 RIKEN cDNA 3110079L04 gene771 0.02200 1.80 up Mm.21473 1190017B19Rik 160135_at AW122914 RIKEN cDNA 1190017B19 gene772 0.02203 2.36 down Mm.41629 2310004N24Rik 99157_at AI846684 RIKEN cDNA 2310004N24 gene773 0.02205 2.63 up Mm.214943 4921538B03Rik 96193_at Z38011 RIKEN cDNA 4921538B03 gene774 0.02206 1.94 down Mm.29968 Rab3d 97415_at M89777 RAB3D, member RAS oncogene family775 0.02207 1.86 up Mm.1848 Cd3e 102971_at M23376 CD3 antigen, epsilon polypeptide776 0.02208 1.42 up Mm.35777 Mm.35777 97176_at AI645547 ESTs777 0.02210 2.07 down Mm.2442 Cai 95423_at Y00884 calcium binding protein, intestinal778 0.02219 3.27 up Mm.14092 Foxc2 102800_at X74040 forkhead box C2779 0.02228 1.68 down Mm.16763 Aldo1 160090_f_at Y00516 aldolase 1, A isoform780 0.02235 1.35 up Mm.589 Gpi1 100573_f_at M14220 glucose phosphate isomerase 1 complex781 0.02239 2.03 down Mm.140619 Egln1 95468_at AI850202 EGL nine homolog 1 (C. elegans)782 0.02242 2.26 up Mm.200920 Rps28 98086_r_at U11248 ribosomal protein S28783 0.02243 4.91 up Mm.14300 Xmr 102818_at X72697 Xlr-related, meiosis regulated784 0.02245 1.73 down Mm.46412 1810005H09Rik 97798_at AW121496 RIKEN cDNA 1810005H09 gene785 0.02248 2.88 up Mm.189988 Mm.189988 161803_r_at AV350751 EST786 0.02250 2.21 down Mm.1211 Tiam1 102283_at U05245 T-cell lymphoma invasion and metastasis 1787 0.02254 1.83 down Mm.24437 Vps4a 104711_at AW122109 vacuolar protein sorting protein 4a788 0.02261 1.94 up Mm.21612 C80611 104068_at AI845621 expressed sequence C80611789 0.02263 1.58 down Mm.4593 Ugalt2 100091_at D87990 UDP-galactose translocator 2790 0.02266 2.97 down Mm.2017 Etv6 160119_at AI845538 ets variant gene 6 (TEL oncogene)791 0.02271 3.39 up Mm.23520 Spz1-pending 104104_at AA666904 spermatogenic Zip 1792 0.02287 2.48 up Mm.1923 Pola1 103207_at D13543 DNA polymerase alpha 1, 180 kDa793 0.02288 1.62 up Mm.29762 C80501 97383_at AI848623 expressed sequence C80501794 0.02294 2.22 down Mm.21485 2610102M01Rik 104045_at AW122372 RIKEN cDNA 2610102M01 gene795 0.02294 1.80 up Mm.25013 1110002C08Rik 94339_at AI841330 RIKEN cDNA 1110002C08 gene796 0.02296 1.42 down Mm.31018 0610009N12Rik 98533_at AI854779 RIKEN cDNA 0610009N12 gene797 0.02299 2.17 down Mm.30074 AA409584 96879_at AI852338 expressed sequence AA409584798 0.02302 2.61 up Mm.214647 Hmx3 92977_s_at X75330 H6 homeo box 3799 0.02303 3.00 up Mm.6381 AW112010 100944_at AA958903 expressed sequence AW112010800 0.02307 2.02 up Mm.57110 Col4a4 101774_at Z35167 procollagen, type IV, alpha 4801 0.02307 2.72 up Mm.517 Mfng 100508_at AF015769 manic fringe homolog (Drosophila)802 0.02313 1.59 up Mm.87062 Mrps25 102128_f_at C77227 mitochondrial ribosomal protein S25803 0.02323 3.77 up Mm.2619 Cck 96055_at X59520 cholecystokinin804 0.02325 2.41 down Mm.35727 Rab11b 98150_at L26528 RAB11B, member RAS oncogene family805 0.02327 2.78 up Mm.983 Il3 94086_at K01668 interleukin 3806 0.02328 3.09 up Mm.25652 Gjb6 94391_at AW123650 gap junction membrane channel protein beta 6807 0.02329 3.01 up Mm.28042 9030623C06Rik 95621_at AA606367 RIKEN cDNA 9030623C06 gene808 0.02337 2.55 up Mm.12669 Tex19 102418_at AA793009 testis expressed gene 19809 0.02339 1.87 down Mm.155579 Col4a5 93220_at Z35168 procollagen, type IV, alpha 5810 0.02340 1.54 down Mm.63479 Slc15a2 103918_at AI846682 solute carrier family 15 (H+/peptide transporter), member 2Page 9 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description811 0.02342 2.43 up Mm.33796 Mm.33796 92180_at AI851599 ESTs, Weakly similar to HISTONE H1.4 [M.musculus]812 0.02344 1.52 down Mm.17898 Cirbp 93284_at D78135 cold inducible RNA binding protein813 0.02345 1.29 up Mm.35650 2700085A14Rik 98144_f_at AI844321 RIKEN cDNA 2700085A14 gene814 0.02345 2.44 down Mm.200446 AW540062 161073_at AI846304 expressed sequence AW540062815 0.02349 1.77 up Mm.1749 Serf1 103094_at AI036894 small EDRK-rich factor 1816 0.02349 1.56 down Mm.204893 AI430822 97386_at AI853294 expressed sequence AI430822817 0.02351 2.41 up Mm.34946 C80197 97146_g_at C80197 expressed sequence C80197818 0.02353 1.51 down Mm.27942 Trrp4ap-pending 95602_at AI848135 transient receptor protein 4, associated protein819 0.02356 2.12 up Mm.2011 Gstm1 161633_r_at AV003177 glutathione S-transferase, mu 1820 0.02358 1.56 down Mm.35856 Pts 160844_at AF043225 6-pyruvoyl-tetrahydropterin synthase821 0.02363 5.55 up Mm.25547 0610037B21Rik 161473_f_at AV031985 RIKEN cDNA 0610037B21 gene822 0.02372 2.30 down Mm.87858 Bglap1 100336_s_at L24431 bone gamma carboxyglutamate protein 1823 0.02376 1.81 down Mm.22087 1700001E16Rik 94067_at AW212399 RIKEN cDNA 1700001E16 gene824 0.02382 1.95 up Mm.3297 Zfp35 98032_at M36146 zinc finger protein 35825 0.02385 2.20 up Mm.29096 Nrbf1 160798_at AW046483 nuclear receptor binding factor 1826 0.02389 1.47 down Mm.4338 Psen2 99930_s_at U57325 presenilin 2827 0.02396 2.80 up Mm.47747 Mm.47747 162330_f_at AV089248 EST828 0.02398 1.73 down Mm.9052 Pgrmc1 101585_at AF042491 progesterone receptor membrane component 1829 0.02399 1.77 down Mm.154307 0610009H04Rik 101518_at U38981 RIKEN cDNA 0610009H04 gene830 0.02405 2.47 up Mm.24219 1810037I17Rik 102234_at AW047207 RIKEN cDNA 1810037I17 gene831 0.02415 1.76 down Mm.24260 AU024582 104624_at AI851539 expressed sequence AU024582832 0.02416 1.44 up Mm.29247 2310009N05Rik 160801_at AW061073 RIKEN cDNA 2310009N05 gene833 0.02418 3.02 up Mm.196526 Arf6 100462_at D87903 ADP-ribosylation factor 6834 0.02419 6.65 up Mm.8038 Zap70 93662_s_at AI386093 zeta-chain (TCR) associated protein kinase (70kD)835 0.02421 2.51 up Mm.20436 Fgd3 102619_at AF017369 faciogenital dysplasia homolog 3836 0.02423 1.63 up Mm.23965 Efnb3 94160_at AF025288 ephrin B3837 0.02426 2.37 up Mm.25091 D4Ertd335e 96392_at C80868 DNA segment, Chr 4, ERATO Doi 335, expressed838 0.02432 3.77 up Mm.31387 Nr5a1 100700_s_at AB000490 nuclear receptor subfamily 5, group A, member 1839 0.02443 4.09 up Mm.27026 Clgn 104029_at U08373 calmegin840 0.02443 1.65 up Mm.70127 Rpl12 99778_at AU020239 ribosomal protein L12841 0.02454 2.12 up Mm.205045 AI324246 160663_at AW047871 expressed sequence AI324246842 0.02455 1.70 down Mm.29652 Gstz1 160350_at AW060750 glutathione transferase zeta 1 (maleylacetoacetate isomerase)843 0.02457 2.66 down Mm.4098 Sca10 99127_at X61506 spinocerebellar ataxia 10 homolog (human)844 0.02460 1.49 down Mm.27259 AL022610 94976_at AI845877 expressed sequence AL022610845 0.02467 1.78 up Mm.141773 1200009I24Rik 95357_at AI325802 RIKEN cDNA 1200009I24 gene846 0.02469 4.02 up Mm.41980 Ly94 97781_at AJ223765 lymphocyte antigen 94847 0.02470 1.72 up Mm.29931 Cdc20 96319_at AW061324 cell division cycle 20 homolog (S. cerevisiae)848 0.02473 2.32 up Mm.29082 1110037A17Rik 96784_at AW123269 RIKEN cDNA 1110037A17 gene849 0.02474 4.26 up Mm.3390 Myo1b 162008_r_at AV245773 myosin Ib850 0.02474 1.84 down Mm.24356 9130427A09Rik 93484_at AW061306 RIKEN cDNA 9130427A09 gene851 0.02475 1.48 down Mm.2507 Dj1-pending 95491_at AB015652 RNA binding protein regulatory subunit852 0.02478 1.61 down Mm.20927 Tgfb1i4 93728_at X62940 transforming growth factor beta 1 induced transcript 4853 0.02481 1.73 down Mm.26944 1700057K18Rik 94942_at AI854108 RIKEN cDNA 1700057K18 gene854 0.02484 1.57 up Mm.24091 1110001J03Rik 94907_f_at AW045632 RIKEN cDNA 1110001J03 gene855 0.02492 1.37 down Mm.196574 Grhpr 95084_f_at AI844995 glyoxylate reductase/hydroxypyruvate reductase856 0.02499 2.83 up Mm.20441 Atp2b2 95324_at AF053471 ATPase, Ca++ transporting, plasma membrane 2857 0.02499 2.43 up Mm.1114 Gla 160080_r_at U58105 galactosidase, alpha858 0.02501 1.49 down Mm.29340 Gclm 160335_at U95053 glutamate-cysteine ligase , modifier subunit859 0.02507 4.28 up Mm.35134 Atp2a1 98126_s_at X67140 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1860 0.02514 2.93 up Mm.33853 1600014J01Rik 97555_at AI851678 RIKEN cDNA 1600014J01 gene861 0.02516 2.99 up Mm.3628 AA409749 100742_at AA409749 expressed sequence AA409749862 0.02522 2.81 up Mm.1008 Ptgds 92545_f_at AB006361 prostaglandin D2 synthase (21 kDa, brain)863 0.02525 2.66 up Mm.4999 Ddr2 92969_at X76505 discoidin domain receptor family, member 2864 0.02526 1.40 down Mm.21606 Rtn3 93839_at AI854888 reticulon 3865 0.02530 1.51 up Mm.29646 0610010E05Rik 160349_at AI854839 RIKEN cDNA 0610010E05 gene866 0.02540 4.21 up Mm.3370 Scya5 98406_at AF065947 small inducible cytokine A5867 0.02544 1.40 down Mm.24593 4930558H15Rik 95445_at AW124194 RIKEN cDNA 4930558H15 gene868 0.02547 3.51 up Mm.206159 Pdxk 96519_at AI450876 pyridoxal (pyridoxine, vitamin B6) kinase869 0.02551 1.55 down Mm.957 Cops4 101976_at AF071314 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thal870 0.02553 2.80 up Mm.1360 Gadd45b 161666_f_at AV138783 growth arrest and DNA-damage-inducible 45 beta871 0.02554 2.23 up Mm.31308 Entpd2 161821_f_at AV378405 ectonucleoside triphosphate diphosphohydrolase 2872 0.02555 1.64 down Mm.196581 Mapk1 93254_at AI839142 mitogen activated protein kinase 1873 0.02557 1.77 down Mm.22508 Mtx 161898_i_at AV108173 metaxin874 0.02558 1.71 down Mm.21514 C85457 93821_at AW046101 expressed sequence C85457875 0.02565 3.43 up Mm.21567 S100a8 103448_at M83218 S100 calcium binding protein A8 (calgranulin A)876 0.02567 1.69 up Mm.22353 1810029F08Rik 161888_r_at AV371196 RIKEN cDNA 1810029F08 gene877 0.02571 1.39 down Mm.25777 Inpp5b 94399_at AI843172 inositol polyphosphate-5-phosphatase, 75 kDa878 0.02579 3.24 up Mm.6718 Ifit1 100981_at U43084 interferon-induced protein with tetratricopeptide repeats 1879 0.02579 1.62 up Mm.7971 Foxb2 94618_at X92591 forkhead box B2880 0.02580 3.35 up Mm.38487 Mm.38487 97714_r_at W91600 ESTs, Weakly similar to TYROSINE-PROTEIN KINASE JAK3 [M.musculus]881 0.02583 2.03 up Mm.182692 Sh3glb1 98945_at AW125190 SH3-domain GRB2-like B1 (endophilin)882 0.02587 5.58 up Mm.22379 Mm.22379 161387_i_at AV253622 Mus musculus, Similar to hypothetical protein FLJ13213, clone MGC:28555883 0.02597 1.69 up Mm.33902 Gtpi-pending 98410_at AJ007972 interferon-g induced GTPase884 0.02599 2.44 up Mm.6149 AA673245 93375_at AA673487 expressed sequence AA673245885 0.02606 1.87 up Mm.16549 Pold1 103057_at AF024570 DNA polymerase delta 1, catalytic domain886 0.02607 1.85 down Mm.28297 BC002318 96155_at AW049359 hypothetical protein, MGC:8303887 0.02608 1.91 down Mm.5087 Fgf1 100494_at M30641 fibroblast growth factor 1888 0.02609 1.66 down Mm.200912 Prkab1 160808_at AI854287 protein kinase, AMP-activated, beta 1 non-catalytic subunit889 0.02609 1.84 up Mm.86541 Ccr4 93909_f_at X04120 carbon catabolite repression 4 homolog (S. cerevisiae)890 0.02616 5.90 up Mm.21983 Bhmt 94049_at AF033381 betaine-homocysteine methyltransferase891 0.02619 1.95 up Mm.13123 AI853584 102770_at M26385 expressed sequence AI853584892 0.02623 1.66 down Mm.10160 AA960172 160575_at AW045426 expressed sequence AA960172893 0.02625 7.69 up Mm.24053 AA986766 103702_i_at AI647632 expressed sequence AA986766894 0.02629 4.04 up Mm.46749 AI643885 99863_at AI608436 expressed sequence AI643885895 0.02638 2.06 up Mm.7165 1110014J22Rik 101387_at AI852646 RIKEN cDNA 1110014J22 gene896 0.02644 1.39 down Mm.206159 Pdxk 104320_at AI841777 pyridoxal (pyridoxine, vitamin B6) kinase897 0.02645 1.49 down Mm.6698 Sara 100635_at L20294 SAR1a gene homolog (S. cerevisiae)898 0.02647 2.37 down Mm.171337 Mm.171337 96054_f_at Y17345 Mus musculus mRNA for protein-tyrosine-phosphatase IF1899 0.02648 1.45 down Mm.28882 Hbs1l 94484_at AW227778 Hbs1-like (S. cerevisiae)900 0.02651 2.19 down Mm.2409 Adh1 94906_at M22679 alcohol dehydrogenase 1, complexPage 10 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description901 0.02656 3.75 up Mm.42124 Slfn2 92472_f_at AF099973 schlafen 2902 0.02657 1.81 up Mm.3110 Ktn1 97976_at L43326 kinectin 1903 0.02659 2.53 down Mm.21503 B3gnt1 160137_at AW260308 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1904 0.02663 1.55 down Mm.181237 0610007O07Rik 96653_at AI851762 RIKEN cDNA 0610007O07 gene905 0.02665 1.40 up Mm.2038 G3bp-pending 103642_at AB001927 Ras-GTPase-activating protein SH3-domain binding protein906 0.02674 2.50 up Mm.96903 Mm.96903 162278_r_at AV369255 EST907 0.02678 4.11 up Mm.46366 AV065366 162045_r_at AV376560 expressed sequence AV065366908 0.02684 1.85 down Mm.26282 Mm.26282 94423_at AW049551 Mus musculus, Similar to hypothetical protein from clone 643, clone MGC:79909 0.02690 2.47 down Mm.214950 Acta1 100381_at M12347 actin, alpha 1, skeletal muscle910 0.02691 1.63 up 99701_f_at AJ005560911 0.02692 1.44 down Mm.30092 1300002A08Rik 96890_at AW060971 RIKEN cDNA 1300002A08 gene912 0.02697 1.33 down Mm.1444 Cops7a 92874_f_at AF071316 COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis tha913 0.02698 2.09 up Mm.198246 AA987153 96026_at AA987153 expressed sequence AA987153914 0.02700 2.19 down Mm.22218 1300013N08Rik 104277_at AI834815 RIKEN cDNA 1300013N08 gene915 0.02708 2.85 up Mm.219620 Slc34a1 101552_at L33878 solute carrier family 34 (sodium phosphate), member 1916 0.02711 1.45 down Mm.3624 Guk1 98544_at U53514 guanylate kinase 1917 0.02715 2.04 down Mm.42193 Spin 92477_at AA681862 spindlin918 0.02715 1.46 down Mm.43760 Spc18-pending 99655_at AB025405 signal peptidase complex (18kD)919 0.02715 1.94 up Mm.19904 Bax 93536_at L22472 Bcl2-associated X protein920 0.02720 1.49 down Mm.30204 2610008L04Rik 96948_at AI845337 RIKEN cDNA 2610008L04 gene921 0.02724 1.75 down Mm.24779 Arhgef5 160977_at AA726063 Rho guanine nucleotide exchange factor (GEF) 5922 0.02725 2.84 up Mm.30370 Xtrp2 97465_at AF075267 X transporter protein 2923 0.02727 1.78 down Mm.28848 AI182287 94469_at AW120950 expressed sequence AI182287924 0.02728 1.48 down Mm.203930 AI035702 102003_at AI842159 expressed sequence AI035702925 0.02737 1.76 down Mm.196142 Dnajc7 160153_at AI835917 DnaJ (Hsp40) homolog, subfamily C, member 7926 0.02738 2.21 down Mm.6221 Capn1 100932_at AF084459 calpain 1927 0.02739 1.54 down Mm.29845 Suclg1 96268_at AI840979 succinate-CoA ligase, GDP-forming, alpha subunit928 0.02739 3.44 up Mm.30083 2510015F01Rik 96885_at AW122271 RIKEN cDNA 2510015F01 gene929 0.02743 3.32 up Mm.6217 Kcns1 101624_at AF008573 K+ voltage-gated channel, subfamily S, 1930 0.02744 1.36 down Mm.154570 Erp29 98076_at AI835644 endoplasmic reticulum protein 29931 0.02758 1.37 down Mm.24231 Smap-pending 95411_at AB025407 small acidic protein932 0.02763 1.52 up Mm.6523 S100a13 100960_g_at X99921 S100 calcium binding protein A13933 0.02765 1.55 down Mm.45155 1810059G22Rik 160497_at AW060728 RIKEN cDNA 1810059G22 gene934 0.02769 1.52 down Mm.154580 9430059D04Rik 99592_f_at AB030505 RIKEN cDNA 9430059D04 gene935 0.02771 1.77 up Mm.27649 4930588A18Rik 162489_i_at AV138018 RIKEN cDNA 4930588A18 gene936 0.02772 2.63 up Mm.200936 Lnk 93939_at U89993 linker of T-cell receptor pathways937 0.02773 4.43 up Mm.218770 Ifi202a 94774_at M31418 interferon activated gene 202A938 0.02778 2.93 up Mm.34953 Slc25a14 98470_at AF076981 solute carrier family 25 (mitochondrial carrier, brain), member 14939 0.02778 2.17 up Mm.200907 Slc25a15 104007_at AA986782 solute carrier family 25 (mitochondrial carrier; ornithine transporter), member940 0.02784 3.39 up Mm.21882 Cd84 94027_at AA815831 CD84 antigen941 0.02785 2.12 up Mm.20415 1110031C13Rik 103651_r_at AI841186 RIKEN cDNA 1110031C13 gene942 0.02786 1.42 down Mm.43482 D6Wsu147e 99635_at AI845183 DNA segment, Chr 6, Wayne State University 147, expressed943 0.02804 1.91 down Mm.205421 D14Ertd453e 104419_at AI132380 DNA segment, Chr 14, ERATO Doi 453, expressed944 0.02809 3.33 up Mm.19943 Prg3 95300_at AI326147 proteoglycan 3945 0.02812 3.43 up Mm.4910 Evx1 98816_s_at AW049988 even skipped homeotic gene 1 homolog946 0.02818 1.75 down Mm.203947 AU040868 103899_at AA690863 expressed sequence AU040868947 0.02834 2.02 down Mm.29772 Nagk 97385_at AJ242909 N-acetylglucosamine kinase948 0.02837 1.97 down Mm.10699 Vamp4 102317_at AF061516 vesicle-associated membrane protein 4949 0.02843 2.05 up Mm.14838 Rpl44 160081_at AW045418 ribosomal protein L44950 0.02846 1.99 up Mm.29356 C80758 160336_at AI850692 expressed sequence C80758951 0.02846 2.52 up Mm.409 Mm.409 102160_at X87638 Mouse intracisternal A-particle-related retroviral elements and envelope pseu952 0.02849 2.67 up Mm.19945 Mmp14 160118_at AF022432 matrix metalloproteinase 14 (membrane-inserted)953 0.02855 2.19 down Mm.205997 AI481106 92941_at AA833509 expressed sequence AI481106954 0.02863 3.48 up Mm.18422 AI462243 103355_at AI120671 expressed sequence AI462243955 0.02864 2.34 up Mm.40615 Kcnq2 99450_at AB000503 potassium voltage-gated channel, subfamily Q, member 2956 0.02866 2.23 up Mm.2144 Evl 161808_f_at AV371846 Ena-vasodilator stimulated phosphoprotein957 0.02875 2.16 up Mm.12968 Chst2 102639_at AB011451 carbohydrate sulfotransferase 2958 0.02879 2.00 down Mm.14719 Gsta3 93015_at X65021 glutathione S-transferase, alpha 3959 0.02879 2.45 up Mm.2758 Mkrn3 96704_at AF058798 makorin, ring finger protein, 3960 0.02879 2.30 up Mm.197519 5031415C07Rik 103517_at AA822898 RIKEN cDNA 5031415C07 gene961 0.02880 1.96 up Mm.30011 Rps23 96358_at AI837403 ribosomal protein S23962 0.02886 1.73 up Mm.28438 Plunc 97900_at AI845714 palate, lung, and nasal epithelium expressed transcript963 0.02890 1.86 up Mm.29491 Mm.29491 95641_at AI853899 ESTs964 0.02895 1.57 down Mm.195451 Gosr2 94071_at AI847904 golgi SNAP receptor complex member 2965 0.02896 2.85 down Mm.12286 Alox12 102290_at U04334 arachidonate 12-lipoxygenase966 0.02897 1.89 down Mm.19006 AL024210 103429_i_at AW125330 expressed sequence AL024210967 0.02897 1.98 up Mm.28379 Nup50 93047_at AI849144 nucleoprotein 50968 0.02903 5.24 up Mm.180499 2610029G23Rik 161520_at AV217463 RIKEN cDNA 2610029G23 gene969 0.02909 1.46 down Mm.27657 Sssca1 96718_at AB012727 Sjogren's syndrome/scleroderma autoantigen 1 homolog (human)970 0.02912 1.58 down Mm.3074 Ube2l3 97479_at AJ130961 ubiquitin-conjugating enzyme E2L 3971 0.02914 1.80 down Mm.3840 Flot2 99007_at U07890 flotillin 2972 0.02914 1.99 down Mm.196031 Nfkbib 99982_at U19799 nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta973 0.02915 4.31 up 100001_at M18228974 0.02930 1.58 down Mm.45146 Pphn 96019_at AI843476 pantophysin975 0.02931 1.64 up Mm.7049 AI413331 93472_at AA796989 expressed sequence AI413331976 0.02934 1.56 down Mm.13705 Rrbp1 92850_at AI836446 ribosome binding protein 1977 0.02936 1.53 down Mm.181278 4921505F14Rik 96002_at AW123936 RIKEN cDNA 4921505F14 gene978 0.02958 1.90 down Mm.4082 Emk 99458_i_at X70764 ELKL motif kinase979 0.02958 3.31 up Mm.204646 Mm.204646 161511_f_at AV152244 Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched lib980 0.02967 2.17 up Mm.644 Mef2b 93417_at D50311 myocyte enhancer factor 2B981 0.02974 5.87 up Mm.29499 Cpt2 161978_r_at AV372996 carnitine palmitoyltransferase 2982 0.02974 1.75 down Mm.196449 Rnp24-pending 93818_g_at AB025218 coated vesicle membrane protein983 0.02976 1.98 down Mm.26944 1700057K18Rik 161631_f_at AV046503 RIKEN cDNA 1700057K18 gene984 0.02977 1.81 up Mm.29390 2400007P05Rik 95121_at AW060791 RIKEN cDNA 2400007P05 gene985 0.02981 2.64 up Mm.2470 2610201A13Rik 161134_at AV298639 RIKEN cDNA 2610201A13 gene986 0.02984 3.37 up 95184_f_at AA419684987 0.02985 2.19 down Mm.30435 Tsc2 97953_g_at U39818 tuberous sclerosis 2988 0.02986 2.26 up Mm.16332 Efna4 103041_at U92890 ephrin A4989 0.02987 2.44 up Mm.12897 Gp9 102311_at AB007464 glycoprotein 9 (platelet)990 0.02988 1.64 down Mm.203878 AI449174 103251_at AW125822 expressed sequence AI449174Page 11 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description991 0.02993 3.99 up Mm.1902 AI225904 103200_at AA711773 expressed sequence AI225904992 0.03006 1.59 up Mm.200920 Rps28 98085_f_at U11248 ribosomal protein S28993 0.03015 1.90 down Mm.1040 2610511I23Rik 102232_at AI850740 RIKEN cDNA 2610511I23 gene994 0.03016 2.10 up Mm.213458 Mm.213458 93224_at M31649 Mouse T-cell receptor rearranged alpha-chain mRNA V-J-C region, 3' end995 0.03020 1.44 up Mm.218848 3010002G01Rik 99179_at AI846233 RIKEN cDNA 3010002G01 gene996 0.03030 1.54 down Mm.27502 D16H22S680E 95025_at X74504 DNA segment, Chr 16, human D22S680E, expressed997 0.03032 2.25 down Mm.30041 AU040324 96854_at AJ010391 expressed sequence AU040324998 0.03033 3.22 up Mm.7973 Ids 99882_at L07921 iduronate 2-sulfatase999 0.03038 5.07 up Mm.196055 D6Ertd439e 95354_at AI605585 DNA segment, Chr 6, ERATO Doi 439, expressed1000 0.03042 1.29 up Mm.87776 H2-T10 93865_s_at M35244 histocompatibility 2, T region locus 101001 0.03044 5.62 up Mm.1736 Chl1 103088_at X94310 close homolog of L11002 0.03047 3.83 up Mm.154039 Atp4b 100501_at M80251 ATPase, H+/K+ transporting, beta polypeptide, gastric specific1003 0.03051 6.69 up Mm.392 Indo 161824_r_at AV381044 indoleamine-pyrrole 2,3 dioxygenase1004 0.03053 1.99 down Mm.25044 Fliih 97594_r_at C79694 flightless I homolog (Drosophila)1005 0.03059 2.68 down Mm.12616 Dnajc3 102415_r_at U28423 DnaJ (Hsp40) homolog, subfamily C, member 31006 0.03066 2.30 up Mm.18814 1300006M19Rik 103409_at AA656550 RIKEN cDNA 1300006M19 gene1007 0.03067 1.89 up Mm.3401 Pcsk5 92193_r_at D12619 proprotein convertase subtilisin/kexin type 51008 0.03070 1.94 down Mm.3526 Ank3 98477_s_at L40632 ankyrin 3, epithelial1009 0.03073 1.99 down Mm.28150 Sf3b1 97808_at AI844532 splicing factor 3b, subunit 1, 155 kDa1010 0.03082 1.72 down Mm.21824 2810449C13Rik 104092_at AW124926 RIKEN cDNA 2810449C13 gene1011 0.03086 1.56 up Mm.197437 2810008P14Rik 104150_at AW121957 RIKEN cDNA 2810008P14 gene1012 0.03096 1.49 down Mm.12887 Tulp3 102308_at AF045582 tubby-like protein 31013 0.03099 2.03 up Mm.28073 D11Ertd172e 161441_f_at AV350341 DNA segment, Chr 11, ERATO Doi 172, expressed1014 0.03108 1.88 up Mm.702 Rps16 97647_at M11408 ribosomal protein S161015 0.03110 2.27 up Mm.5725 Mm.5725 101233_at C78616 ESTs1016 0.03114 3.51 up Mm.41456 Pcp2 102376_r_at M21532 Purkinje cell protein 2 (L7)1017 0.03114 1.37 up Mm.29503 1110007B08Rik 95649_at AI844440 RIKEN cDNA 1110007B08 gene1018 0.03123 2.06 up Mm.6159 Mm.6159 101615_at AA673515 EST1019 0.03125 3.58 up Mm.28362 AI326478 102158_at K02138 expressed sequence AI3264781020 0.03126 1.64 up Mm.212712 Iap 101787_f_at X16672 intracisternal A particles1021 0.03126 2.55 up Mm.203895 AW124766 162095_f_at AV341518 expressed sequence AW1247661022 0.03130 1.78 down Mm.202871 1190005L06Rik 102883_at AW107702 RIKEN cDNA 1190005L06 gene1023 0.03134 3.42 up Mm.4155 Ros1 97765_g_at U15443 Ros1 proto-oncogene1024 0.03139 1.75 up Mm.4708 Syk 100425_at U25685 spleen tyrosine kinase1025 0.03146 1.76 up Mm.8771 Pip5k2a 95358_at AI843864 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha1026 0.03154 2.15 up Mm.3730 Sema3e 92295_at Z80941 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se1027 0.03154 1.56 down Mm.30206 Atp6m 96951_at AI839795 ATPase, H+ transporting lysosomal (vacuolar proton pump)1028 0.03173 2.15 up Mm.87835 V2r12 101352_g_at AF022251 vomeronasal 2, receptor, 121029 0.03173 2.65 up Mm.14768 Rex3 93021_at AA790008 reduced expression 31030 0.03198 3.12 down Mm.200499 Eif2ak1 93737_at AF028808 eukaryotic translation initiation factor 2 alpha kinase 11031 0.03199 2.19 up Mm.147693 Rps3 101137_at X76772 ribosomal protein S31032 0.03206 2.13 down Mm.46513 2610200G18Rik 104229_at AI840035 RIKEN cDNA 2610200G18 gene1033 0.03214 5.72 up Mm.22451 Khk 104323_at Y09335 ketohexokinase1034 0.03222 1.64 down Mm.17 Bcap31 93252_at X81816 B-cell receptor-associated protein 311035 0.03225 1.64 up Mm.262 Arhc 96056_at X80638 ras homolog 9 (RhoC)1036 0.03229 2.88 up Mm.4708 Syk 100426_s_at U36776 spleen tyrosine kinase1037 0.03235 1.57 up Mm.24788 Mm.24788 104756_at AA739415 ESTs1038 0.03242 2.04 up Mm.29363 2310044F10Rik 95109_at AW121447 RIKEN cDNA 2310044F10 gene1039 0.03250 2.38 up Mm.4799 Gcet 101147_at U13263 germinal center expressed transcript1040 0.03254 1.48 down Mm.7138 Plrg1 101064_at AF044334 pleiotropic regulator 1, PRL1 homolog (Arabidopsis)1041 0.03260 1.51 down Mm.7729 Aldo3 160546_at AW121134 aldolase 3, C isoform1042 0.03260 2.13 up Mm.34330 Blcap 98055_at AW121500 bladder cancer associated protein homolog (human)1043 0.03268 1.82 down Mm.27585 AA407270 161001_at AV367683 expressed sequence AA4072701044 0.03268 3.49 up Mm.26688 Thbs2 94930_at L07803 thrombospondin 21045 0.03269 2.01 up Mm.78093 AV308913 101443_at AI846119 expressed sequence AV3089131046 0.03272 2.85 up Mm.25056 C79741 95992_at C79950 expressed sequence C797411047 0.03279 1.63 down Mm.6560 2810403H05Rik 100963_at AI854243 RIKEN cDNA 2810403H05 gene1048 0.03283 1.43 down Mm.12468 Gbas 102402_at AJ001261 glioblastoma amplified sequence1049 0.03288 1.63 up Mm.34589 Rpo1-2 92225_f_at U58280 RNA polymerase 1-2 (128 kDa subunit)1050 0.03291 1.73 down Mm.10800 Kcnk1 102335_at AF033017 potassium channel, subfamily K, member 11051 0.03297 1.79 down Mm.4079 2300007F24Rik 92398_at AI848723 RIKEN cDNA 2300007F24 gene1052 0.03303 1.69 down Mm.28765 1810049E02Rik 98956_at AI844979 RIKEN cDNA 1810049E02 gene1053 0.03310 2.05 down Mm.28922 Farsl 94494_at AI840856 phenylalanine-tRNA synthetase-like1054 0.03317 2.72 down Mm.27432 Dnajb9 96680_at AI835630 DnaJ (Hsp40) homolog, subfamily B, member 91055 0.03322 1.98 up Mm.7992 Cnr1 99892_at U17985 cannabinoid receptor 1 (brain)1056 0.03333 5.06 up Mm.918 Hspa5 162445_at AV351546 heat shock 70kD protein 5 (glucose-regulated protein, 78kD)1057 0.03338 2.11 up Mm.87801 Pira3 100328_s_at U96684 paired-Ig-like receptor A31058 0.03339 1.89 up Mm.30200 0610009I16Rik 162144_at AV351508 RIKEN cDNA 0610009I16 gene1059 0.03343 2.50 up Mm.6756 Mtr 101660_at AA415486 5-methyltetrahydrofolate-homocysteine methyltransferase1060 0.03364 3.16 up Mm.5674 C78067 101228_at C78067 expressed sequence C780671061 0.03365 1.87 down Mm.30729 1110002O23Rik 97964_at AW122851 RIKEN cDNA 1110002O23 gene1062 0.03371 2.49 up Mm.3233 Irf7 162202_f_at AV373853 interferon regulatory factor 71063 0.03374 3.40 up Mm.20271 Fbn2 103623_at L39790 fibrillin 21064 0.03380 2.41 down Mm.16497 Tcf21 103050_at AF035717 transcription factor 211065 0.03386 1.44 down Mm.12677 Atp5c1 92799_g_at AA870675 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypepti1066 0.03395 2.03 up Mm.5 Hoxa10 92970_at L08757 homeo box A101067 0.03395 4.38 up Mm.43005 Uba52 95907_at AW124972 ubiquitin A-52 residue ribosomal protein fusion product 11068 0.03397 1.86 down Mm.1266 Prkca 102299_at M25811 protein kinase C, alpha1069 0.03408 2.75 up Mm.21414 Ccsd 162351_f_at AV174603 copper chaperone for superoxide dismutase1070 0.03421 1.37 down Mm.21451 4933434E20Rik 102141_f_at AI462340 RIKEN cDNA 4933434E20 gene1071 0.03428 2.55 down Mm.24261 AI848335 160970_at AI848335 expressed sequence AI8483351072 0.03432 5.77 up Mm.20285 Krt2-19 161175_r_at AV241614 keratin complex 2, basic, gene 191073 0.03432 1.39 up Mm.34708 2610019N19Rik 98096_f_at AI840219 RIKEN cDNA 2610019N19 gene1074 0.03432 5.21 up Mm.1160 AI597080 161541_r_at AV239332 expressed sequence AI5970801075 0.03447 3.03 up Mm.141741 Clp-pending 95466_at AI837006 coactosin-like protein1076 0.03448 3.15 up Mm.116700 Crlf1 161046_at AA270365 cytokine receptor-like factor 11077 0.03451 2.15 up Mm.25888 1700003F10Rik 160214_at AW122235 RIKEN cDNA 1700003F10 gene1078 0.03453 2.32 down Mm.25293 Pcmt1 94347_i_at AW124044 protein-L-isoaspartate (D-aspartate) O-methyltransferase 11079 0.03459 1.92 down Mm.193096 Scd2 95758_at M26270 stearoyl-Coenzyme A desaturase 21080 0.03461 6.04 up Mm.6863 C80129 93458_at AA501129 expressed sequence C80129Page 12 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1081 0.03468 2.32 up Mm.10205 Utf1 102220_at AB017360 undifferentiated embryonic cell transcription factor 11082 0.03469 2.06 down Mm.7880 Amd1 101489_at D12780 S-adenosylmethionine decarboxylase 11083 0.03470 2.23 down Mm.4471 1810041M12Rik 99988_at AW122115 RIKEN cDNA 1810041M12 gene1084 0.03476 1.77 up Mm.57170 Gdf11 101814_at AF100906 growth differentiation factor 111085 0.03479 1.53 down Mm.123240 1700016D08Rik 162350_at AV173777 RIKEN cDNA 1700016D08 gene1086 0.03480 2.55 up Mm.4219 Man2b1 162150_r_at AV327201 mannosidase 2, alpha B11087 0.03489 1.51 down Mm.20946 Psmc3 93734_i_at D49686 proteasome (prosome, macropain) 26S subunit, ATPase 31088 0.03498 3.02 up Mm.2699 Igsf7 104023_at AW060457 immunoglobulin superfamily, member 71089 0.03499 1.39 up Mm.28203 2410130M07Rik 97824_at AW121031 RIKEN cDNA 2410130M07 gene1090 0.03506 1.59 down Mm.10093 1110007A04Rik 102022_at AW124555 RIKEN cDNA 1110007A04 gene1091 0.03507 3.97 up Mm.1412 Dspp 94721_at AJ002141 dentin sialophosphoprotein1092 0.03507 2.08 up Mm.205258 D17892 100347_at AA154606 expressed sequence D178921093 0.03509 1.67 down Mm.19130 1110059L23Rik 93496_at AI852098 RIKEN cDNA 1110059L23 gene1094 0.03516 3.26 up Mm.135114 AA408225 104083_at AI853217 expressed sequence AA4082251095 0.03524 1.71 up Mm.565 Sptlc2 100893_at U27455 serine palmitoyltransferase, long chain base subunit 21096 0.03524 1.58 up Mm.25732 1200014H24Rik 96027_at AW120546 RIKEN cDNA 1200014H24 gene1097 0.03527 1.80 down Mm.3996 Chuk 99070_at U12473 conserved helix-loop-helix ubiquitous kinase1098 0.03533 1.93 down Mm.195923 3110001K11Rik 97579_f_at AJ224343 RIKEN cDNA 3110001K11 gene1099 0.03535 3.96 down Mm.25122 AA408985 94343_at AI604013 expressed sequence AA4089851100 0.03535 3.31 up Mm.177725 Arf3 96587_at D87900 ADP-ribosylation factor 31101 0.03536 1.90 down Mm.22363 Mm.22363 104305_at AW120679 Mus musculus, similar to Unknown (protein for MGC:14993), clone MGC:2821102 0.03549 2.74 up Mm.20842 Cdc7l1 103797_at AB019388 cell division cycle 71 homolog (S. cerevisiae)-like 11103 0.03551 2.35 down Mm.14114 Ceacam1 102804_at X67279 CEA-related cell adhesion molecule 11104 0.03552 1.49 down Mm.29182 Taldo1 95066_at U67611 transaldolase 11105 0.03563 1.58 down Mm.89927 Srp9 101579_at X78304 signal recognition particle 9 kDa1106 0.03567 1.79 down Mm.10682 Capn5 102316_at Y10656 calpain 51107 0.03571 2.90 down Mm.36850 Smtn 98559_at AJ010305 smoothelin1108 0.03581 6.81 up Mm.3862 Igf2 98623_g_at X71922 insulin-like growth factor 21109 0.03590 2.00 up Mm.3834 Cnlp 92322_at X94353 cathelin-like protein1110 0.03594 2.87 up Mm.39469 Tnni2 93532_at J04992 troponin I, skeletal, fast 21111 0.03600 1.71 down Mm.3545 Ica1 98484_at U37186 islet cell autoantigen 1, 69 kDa1112 0.03611 7.46 up Mm.6853 Sprr2a 101024_i_at AJ005559 small proline-rich protein 2A1113 0.03612 1.63 down Mm.196604 Aamp-rs 98064_at AW125378 angio-associated migratory protein, related sequence1114 0.03614 1.88 down Mm.16519 Nr2f2 103052_r_at X76653 nuclear receptor subfamily 2, group F, member 21115 0.03633 2.86 down Mm.14601 Gstm2 93009_at J04696 glutathione S-transferase, mu 21116 0.03634 2.01 down Mm.25608 1110057K04Rik 94382_at AI851901 RIKEN cDNA 1110057K04 gene1117 0.03649 2.93 up Mm.2253 Klkb1 104344_at M58588 kallikrein B, plasma 11118 0.03653 2.24 down Mm.218793 Xlr3b 101883_s_at L22977 X-linked lymphocyte-regulated 3b1119 0.03656 2.23 up Mm.6258 Eda 93393_at AF016628 ectodysplasin-A1120 0.03661 1.75 up Mm.2548 U90926 100717_at U90926 cDNA sequence U909261121 0.03662 3.61 up Mm.18628 Cd36 161704_r_at AV091761 CD36 antigen1122 0.03669 3.92 up Mm.195048 Defcr6 93863_f_at U03003 defensin related cryptdin 61123 0.03670 4.10 up Mm.2999 Fin16 97421_at U42385 fibroblast growth factor inducible 161124 0.03671 2.00 up Mm.6221 Capn1 161423_r_at AV294809 calpain 11125 0.03672 2.78 up Mm.197478 Imap38 161384_r_at AV250661 immunity-associated protein, 38 kDa1126 0.03675 1.31 up Mm.172945 2610028J07Rik 98369_f_at AW048053 RIKEN cDNA 2610028J07 gene1127 0.03676 1.49 up Mm.29824 Psa 162440_r_at AV347344 puromycin-sensitive aminopeptidase1128 0.03686 1.77 down Mm.28668 Cope 98930_at AI844701 coatomer protein complex, subunit epsilon1129 0.03694 2.07 up Mm.24517 1110029L11Rik 161220_f_at AV252802 RIKEN cDNA 1110029L11 gene1130 0.03697 2.22 up Mm.42192 Kip2-pending 99536_at AB016080 kinase interacting protein 21131 0.03699 2.33 up Mm.1 S100a10 162340_r_at AV128077 S100 calcium binding protein A10 (calpactin)1132 0.03705 1.73 down Mm.196484 Csrp 92608_at D88793 cysteine rich protein1133 0.03706 2.68 up Mm.14126 Mmp10 94724_at Y13185 matrix metalloproteinase 101134 0.03706 1.42 down Mm.18353 Dpagt2 103352_at X65603 dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 21135 0.03710 2.19 up Mm.34483 Mm.34483 103326_at AI852663 ESTs, Weakly similar to C52B9.3.p [Caenorhabditis elegans] [C.elegans]1136 0.03718 1.61 up Mm.141587 Csda 95755_at D14485 cold shock domain protein A1137 0.03730 1.50 down Mm.1605 Pdcd4 103029_at D86344 programmed cell death 41138 0.03737 1.73 down Mm.19091 AU042646 103557_at AI850046 expressed sequence AU0426461139 0.03745 1.68 up Mm.361 Ptpn18 92273_at U49853 protein tyrosine phosphatase, non-receptor type 181140 0.03756 1.64 up Mm.925 Tfdp1 101959_r_at X72310 transcription factor Dp 11141 0.03758 1.39 down Mm.23723 AI573938 103547_at AI837116 expressed sequence AI5739381142 0.03762 1.63 up Mm.4046 Ms4a2 104173_at AA797989 membrane-spanning 4-domains, subfamily A, member 21143 0.03764 2.10 down Mm.2875 1100001J13Rik 98951_at AI843258 RIKEN cDNA 1100001J13 gene1144 0.03769 2.88 up Mm.1514 Lpl 95611_at AA726364 lipoprotein lipase1145 0.03773 1.64 down Mm.7838 Maid 101483_at AI850862 maternal inhibition of differentiation1146 0.03778 2.83 up Mm.22662 Krt1-10 162121_at AV374020 keratin complex 1, acidic, gene 101147 0.03779 3.47 up Mm.2561 Esr2 96514_at U81451 estrogen receptor 2 (beta)1148 0.03780 5.82 up Mm.1461 Sell 102838_at M36058 selectin, lymphocyte1149 0.03789 6.00 up Mm.9257 D10Wsu52e 161197_r_at AV255941 DNA segment, Chr 10, Wayne State University 52, expressed1150 0.03795 3.73 up Mm.14438 AU044919 102824_g_at X67210 expressed sequence AU0449191151 0.03802 2.12 up Mm.24615 Gja4 104729_at X57971 gap junction membrane channel protein alpha 41152 0.03804 2.13 down Mm.8108 Wee1 101458_at D30743 wee 1 homolog (S. pombe)1153 0.03817 1.45 down Mm.22276 AW495282 104288_at AI853265 expressed sequence AW4952821154 0.03818 1.73 up Mm.200373 Sgpl1 96126_at AF036894 sphingosine phosphate lyase 11155 0.03820 3.82 up Mm.30250 D18Wsu181e 161783_at AV362606 DNA segment, Chr 18, Wayne State University 181, expressed1156 0.03822 1.91 down Mm.39040 Mal 99089_at Y07812 myelin and lymphocyte protein, T-cell differentiation protein1157 0.03822 4.02 up Mm.13211 Mm.13211 94685_at C76510 ESTs1158 0.03826 1.41 up Mm.8575 Sox13 93698_at AB006329 SRY-box containing gene 131159 0.03844 2.04 up Mm.29279 Smoh 96812_at AF089721 smoothened homolog (Drosophila)1160 0.03846 2.06 up Mm.27291 Bysl 160227_s_at AI132491 bystin-like1161 0.03846 1.75 up Mm.24035 D16Ertd480e 103701_at AA420331 DNA segment, Chr 16, ERATO Doi 480, expressed1162 0.03854 3.31 up Mm.1643 AW413625 161142_at AV204395 expressed sequence AW4136251163 0.03856 3.75 up Mm.4669 Adam2 92732_at U16242 a disintegrin and metalloprotease domain 21164 0.03860 1.86 up Mm.200540 R74921 102312_r_at AW046728 expressed sequence R749211165 0.03861 4.03 up Mm.108242 Dnahc8 95309_at AA789879 dynein, axon, heavy chain 81166 0.03861 1.57 down Mm.29426 Sfrs9 96834_at AI843586 splicing factor, arginine/serine rich 9 (25 kDa)1167 0.03875 10.13 up Mm.34545 Mm.34545 97129_at AA617494 ESTs, Weakly similar to I49636 DNA-binding protein - mouse [M.musculus]1168 0.03887 1.81 down Mm.26422 Copg1 94427_at AI841737 coatomer protein complex, subunit gamma 11169 0.03891 1.87 up Mm.37215 Siah1b 92290_at Z19580 seven in absentia 1B1170 0.03894 5.51 up Mm.788 Ly6e 161299_r_at AV049751 lymphocyte antigen 6 complex, locus EPage 13 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1171 0.03904 1.91 down Mm.88704 Ppp1r7 97979_at AI849126 protein phosphatase 1, regulatory (inhibitor) subunit 71172 0.03910 1.36 down Mm.35698 Prei2 98146_at AW120775 preimplantation protein 21173 0.03910 2.58 up Mm.141702 Myoz1 104555_at AA733946 myozenin 11174 0.03914 1.56 down Mm.28017 Fbxw1b 160764_at AW046376 F-box and WD-40 domain protein 1B1175 0.03915 4.60 up Mm.196085 Igh-4 97720_at AF000913 immunoglobulin heavy chain 4 (serum IgG1)1176 0.03916 2.89 up Mm.22574 Csf1r 104354_at X06368 colony stimulating factor 1 receptor1177 0.03916 2.89 up Mm.198 Mm.198 160642_at AI853079 Mus musculus, Similar to transmembrane protein 5, clone MGC:28135 IMAG1178 0.03917 1.26 down Mm.7463 Mm.7463 93627_at AI852287 ESTs1179 0.03924 1.69 down Mm.42855 1110030G05Rik 99599_s_at AW210320 RIKEN cDNA 1110030G05 gene1180 0.03925 1.47 down Mm.3874 Adh5 98625_s_at M84147 alcohol dehydrogenase 51181 0.03930 1.56 up Mm.3295 Bok 98031_at AF027707 Bcl-2-related ovarian killer protein1182 0.03931 1.99 down Mm.7308 Smarcd1 101405_at M25773 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,1183 0.03932 3.04 up Mm.23999 Mm.23999 95887_at AI451008 ESTs1184 0.03935 3.02 up Mm.6018 AA675346 93245_at AI645718 expressed sequence AA6753461185 0.03939 2.17 down Mm.176927 2610301I15Rik 94010_g_at AI848888 RIKEN cDNA 2610301I15 gene1186 0.03942 1.95 up Mm.181860 2310057H16Rik 160461_f_at AW215736 RIKEN cDNA 2310057H16 gene1187 0.03943 1.90 up Mm.5291 Rps5 99336_at U78085 ribosomal protein S51188 0.03946 1.54 down Mm.24875 Mrps18a 94327_at AW230209 mitochondrial ribosomal protein S18A1189 0.03959 2.47 up Mm.7386 Mfap2 101095_at L23769 microfibrillar-associated protein 21190 0.03968 1.59 up Mm.143755 Brd4 104352_at AI838366 bromodomain-containing 41191 0.03977 1.97 down Mm.29382 1110038D17Rik 161534_f_at AV234294 RIKEN cDNA 1110038D17 gene1192 0.04004 1.38 up Mm.23910 Etohd2 104572_at AI852047 ethanol decreased 21193 0.04007 1.47 down Mm.27476 Mm.27476 95021_at AW124028 ESTs, Highly similar to hypothetical protein FLJ10154 [Homo sapiens] [H.sa1194 0.04014 1.80 down Mm.30250 D18Wsu181e 97450_s_at AA986258 DNA segment, Chr 18, Wayne State University 181, expressed1195 0.04015 1.92 up Mm.21569 2700069E09Rik 96843_at AF068116 RIKEN cDNA 2700069E09 gene1196 0.04018 1.49 up Mm.1896 AW536594 102980_at AI849119 expressed sequence AW5365941197 0.04022 2.62 up Mm.13351 Mm.13351 99756_at C81515 ESTs1198 0.04028 11.47 up Mm.28057 1110064N10Rik 161746_i_at AV320590 RIKEN cDNA 1110064N10 gene1199 0.04031 2.03 down Mm.12616 Dnajc3 102414_i_at U28423 DnaJ (Hsp40) homolog, subfamily C, member 31200 0.04037 2.21 up Mm.2720 Mapk8ip 161619_f_at AV354894 mitogen activated protein kinase 8 interacting protein1201 0.04040 3.79 up Mm.2021 AI788959 103227_at AI788959 expressed sequence AI7889591202 0.04043 1.69 down Mm.28287 AU015605 97853_at AW047331 expressed sequence AU0156051203 0.04044 4.91 up Mm.5330 Olr1 93167_f_at AA104818 oxidised low density lipoprotein (lectin-like) receptor 11204 0.04047 4.65 up Mm.272 Spink3 96630_at X06342 serine protease inhibitor, Kazal type 31205 0.04047 1.96 down Mm.30051 Rnf10 96859_at AB026621 ring finger protein 101206 0.04052 2.22 up Mm.196637 1200003I10Rik 161124_at AV237354 RIKEN cDNA 1200003I10 gene1207 0.04060 3.05 down 93573_at V008351208 0.04062 1.46 down Mm.27839 4930455J02Rik 97240_g_at AI845106 RIKEN cDNA 4930455J02 gene1209 0.04066 1.34 up Mm.29586 Basp1 95674_r_at AI851985 brain abundant, membrane attached signal protein 11210 0.04069 3.83 up Mm.218310 Mm.218310 160934_s_at X05546 Murine (DBA/2) mRNA fragment for gag related peptide1211 0.04070 3.98 up Mm.28480 Fkbp3 161795_r_at AV366904 FK506 binding protein 3 (25kD)1212 0.04073 1.58 down Mm.163 B2m 93088_at X01838 beta-2 microglobulin1213 0.04074 1.91 up Mm.28275 Rbmx 97848_at AJ237846 RNA binding motif protein, X chromosome1214 0.04079 2.47 up Mm.16861 C78142 94782_at C78137 expressed sequence C781421215 0.04087 2.40 up Mm.25086 C80731 103927_at AW212672 expressed sequence C807311216 0.04092 2.24 up Mm.3869 Prrx1 99021_at U03873 paired related homeobox 11217 0.04106 1.71 down Mm.103551 Tollip-pending 160809_at AI842752 toll interacting protein1218 0.04108 2.35 up Mm.196591 Spi1-3 101565_f_at M75720 serine protease inhibitor 1-31219 0.04112 2.06 down Mm.24006 1110013O05Rik 162428_i_at AV293396 RIKEN cDNA 1110013O05 gene1220 0.04116 5.17 up Mm.2068 Ncf4 103662_at U59488 neutrophil cytosolic factor 41221 0.04117 1.78 up Mm.3711 Gdm1 98984_f_at D50430 glycerol phosphate dehydrogenase 1, mitochondrial1222 0.04119 1.55 down Mm.4294 Adcy9 92527_at Z50190 adenylate cyclase 91223 0.04122 1.76 down Mm.2559 Umpk 94381_at L31783 uridine monophosphate kinase1224 0.04125 1.57 down Mm.2261 Psmd4 94302_at AF013099 proteasome (prosome, macropain) 26S subunit, non-ATPase, 41225 0.04127 13.57 up Mm.30438 Tyrp1 161538_r_at AV237026 tyrosinase-related protein 11226 0.04132 4.03 up Mm.17484 Snca 93273_at AF044672 synuclein, alpha1227 0.04134 1.84 up Mm.10303 Nol5 92569_f_at AF053232 nucleolar protein 51228 0.04136 1.90 up Mm.28040 1500036F01Rik 160264_s_at AI836143 RIKEN cDNA 1500036F01 gene1229 0.04136 2.06 down Mm.205791 Atp1a1 93797_g_at AW123952 ATPase, Na+/K+ transporting, alpha 1 polypeptide1230 0.04139 1.65 up Mm.196189 Angptl4 96119_s_at AA797604 angiopoietin-like 41231 0.04144 3.34 up Mm.9821 Sah 102192_r_at AF068246 SA rat hypertension-associated homolog1232 0.04147 2.87 up Mm.143603 Sh3d2a 92673_at U58886 SH3 domain protein 2A1233 0.04156 2.68 up Mm.10374 2610002J02Rik 102057_r_at AA839379 RIKEN cDNA 2610002J02 gene1234 0.04163 1.45 down Mm.28580 Mtm1 96199_at AF073996 X-linked myotubular myopathy gene 11235 0.04169 1.34 down Mm.235 Ubb 101255_at X51703 ubiquitin B1236 0.04171 1.81 down Mm.27843 Mm.27843 104215_at AA592069 ESTs1237 0.04174 2.03 down Mm.46719 4933432H23Rik 160959_at AA597220 RIKEN cDNA 4933432H23 gene1238 0.04177 1.40 up Mm.4609 Pex14 100029_at AW208667 peroxisomal biogenesis factor 141239 0.04177 1.81 down Mm.203924 AW259572 92348_at AI841022 expressed sequence AW2595721240 0.04187 2.06 up Mm.5080 Sox17 92996_at D49473 SRY-box containing gene 171241 0.04192 2.86 up Mm.2375 Ckmm 161569_f_at AV086797 creatine kinase, muscle1242 0.04193 3.09 up Mm.6523 S100a13 161121_f_at AV007820 S100 calcium binding protein A131243 0.04194 2.30 down Mm.7892 Rfx1 99880_at X76088 regulatory factor (trans-acting) 11244 0.04202 1.51 up Mm.21772 Smarcd2 161077_f_at AV252495 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,1245 0.04209 1.58 down Mm.4730 Ppox 100429_at U89155 protoporphyrinogen oxidase1246 0.04215 2.35 down Mm.41625 Sirt3 160869_at AI849490 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisia1247 0.04219 1.69 down Mm.2389 Mll 104569_at AW122024 myeloid/lymphoid or mixed-lineage leukemia1248 0.04227 1.77 down Mm.22338 Mm.22338 104299_at AI842472 Mus musculus, Similar to hypothetical protein FLJ20984, clone MGC:291941249 0.04239 3.35 down Mm.18502 Osbpl1a 93316_at AB017026 oxysterol binding protein-like 1A1250 0.04243 2.52 up Mm.214491 Pld1 92474_at AF083497 phospholipase D11251 0.04245 1.54 up Mm.28327 2510049I19Rik 97864_at AW258842 RIKEN cDNA 2510049I19 gene1252 0.04245 1.76 down Mm.18651 Lorsdh 103389_at AJ224761 lysine oxoglutarate reductase, saccharopine dehydrogenase1253 0.04248 7.86 up Mm.2496 Ina 94334_f_at L27220 internexin neuronal intermediate filament protein, alpha1254 0.04249 1.26 down Mm.27733 1110034F20Rik 97217_at AI842095 RIKEN cDNA 1110034F20 gene1255 0.04256 1.59 down Mm.6836 Arf1 101016_at D87898 ADP-ribosylation factor 11256 0.04258 1.39 up Mm.833 Ap1s1 160552_at M62418 adaptor protein complex AP-1, sigma 11257 0.04261 3.85 up Mm.24928 C76972 95857_at C76972 expressed sequence C769721258 0.04263 1.73 up Mm.25194 Myo1c 95506_at U96723 myosin Ic1259 0.04264 1.39 down Mm.21185 Ap3b1 103878_at AF103809 adaptor-related protein complex AP-3, beta 1 subunit1260 0.04266 2.29 up Mm.2995 Ect2 97411_at L11316 ect2 oncogenePage 14 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1261 0.04270 3.26 up Mm.3468 Cish3 162206_f_at AV374868 cytokine inducible SH2-containing protein 31262 0.04273 3.74 up Mm.3894 Fkbp10 162414_f_at AV320580 FK506 binding protein 10 (65 kDa)1263 0.04275 2.72 up Mm.29625 Mm.29625 97351_i_at AW123567 ESTs, Weakly similar to COXG MOUSE CYTOCHROME C OXIDASE POLY1264 0.04282 1.39 down Mm.6636 4930564D15Rik 93440_at AA692530 RIKEN cDNA 4930564D15 gene1265 0.04287 1.47 down Mm.27404 1110002A21Rik 96675_at AW124245 RIKEN cDNA 1110002A21 gene1266 0.04289 2.21 up 100616_at AF0127101267 0.04291 1.34 down Mm.27624 C530002L11Rik 96710_at AI854262 RIKEN cDNA C530002L11 gene1268 0.04291 3.66 up Mm.5199 Cyp19 101200_at D00659 cytochrome P450, 19, aromatase1269 0.04295 7.30 up Mm.1721 Lipe 161411_i_at AV315398 lipase, hormone sensitive1270 0.04301 1.75 down Mm.28465 Lrp10 96186_at AI839286 low-density lipoprotein receptor-related protein 101271 0.04303 1.34 down Mm.20207 2510029B14Rik 93551_at AW121424 RIKEN cDNA 2510029B14 gene1272 0.04307 1.82 up Mm.10474 3110005M08Rik 92577_f_at AW047116 RIKEN cDNA 3110005M08 gene1273 0.04314 1.55 down Mm.24411 1110017N23Rik 103739_at AW230977 RIKEN cDNA 1110017N23 gene1274 0.04321 2.17 up Mm.30465 Cktsf1b1 101758_at AF045801 cysteine knot superfamily 1, BMP antagonist 11275 0.04325 2.65 up Mm.6253 Crygs 93391_at AF032995 crystallin, gamma S1276 0.04328 9.32 up Mm.46856 Pawr 162434_i_at AV307886 PRKC, apoptosis, WT1, regulator1277 0.04333 2.09 up Mm.858 Igtp 160933_at U53219 interferon gamma induced GTPase1278 0.04335 1.24 up Mm.7405 Bat4 101416_f_at L76155 HLA-B associated transcript 41279 0.04336 1.58 down Mm.8911 Psmb5 101741_at AB003305 proteasome (prosome, macropain) subunit, beta type 51280 0.04341 2.73 up Mm.5510 Mm.5510 161484_r_at AV077293 Mus musculus, Similar to gene overexpressed in astrocytoma, clone IMAGE1281 0.04344 3.50 up Mm.24310 Mm.24310 95903_at AI842525 ESTs1282 0.04347 3.14 up Mm.27584 AW547774 102115_r_at AI482351 expressed sequence AW5477741283 0.04352 2.61 up Mm.448 Cyba 100059_at M31775 cytochrome b-245, alpha polypeptide1284 0.04354 1.35 up Mm.22884 2410012M21Rik 94843_at AW045413 RIKEN cDNA 2410012M21 gene1285 0.04359 2.27 up Mm.218758 Pcdha14 101769_at AB008178 protocadherin alpha 141286 0.04363 2.68 up Mm.20164 3110050F08Rik 103607_at AI882309 RIKEN cDNA 3110050F08 gene1287 0.04364 3.71 up Mm.34102 Odc 162386_at AV255366 ornithine decarboxylase, structural1288 0.04366 1.57 down Mm.29702 D3Ucla1 95708_at AI843466 DNA segment, Chr 3, University of California at Los Angeles 11289 0.04369 1.45 up Mm.29746 Mrpl3 95734_at AI852230 mitochondrial ribosomal protein L31290 0.04379 1.60 down Mm.142872 Hnrpk 94041_at AI840643 heterogeneous nuclear ribonucleoprotein K1291 0.04379 1.39 up Mm.21577 Mm.21577 103449_at AA795923 ESTs1292 0.04380 2.60 up Mm.3180 Tnfrsf18 104662_at U82534 tumor necrosis factor receptor superfamily, member 181293 0.04384 2.80 up Mm.28859 Gnai1 97195_at U38501 guanine nucleotide binding protein, alpha inhibiting 11294 0.04392 1.52 down Mm.3886 2810012H18Rik 99080_at AI853930 RIKEN cDNA 2810012H18 gene1295 0.04393 2.73 up Mm.201109 C77386 95963_at C77386 expressed sequence C773861296 0.04396 1.88 up Mm.4375 Smstr2 99889_at AF030441 somatostatin receptor 21297 0.04403 1.56 down Mm.181830 Ntan1 96666_at U57692 N-terminal Asn amidase1298 0.04409 1.82 down Mm.41043 AW545363 99129_at AW124529 expressed sequence AW5453631299 0.04411 1.54 down Mm.27107 5730536A07Rik 96613_at AI852095 RIKEN cDNA 5730536A07 gene1300 0.04418 2.71 up Mm.903 Btg2 101583_at M64292 B-cell translocation gene 2, anti-proliferative1301 0.04424 1.44 down Mm.18729 Copb2 93341_r_at AF043120 coatomer protein complex, subunit beta 2 (beta prime)1302 0.04432 1.39 down Mm.4179 Irf6 92440_at U73029 interferon regulatory factor 61303 0.04433 1.55 up Mm.30177 2700047N05Rik 160395_at AW046672 RIKEN cDNA 2700047N05 gene1304 0.04444 1.33 up Mm.4505 Gart 100066_at U20892 phosphoribosylglycinamide formyltransferase1305 0.04445 2.11 up Mm.104747 Igk-V28 101640_f_at M15593 immunoglobulin kappa chain variable 28 (V28)1306 0.04446 1.59 up Mm.28690 1500026D16Rik 98938_at AI852184 RIKEN cDNA 1500026D16 gene1307 0.04447 1.59 down Mm.27792 0610011C19Rik 97228_at AI844417 RIKEN cDNA 0610011C19 gene1308 0.04452 1.86 up Mm.27575 Zfp68 95521_s_at AB024005 Zinc finger protein 681309 0.04457 1.77 up Mm.193418 Spi1-2 101575_i_at M25529 serine protease inhibitor 1-21310 0.04458 1.50 down Mm.29030 Sh3d5 160320_at U58883 SH3 domain protein 51311 0.04463 3.57 up Mm.27669 Snrpe 161311_at AV080357 small nuclear ribonucleoprotein E1312 0.04467 2.38 up Mm.30109 1110055L24Rik 160387_at AI853900 RIKEN cDNA 1110055L24 gene1313 0.04469 2.21 up Mm.6818 Itgb1bp1 100991_at AI852849 integrin beta 1 binding protein 11314 0.04471 1.61 up Mm.4521 Traf4 100005_at X92346 Tnf receptor associated factor 41315 0.04480 1.48 down Mm.4342 Tjp1 99935_at D14340 tight junction protein 11316 0.04484 2.14 up Mm.200941 Saa2 101306_f_at M17790 serum amyloid A 21317 0.04484 1.38 down Mm.38746 1810017G16Rik 98626_at AW047503 RIKEN cDNA 1810017G16 gene1318 0.04486 4.37 up Mm.1432 Trrp1 94740_g_at U73625 transient receptor protein 11319 0.04493 1.54 up Mm.23925 4833422P03Rik 104573_at AA921069 RIKEN cDNA 4833422P03 gene1320 0.04496 1.75 up Mm.203905 AU021838 95018_r_at AA607053 expressed sequence AU0218381321 0.04499 1.69 up Mm.4186 Pla2g4a 99513_at M72394 phospholipase A2, group IVA (cytosolic, calcium-dependent)1322 0.04505 1.74 up Mm.13859 Rpl41 100213_f_at U93862 ribosomal protein L411323 0.04506 1.73 up Mm.3487 Rpl30 98119_at K02928 ribosomal protein L301324 0.04511 1.19 up Mm.17905 Rpia 103322_at L35034 ribose 5-phosphate isomerase A1325 0.04515 2.62 up Mm.798 5031419I10Rik 93647_at AI152195 RIKEN cDNA 5031419I10 gene1326 0.04516 1.21 down Mm.8131 Ilk 101499_at U94479 integrin linked kinase1327 0.04517 2.64 up 102762_r_at AF0575271328 0.04527 4.01 up Mm.143846 Ptprc 161410_r_at AV313844 protein tyrosine phosphatase, receptor type, C1329 0.04528 3.50 up Mm.548 Cox6c 100551_r_at AW060422 cytochrome c oxidase, subunit VIc1330 0.04531 5.13 up Mm.5137 Doc2b 101191_at D85037 double C2, beta1331 0.04540 1.79 up Mm.35801 C76683 97179_at C76543 expressed sequence C766831332 0.04541 2.27 up Mm.28561 Prkcz 161964_r_at AV367375 protein kinase C, zeta1333 0.04547 1.60 up Mm.28630 Rnac-pending 98923_at AI852608 RNA cyclase homolog1334 0.04552 2.04 down Mm.2642 Pabpc1 100720_at X65553 poly A binding protein, cytoplasmic 11335 0.04558 1.46 down Mm.41502 Fh1 99148_at AI852862 fumarate hydratase 11336 0.04560 1.28 down Mm.21606 Rtn3 97077_f_at AW213991 reticulon 31337 0.04570 5.58 up Mm.22306 1810045K06Rik 161245_r_at AV312754 RIKEN cDNA 1810045K06 gene1338 0.04574 6.29 up Mm.34797 Crabp1 98108_at X15789 cellular retinoic acid binding protein I1339 0.04576 1.65 down Mm.24855 1110020N13Rik 95480_at AI847163 RIKEN cDNA 1110020N13 gene1340 0.04581 2.34 up Mm.6211 Amac1 93386_at AF016712 acyl-malonyl condensing enzyme1341 0.04590 1.81 up Mm.26166 Acp1 104160_at AW049866 acid phosphatase 1, soluble1342 0.04594 2.49 up Mm.195071 Pcdha11 101772_r_at AB008182 protocadherin alpha 111343 0.04597 3.89 up Mm.14087 C4bp 102799_at M17122 complement component 4 binding protein1344 0.04600 3.49 up Mm.198513 AI266795 95454_at AI266795 expressed sequence AI2667951345 0.04602 3.12 up Mm.3075 Dnajb3 97480_f_at U95607 DnaJ (Hsp40) homolog, subfamily B, member 31346 0.04603 3.22 up Mm.12955 Kcna7 94193_at AF032099 potassium voltage-gated channel, shaker-related subfamily, member 71347 0.04606 1.68 up Mm.42247 Rbms2 92517_at AB026583 RNA binding motif, single stranded interacting protein 21348 0.04609 3.16 up Mm.41886 Gfra2 92449_at AF002701 glial cell line derived neurotrophic factor family receptor alpha 21349 0.04611 2.22 down Mm.10103 Zfp98 94101_at AB007407 zinc finger protein 981350 0.04614 1.76 up Mm.1129 Rps2 100686_at M20632 ribosomal protein S2Page 15 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1351 0.04620 1.68 up Mm.157069 Dlk1 101975_at Z12171 delta-like 1 homolog (Drosophila)1352 0.04622 3.89 up Mm.14116 Gabrr1 100675_at AF024620 gamma-aminobutyric acid (GABA-A) receptor, subunit rho 11353 0.04623 1.54 down Mm.30181 Map17-pending 96935_at AW011791 membrane-associated protein 171354 0.04624 2.77 up Mm.22982 AI326115 104523_at AI049391 expressed sequence AI3261151355 0.04624 2.71 up 99374_at M124821356 0.04632 1.60 down Mm.15351 1110054N06Rik 93054_at AI846368 RIKEN cDNA 1110054N06 gene1357 0.04634 2.00 up Mm.5866 D18Ertd232e 99823_r_at C79676 DNA segment, Chr 18, ERATO Doi 232, expressed1358 0.04638 2.19 up Mm.86686 H2-M10.1 100305_g_at AI449957 histocompatibility 2, M region locus 10.11359 0.04638 1.77 down Mm.7884 1810010A06Rik 101490_at AW122692 RIKEN cDNA 1810010A06 gene1360 0.04645 2.26 up Mm.21981 AI327276 162339_r_at AV113685 expressed sequence AI3272761361 0.04651 1.36 up Mm.30252 4121402D02Rik 97935_at AI842970 RIKEN cDNA 4121402D02 gene1362 0.04651 1.86 up Mm.3747 2210414H16Rik 160465_at AA882285 RIKEN cDNA 2210414H16 gene1363 0.04653 1.31 up Mm.41486 2700001K05Rik 99147_at AI843986 RIKEN cDNA 2700001K05 gene1364 0.04654 1.46 up Mm.787 Psmb10 101486_at Y10875 proteasome (prosome, macropain) subunit, beta type 101365 0.04657 1.83 up Mm.7221 Lrp1 101073_at X67469 low density lipoprotein receptor-related protein 11366 0.04658 1.95 down Mm.27900 1810013D10Rik 97265_at AI835060 RIKEN cDNA 1810013D10 gene1367 0.04659 2.84 up Mm.149029 Siat1 94432_at AI117157 sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)1368 0.04663 1.78 up Mm.57096 Htr1d 101764_at X94908 5-hydroxytryptamine (serotonin) receptor 1D1369 0.04674 1.62 down Mm.2726 Itpr1 94977_at X15373 inositol 1,4,5-triphosphate receptor 11370 0.04675 4.68 up Mm.1382 Krt2-17 94703_at M24151 keratin complex 2, basic, gene 171371 0.04680 1.88 down Mm.28548 Lpin1 98892_at AI846934 lipin 11372 0.04682 1.56 up Mm.3484 Npc1 98114_at AF003348 Niemann Pick type C11373 0.04687 2.35 up Mm.28184 2210408E11Rik 161310_at AV079187 RIKEN cDNA 2210408E11 gene1374 0.04688 2.41 up Mm.24897 Mm.24897 95852_at C76202 ESTs1375 0.04694 4.39 up Mm.4078 Mki67 99457_at X82786 antigen identified by monoclonal antibody Ki 671376 0.04697 1.79 down Mm.29816 Pdcd6ip 96252_at AJ005073 programmed cell death 6 interacting protein1377 0.04699 1.80 up Mm.15918 Map3k1 103020_s_at AI317205 mitogen activated protein kinase kinase kinase 11378 0.04704 2.39 up Mm.66913 Zfp60 93447_at AA220047 zinc finger protein 601379 0.04705 1.55 down Mm.43212 1500031M19Rik 99619_at AI847483 RIKEN cDNA 1500031M19 gene1380 0.04705 1.22 down Mm.30167 Mm.30167 97923_at AW046532 Mus musculus, clone MGC:38846 IMAGE:5360921, mRNA, complete cds1381 0.04705 1.62 down Mm.214593 Prkcsh 100684_at U92794 protein kinase C substrate 80K-H1382 0.04706 1.64 down Mm.18847 Wrnip 103415_at AI840925 Werner syndrome homolog (human) interacting protein1383 0.04711 2.37 down Mm.20964 Gnao 161902_f_at AV374213 guanine nucleotide binding protein, alpha o1384 0.04713 2.96 up Mm.10098 Nsccn1 96414_at D50656 non-selective cation channel 11385 0.04717 2.49 up Mm.21005 Cst9 103296_at Y18243 cystatin 91386 0.04718 2.62 up Mm.5237 Ddef1 100513_at AF075461 development and differentiation enhancing1387 0.04719 1.86 down Mm.3105 Zfpm1 97974_at AF006492 zinc finger protein, multitype 11388 0.04719 2.49 up Mm.1098 Gpiap1 161232_r_at AV276689 GPI-anchored membrane protein 11389 0.04719 3.50 up Mm.46089 1600031J20Rik 160504_at AI197077 RIKEN cDNA 1600031J20 gene1390 0.04720 1.44 down Mm.19834 0610033L03Rik 93531_at AI853855 RIKEN cDNA 0610033L03 gene1391 0.04722 3.73 up Mm.30138 1110014F24Rik 96908_at AW060590 RIKEN cDNA 1110014F24 gene1392 0.04733 2.98 up Mm.34248 Dab2 98044_at U18869 disabled homolog 2 (Drosophila)1393 0.04734 2.62 up Mm.86487 Pspn 100298_at AF040960 persephin1394 0.04736 1.63 down Mm.794 R75223 101449_at AW120841 expressed sequence R752231395 0.04737 1.74 down Mm.42234 Dguok 99544_at AA980916 deoxyguanosine kinase1396 0.04739 1.88 up Mm.24291 Mm.24291 103727_at AI850972 ESTs1397 0.04757 1.75 up Mm.34801 Mrpl55 98109_at AI839528 mitochondrial ribosomal protein L551398 0.04769 2.89 up Mm.1021 Vcam1 92559_at U12884 vascular cell adhesion molecule 11399 0.04773 1.70 up Mm.4449 Endog 160494_at AB012108 endonuclease G1400 0.04775 6.26 up Mm.25083 Mm.25083 96482_at C80635 ESTs1401 0.04780 1.50 down Mm.87521 Pip5k1b 104663_at D86177 phosphatidylinositol-4-phosphate 5-kinase, type 1 beta1402 0.04780 3.91 up Mm.3900 Ltbp2 92335_at AF004874 latent transforming growth factor beta binding protein 21403 0.04783 1.73 up Mm.22723 Mm.22723 94823_at AI835315 Mus musculus, ribosomal protein L23a, clone IMAGE:4988735, mRNA, parti1404 0.04784 1.62 up Mm.21373 Igfbp6 103904_at X81584 insulin-like growth factor binding protein 61405 0.04785 3.10 up Mm.12825 Rbp2 92811_at X74154 retinol binding protein 2, cellular1406 0.04785 1.92 down Mm.24510 Slc12a7 104719_at AI182203 solute carrier family 12, member 71407 0.04789 2.45 down Mm.126873 Ppie 102278_at AA597254 peptidylprolyl isomerase E (cyclophilin E)1408 0.04789 1.47 down Mm.28111 2210409M21Rik 97797_at AW123142 RIKEN cDNA 2210409M21 gene1409 0.04803 2.60 up Mm.40339 Cysltr1-pending 94159_at D50872 cysteinyl leukotriene receptor 11410 0.04808 2.02 down Mm.155620 Pla2g6 97965_at U88624 phospholipase A2, group VI1411 0.04815 1.87 down Mm.146332 C87808 102859_at AW121304 expressed sequence C878081412 0.04816 2.00 down Mm.4514 Aldh1a1 100068_at M74570 aldehyde dehydrogenase family 1, subfamily A11413 0.04823 1.63 up Mm.133851 1500031N16Rik 160431_at AW124432 RIKEN cDNA 1500031N16 gene1414 0.04823 1.63 up Mm.25264 Ddx21 94361_at AI836083 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu)1415 0.04827 2.17 up Mm.24381 Ppp3cb 97989_at M81483 protein phosphatase 3, catalytic subunit, beta isoform1416 0.04836 1.76 up Mm.181894 2900092E17Rik 162165_f_at AV360672 RIKEN cDNA 2900092E17 gene1417 0.04837 2.20 down Mm.158423 5730543C08Rik 93614_at AA600647 RIKEN cDNA 5730543C08 gene1418 0.04837 2.51 up Mm.2863 Itm1 161285_r_at AV299547 intergral membrane protein 11419 0.04845 1.91 up Mm.3304 Nsg2 160413_at U17259 neuron specific gene family member 21420 0.04848 3.43 up Mm.46309 2010013B10Rik 97702_at AU015180 RIKEN cDNA 2010013B10 gene1421 0.04862 2.87 up Mm.1211 Tiam1 161845_at AV331929 T-cell lymphoma invasion and metastasis 11422 0.04875 1.66 up Mm.3511 Matn2 98475_at U69262 matrilin 21423 0.04893 2.22 down Mm.22061 Sema4a 94063_at X85991 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) an1424 0.04893 2.61 up Mm.46797 Adrb1 102151_at L10084 adrenergic receptor, beta 11425 0.04894 1.67 down Mm.4053 Tln 99448_at X56123 talin1426 0.04906 1.71 up Mm.33903 Sema4d 160836_at U69535 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) an1427 0.04909 4.13 up Mm.25160 Mm.25160 161943_at AV341572 ESTs1428 0.04909 2.55 up Mm.24174 AI316495 161526_r_at AV226134 expressed sequence AI3164951429 0.04911 1.84 up Mm.200796 AV028413 161698_f_at AV232762 expressed sequence AV0284131430 0.04916 3.43 up Mm.5032 Prph2 101169_at X14770 peripherin 21431 0.04917 2.27 up Mm.26658 Il10ra 96525_at L12120 interleukin 10 receptor, alpha1432 0.04919 1.70 up Mm.16080 Dnm 103031_g_at L31397 dynamin1433 0.04923 1.45 down Mm.23889 4632417G13Rik 94885_at AI840062 RIKEN cDNA 4632417G13 gene1434 0.04932 1.65 down Mm.203896 Lman1 160270_at AW108371 lectin, mannose-binding, 11435 0.04933 2.04 up Mm.41213 Abcb9 92418_at AB027520 ATP-binding cassette, sub-family B (MDR/TAP), member 91436 0.04939 1.82 up Mm.25292 Krt2-16 162328_f_at AV085755 keratin complex 2, basic, gene 161437 0.04957 2.59 up Mm.30366 Pcdha6 101650_at D86917 protocadherin alpha 61438 0.04958 1.87 up Mm.3597 Maged3 92270_at AI847616 melanoma antigen, family D, 31439 0.04962 1.71 down Mm.28584 9030401P18Rik 98906_at AI853035 RIKEN cDNA 9030401P18 gene1440 0.04969 3.11 up Mm.2682 Mep1b 162186_r_at AV369219 meprin 1 betaPage 16 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1441 0.04978 1.51 up Mm.27856 Ptprk 160760_at L10106 protein tyrosine phosphatase, receptor type, K1442 0.04981 1.69 down Mm.3747 2210414H16Rik 101916_at AA733674 RIKEN cDNA 2210414H16 gene1443 0.04985 1.38 down Mm.29042 2310005O14Rik 94531_at AW124582 RIKEN cDNA 2310005O14 gene1444 0.04986 1.71 down Mm.27591 2400006A19Rik 160239_at AI844762 RIKEN cDNA 2400006A19 gene1445 0.04990 2.76 up Mm.24957 C77545 95965_at C77545 expressed sequence C775451446 0.04990 2.33 up Mm.27668 Mm.27668 161209_r_at AV262402 ESTs, Moderately similar to I57546 Rabin3 - rat [R.norvegicus]1447 0.04997 1.50 down Mm.143830 Actn4 96343_at AI836968 alpha actinin 41448 0.05000 4.26 up Mm.3437 Pald 161564_r_at AV266918 paladin1449 0.05005 4.73 up Mm.20852 Epb4.1l1 103265_r_at AF061283 erythrocyte protein band 4.1-like 11450 0.05009 1.53 down Mm.200876 R74732 160252_at AI840975 expressed sequence R747321451 0.05017 1.65 down Mm.148425 1110028E10Rik 99445_at AW047012 RIKEN cDNA 1110028E10 gene1452 0.05026 1.89 down Mm.29965 2410104I19Rik 96329_at AI837793 RIKEN cDNA 2410104I19 gene1453 0.05027 1.73 up 161329_f_at AV1071531454 0.05033 1.66 up Mm.29088 0610013D04Rik 100758_at AF110520 RIKEN cDNA 0610013D04 gene1455 0.05037 3.46 up Mm.20285 Krt2-19 161174_i_at AV240674 keratin complex 2, basic, gene 191456 0.05039 2.24 down Mm.1192 Igj 102372_at M90766 immunoglobulin joining chain1457 0.05049 2.46 up Mm.3915 Mobp 99047_at U81317 myelin-associated oligodendrocytic basic protein1458 0.05054 3.37 up Mm.27917 1200003E16Rik 161203_f_at AV242890 RIKEN cDNA 1200003E16 gene1459 0.05061 1.70 down Mm.21848 1200015E15Rik 94019_at AI852534 RIKEN cDNA 1200015E15 gene1460 0.05075 5.14 up Mm.4858 Ctsg 92924_at X70057 cathepsin G1461 0.05083 1.91 up Mm.132208 2510001A17Rik 104297_at AW124742 RIKEN cDNA 2510001A17 gene1462 0.05088 4.62 up Mm.4886 Csnd 98814_at V00740 casein delta1463 0.05094 1.68 down Mm.45179 Ciao1-pending 100072_at AW046227 WD40 protein Ciao11464 0.05096 1.60 up Mm.6586 AI836376 161983_f_at AV377350 expressed sequence AI8363761465 0.05098 1.69 down Mm.139787 5930418K15Rik 102870_at AW125272 RIKEN cDNA 5930418K15 gene1466 0.05107 4.03 up Mm.35793 Ssa2 161416_r_at AV318871 Sjogren syndrome antigen A21467 0.05113 1.69 down Mm.38522 Nphp1 98614_at AJ243223 nephronophthisis 1 (juvenile) homolog (human)1468 0.05113 1.61 down Mm.22144 Copz2 104143_at AI843212 coatomer protein complex, subunit zeta 21469 0.05122 2.50 up Mm.30060 2310008N12Rik 96866_at AW047756 RIKEN cDNA 2310008N12 gene1470 0.05125 1.74 down Mm.29000 Stub1 160318_at AI844511 STIP1 homology and U-Box containing protein 11471 0.05128 1.66 down Mm.139738 C77245 94979_at AW121624 expressed sequence C772451472 0.05128 1.59 down Mm.4356 Cnn1 99942_s_at U28932 calponin 11473 0.05128 2.89 up Mm.148348 1500005G05Rik 162254_f_at AV336704 RIKEN cDNA 1500005G05 gene1474 0.05134 3.13 up Mm.7562 Col6a3 101110_at AF064749 procollagen, type VI, alpha 31475 0.05142 1.97 down Mm.73172 Serpina5 161259_f_at AV283483 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, anti1476 0.05143 2.45 up Mm.4191 Oprm 97774_at U19380 opioid receptor, mu1477 0.05145 1.52 up Mm.1451 Mfge8 92880_at M38337 milk fat globule-EGF factor 8 protein1478 0.05147 2.43 up Mm.3968 Map3k7 160854_at D76446 mitogen activated protein kinase kinase kinase 71479 0.05148 1.30 down Mm.34315 AI114950 98051_at AI852808 expressed sequence AI1149501480 0.05148 1.66 down Mm.19027 Mocs2 160637_at AW060325 molybdenum cofactor synthesis 21481 0.05154 1.93 up Mm.46801 Mm.46801 99420_at X94418 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain1482 0.05157 1.92 down Mm.2875 1100001J13Rik 98952_at AW120971 RIKEN cDNA 1100001J13 gene1483 0.05158 2.48 up Mm.9024 Slc30a1 93938_at U17132 solute carrier family 30 (zinc transporter), member 11484 0.05159 1.34 down Mm.34951 Mrpl27 98120_at AI844807 mitochondrial ribosomal protein L271485 0.05162 4.82 up Mm.23502 Sult1b1 104539_at AF022894 sulfotransferase family 1B, member 11486 0.05167 1.49 down Mm.22123 D15Wsu75e 104141_at AI850401 DNA segment, Chr 15, Wayne State University 75, expressed1487 0.05167 1.82 up Mm.2559 Umpk 161167_r_at AV223645 uridine monophosphate kinase1488 0.05170 1.86 up Mm.1645 Dtx1 102924_at U38252 deltex 1 homolog (Drosophila)1489 0.05172 1.52 down Mm.19352 Mm.19352 93512_f_at AW121801 Mus musculus, Similar to Adenosin kinase, clone MGC:6593 IMAGE:3485951490 0.05177 3.12 up Mm.6062 C81600 101612_at C81600 expressed sequence C816001491 0.05182 1.91 up Mm.20693 2810452K22Rik 103664_r_at AA959648 RIKEN cDNA 2810452K22 gene1492 0.05184 1.32 down Mm.27453 D5Wsu31e 96684_at AI846123 DNA segment, Chr 5, Wayne State University 31, expressed1493 0.05186 1.65 down Mm.22494 Urod 94275_at U34691 uroporphyrinogen decarboxylase1494 0.05188 2.00 up Mm.218369 Mm.218369 100379_f_at AI837905 EST1495 0.05191 2.18 up Mm.4561 Mmp11 100016_at Z12604 matrix metalloproteinase 111496 0.05195 1.72 up Mm.219118 Mm.219118 103600_at AW124890 Mus musculus dematin 52 kDa subunit mRNA, complete cds1497 0.05198 1.64 up Mm.25170 3110013H01Rik 160204_at AI838470 RIKEN cDNA 3110013H01 gene1498 0.05199 1.76 down Mm.205830 Gdi1 97313_at U07950 guanosine diphosphate (GDP) dissociation ihibitor 11499 0.05201 1.68 up Mm.21578 Cln8 160671_at AW124836 ceroid-lipofuscinosis, neuronal 81500 0.05222 1.55 down Mm.38433 Wars 161337_f_at AV121930 tryptophanyl-tRNA synthetase1501 0.05223 1.46 down Mm.30050 Pdcd8 96858_at AF100927 programmed cell death 8 (apoptosis inducing factor)1502 0.05229 4.41 up Mm.37952 Krt1-24 98997_f_at AF020790 keratin complex 1, acidic, gene 241503 0.05230 1.81 up Mm.1484 Hcph 102851_s_at M68902 hemopoietic cell phosphatase1504 0.05234 1.85 down Mm.27510 Usp21 95027_at AW050342 ubiquitin specific protease 211505 0.05238 1.61 down Mm.15312 Tst 160085_at U35741 thiosulfate sulfurtransferase, mitochondrial1506 0.05244 2.46 up Mm.1894 Cd1d1 103422_at M63695 CD1d1 antigen1507 0.05247 1.97 up 94517_r_at M551811508 0.05248 2.35 up Mm.144089 Pdgfb 99890_at M64849 platelet derived growth factor, B polypeptide1509 0.05260 4.52 up Mm.140810 Mm.140810 101124_at AA522008 ESTs, Weakly similar to YO11 MOUSE HYPOTHETICAL PROTEIN ORF-111510 0.05263 2.70 up Mm.42190 Uncx4.1 92499_at AJ001116 Unc4.1 homeobox (C. elegans)1511 0.05266 1.97 up Mm.3731 AA408865 97687_at AA408865 expressed sequence AA4088651512 0.05271 4.19 up Mm.4815 Ccna1 92911_at X84311 cyclin A11513 0.05276 2.80 down Mm.5341 Defb1 100882_at AF003525 defensin beta 11514 0.05282 1.38 down Mm.28385 1810009M01Rik 97885_at AB031386 RIKEN cDNA 1810009M01 gene1515 0.05296 1.65 up Mm.5381 Mrpl45 100886_f_at AI841415 mitochondrial ribosomal protein L451516 0.05297 1.60 down Mm.142822 Ewsh 94810_at X79233 Ewing sarcoma homolog1517 0.05302 3.14 down Mm.28405 Sgk 97890_at AW046181 serum/glucocorticoid regulated kinase1518 0.05314 1.66 down Mm.8686 1200014H14Rik 101675_at AI447407 RIKEN cDNA 1200014H14 gene1519 0.05314 4.50 up Mm.197551 Hspa8 161200_i_at AV257761 heat shock 70kD protein 81520 0.05316 2.32 up Mm.29098 AU015645 162038_f_at AV372745 expressed sequence AU0156451521 0.05323 1.59 down Mm.22676 Pdhb 94806_at AW125336 pyruvate dehydrogenase (lipoamide) beta1522 0.05328 1.84 down Mm.7821 Tpd52l1 101446_at AF004428 tumor protein D52-like 11523 0.05329 1.90 down Mm.157900 1300007C21Rik 103562_f_at M26005 RIKEN cDNA 1300007C21 gene1524 0.05335 1.29 down Mm.18921 Vcp 100710_at Z14044 valosin containing protein1525 0.05343 1.44 down Mm.41271 AI852671 99471_at AF158183 expressed sequence AI8526711526 0.05344 2.19 down Mm.196478 AA536966 160608_at AI854462 expressed sequence AA5369661527 0.05351 1.87 up Mm.1137 Itgb2 102353_at M31039 integrin beta 21528 0.05357 2.62 up Mm.42019 Myo1f 101708_at X97650 myosin If1529 0.05359 3.05 down Mm.27772 2810002D13Rik 160752_at AA667021 RIKEN cDNA 2810002D13 gene1530 0.05359 2.14 up Mm.141150 2410012H22Rik 93138_at AI853219 RIKEN cDNA 2410012H22 genePage 17 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1531 0.05360 1.64 up Mm.143889 Adam5 162388_r_at AV256143 a disintegrin and metalloprotease domain 51532 0.05362 1.54 up Mm.2672 Mgat1 96087_at L07037 mannoside acetylglucosaminyltransferase 11533 0.05370 1.68 up Mm.36878 Psg19 99871_f_at AA408180 pregnancy specific glycoprotein 191534 0.05379 2.61 up Mm.86948 Ear1 100311_f_at U72032 eosinophil-associated ribonuclease 11535 0.05380 2.62 up Mm.44238 Kcnj15 99973_s_at AF085696 potassium inwardly-rectifying channel, subfamily J, member 151536 0.05387 2.19 down Mm.4163 Dsc2 103506_f_at AW228162 desmocollin 21537 0.05389 2.28 down Mm.28015 Pdzk1 97288_at AW260404 PDZ domain containing 11538 0.05390 1.59 down Mm.5203 1500009C23Rik 100528_at AI852278 RIKEN cDNA 1500009C23 gene1539 0.05396 2.84 up Mm.125614 Mybph 100017_at U68267 myosin binding protein H1540 0.05397 1.26 down Mm.173119 2610204K03Rik 99617_at AI846299 RIKEN cDNA 2610204K03 gene1541 0.05398 2.52 up Mm.1377 Tgfbr2 94702_at D32072 transforming growth factor, beta receptor II1542 0.05400 6.41 up Mm.9495 Kdap 101972_at D88899 kidney-derived aspartic protease-like protein1543 0.05401 4.20 up Mm.18916 Got2 93355_at U82470 glutamate oxaloacetate transaminase 2, mitochondrial1544 0.05408 1.51 up Mm.45194 5930412E23Rik 100004_at AW120890 RIKEN cDNA 5930412E23 gene1545 0.05408 3.17 up Mm.27446 Siat7d 160232_at AJ007310 sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-ace1546 0.05418 4.04 up Mm.57033 Mm.57033 99405_at U30241 M.musculus immunoglobulin kappa chain variable region1547 0.05419 1.81 down Mm.23809 Hirip5 160176_at AJ132616 histone cell cycle regulation defective interacting protein 51548 0.05422 4.19 up Mm.4933 Mcmd6 162195_i_at AV058276 mini chromosome maintenance deficient 6 (S. cerevisiae)1549 0.05426 2.79 up Mm.41332 Col14a1 99476_at AJ131395 procollagen, type XIV, alpha 11550 0.05435 1.99 down Mm.2350 Tec 103539_at X55663 cytoplasmic tyrosine kinase, Dscr28C related (Drosophila)1551 0.05437 1.94 up Mm.180003 Rps27a 93030_at AI844457 ribosomal protein S27a1552 0.05438 2.20 up Mm.24792 Mm.24792 95933_f_at AA574904 ESTs1553 0.05438 2.30 up Mm.21724 3110001N18Rik 93987_f_at AW121568 RIKEN cDNA 3110001N18 gene1554 0.05445 1.63 up Mm.1526 Myod1 102986_at M18779 myogenic differentiation 11555 0.05448 1.37 up Mm.35600 AI481279 98492_at AA920419 expressed sequence AI4812791556 0.05449 3.05 up Mm.448 Cyba 97013_f_at AW046124 cytochrome b-245, alpha polypeptide1557 0.05450 1.92 down Mm.27091 Mm.27091 96530_at AI503926 ESTs1558 0.05451 1.60 down Mm.29750 1200015A19Rik 95737_at AW120814 RIKEN cDNA 1200015A19 gene1559 0.05457 2.03 up Mm.20388 Dpep1 103644_at D13139 dipeptidase 1 (renal)1560 0.05463 1.42 up Mm.182471 2610524G07Rik 93774_at AW049040 RIKEN cDNA 2610524G07 gene1561 0.05473 1.74 up Mm.204 2610042L04Rik 93569_f_at AI853444 RIKEN cDNA 2610042L04 gene1562 0.05479 19.17 down Mm.2540 Msmb 100715_at U89840 beta-microseminoprotein1563 0.05493 1.86 up Mm.188587 Mm.188587 101678_r_at AI451701 EST1564 0.05494 1.37 up Mm.28228 4930534E15Rik 96145_at AW211407 RIKEN cDNA 4930534E15 gene1565 0.05502 1.66 down Mm.29741 Tce2 95730_at AI840884 T-complex expressed gene 21566 0.05502 1.74 down Mm.1830 Ufd1l 93303_at U64445 ubiquitin fusion degradation 1 like1567 0.05505 1.75 down Mm.15974 1810030O07Rik 103027_at AA739413 RIKEN cDNA 1810030O07 gene1568 0.05509 1.64 down Mm.26550 Pfkm 94438_at AI852672 phosphofructokinase, muscle1569 0.05510 2.14 down Mm.25237 Slc5a1 94357_at AA591002 solute carrier family 5, member 11570 0.05512 4.29 up Mm.22693 Mcpt4 104382_at M55617 mast cell protease 41571 0.05517 1.59 down Mm.218533 1500016H10Rik 161499_f_at AV100072 RIKEN cDNA 1500016H10 gene1572 0.05523 1.62 up Mm.57182 Mas1 99439_at X67735 MAS1 oncogene1573 0.05524 1.77 up Mm.57181 Chrm4 101821_at X63473 cholinergic receptor, muscarinic 41574 0.05525 3.02 up Mm.1353 Egr2 102661_at M24377 early growth response 21575 0.05531 2.12 up Mm.2873 Mm.2873 104405_at AW107973 ESTs1576 0.05541 1.80 down Mm.143768 Fbxo3 103379_at AW046579 f-box only protein 31577 0.05541 1.94 up Mm.21056 Cdk7 160658_at X74145 cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase1578 0.05543 6.34 up Mm.324 Amy2 97523_i_at X02578 amylase 2, pancreatic1579 0.05552 1.70 up Mm.176369 Sox15 96824_at AB025354 SRY-box containing gene 151580 0.05566 2.26 up Mm.5097 Cncg4 101181_at U49391 cyclic nucleotide gated channel 41581 0.05570 1.69 down Mm.196508 Tex189 94007_at AW122469 testis expressed gene 1891582 0.05572 2.73 up Mm.43784 1110025H10Rik 99659_r_at AW047907 RIKEN cDNA 1110025H10 gene1583 0.05573 1.77 down Mm.3935 Ddx24 99096_at U46690 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA helicase A)1584 0.05573 4.37 up Mm.10306 Plscr2 102053_at AF015790 phospholipid scramblase 21585 0.05576 3.64 up Mm.20954 Rgs5 103294_at U67188 regulator of G-protein signaling 51586 0.05577 2.63 up Mm.1870 Fxyd5 103394_at U72680 FXYD domain-containing ion transport regulator 51587 0.05582 2.03 down Mm.41891 2310034L04Rik 160475_at AI839116 RIKEN cDNA 2310034L04 gene1588 0.05582 1.43 down Mm.33808 AI480629 97553_at AI841884 expressed sequence AI4806291589 0.05584 2.87 up Mm.143767 Xrcc2 94172_at Y17040 X-ray repair complementing defective repair in Chinese hamster cells 21590 0.05585 2.33 up Mm.3328 Myln 97542_at U04443 myosin light chain, alkali, nonmuscle1591 0.05595 2.30 up Mm.143774 Rangnrf-pending 100562_at AI846319 RAN guanine nucleotide release factor1592 0.05596 2.06 up Mm.6213 Nrg3 99834_at AF010130 neuregulin 31593 0.05597 1.29 up Mm.6844 0610010E21Rik 101023_f_at AI843605 RIKEN cDNA 0610010E21 gene1594 0.05615 2.53 down Mm.1597 Mov10 103025_at X52574 Moloney leukemia virus 101595 0.05617 1.39 up Mm.212499 Hras1 160536_at Z50013 Harvey rat sarcoma virus oncogene1596 0.05621 2.53 up Mm.3475 Rxrg 92237_at X66225 retinoid X receptor gamma1597 0.05621 2.22 up Mm.175661 1110036C17Rik 160254_at AW123191 RIKEN cDNA 1110036C17 gene1598 0.05623 2.28 up Mm.142727 Prg2 92728_at L46768 proteoglycan 2, bone marrow1599 0.05629 1.78 down Mm.28927 2310005N03Rik 160316_at AA981581 RIKEN cDNA 2310005N03 gene1600 0.05638 5.10 up Mm.212870 Ifi204 98466_r_at M31419 interferon activated gene 2041601 0.05653 2.28 up Mm.40331 Baz1b 92381_at AF084480 bromodomain adjacent to zinc finger domain, 1B1602 0.05655 2.38 up Mm.21389 Dio2 103438_at AF096875 deiodinase, iodothyronine, type II1603 0.05661 1.84 up Mm.10233 Cpx2-pending 102226_at AF017639 metallocarboxypeptidase 21604 0.05672 2.28 up Mm.25289 Rad51l1 103944_at U92068 RAD51-like 1 (S. cerevisiae)1605 0.05672 1.23 down Mm.34456 2400003N08Rik 98069_s_at AI854467 RIKEN cDNA 2400003N08 gene1606 0.05695 2.03 up Mm.100144 S100a6 92770_at X66449 S100 calcium binding protein A6 (calcyclin)1607 0.05696 2.44 up Mm.3742 F3 97689_at M26071 coagulation factor III1608 0.05701 1.79 down Mm.3117 Tdag 160829_at U44088 T-cell death associated gene1609 0.05703 1.88 up Mm.140568 1100001I22Rik 96307_s_at AW121947 RIKEN cDNA 1100001I22 gene1610 0.05704 2.46 up Mm.4598 Bcan 161996_f_at AV328452 brevican1611 0.05709 2.40 up Mm.5265 2310016M24Rik 100537_at AI836443 RIKEN cDNA 2310016M24 gene1612 0.05711 2.03 up Mm.7316 Sult2b1 101406_at AF026072 sulfotransferase family, cytosolic, 2B, member 11613 0.05715 3.47 up Mm.14088 Mm.14088 100669_at L13839 Mus musculus or Rattus rattus (clone 2.6) CTLA-8 mRNA sequence, comple1614 0.05718 9.48 up Mm.30151 Mm.30151 104486_at AI850558 ESTs, Moderately similar to A2M2 MOUSE MURINOGLOBULIN 2 PRECUR1615 0.05720 1.39 down Mm.37613 2010319C14Rik 160444_at AI848397 RIKEN cDNA 2010319C14 gene1616 0.05727 1.71 up Mm.4393 Mm.4393 98355_at AA544993 ESTs1617 0.05731 2.69 down Mm.21288 Mm.21288 103891_i_at AI197161 Mus musculus, clone MGC:11987 IMAGE:3601737, mRNA, complete cds1618 0.05738 1.45 down Mm.459 Creg 160502_at AF084524 cellular repressor of E1A-stimulated genes1619 0.05739 1.59 down Mm.196444 Ubc 95215_f_at D50527 ubiquitin C1620 0.05744 2.32 up Mm.63082 Mm.63082 100743_at AA407663 ESTs, Weakly similar to YEF4_YEAST HYPOTHETICAL 18.5 KDA PROTEIPage 18 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1621 0.05746 1.52 down Mm.1710 Hmbs 93258_at M28666 hydroxymethylbilane synthase1622 0.05748 1.58 up Mm.2237 Ap1m1 161439_f_at AV349844 adaptor-related protein complex AP-1, mu subunit 11623 0.05766 5.79 up Mm.8245 Timp 101464_at V00755 tissue inhibitor of metalloproteinase1624 0.05781 1.39 down Mm.28842 Clcn3 102786_at AI849432 chloride channel 31625 0.05783 4.97 up 101917_at M262711626 0.05784 2.58 up Mm.5172 Traf6 98874_at D84655 Tnf receptor-associated factor 61627 0.05784 2.40 up Mm.2927 Zfp30 104438_at AI153791 zinc finger protein 301628 0.05789 3.44 up Mm.3383 Ager 92181_at L33412 advanced glycosylation end product-specific receptor1629 0.05789 1.57 down Mm.20838 Mic2l1 160435_at AW050035 MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 11630 0.05791 1.60 down Mm.3776 Myhca 101072_at AW124250 myosin heavy chain, cardiac muscle, adult1631 0.05792 2.86 up Mm.12814 Fgf17 98730_at AB009250 fibroblast growth factor 171632 0.05802 1.83 up Mm.41780 Gng10 99175_at AI843396 guanine nucleotide binding protein (G protein), gamma 101633 0.05803 2.06 up Mm.1155 Tuba4 92635_at M13444 tubulin alpha 41634 0.05803 4.73 up Mm.10414 Mlf1 102061_at AF100171 myeloid leukemia factor 11635 0.05812 1.88 up Mm.38786 Mm.38786 96745_at AA867881 Mus musculus, clone IMAGE:3586777, mRNA, partial cds1636 0.05817 2.97 up Mm.170508 0610038H21Rik 100995_at AA690742 RIKEN cDNA 0610038H21 gene1637 0.05823 1.68 down Mm.28454 0610027F08Rik 97903_at AW050078 RIKEN cDNA 0610027F08 gene1638 0.05825 1.55 down Mm.27558 Psmd5 96698_at AI835520 proteasome (prosome, macropain) 26S subunit, non-ATPase, 51639 0.05826 2.45 up Mm.4726 Pit1 98788_at D12885 pituitary specific transcription factor 11640 0.05836 1.85 up Mm.103634 Rps19 94068_at AW048899 ribosomal protein S191641 0.05836 2.36 up Mm.1383 Arhgdig 102677_at U73198 Rho GDP dissociation inhibitor (GDI) gamma1642 0.05838 2.35 up Mm.196517 1100001J08Rik 160456_at AW106645 RIKEN cDNA 1100001J08 gene1643 0.05841 1.40 down Mm.9749 Ly57 100772_g_at AF068182 lymphocyte antigen 571644 0.05847 2.71 up Mm.104747 Igk-V28 93087_r_at AA267185 immunoglobulin kappa chain variable 28 (V28)1645 0.05859 1.82 down Mm.29025 Dctn3 94522_at AF098508 dynactin 31646 0.05860 1.91 down Mm.4218 Tob1 99532_at D78382 transducer of ErbB-2.11647 0.05862 2.05 up Mm.27407 Recql 160741_at AB017104 RecQ protein-like1648 0.05879 1.41 down Mm.2026 Birc2 160645_at U88908 baculoviral IAP repeat-containing 21649 0.05883 3.08 up Mm.1391 Gata2 161820_f_at AV377670 GATA binding protein 21650 0.05885 3.77 up Mm.15969 Adam8 103024_at X13335 a disintegrin and metalloprotease domain 81651 0.05885 1.55 down Mm.29649 Tm9sf1 97359_at AI851160 transmembrane 9 superfamily member 11652 0.05886 2.90 up Mm.17235 Csrp3 103084_at D88791 cysteine-rich protein 31653 0.05901 1.75 down Mm.293 Ppp3ca 95092_at J05479 protein phosphatase 3, catalytic subunit, alpha isoform1654 0.05907 1.48 up Mm.18916 Got2 161995_r_at AV328137 glutamate oxaloacetate transaminase 2, mitochondrial1655 0.05916 1.60 up Mm.21230 1200004M23Rik 160664_at AW060656 RIKEN cDNA 1200004M23 gene1656 0.05917 1.94 up Mm.23795 LOC56552 99700_at AF053985 tissue-type vomeronasal neurons putative pheromone receptor V2R11657 0.05924 1.42 down Mm.2706 Atf3 104155_f_at U19118 activating transcription factor 31658 0.05926 1.54 down Mm.163230 D9Ertd85e 94975_at AI845607 DNA segment, Chr 9, ERATO Doi 85, expressed1659 0.05927 2.13 up Mm.42034 Znfn1a4 98277_at AB017615 zinc finger protein, subfamily 1A, 41660 0.05941 2.16 up Mm.27090 C78212 104157_at AW125643 expressed sequence C782121661 0.05952 1.92 up Mm.22506 G7e-pending 104333_at U69488 G7e protein1662 0.05955 4.23 up Mm.7522 Folh1 97089_at AA986395 folate hydrolase1663 0.05958 1.97 up Mm.16234 Itga5 103039_at X79003 integrin alpha 5 (fibronectin receptor alpha)1664 0.05960 1.72 up Mm.2005 5031425D22Rik 103221_at AA940352 RIKEN cDNA 5031425D22 gene1665 0.05966 2.23 up Mm.3590 AA407948 92269_r_at AI836610 EST AA4079481666 0.05976 1.23 down Mm.26991 H13 96117_r_at AI843732 histocompatibility 131667 0.05980 2.42 up Mm.25633 Spaf-pending 94387_at AF016544 spermatogenesis associated factor1668 0.05981 1.51 up Mm.24822 AI593864 103776_at AA597222 expressed sequence AI5938641669 0.05983 1.19 up Mm.5241 Pcsk3 100515_at X54056 proprotein convertase subtilisin/kexin type 31670 0.05984 2.59 down Mm.46418 Chia-pending 160509_at AI594518 chitinase, acidic1671 0.05986 1.90 down Mm.2563 Esrra 102145_f_at AW046732 estrogen related receptor, alpha1672 0.05987 2.07 up Mm.139222 Map3k11 161658_at AV115284 mitogen activated protein kinase kinase kinase 111673 0.05987 1.50 down Mm.22470 Ubl5 94267_i_at AW124386 ubiquitin-like 51674 0.05988 3.08 up Mm.45235 Syt8 92682_at AB026805 synaptotagmin 81675 0.05992 1.46 down Mm.38795 Mad4 99024_at U32395 Max dimerization protein 41676 0.05994 1.54 down Mm.29619 1200007E24Rik 160812_at AW121839 RIKEN cDNA 1200007E24 gene1677 0.05997 2.81 up Mm.15409 Limk1 102888_s_at U15159 LIM-domain containing, protein kinase1678 0.06000 3.81 up Mm.40672 Kcna3 92392_at AI850484 potassium voltage-gated channel, shaker-related subfamily, member 31679 0.06002 1.82 up Mm.21128 2410099E07Rik 103866_at AW124359 RIKEN cDNA 2410099E07 gene1680 0.06007 2.00 up Mm.42102 Tulp1 98296_at AF085681 tubby like protein 11681 0.06009 2.89 up Mm.2161 Apom 162148_r_at AV310855 apolipoprotein M1682 0.06018 2.25 up Mm.200527 2410197A17Rik 92238_at AW122193 RIKEN cDNA 2410197A17 gene1683 0.06025 1.99 up Mm.183608 Mm.183608 161131_r_at AV250694 EST1684 0.06044 4.28 up Mm.4752 Srms 98794_at D26186 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myri1685 0.06045 1.53 down Mm.12677 Atp5c1 92798_at AA870675 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypepti1686 0.06049 2.62 up Mm.24871 AA675344 95941_at AA675344 expressed sequence AA6753441687 0.06056 2.47 up Mm.5316 Actn3 100879_at AF093775 actinin alpha 31688 0.06066 1.46 down Mm.28202 D16Ertd269e 97822_at AW122689 DNA segment, Chr 16, ERATO Doi 269, expressed1689 0.06066 2.52 up Mm.20350 Mad3 103237_at U32394 Max dimerization protein 31690 0.06075 2.35 down Mm.41170 Klf13 160617_at AW125783 Kruppel-like factor 131691 0.06075 2.33 up Mm.42205 Mm.42205 160452_at U00478 Mus musculus DNaseI precursor mRNA, complete cds1692 0.06082 1.66 down Mm.9749 Ly57 100771_at AF068182 lymphocyte antigen 571693 0.06084 2.12 up Mm.28642 AI428936 161857_r_at AV060123 expressed sequence AI4289361694 0.06084 1.94 down Mm.38151 Adsl 98999_at AA606587 adenylosuccinate lyase1695 0.06085 5.18 up Mm.140956 Nnat 97520_s_at X83569 neuronatin1696 0.06086 2.43 up Mm.766 Scyb9 101436_at M34815 small inducible cytokine B subfamily (Cys-X-Cys), member 91697 0.06095 4.15 up Mm.4669 Adam2 162062_r_at AV276538 a disintegrin and metalloprotease domain 21698 0.06097 1.80 down Mm.104 C78977 99004_r_at AA816070 expressed sequence C789771699 0.06099 1.68 down Mm.6483 Pld3 100607_at AF026124 phospholipase D31700 0.06111 2.65 up Mm.37854 Ptprm 92308_at AI847852 protein tyrosine phosphatase, receptor-type, M1701 0.06113 3.18 up Mm.30303 Cyp3a16 101638_s_at D26137 cytochrome P450, 3a161702 0.06117 5.13 up Mm.3453 C1qc 92223_at X66295 complement component 1, q subcomponent, c polypeptide1703 0.06118 1.77 down Mm.1786 Aprt 93283_at AA869401 adenine phosphoribosyl transferase1704 0.06123 1.91 down Mm.28814 Casp6 94458_at Y13087 caspase 61705 0.06125 2.48 up Mm.28413 2410004C24Rik 162131_f_at AV378780 RIKEN cDNA 2410004C24 gene1706 0.06128 1.48 up Mm.21904 Rab6ip1 104108_at AJ245569 Rab6 interacting protein 11707 0.06128 1.53 down Mm.10530 Acadm 92581_at U07159 acetyl-Coenzyme A dehydrogenase, medium chain1708 0.06134 2.59 up Mm.29257 6530405F15Rik 95916_at AA536958 RIKEN cDNA 6530405F15 gene1709 0.06137 1.35 down Mm.29824 Psa 96259_at U35646 puromycin-sensitive aminopeptidase1710 0.06139 3.91 up Mm.153 2010109K11Rik 102987_at AA874367 RIKEN cDNA 2010109K11 genePage 19 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1711 0.06143 2.06 up Mm.195444 Ear3 103240_f_at AF017258 eosinophil-associated ribonuclease 31712 0.06151 5.00 up Mm.2160 Kng 93837_at AI786089 kininogen1713 0.06151 2.96 up Mm.335 Hsd3b3 98401_at M77015 hydroxysteroid dehydrogenase-3, delta-3-beta1714 0.06153 1.39 down Mm.25203 Nckap1 95508_at X61453 NCK-associated protein 11715 0.06156 3.12 up Mm.2780 Myh3 160753_at M74753 myosin, heavy polypeptide 3, skeletal muscle, embryonic1716 0.06180 1.43 down Mm.22478 Smarcf1 104331_at AA832935 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,1717 0.06183 1.54 down Mm.2942 Asns 161221_f_at AV253908 asparagine synthetase1718 0.06188 1.51 down Mm.10756 Pfdn2 102252_at Y17393 prefoldin 21719 0.06190 1.14 down Mm.2314 Prkcd 160698_s_at AB011812 protein kinase C, delta1720 0.06193 1.51 down Mm.29778 Armet 95749_at AW122364 arginine-rich, mutated in early stage tumors1721 0.06198 2.16 up Mm.24209 Mesdc2 162231_r_at AV309750 mesoderm development candiate 21722 0.06199 2.95 up Mm.31041 Gstm6 104636_at AJ000413 glutathione S-transferase, mu 61723 0.06199 1.60 up Mm.10280 Lat 102228_at AF036907 linker for activation of T cells1724 0.06200 2.45 up Mm.35868 Srst 101684_r_at X67863 simple repeat sequence-containing transcript1725 0.06202 1.80 up 103832_at AF0971811726 0.06209 1.58 down Mm.205030 Mm.205030 96850_at AI853642 Mus musculus, clone IMAGE:4975180, mRNA1727 0.06212 1.74 up Mm.41938 Mm.41938 160870_at AI847423 Mus musculus adenylyl cyclase 3 (Adcy3) mRNA, complete cds1728 0.06214 2.28 up Mm.28362 AI326478 93584_at V00821 expressed sequence AI3264781729 0.06215 1.61 up Mm.219627 Pgam2 92599_at AF029843 phosphoglycerate mutase 21730 0.06222 1.51 up Mm.254 Tpt1 102599_at X06407 tumor protein, translationally-controlled 11731 0.06222 3.08 up Mm.4516 Mup2 100071_at M16356 major urinary protein 21732 0.06223 1.67 down Mm.180734 Rpa1 95427_at AI843650 replication protein A1 (70 kDa)1733 0.06226 2.75 up Mm.175971 Mm.175971 162391_r_at AV260455 ESTs, Moderately similar to LC4S MOUSE LEUKOTRIENE C4 SYNTHASE1734 0.06228 1.65 down Mm.18634 1810024J13Rik 103381_at AI838735 RIKEN cDNA 1810024J13 gene1735 0.06230 1.47 up Mm.8074 Nrtn 93673_at U78109 neurturin1736 0.06230 1.61 up Mm.20433 Ntsr 95319_at AB017027 neurotensin receptor1737 0.06238 1.57 down Mm.7472 Dcra 162486_f_at AV122030 Down syndrome critical region gene a1738 0.06242 4.58 up Mm.41718 AI448216 162210_r_at AV378802 expressed sequence AI4482161739 0.06245 2.39 up Mm.653 H2-Bf 161365_r_at AV224353 histocompatibility 2, complement component factor B1740 0.06250 3.24 up Mm.395 Ptpn8 92356_at M90388 protein tyrosine phosphatase, non-receptor type 81741 0.06256 3.28 up Mm.16106 C4 103033_at X06454 complement component 4 (within H-2S)1742 0.06259 2.53 up Mm.197698 Htr2b 95332_at AJ012488 5-hydroxytryptamine (serotonin) receptor 2B1743 0.06260 2.41 up Mm.3915 Mobp 99046_at AI834776 myelin-associated oligodendrocytic basic protein1744 0.06281 1.54 down Mm.12758 Fkbp4 92809_r_at X17069 FK506 binding protein 4 (59 kDa)1745 0.06285 2.37 up Mm.24270 Mm.24270 95901_f_at AI662099 ESTs1746 0.06286 1.97 up Mm.4390 Numb 161912_r_at AV377244 numb gene homolog (Drosophila)1747 0.06293 4.44 up Mm.3288 Trim30 98030_at J03776 tripartite motif protein 301748 0.06293 2.97 up Mm.104363 Cyp2d9 162174_at AV003830 cytochrome P450, 2d91749 0.06294 1.89 up Mm.8256 Khdrbs1 101508_at U17961 KH domain containing, RNA binding, signal transduction associated 11750 0.06300 1.60 up Mm.1664 Rab33b 103062_at AB004664 RAB33B, member of RAS oncogene family1751 0.06301 2.23 up Mm.3267 Anxa8 97529_at AJ002390 annexin A81752 0.06301 2.76 up Mm.42240 Zfp162 161894_r_at AV103574 zinc finger protein 1621753 0.06302 2.10 up Mm.604 Tnni3 100921_at U09181 troponin I, cardiac1754 0.06307 2.60 up Mm.24521 AA407930 161376_f_at AV243059 expressed sequence AA4079301755 0.06309 2.34 up Mm.40566 Ppfia4 103943_at AI838513 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacti1756 0.06313 2.87 up Mm.24842 2310046B19Rik 162034_r_at AV369210 RIKEN cDNA 2310046B19 gene1757 0.06318 1.48 up Mm.29196 Cyc1 162469_r_at AV069997 cytochrome c-11758 0.06324 1.85 up Mm.190386 Gja5 101778_at X61675 gap junction membrane channel protein alpha 51759 0.06331 1.68 up Mm.7319 Frda 101407_at U95736 Friedreich ataxia1760 0.06340 2.45 up Mm.304 Rb1 97948_at M26391 retinoblastoma 11761 0.06350 2.61 up Mm.19119 2210402C18Rik 103560_at AW124401 RIKEN cDNA 2210402C18 gene1762 0.06353 2.40 up Mm.3249 Epha4 104673_at X65138 Eph receptor A41763 0.06365 2.05 up Mm.3243 Procr 98018_at L39017 protein C receptor, endothelial1764 0.06366 1.91 up Mm.1949 Col6a2 93517_at Z18272 procollagen, type VI, alpha 21765 0.06367 1.77 down Mm.6534 Capns1 100610_at AF058298 calpain, small subunit 11766 0.06372 1.46 up Mm.218533 1500016H10Rik 98138_at AI854776 RIKEN cDNA 1500016H10 gene1767 0.06388 1.99 up Mm.23856 Mm.23856 160178_r_at AW047190 ESTs, Weakly similar to YAE6_YEAST HYPOTHETICAL 13.4 KD PROTEIN1768 0.06393 2.32 down Mm.30728 Arpp19-pending 97260_at AW121489 cyclic AMP phosphoprotein, 19 kDa1769 0.06394 2.82 up Mm.196407 Igk-V21 101633_at X16678 immunoglobulin kappa chain variable 21 (V21)1770 0.06400 1.98 up Mm.5388 Mm.5388 93177_at AW121661 ESTs1771 0.06401 2.65 up Mm.22030 Ha1r-pending 161279_f_at AV291749 Hoxa1 regulated gene1772 0.06402 1.51 down Mm.29588 Mm.29588 95675_at AW121182 Mus musculus, Similar to mitogen-activated protein kinase kinase kinase kin1773 0.06403 3.39 up Mm.3092 Inhbb 160828_at X69620 inhibin beta-B1774 0.06403 2.50 up Mm.1738 Cd48 103089_at X53526 CD48 antigen1775 0.06405 4.17 up Mm.28395 AU019574 96172_at AA795946 expressed sequence AU0195741776 0.06411 1.74 up Mm.29368 Agtrl1 99368_at AJ007612 angiotensin receptor-like 11777 0.06412 2.95 up Mm.4149 Ncf1 97763_at AB002663 neutrophil cytosolic factor 11778 0.06412 1.68 down Mm.4266 Itm2b 101123_at U76253 integral membrane protein 2B1779 0.06429 1.44 down Mm.18230 1300007B12Rik 93301_at AW124624 RIKEN cDNA 1300007B12 gene1780 0.06430 1.34 up Mm.140151 Sprr1b 100446_r_at X91825 small proline-rich protein 1B1781 0.06433 1.65 up Mm.6803 1500019G21Rik 100987_f_at AW045230 RIKEN cDNA 1500019G21 gene1782 0.06433 1.36 up Mm.29860 Mm.29860 160820_at AW061299 Mus musculus immunoglobulin superfamily receptor PGRL (Pgrl) mRNA, com1783 0.06434 2.85 down Mm.26132 D9Ertd720e 162412_r_at AV317927 DNA segment, Chr 9, ERATO Doi 720, expressed1784 0.06439 2.03 up Mm.36725 2410008G02Rik 98975_at AI019999 RIKEN cDNA 2410008G02 gene1785 0.06443 1.41 down Mm.88061 Ncor1 101536_at U35312 nuclear receptor co-repressor 11786 0.06455 1.82 up Mm.10109 Tert 94104_at AF051911 telomerase reverse transcriptase1787 0.06460 1.97 up Mm.37415 1200009F10Rik 95885_at AA177621 RIKEN cDNA 1200009F10 gene1788 0.06468 1.72 up Mm.116 H2-Oa 100897_f_at AF100956 histocompatibility 2, O region alpha locus1789 0.06481 1.63 down Mm.4387 Bad 99670_at L37296 Bcl-associated death promoter1790 0.06494 2.23 up Mm.232 AW488865 161100_at AV305843 expressed sequence AW4888651791 0.06498 3.48 up Mm.2226 Hmgcr 104285_at M62766 3-hydroxy-3-methylglutaryl-Coenzyme A reductase1792 0.06499 1.91 down Mm.6840 5730507C05Rik 160539_at X66091 RIKEN cDNA 5730507C05 gene1793 0.06499 2.23 up Mm.7336 Cmkbr1l2 93617_at AF030185 chemokine (C-C) receptor 1,-like 21794 0.06500 4.13 up Mm.372 Rps26 98565_at AA755219 ribosomal protein S261795 0.06500 1.26 up Mm.171335 AW125446 95593_at AW125446 expressed sequence AW1254461796 0.06502 2.25 up Mm.20829 Emp3 93593_f_at U87948 epithelial membrane protein 31797 0.06505 1.56 down Mm.13146 Mm.13146 102645_at AI155285 ESTs1798 0.06507 2.16 up Mm.40740 AI605384 99864_at AA608277 expressed sequence AI6053841799 0.06510 2.66 up Mm.210047 Thea 100913_at AI847418 thioesterase, adipose associated1800 0.06511 1.46 down Mm.5197 AI854602 93144_at AI854602 expressed sequence AI854602Page 20 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1801 0.06511 4.26 up Mm.205855 D13Wsu123e 161805_r_at AV370628 DNA segment, Chr 13, Wayne State University 123, expressed1802 0.06511 2.51 up Mm.34126 Risc-pending 98042_at AW049787 retinoid-inducible serine caroboxypetidase1803 0.06512 2.29 up Mm.3373 Cfl2 162088_r_at AV335882 cofilin 2, muscle1804 0.06512 1.72 up Mm.1395 Slpi 161650_at AV090497 secretory leukocyte protease inhibitor1805 0.06518 4.04 up Mm.3153 Myh11 96980_at U34303 myosin heavy chain 11, smooth muscle1806 0.06525 2.18 up Mm.215 Hoxb6 102580_r_at M11988 homeo box B61807 0.06528 1.37 down Mm.7793 Ppp1cc 101482_at D85137 protein phosphatase 1, catalytic subunit, gamma isoform1808 0.06528 1.57 down Mm.154457 1110008J20Rik 100899_s_at AI265210 RIKEN cDNA 1110008J20 gene1809 0.06529 1.83 down Mm.10633 Hmgcs2 92590_at U12791 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 21810 0.06529 2.60 up Mm.175392 Defcr3 93879_f_at U02999 defensin related cryptdin 31811 0.06535 1.53 down Mm.30147 Mm.30147 96913_at AW122615 Mus musculus, Similar to hydroxyacyl-Coenzyme A dehydrogenase/3-ketoac1812 0.06540 3.95 up Mm.2214 4-Sep 161234_f_at AV277998 septin 41813 0.06556 1.55 down Mm.4002 1810015P09Rik 92375_at AW211207 RIKEN cDNA 1810015P09 gene1814 0.06557 2.60 up Mm.3115 Clecsf13 104642_at D88577 C-type (calcium dependent, carbohydrate recognition domain) lectin, superfa1815 0.06558 2.75 up Mm.219560 AI596360 161013_f_at AI596360 expressed sequence AI5963601816 0.06559 2.40 up Mm.15802 Epb4.2 161151_at AV227925 erythrocyte protein band 4.21817 0.06578 2.43 up Mm.34335 Mup4 101682_f_at M16358 major urinary protein 41818 0.06578 4.57 up Mm.22650 Spi2-2 104374_at M64086 serine protease inhibitor 2-21819 0.06582 3.12 up Mm.28022 1500011O09Rik 101654_at X80328 RIKEN cDNA 1500011O09 gene1820 0.06586 1.28 down Mm.5731 Ddt 100564_at AF068199 D-dopachrome tautomerase1821 0.06589 1.90 up Mm.20848 Rfxank 161841_r_at AV328604 regulatory factor X-associated ankyrin-containing protein1822 0.06590 1.56 down Mm.1554 AW111961 160611_at AA212964 expressed sequence AW1119611823 0.06602 3.04 up Mm.24767 Zp1 95932_at U20448 zona pellucida glycoprotein 11824 0.06603 3.01 up Mm.142455 Slc7a7 103818_at AJ012754 solute carrier family 7 (cationic amino acid transporter, y+ system), member1825 0.06603 1.39 down Mm.9043 Hnrpl 95232_at AB009392 heterogeneous nuclear ribonucleoprotein L1826 0.06608 2.03 down Mm.35465 1300002E07Rik 98485_at AI850288 RIKEN cDNA 1300002E07 gene1827 0.06609 2.49 up Mm.1135 Cpa3 162348_r_at AV172041 carboxypeptidase A3, mast cell1828 0.06610 1.56 down Mm.645 Stim1 100952_at U47323 stromal interaction molecule 11829 0.06612 2.18 down Mm.29603 Pkp3 160944_at AW120906 plakophilin 31830 0.06614 1.34 up Mm.30156 Prss11 96920_at AW125478 protease, serine, 11 (Igf binding)1831 0.06615 2.08 down Mm.488 Selel 100457_at X84037 selectin, endothelial cell, ligand1832 0.06620 1.37 down Mm.29122 0610012D09Rik 95045_at AI844469 RIKEN cDNA 0610012D09 gene1833 0.06624 2.19 up Mm.22288 Ccnd1 94231_at M64403 cyclin D11834 0.06640 3.16 up Mm.181040 Vps35 162393_at AV266447 vacuolar protein sorting 351835 0.06640 1.39 up Mm.196137 1300006N24Rik 104044_at AI853663 RIKEN cDNA 1300006N24 gene1836 0.06641 1.75 up Mm.3390 Myo1b 99776_at D17826 myosin Ib1837 0.06647 1.92 up Mm.17493 Cradd 102952_g_at AJ224738 CASP2 and RIPK1 domain containing adaptor with death domain1838 0.06648 2.17 down Mm.25044 Fliih 95489_at AW047953 flightless I homolog (Drosophila)1839 0.06649 2.03 up Mm.42228 Tnfsf7 98318_at Y13637 tumor necrosis factor (ligand) superfamily, member 71840 0.06653 1.69 up Mm.8040 Prkch 99916_at D90242 protein kinase C, eta1841 0.06657 3.10 up Mm.4504 Gja1 100065_r_at M63801 gap junction membrane channel protein alpha 11842 0.06668 1.94 up Mm.2032 Isgf3g 103634_at U51992 interferon dependent positive acting transcription factor 3 gamma1843 0.06668 1.67 down Mm.182053 1810030E05Rik 99575_at AA517835 RIKEN cDNA 1810030E05 gene1844 0.06678 2.42 down Mm.7800 Itpr5 101441_i_at AF031127 inositol 1,4,5-triphosphate receptor 51845 0.06678 2.29 up Mm.38888 Serping1 99081_at AF010254 serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 11846 0.06684 1.70 down Mm.7356 Snx3 160543_at AF062482 sorting nexin 31847 0.06686 1.71 down Mm.3051 2010005I16Rik 97958_at AW122355 RIKEN cDNA 2010005I16 gene1848 0.06687 2.68 up Mm.25137 2410004B18Rik 94344_at AI845960 RIKEN cDNA 2410004B18 gene1849 0.06687 1.35 down Mm.28375 Sec61a 97882_at AB032902 SEC61, alpha subunit (S. cerevisiae)1850 0.06688 2.45 up Mm.4182 Prkcb 99511_at X53532 protein kinase C, beta1851 0.06689 2.36 up Mm.196548 Pknox1 102257_at AF061270 Pbx/knotted 1 homeobox1852 0.06698 3.60 up Mm.19353 LOC56304 99396_at U88675 recombinant antineuraminidase single chain Ig VH and VL domains1853 0.06701 1.20 down Mm.24870 AA409944 95482_at AW124247 expressed sequence AA4099441854 0.06703 2.03 up Mm.2081 C2 103673_at M57891 complement component 2 (within H-2S)1855 0.06703 3.40 up Mm.5346 Mep1a 100542_at U62765 meprin 1 alpha1856 0.06704 2.41 up Mm.12553 Rfc3 160072_at AV026570 replication factor C (activator 1) 3 (38 kDa)1857 0.06707 1.66 down Mm.2823 Btg3 96146_at D83745 B-cell translocation gene 31858 0.06714 2.57 up Mm.2322 Pim1 99384_at M13945 proviral integration site 11859 0.06722 1.31 down Mm.219581 Mm.219581 100482_at AI836408 Mus musculus, clone IMAGE:4010394, mRNA, partial cds1860 0.06724 2.00 down Mm.5904 2700038P16Rik 161071_at AV375886 RIKEN cDNA 2700038P16 gene1861 0.06727 1.25 down Mm.2314 Prkcd 104531_at X60304 protein kinase C, delta1862 0.06729 1.51 down Mm.18729 Copb2 93340_f_at AF043120 coatomer protein complex, subunit beta 2 (beta prime)1863 0.06732 3.46 up Mm.3157 Fgfr1 97509_f_at U22324 fibroblast growth factor receptor 11864 0.06733 2.45 up Mm.203915 AI132321 103299_at AW123773 expressed sequence AI1323211865 0.06741 1.80 up Mm.3486 Rpl3 162177_f_at AV365838 ribosomal protein L31866 0.06752 3.33 up Mm.4073 Acrbp 99455_s_at D17574 proacrosin binding protein1867 0.06754 5.00 up Mm.14438 AU044919 102823_at X67210 expressed sequence AU0449191868 0.06764 1.47 down Mm.29079 Snx1 94550_at AW121324 sorting nexin 11869 0.06768 1.54 down Mm.206715 Btbd1 94818_at AW047223 BTB (POZ) domain containing 11870 0.06769 1.30 down Mm.23879 AI849128 103678_at AI841139 expressed sequence AI8491281871 0.06774 1.53 down Mm.22227 0610010E03Rik 94216_at AW121091 RIKEN cDNA 0610010E03 gene1872 0.06790 2.87 up Mm.20332 Mm.20332 103232_at AW060580 ESTs, Weakly similar to MICROTUBULE-ASSOCIATED PROTEIN 1B [M.mu1873 0.06792 2.78 up Mm.1222 Basp2 102389_s_at AI841303 brain abundant, membrane attached signal protein 21874 0.06794 1.62 down Mm.22593 Gtf2i 94296_s_at AF043220 general transcription factor II I1875 0.06803 4.33 up Mm.5193 Klk8 104497_f_at X03994 kallikrein 81876 0.06804 1.58 down Mm.22718 Xbp1 94821_at AW123880 X-box binding protein 11877 0.06804 2.22 up Mm.193539 H1f2 99481_at AI839697 H1 histone family, member 21878 0.06805 3.07 up Mm.26609 D8Ertd69e 160728_r_at AW048694 DNA segment, Chr 8, ERATO Doi 69, expressed1879 0.06809 1.44 down Mm.22086 Rnf14 94066_at AW123517 ring finger protein 141880 0.06810 5.69 up Mm.4261 Kai1 161861_i_at AV064428 kangai 1 (suppression of tumorigenicity 6, prostate)1881 0.06828 1.44 up Mm.30237 Psmd9 97929_r_at AW124782 proteasome (prosome, macropain) 26S subunit, non-ATPase, 91882 0.06833 1.26 down Mm.28551 Sudd 160301_at AI848114 sudD, suppressor of bimD6 homolog (Aspergillus nidulans)1883 0.06838 1.47 down Mm.4526 Tra1 160499_at J03297 tumor rejection antigen gp961884 0.06842 2.08 up Mm.1963 Srrm1 93520_at AF062655 serine/arginine repetitive matrix 11885 0.06845 2.45 up Mm.177966 Mkrn2 160157_at AW124942 makorin, ring finger protein, 21886 0.06851 1.69 up Mm.28053 1110017C15Rik 97305_at AW123267 RIKEN cDNA 1110017C15 gene1887 0.06862 2.43 up Mm.23987 AA407980 103693_at AA288979 expressed sequence AA4079801888 0.06882 2.08 up Mm.196054 Klra3 93893_f_at U56404 killer cell lectin-like receptor, subfamily A, member 31889 0.06887 2.18 up Mm.5242 2900086B20Rik 162085_r_at AV334165 RIKEN cDNA 2900086B20 gene1890 0.06893 2.20 up Mm.10193 Gprk6 102040_at Y15798 G protein-coupled receptor kinase 6Page 21 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1891 0.06894 1.30 up Mm.5246 Ppia 101207_at X52803 peptidylprolyl isomerase A1892 0.06903 1.64 down Mm.28958 Mm.28958 96748_i_at AA619554 ESTs, Weakly similar to T47140 hypothetical protein DKFZp761K1115.1 [H.s1893 0.06917 4.01 up Mm.39486 Mm.39486 97736_at AI838823 ESTs1894 0.06920 2.48 up Mm.8308 Pfc 101468_at X12905 properdin factor, complement1895 0.06927 1.84 up Mm.7202 Mm.7202 99866_at AI642417 ESTs1896 0.06930 1.47 down Mm.139700 6330544B05Rik 98084_at AI849834 RIKEN cDNA 6330544B05 gene1897 0.06934 2.56 up Mm.12929 Fhit 102628_at AF047699 fragile histidine triad gene1898 0.06935 3.21 up Mm.44552 Txnrd1 161043_r_at AV277568 thioredoxin reductase 11899 0.06942 1.31 down Mm.30246 Cd151 97930_f_at AF033620 CD151 antigen1900 0.06943 1.82 up 93583_s_at V008171901 0.06953 1.48 up Mm.4620 Rgnef 92710_at U73199 Rho-guanine nucleotide exchange factor1902 0.06955 2.34 up Mm.29261 Il1f5 104436_at AJ250429 interleukin 1 family, member 5 (delta)1903 0.06957 2.18 up Mm.4197 Mm.4197 101118_at AA511266 ESTs1904 0.06958 4.95 up Mm.413 Mtap2 97760_at M21041 microtubule-associated protein 21905 0.06958 1.73 down Mm.202734 Mgea5 94499_at AI835427 meningioma expressed antigen 5 (hyaluronidase)1906 0.06959 2.13 up Mm.9397 Odf1 101968_at X79446 outer dense fiber of sperm tails 11907 0.06962 1.94 down Mm.157012 Tcrb-V13 101338_f_at AE000664 T-cell receptor beta, variable 131908 0.06965 1.66 down Mm.11535 0710008A13Rik 102356_at AI836272 RIKEN cDNA 0710008A13 gene1909 0.06973 5.15 up Mm.22715 Ctla2b 103518_at X15592 cytotoxic T lymphocyte-associated protein 2 beta1910 0.06973 1.26 down Mm.29814 Sbdn 160361_at AW120963 synbindin1911 0.06975 1.93 down Mm.21288 Mm.21288 103892_r_at AI197161 Mus musculus, clone MGC:11987 IMAGE:3601737, mRNA, complete cds1912 0.06977 1.65 up Mm.26995 Thop1 104025_at AW047185 thimet oligopeptidase 11913 0.06987 1.39 up Mm.18617 3830408D16Rik 103925_at AW120605 RIKEN cDNA 3830408D16 gene1914 0.06989 1.57 down Mm.3077 Nr1i3 104506_at AF009328 nuclear receptor subfamily 1, group I, member 31915 0.06992 1.97 up Mm.1618 Itgal 94764_at M60778 integrin alpha L1916 0.06996 1.49 down Mm.14287 Hspa1l 97809_at AF109906 heat shock 70kD protein 1-like1917 0.07000 5.13 up Mm.27035 Qscn6 96602_g_at AW045751 quiescin Q61918 0.07001 2.61 up Mm.4927 Aco1 100147_at X61147 aconitase 11919 0.07015 1.99 up Mm.57064 Adra1a 101740_at AF031431 adrenergic receptor, alpha 1a1920 0.07016 1.77 up Mm.2945 Cappb1 95141_at U10406 capping protein beta 11921 0.07031 1.60 down Mm.1034 Ppp2r1a 92573_at AB021743 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha iso1922 0.07036 2.19 down Mm.25110 C81072 96487_at C81072 expressed sequence C810721923 0.07046 1.99 down Mm.28308 Nkx6-2 97859_at AA762325 NK6 transcription factor related, locus 2 (Drosophila)1924 0.07050 1.62 down Mm.183076 2510039O18Rik 96325_at AW124874 RIKEN cDNA 2510039O18 gene1925 0.07053 2.07 up Mm.320 Pola2 98006_at D13546 DNA polymerase alpha 2, 68 kDa1926 0.07054 2.78 up Mm.29394 2410008J01Rik 161323_f_at AV095547 RIKEN cDNA 2410008J01 gene1927 0.07056 1.54 down Mm.17675 ln 96540_at AW228792 leaden1928 0.07057 1.44 up Mm.21228 C79684 103312_f_at AW047929 expressed sequence C796841929 0.07058 1.73 up Mm.25717 Dri2 103970_at AF116847 dead ringer homolog 2 (Drosophila)1930 0.07062 1.46 down Mm.28073 D11Ertd172e 95629_at AI843679 DNA segment, Chr 11, ERATO Doi 172, expressed1931 0.07065 1.59 down Mm.102496 N4wbp5-pending 93025_at AI835257 Nedd4 WW binding protein 51932 0.07067 4.25 up Mm.20973 Lgals7 103846_at AF038562 lectin, galactose binding, soluble 71933 0.07068 1.31 down Mm.3874 Adh5 95765_at U48971 alcohol dehydrogenase 51934 0.07072 1.57 down Mm.28850 DXImx38e 96728_at AI844151 DNA segment, Chr X, Immunex 38, expressed1935 0.07073 1.73 down Mm.27546 8430408O15Rik 161250_at AV277344 RIKEN cDNA 8430408O15 gene1936 0.07093 6.37 up Mm.198677 Mm.198677 103509_at AA798611 Mus musculus 11 days pregnant adult female ovary and uterus cDNA, RIKE1937 0.07103 1.97 up Mm.7236 Ddost 162020_at AV361027 dolichyl-di-phosphooligosaccharide-protein glycotransferase1938 0.07104 2.98 up Mm.200410 Klk9 94716_f_at M17962 kallikrein 91939 0.07104 3.40 up Mm.41158 Adam12 92414_at D50411 a disintegrin and metalloproteinase domain 12 (meltrin alpha)1940 0.07109 2.61 up Mm.147697 Psmd2 92645_at AW125458 proteasome (prosome, macropain) 26S subunit, non-ATPase, 21941 0.07114 1.77 up Mm.451 Akr1b3 162341_r_at AV133992 aldo-keto reductase family 1, member B3 (aldose reductase)1942 0.07114 2.77 up Mm.14450 Mm.14450 94743_f_at M29009 Mouse complement factor H-related protein mRNA, complete cds, clone 9C41943 0.07118 1.36 up Mm.46269 Ins1 97659_r_at X04725 insulin I1944 0.07121 2.92 up Mm.4655 Gal 161591_r_at AV290941 galanin1945 0.07123 1.90 up Mm.5692 C78228 101229_at C78228 expressed sequence C782281946 0.07125 2.73 up Mm.8037 Camk2a 93659_at X14836 calcium/calmodulin-dependent protein kinase II alpha1947 0.07127 1.59 down Mm.20450 Nsbp1 103654_at AB018374 nucleosome binding protein 11948 0.07128 1.82 up Mm.27584 AW547774 161198_r_at AV257404 expressed sequence AW5477741949 0.07128 2.15 up Mm.2553 Pap 96009_s_at D63359 pancreatitis-associated protein1950 0.07131 1.35 up Mm.21874 Psmb3 94025_at AW045339 proteasome (prosome, macropain) subunit, beta type 31951 0.07133 1.81 up Mm.196204 1810047J07Rik 102340_at AA833077 RIKEN cDNA 1810047J07 gene1952 0.07133 1.60 down Mm.28150 Sf3b1 96777_at AW049372 splicing factor 3b, subunit 1, 155 kDa1953 0.07134 2.35 down Mm.28111 2210409M21Rik 161389_f_at AV255078 RIKEN cDNA 2210409M21 gene1954 0.07146 2.35 up Mm.88841 Olfr37a 97002_f_at AJ133427 olfactory receptor 37a1955 0.07158 2.76 up Mm.25085 C80719 96389_at C80719 expressed sequence C807191956 0.07162 3.46 up Mm.42207 Crtl1 92506_at AF098460 cartilage link protein 11957 0.07171 1.49 down Mm.29193 Pdcd7 96802_at AW124656 programmed cell death protein 71958 0.07172 1.65 down Mm.13725 Pcee-pending 102781_at U37351 Paneth cell enhanced expression1959 0.07177 1.49 down Mm.24383 AA409780 160710_at AI846787 expressed sequence AA4097801960 0.07182 1.55 up Mm.90587 Eno1 160568_at AI841389 enolase 1, alpha non-neuron1961 0.07191 2.90 up Mm.43330 0610025G13Rik 99626_i_at AA638667 RIKEN cDNA 0610025G13 gene1962 0.07192 2.31 up Mm.24890 Mm.24890 95943_at C76080 ESTs1963 0.07193 2.50 up Mm.214500 1810027O01Rik 93638_s_at J00579 RIKEN cDNA 1810027O01 gene1964 0.07194 1.56 down Mm.29131 1110049F12Rik 160329_at AA798365 RIKEN cDNA 1110049F12 gene1965 0.07197 3.87 up Mm.19131 C3 93497_at K02782 complement component 31966 0.07201 3.25 up Mm.28870 Mm.28870 94477_at AW123796 Mus musculus, clone MGC:6827 IMAGE:2649084, mRNA, complete cds1967 0.07202 1.90 up Mm.3292 Grin1 104684_at AI847120 glutamate receptor, ionotropic, NMDA1 (zeta 1)1968 0.07207 4.06 up Mm.370 C1qa 98562_at X58861 complement component 1, q subcomponent, alpha polypeptide1969 0.07210 1.46 down Mm.193091 Mm.193091 160414_at AI849431 Mus musculus, clone IMAGE:3708675, mRNA, partial cds1970 0.07212 1.84 up Mm.532 Mm.532 100880_at AA816121 ESTs, Weakly similar to A Chain A, Crystal Structure Of The Human Acyl Pro1971 0.07220 2.93 up Mm.195900 Ryr2 102653_at X78667 ryanodine receptor 2, cardiac1972 0.07227 1.75 up Mm.4161 Krt1-2 97767_at X75649 keratin complex 1, acidic, gene 21973 0.07228 1.33 up Mm.19155 Sfrp2 93503_at U88567 secreted frizzled-related sequence protein 21974 0.07230 1.83 down 104255_at AA7952851975 0.07233 1.42 up Mm.21103 D7Wsu128e 103862_r_at AA388099 DNA segment, Chr 7, Wayne State University 128, expressed1976 0.07237 1.91 up Mm.139222 Map3k11 161615_f_at AV352346 mitogen activated protein kinase kinase kinase 111977 0.07238 1.43 up Mm.28421 2410071B14Rik 97895_f_at AW125218 RIKEN cDNA 2410071B14 gene1978 0.07241 2.28 up Mm.26069 Trfr 103957_at X57349 transferrin receptor1979 0.07242 1.88 down Mm.10027 Prpk 102017_at AF033663 pre-mRNA protein kinase1980 0.07253 2.43 up Mm.6173 Dpysl4 93379_at Y09079 dihydropyrimidinase-like 4Page 22 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2071 0.07664 2.14 up Mm.5789 Mm.5789 101603_g_at C79108 ESTs2072 0.07674 7.16 up Mm.4218 Tob1 161567_r_at AV356682 transducer of ErbB-2.12073 0.07677 1.50 up Mm.28032 C75969 95618_at AI843884 expressed sequence C759692074 0.07677 2.10 up Mm.14860 Anxa1 93038_f_at M69260 annexin A12075 0.07688 1.65 up Mm.29492 Elovl1 95642_at AI842813 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like2076 0.07689 2.49 up Mm.4692 R75424 92744_at AI854774 expressed sequence R754242077 0.07700 1.55 down Mm.22147 Gtpbp2 104144_at AW124369 GTP binding protein 22078 0.07706 4.55 up Mm.42170 Kif9 161035_at AA122519 kinesin 92079 0.07707 2.80 up Mm.1268 Plp 92802_s_at M16472 proteolipid protein (myelin)2080 0.07709 1.73 down Mm.146516 2310075C12Rik 96271_at AA914105 RIKEN cDNA 2310075C12 gene2081 0.07709 2.68 up Mm.8315 Nedd9 101469_at AF009366 neural precursor cell expressed, developmentally down-regulated gene 92082 0.07727 1.24 down Mm.20885 Golga5 103808_at AB016784 golgi autoantigen, golgin subfamily a, 52083 0.07727 1.55 down Mm.29791 Mbtps1 95754_at AI838216 membrane-bound transcription factor protease, site 12084 0.07731 2.01 up Mm.6900 Grb2 101034_at U07617 growth factor receptor bound protein 22085 0.07732 1.54 down Mm.5885 Tm9sf2 100572_at AI851289 transmembrane 9 superfamily member 22086 0.07735 3.64 up Mm.23845 1600017K21Rik 103676_at AI551306 RIKEN cDNA 1600017K21 gene2087 0.07739 1.88 up Mm.202774 AA407676 161758_r_at AV298880 expressed sequence AA4076762088 0.07742 3.63 up Mm.5697 Mm.5697 93204_r_at AW107463 ESTs2089 0.07743 1.96 up Mm.80559 Mm.80559 162432_f_at AV297484 ESTs, Weakly similar to W01A11.2.p [Caenorhabditis elegans] [C.elegans]2090 0.07749 2.15 down Mm.7226 Tcf2 101396_at AB008174 transcription factor 22091 0.07749 1.66 up Mm.25317 Mm.25317 98346_at AI593759 ESTs, Weakly similar to JG0193 G protein-coupled receptor FEX - mouse [M2092 0.07764 3.95 up Mm.144235 Pxf 95073_at Y09046 peroxisomal farnesylated protein2093 0.07780 3.84 up Mm.5073 Sp4 92991_at U62522 trans-acting transcription factor 42094 0.07783 1.51 down Mm.2368 Timm17a 94860_at AW121821 translocator of inner mitochondrial membrane 17 kDa, a2095 0.07785 1.59 up Mm.7454 AI662457 162460_f_at AV048486 expressed sequence AI6624572096 0.07794 1.40 down Mm.22526 2310004B05Rik 104343_f_at AI845798 RIKEN cDNA 2310004B05 gene2097 0.07801 3.77 up Mm.46754 AI316867 162135_r_at AV379830 expressed sequence AI3168672098 0.07821 2.43 up Mm.57250 Hic1 93231_at AJ007511 hypermethylated in cancer 12099 0.07834 2.58 up Mm.24794 2410001E19Rik 161617_f_at AV354124 RIKEN cDNA 2410001E19 gene2100 0.07839 1.52 down Mm.27670 4831443O22Rik 94242_at AA881309 RIKEN cDNA 4831443O22 gene2101 0.07844 1.86 down Mm.34044 Daf2 92198_s_at L41365 decay accelerating factor 22102 0.07845 1.27 down Mm.28095 AL024016 95637_at AI838592 expressed sequence AL0240162103 0.07848 2.21 up Mm.25049 C79777 95989_at AI448172 expressed sequence C797772104 0.07849 2.56 up Mm.56902 Olfr49 101281_at AF102523 olfactory receptor 492105 0.07864 1.76 up Mm.2020 Csrp2 93550_at D88792 cysteine-rich protein 22106 0.07864 1.78 down Mm.2167 Rev3l 103457_at AF083464 REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisi2107 0.07867 1.64 down Mm.22670 Mdm2 98110_at AI853375 transformed mouse 3T3 cell double minute 22108 0.07869 2.01 up Mm.28961 Cpsf5 94506_at AI853113 cleavage and polyadenylation specific factor 5, 25 kD subunit2109 0.07879 1.88 up Mm.142716 Fabp6 99977_at U00938 fatty acid binding protein 6, ileal (gastrotropin)2110 0.07895 2.23 up Mm.1367 Wnt3a 102667_at X56842 wingless-related MMTV integration site 3A2111 0.07896 1.44 down Mm.28458 Lrba 104264_at AW122230 LPS-responsive beige-like anchor2112 0.07899 1.34 down Mm.27278 Nme3 94981_i_at AI852470 expressed in non-metastatic cells 32113 0.07899 2.49 up Mm.24204 AV328152 160968_at AI390412 expressed sequence AV3281522114 0.07919 2.26 up Mm.4511 AI504145 160889_at AI846313 expressed sequence AI5041452115 0.07920 3.51 up Mm.197478 Imap38 92489_at Y08026 immunity-associated protein, 38 kDa2116 0.07943 1.85 down Mm.1304 Slc11a2 104451_at AI852578 solute carrier family 11 (proton-coupled divalent metal ion transporters), mem2117 0.07947 1.98 up Mm.4931 Hoxd11 92951_at X71422 homeo box D112118 0.07949 1.58 down Mm.200196 Il15ra 161023_at U22339 interleukin 15 receptor, alpha chain2119 0.07950 1.95 up Mm.5376 1110036H21Rik 100883_at AI877468 RIKEN cDNA 1110036H21 gene2120 0.07952 4.39 up Mm.752 AI848610 101426_at AW125333 expressed sequence AI8486102121 0.07956 2.16 up Mm.21450 2310016E02Rik 93807_at AW122507 RIKEN cDNA 2310016E02 gene2122 0.07959 2.00 up Mm.3925 S100a4 99051_at M36579 S100 calcium binding protein A42123 0.07970 1.29 down Mm.218627 Ppil2 95112_f_at AW122632 peptidylprolyl isomerase (cyclophilin)-like 22124 0.07971 4.50 up Mm.104295 Slc10a1 100340_at U95132 solute carrier family 10 (sodium/bile acid cotransporter family), member 12125 0.07972 2.12 up Mm.2718 Eef1b2 96624_r_at AI837393 eukaryotic translation elongation factor 1 beta 22126 0.07984 3.11 up Mm.10737 Cideb 102329_at AF041377 cell death-inducing DNA fragmentation factor, alpha subunit-like effector B2127 0.07987 3.64 up Mm.20363 Gale 93566_at AI847878 galactose-4-epimerase, UDP2128 0.07989 3.28 up Mm.28577 1110006I11Rik 98902_at AI835066 RIKEN cDNA 1110006I11 gene2129 0.07995 3.02 up Mm.196520 Tcp1-rs1 162443_at AV349894 t-complex protein 1, related sequence 12130 0.07997 2.81 up Mm.10729 Ncf2 102326_at AB002664 neutrophil cytosolic factor 22131 0.08000 2.95 down Mm.29917 2810002B19Rik 96306_at AI852210 RIKEN cDNA 2810002B19 gene2132 0.08000 2.44 up Mm.200955 Catnal1 94174_at AF006071 catenin alpha-like 12133 0.08003 1.45 down Mm.6562 Sult-x1 93434_at AF026074 sulfotransferase-related protein SULT-X12134 0.08012 3.00 up Mm.5193 Klk8 99327_at D30785 kallikrein 82135 0.08014 1.85 up Mm.5593 D5Ertd102e 101225_at C77257 DNA segment, Chr 5, ERATO Doi 102, expressed2136 0.08015 2.59 up Mm.41075 Drd4 97755_at U19880 dopamine receptor 42137 0.08016 1.81 up Mm.37263 Mm.37263 92293_at AI850463 ESTs, Weakly similar to L1 cell adhesion molecule [Mus musculus] [M.musc2138 0.08020 1.74 up Mm.29856 9130022B02Rik 162462_r_at AV054247 RIKEN cDNA 9130022B02 gene2139 0.08021 1.59 down Mm.20851 Pdi3 103803_at AB013849 peptidyl arginine deiminase, type III2140 0.08021 1.89 up Mm.28253 Mm.28253 100296_at X99253 M.musculus mRNA for protein expressed at high levels in testis2141 0.08026 1.80 down Mm.10724 Ehf 102243_at AF035527 ets homologous factor2142 0.08032 4.21 up Mm.30413 Bmp8b 101657_at U39545 bone morphogenetic protein 8b2143 0.08039 1.54 down Mm.29771 Atp6a1 95744_at U13837 ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, i2144 0.08041 2.41 up Mm.4348 Tnfaip2 160489_at L24118 tumor necrosis factor, alpha-induced protein 22145 0.08052 4.78 up Mm.27970 Mapk13 160763_at U81823 mitogen activated protein kinase 132146 0.08053 5.56 up Mm.46360 Reg2 95786_at D14011 regenerating islet-derived 22147 0.08054 2.45 up 94928_at X871282148 0.08058 2.20 down Mm.19080 Gtpbp1 103436_at U87965 GTP binding protein 12149 0.08067 2.04 up Mm.196549 Mm.196549 161130_f_at AV301574 Mus musculus, Similar to hypothetical protein DKFZp434G0522, clone MGC2150 0.08068 2.18 up Mm.7999 Ptgfrn 99894_at AF006201 prostaglandin F2 receptor negative regulator2151 0.08075 2.84 up Mm.2951 Camk4 104455_at J03057 calcium/calmodulin-dependent protein kinase IV2152 0.08075 1.61 down Mm.28028 Mm.28028 97293_at AI842108 Mus musculus, Similar to RNA binding motif protein 10, clone MGC:7826 IMA2153 0.08076 2.39 up Mm.157893 Mup1 161815_f_at AV355798 major urinary protein 12154 0.08084 2.43 up Mm.5157 Oa1 98871_at X98352 mouse homolog of human ocular albinism 1 (Nettleship-Falls)2155 0.08086 3.08 up Mm.14255 Apbb1ip-pending 102710_at AF020313 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting p2156 0.08087 2.64 up Mm.1440 Tac1 102726_at D17584 tachykinin 12157 0.08095 2.29 up Mm.20874 Pdi4 103278_at AB013850 peptidyl arginine deiminase, type IV2158 0.08098 3.86 up Mm.30313 Ncam2 96582_at AF001287 neural cell adhesion molecule 22159 0.08102 3.22 up Mm.27822 Apobec2 97236_r_at AW124988 apolipoprotein B editing complex 22160 0.08103 2.69 up Mm.29738 Apoa5 95727_at AI785422 apolipoprotein A-VPage 24 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2161 0.08120 1.77 down Mm.7039 1190003A07Rik 101053_at AW046847 RIKEN cDNA 1190003A07 gene2162 0.08128 2.01 up Mm.814 D10Ertd398e 101500_at AI834796 DNA segment, Chr 10, ERATO Doi 398, expressed2163 0.08146 2.16 up Mm.4646 Krt1-13 160510_f_at U13921 keratin complex 1, acidic, gene 132164 0.08147 1.69 down Mm.4290 1110020G17Rik 97279_at AI837615 RIKEN cDNA 1110020G17 gene2165 0.08153 1.86 up Mm.4463 Vipr2 98375_at D28132 vasoactive intestinal peptide receptor 22166 0.08156 2.60 up Mm.18036 E2f1 161427_f_at AV301683 E2F transcription factor 12167 0.08160 1.42 down Mm.142827 DXImx46e 96813_f_at AI852973 DNA segment, Chr X, Immunex 46, expressed2168 0.08160 1.45 down Mm.87450 1110018F06Rik 103348_at AI837688 RIKEN cDNA 1110018F06 gene2169 0.08164 1.48 down Mm.154456 Cyb561 103423_at AI846517 cytochrome b-5612170 0.08170 2.28 up Mm.25170 3110013H01Rik 162491_f_at AV140903 RIKEN cDNA 3110013H01 gene2171 0.08170 3.06 up Mm.14269 Defcr-rs1 102814_f_at M33226 defensin related sequence cryptdin peptide (paneth cells)2172 0.08173 1.72 down Mm.3536 Myo5b 92254_at M55253 myosin Vb2173 0.08174 1.52 down Mm.21435 Sec61a2-pending 103913_at AI851315 SEC61, alpha subunit 2 (S. cerevisiae)2174 0.08176 1.51 down Mm.2291 Tia1 160696_at U00689 cytotoxic granule-associated RNA binding protein 12175 0.08180 3.58 up Mm.22224 Cpx1-pending 103492_at AF077738 metallocarboxypeptidase 12176 0.08189 2.45 up Mm.2953 Grin2a 100726_at D10217 glutamate receptor, ionotropic, NMDA2A (epsilon 1)2177 0.08203 1.54 down Mm.29405 Rbx1 95125_f_at AW122337 ring-box 12178 0.08205 2.75 up Mm.206505 D11Bwg1104e 160116_at AI850047 DNA segment, Chr 11, Brigham & Women's Genetics 1104 expressed2179 0.08212 1.36 down Mm.43636 Zfp289 99644_at AI845855 zinc finger protein 2892180 0.08220 2.93 up Mm.1346 Itga4 102655_at X53176 integrin alpha 42181 0.08248 1.97 up Mm.14465 Gzmc 161834_at AV035955 granzyme C2182 0.08250 3.97 up Mm.26237 Cry1 94421_r_at AB000777 cryptochrome 1 (photolyase-like)2183 0.08255 2.27 up Mm.795 Csf1 101450_at M21952 colony stimulating factor 1 (macrophage)2184 0.08256 1.64 up Mm.35793 Ssa2 92265_f_at AF042139 Sjogren syndrome antigen A22185 0.08257 1.97 down Mm.9326 Rnf13 101966_s_at AF037206 ring finger protein 132186 0.08265 1.96 up Mm.89854 Adam11 93920_at AB009676 a disintegrin and metalloprotease domain 112187 0.08269 1.35 down Mm.21684 Cab39 93976_at AI836686 calcium binding protein, 39 kDa2188 0.08269 1.82 up Mm.6958 Capn2 162112_i_at AV295948 calpain 22189 0.08270 2.86 up Mm.24399 Klra1 95908_at M25775 killer cell lectin-like receptor, subfamily A, member 12190 0.08272 1.53 up Mm.24331 Asb3 104629_at AI876546 ankyrin repeat and SOCS box-containing protein 32191 0.08279 2.22 up Mm.5703 C78334 101231_at C78334 expressed sequence C783342192 0.08280 1.83 down Mm.42948 Prdx2 99608_at U20611 peroxiredoxin 22193 0.08280 4.60 up Mm.4833 Htr5b 98810_at X69867 5-hydroxytryptamine (serotonin) receptor 5B2194 0.08295 1.83 up Mm.200388 Siat5 100279_at X76989 sialyltransferase 52195 0.08296 5.46 up Mm.21795 Mm.21795 161481_f_at AV068206 ESTs, Highly similar to I38863 E1B 19K/Bcl-2-interacting protein Nip1 [H.sap2196 0.08298 2.56 up Mm.7952 Peg3 101451_at AF038939 paternally expressed 32197 0.08298 2.30 down Mm.26171 Lce-pending 103665_at AW122523 long chain fatty acyl elongase2198 0.08302 6.18 up Mm.42791 Crtam 98334_at AF001104 cytotoxic and regulatory T cell molecule2199 0.08306 4.09 up Mm.24851 Mm.24851 162211_r_at AV379320 ESTs2200 0.08329 2.36 up Mm.28697 2310032D16Rik 98941_r_at AA823901 RIKEN cDNA 2310032D16 gene2201 0.08333 1.94 down Mm.10080 Kcnk3 102020_at AB013345 potassium channel, subfamily K, member 32202 0.08340 3.15 up Mm.196322 X83313 100348_at AW214136 EST X833132203 0.08343 1.72 up Mm.38976 AA409661 99085_at AI021421 expressed sequence AA4096612204 0.08351 1.54 down Mm.201339 AW060250 95530_at AW060250 expressed sequence AW0602502205 0.08352 2.67 up Mm.4980 Chrne 92966_g_at J04698 cholinergic receptor, nicotinic, epsilon polypeptide2206 0.08360 2.88 up Mm.21013 Gro1 95349_g_at J04596 GRO1 oncogene2207 0.08363 2.13 up Mm.200362 Cybb 100300_at U43384 cytochrome b-245, beta polypeptide2208 0.08363 3.03 up Mm.5134 Grik1 93132_at X66118 glutamate receptor, ionotropic, kainate 12209 0.08366 1.65 down Mm.28209 Perp-pending 97825_at AI854029 p53 apoptosis effector related to Pmp222210 0.08372 4.30 up Mm.142733 Scn1a 162255_s_at AV336781 sodium channel, voltage-gated, type I, alpha polypeptide2211 0.08378 2.34 up Mm.27521 AA409802 161606_f_at AV345792 expressed sequence AA4098022212 0.08383 1.32 down Mm.147641 Clk3 93311_at AF033565 CDC-like kinase 32213 0.08391 1.69 down Mm.45951 1200016B17Rik 92872_at AI837715 RIKEN cDNA 1200016B17 gene2214 0.08392 2.20 up Mm.18087 Lgals9 103335_at U55060 lectin, galactose binding, soluble 92215 0.08409 3.83 up Mm.897 Pou2af1 162439_at AV346238 POU domain, class 2, associating factor 12216 0.08410 2.54 up Mm.6826 Aatk 100994_at AF011908 apoptosis-associated tyrosine kinase2217 0.08413 1.92 up Mm.8020 Otog 94625_at U96411 otogelin2218 0.08420 1.33 down Mm.21281 Rnf4 93782_at AI844517 ring finger protein 42219 0.08421 1.50 down Mm.28872 Rab5a 94478_at AI841377 RAB5A, member RAS oncogene family2220 0.08428 2.03 up Mm.5305 Gnb2-rs1 99340_at D29802 guanine nucleotide binding protein, beta 2, related sequence 12221 0.08435 2.26 up Mm.6246 Blr1 99841_at X71788 Burkitt lymphoma receptor 12222 0.08447 3.18 up Mm.46817 V1rb6 102167_at Y17567 vomeronasal 1 receptor, B62223 0.08448 2.99 up Mm.1282 Scya3 102424_at J04491 small inducible cytokine A32224 0.08457 3.16 up Mm.6047 2410002E02Rik 161072_at AV352144 RIKEN cDNA 2410002E02 gene2225 0.08464 1.64 up Mm.2543 Ihh 103949_at X76291 Indian hedgehog homolog, (Drosophila)2226 0.08467 1.37 down Mm.27987 AI606441 95609_at AA869927 expressed sequence AI6064412227 0.08470 3.86 up Mm.38315 Mm.38315 92320_f_at AA415783 ESTs, Weakly similar to ZF26 MOUSE ZINC FINGER PROTEIN 26 [M.musc2228 0.08472 3.59 up Mm.41576 Kif5c 98827_i_at X61435 kinesin family member 5C2229 0.08480 2.05 up Mm.28328 Hsd11b1 97867_at X83202 hydroxysteroid 11-beta dehydrogenase 12230 0.08487 2.12 up Mm.10661 Slc2a4 102314_at M23383 solute carrier family 2 (facilitated glucose transporter), member 42231 0.08490 3.23 up Mm.9212 Sema6a 100762_at AF030430 sema domain, transmembrane domain (TM), and cytoplasmic domain, (sema2232 0.08495 2.94 up Mm.24876 Elf1 161584_r_at AV318048 E74-like factor 12233 0.08509 2.95 up Mm.5167 Nov 100507_at Y09257 nephroblastoma overexpressed gene2234 0.08515 1.65 up Mm.15675 Efna1 103007_at U90662 ephrin A12235 0.08515 2.38 down Mm.154284 Slc22a9 92486_at AB018436 solute carrier family 22 (organic cation transporter), member 92236 0.08517 1.32 up Mm.200499 Eif2ak1 160341_at AW122189 eukaryotic translation initiation factor 2 alpha kinase 12237 0.08524 5.61 up Mm.62569 Mm.62569 161448_f_at AV355612 EST2238 0.08524 1.79 up Mm.18425 3110056M06Rik 103356_at AI843267 RIKEN cDNA 3110056M06 gene2239 0.08534 2.05 up Mm.5348 1700010P14Rik 162047_f_at AV264876 RIKEN cDNA 1700010P14 gene2240 0.08536 1.62 down Mm.30076 Bat1a 160384_at AF118128 HLA-B-associated transcript 1A2241 0.08539 2.42 up Mm.10137 Il16 102029_at AF017111 interleukin 162242 0.08540 2.89 up Mm.88833 Mm.88833 100370_at AJ011033 Mus musculus strain ILS K-Cl cotransporter (Slc12a5) mRNA, complete cds2243 0.08541 1.34 down Mm.27653 Zfp106 95533_at AW048037 zinc finger protein 1062244 0.08547 1.37 up Mm.28029 0710001O20Rik 160263_r_at AI840981 RIKEN cDNA 0710001O20 gene2245 0.08552 1.74 up Mm.5048 Mcmd5 100156_at D26090 mini chromosome maintenance deficient 5 (S. cerevisiae)2246 0.08557 2.14 up Mm.24903 C76332 95854_at C76332 expressed sequence C763322247 0.08563 1.82 down Mm.22459 AI265322 104327_at AA755234 expressed sequence AI2653222248 0.08573 3.14 up Mm.104747 Igk-V28 100322_at U48716 immunoglobulin kappa chain variable 28 (V28)2249 0.08574 2.00 up Mm.29497 2310020H20Rik 95645_at AI837440 RIKEN cDNA 2310020H20 gene2250 0.08576 4.99 up Mm.3401 Pcsk5 92192_s_at D12619 proprotein convertase subtilisin/kexin type 5Page 25 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2251 0.08587 3.17 up Mm.90048 Esrrb 100301_at X89594 estrogen related receptor, beta2252 0.08592 2.93 up Mm.214548 Bmp6 92372_at X80992 bone morphogenetic protein 62253 0.08597 1.82 down Mm.200406 Mm.200406 98463_at AW124186 Mus musculus, Similar to SWI/SNF related, matrix associated, actin depende2254 0.08598 1.39 down Mm.10265 Nmt1 102047_at AF043326 N-myristoyltransferase 12255 0.08600 2.49 up Mm.7693 Stk2 101437_at AF039574 serine/threonine kinase 22256 0.08608 1.86 down Mm.5238 AU024132 104316_at AI646098 expressed sequence AU0241322257 0.08613 2.03 up Mm.10948 Slfn1 102264_at AF099972 schlafen 12258 0.08618 1.88 up Mm.25620 Dntt 161409_f_at AV312871 deoxynucleotidyltransferase, terminal2259 0.08627 1.49 down Mm.1465 AI449533 102862_at AA873956 expressed sequence AI4495332260 0.08636 1.64 up Mm.25189 C85331 94349_at AA794923 expressed sequence C853312261 0.08636 2.75 up Mm.4797 Gsh1 101146_at U21224 genomic screened homeo box 12262 0.08638 1.87 down Mm.196027 Cpr2-pending 95341_at U89434 cell cycle progression 2 protein2263 0.08643 1.65 down Mm.6384 Nrap 160913_at U76618 nebulin-related anchoring protein2264 0.08651 1.95 up Mm.7 Vim 101046_at X56397 vimentin2265 0.08653 2.58 up Mm.89205 Jnkbp1-pending 97054_at AB029482 Jun N-terminal kinase binding protein 12266 0.08667 1.41 up Mm.143813 Midn 104410_at AW124785 midnolin2267 0.08672 1.88 up Mm.25296 2310079N02Rik 94366_at AW121767 RIKEN cDNA 2310079N02 gene2268 0.08676 1.69 down Mm.218907 AI854876 99948_at AI854876 expressed sequence AI8548762269 0.08676 2.64 up Mm.22569 Ccnb1-rs1 160159_at X64713 cyclin B1, related sequence 12270 0.08678 2.37 up Mm.5324 A030009H04Rik 160905_s_at AI840713 RIKEN cDNA A030009H04 gene2271 0.08680 1.48 down Mm.641 Atf4 100599_at M94087 activating transcription factor 42272 0.08682 1.71 up Mm.46816 V1rb5 102165_at Y17566 vomeronasal 1 receptor, B52273 0.08683 1.47 down Mm.20242 1810044O22Rik 96878_at AW048566 RIKEN cDNA 1810044O22 gene2274 0.08689 2.61 up Mm.10211 Entpd5 92561_at AJ238636 ectonucleoside triphosphate diphosphohydrolase 52275 0.08696 3.11 up Mm.27644 Mm.27644 96538_at AA472923 ESTs, Weakly similar to ANK1 MOUSE ANKYRIN 1 [M.musculus]2276 0.08701 1.82 down Mm.3308 Ywhah 97535_at D87661 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,2277 0.08708 1.62 up Mm.27673 D6Wsu176e 97770_s_at AA733372 DNA segment, Chr 6, Wayne State University 176, expressed2278 0.08709 3.10 up Mm.21961 Atp6s1 103699_i_at AI646638 ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 12279 0.08721 1.96 up Mm.200569 Zfp260 92409_at D45210 zinc finger protein 2602280 0.08722 1.81 down Mm.12787 2400010G15Rik 102421_at AI847950 RIKEN cDNA 2400010G15 gene2281 0.08725 2.67 up Mm.7914 Gdf1 93642_at M62301 growth differentiation factor 12282 0.08730 2.88 up Mm.25191 Mm.25191 96492_at AI593265 ESTs2283 0.08741 1.49 down Mm.29667 2010320B01Rik 160814_at AI854547 RIKEN cDNA 2010320B01 gene2284 0.08743 1.44 down Mm.4259 Tacstd1 99582_at M76124 tumor-associated calcium signal transducer 12285 0.08752 1.33 down Mm.200237 1110034O24Rik 104071_at AI852433 RIKEN cDNA 1110034O24 gene2286 0.08753 1.56 up Mm.14609 Aldh1a7 94778_at U96401 aldehyde dehydrogenase family 1, subfamily A72287 0.08755 2.84 up Mm.31126 C79562 97080_at C79288 expressed sequence C795622288 0.08761 2.49 up Mm.1296 Tpx1 162454_f_at AV039214 testis specific gene 12289 0.08763 1.45 down Mm.24086 3930401E15Rik 94903_at AI850801 RIKEN cDNA 3930401E15 gene2290 0.08765 1.40 down Mm.5750 2310032K15Rik 100904_at AI852257 RIKEN cDNA 2310032K15 gene2291 0.08772 1.70 up Mm.4038 Fxr1h 99121_at X90875 fragile X mental retardation gene 1, autosomal homolog2292 0.08779 1.85 down Mm.123240 1700016D08Rik 104122_at AW122596 RIKEN cDNA 1700016D08 gene2293 0.08780 1.49 down Mm.19761 AA589616 103580_at AI845588 expressed sequence AA5896162294 0.08782 1.49 up Mm.3080 Mm.3080 97966_at AI848209 Mus musculus, Similar to coactivator independent of AF-2, clone MGC:288642295 0.08788 1.59 up Mm.218381 ep 161367_f_at AV232610 pale ear2296 0.08790 1.41 down Mm.29058 Sra1 160323_at AW122167 steroid receptor RNA activator 12297 0.08791 1.24 down Mm.30064 Gabarap 96869_at AW124839 gamma-aminobutyric acid receptor associated protein2298 0.08792 1.66 up Mm.2212 P4ha1 104139_at U16162 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), a2299 0.08793 2.74 up Mm.1430 Eya3 102716_at U81604 eyes absent 3 homolog (Drosophila)2300 0.08794 1.43 up Mm.21705 1110049G11Rik 161872_f_at AV073962 RIKEN cDNA 1110049G11 gene2301 0.08800 2.43 up Mm.193459 Mglap 93866_s_at D00613 matrix gamma-carboxyglutamate (gla) protein2302 0.08802 4.12 up Mm.2128 S100a9 103887_at M83219 S100 calcium binding protein A9 (calgranulin B)2303 0.08825 3.88 up Mm.14131 Tcstv1-pending 94727_f_at AF067057 2-cell-stage, variable group, member 12304 0.08828 2.01 up Mm.21114 Mm.21114 93463_at AW122517 Mus musculus, clone MGC:11980 IMAGE:3601364, mRNA, complete cds2305 0.08841 3.22 down Mm.214548 Bmp6 161028_at AI850533 bone morphogenetic protein 62306 0.08847 1.82 up Mm.4293 Sax1 98337_at X75384 spinal cord axial homeobox gene 12307 0.08850 2.16 up Mm.2121 1110013J02Rik 93775_at AI841894 RIKEN cDNA 1110013J02 gene2308 0.08851 1.61 down Mm.8556 Cbx4 93697_at U63387 chromobox homolog 4 (Drosophila Pc class)2309 0.08859 2.94 up Mm.1262 Cyp17 161721_f_at AV262299 cytochrome P450, 172310 0.08860 2.13 up Mm.29070 1810042K04Rik 94543_at AW049487 RIKEN cDNA 1810042K04 gene2311 0.08862 5.35 up Mm.23897 Mm.23897 162437_at AV345587 ESTs2312 0.08867 3.02 up Mm.38376 Rad1 99005_at AF073523 RAD1 homolog (S. pombe)2313 0.08867 2.08 up Mm.26096 Akp5 103991_at M61704 alkaline phosphatase 52314 0.08869 1.29 up Mm.28103 1810009A15Rik 103565_at AI843358 RIKEN cDNA 1810009A15 gene2315 0.08871 2.10 up Mm.14098 Cyp2b19 102690_at AF047529 cytochrome P450, 2b192316 0.08874 1.30 down Mm.195084 Tubb2 94835_f_at M28739 tubulin, beta 22317 0.08878 2.25 up Mm.23710 1200011C15Rik 104550_at AW123273 RIKEN cDNA 1200011C15 gene2318 0.08879 1.99 up Mm.200511 AI115024 103889_at AI834833 expressed sequence AI1150242319 0.08887 1.46 down Mm.19803 2310047C21Rik 93529_at AW125219 RIKEN cDNA 2310047C21 gene2320 0.08892 1.50 up Mm.2706 Atf3 161645_r_at AV084197 activating transcription factor 32321 0.08893 1.54 up Mm.182445 Ldlb 160210_at AF109377 low density lipoprotein B2322 0.08905 2.03 up Mm.142568 Disp-pending 93709_at AJ243866 distal intestinal serine protease2323 0.08908 1.56 down Mm.29594 Sart3 97340_at AI839599 squamous cell carcinoma antigen recognized by T-cells 32324 0.08919 3.72 up Mm.147946 Mybbp1a 101010_at U63648 MYB binding protein (P160) 1a2325 0.08921 1.61 down Mm.22397 1300013G12Rik 104311_at AW125241 RIKEN cDNA 1300013G12 gene2326 0.08921 2.88 up Mm.3645 Myo5a 161948_f_at AV214912 myosin Va2327 0.08923 1.56 up Mm.29061 Rrr-pending 96778_at AA656775 regulator for ribosome resistance homolog (S. cerevisiae)2328 0.08925 1.68 down Mm.41785 Fibp 99176_at AI843393 fibroblast growth factor (acidic) intracellular binding protein2329 0.08926 3.81 up Mm.157783 AI893585 101747_f_at X94419 expressed sequence AI8935852330 0.08926 2.33 up Mm.6204 Cort 99831_at AF013253 cortistatin2331 0.08932 3.37 up Mm.3327 AW121776 97110_at AW121776 expressed sequence AW1217762332 0.08939 2.72 up Mm.8025 Abpa 94628_r_at AF039064 androgen binding protein, alpha2333 0.08947 1.55 down Mm.1960 Mm.1960 103211_at AI852574 ESTs, Weakly similar to beta-transducin [Caenorhabditis elegans] [C.elegan2334 0.08947 1.44 up Mm.4117 Cdc37 99135_at U43076 cell division cycle 37 homolog (S. cerevisiae)2335 0.08949 2.84 up Mm.34934 C77614 97139_at C77614 EST C776142336 0.08952 1.74 down Mm.41939 1110018D06Rik 99196_at AI848532 RIKEN cDNA 1110018D06 gene2337 0.08952 1.68 up Mm.4487 Anpep 99993_at U77083 alanyl (membrane) aminopeptidase2338 0.08953 1.58 down Mm.42188 Unc13h1 92498_at AF115848 unc13 homolog (C. elegans) 12339 0.08955 2.69 up Mm.3468 Cish3 92232_at U88328 cytokine inducible SH2-containing protein 32340 0.08972 4.17 up Mm.4405 Chx10 161711_f_at AV246437 C. elegans ceh-10 homeo domain containing homologPage 26 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2341 0.08975 2.88 up Mm.16086 Abcb1a 102910_at M24417 ATP-binding cassette, sub-family B (MDR/TAP), member 1A2342 0.08976 2.14 up Mm.5178 Mylc2pl 101195_at X65979 myosin light chain 2, precursor lymphocyte-specific2343 0.08976 2.53 up Mm.2549 Hk2 94375_at Y11666 hexokinase 22344 0.08979 1.43 up Mm.197534 Baiap2 103098_at AW045765 brain-specific angiogenesis inhibitor 1-associated protein 22345 0.08980 1.28 down Mm.42234 Dguok 99543_s_at AJ133749 deoxyguanosine kinase2346 0.08982 3.25 up Mm.34248 Dab2 98045_s_at U18869 disabled homolog 2 (Drosophila)2347 0.08983 1.91 up Mm.29119 AI195470 95043_at AI047331 expressed sequence AI1954702348 0.08989 3.88 up Mm.14874 Gzmb 102877_at M12302 granzyme B2349 0.08990 1.53 down Mm.206786 Tor1b 95505_at AW060509 torsin family 1, member B2350 0.08995 4.27 up Mm.181623 Mm.181623 161091_r_at AV337823 ESTs2351 0.08996 2.05 up Mm.6840 5730507C05Rik 160141_r_at AI843342 RIKEN cDNA 5730507C05 gene2352 0.08997 2.21 up Mm.103849 Mm.103849 99016_at AA589431 EST, Weakly similar to JAK3 MOUSE TYROSINE-PROTEIN KINASE JAK32353 0.09005 1.90 up Mm.28954 Wrch1-pending 162011_f_at AV246963 Wnt1 responsive Cdc42 homolog2354 0.09006 1.63 down Mm.3037 1700031C13Rik 97947_at AI836959 RIKEN cDNA 1700031C13 gene2355 0.09013 1.78 up Mm.5473 AU021092 93185_at AW045808 expressed sequence AU0210922356 0.09024 1.56 up Mm.22753 Ctsb 92256_at AI853714 cathepsin B2357 0.09025 2.87 up Mm.1909 Gbp3 103202_at AW047476 guanylate nucleotide binding protein 32358 0.09028 1.44 down Mm.46397 3100002B05Rik 103650_at AI846887 RIKEN cDNA 3100002B05 gene2359 0.09035 1.27 down Mm.29623 Ddb1 95683_g_at AB026432 damage specific DNA binding protein 1 (127 kDa)2360 0.09035 3.32 up Mm.33781 Mm.33781 97117_at AA027631 ESTs2361 0.09041 4.11 up Mm.5357 AI447490 161932_r_at AV312014 EST AI4474902362 0.09049 1.50 up Mm.41552 Mm.41552 92259_at AI467526 Mus musculus, clone MGC:28734 IMAGE:4460615, mRNA, complete cds2363 0.09059 4.17 up Mm.4778 Cspg3 98799_g_at X84727 chondroitin sulfate proteoglycan 32364 0.09062 1.47 down Mm.23713 Mm.23713 160702_at AA791885 ESTs, Weakly similar to S48081 GRSF-1 protein [H.sapiens]2365 0.09073 1.45 down Mm.121721 Stat6 94331_at L47650 signal transducer and activator of transcription 62366 0.09076 1.75 up 104458_at AI8412352367 0.09082 1.99 up Mm.97734 Cd38 100778_at L11332 CD38 antigen2368 0.09095 4.36 up Mm.24237 AV046379 161102_at AA242553 expressed sequence AV0463792369 0.09095 1.38 up Mm.12267 MGC6685 92775_at AA656757 similar to poly(A)-binding protein, cytoplasmic 4 (inducible form)2370 0.09111 1.76 down Mm.29998 0610039C21Rik 96348_at AW121217 RIKEN cDNA 0610039C21 gene2371 0.09116 3.49 up Mm.2258 Utg 94291_at L04503 uteroglobin2372 0.09129 2.05 up Mm.27224 2410006H10Rik 94971_at AI317217 RIKEN cDNA 2410006H10 gene2373 0.09130 2.13 up Mm.22240 Sh3bgrl3 94220_at AI836226 SH3 domain binding glutamic acid-rich protein-like 32374 0.09135 1.96 up Mm.34747 Slc4a4 98457_at AF020195 solute carrier family 4 (anion exchanger), member 42375 0.09145 1.55 down Mm.27235 4933405K21Rik 96635_at AW125392 RIKEN cDNA 4933405K21 gene2376 0.09148 4.11 up Mm.89474 Cd80 93905_at L12589 CD80 antigen2377 0.09152 1.36 down Mm.911 Hmgn2 101589_at X12944 high mobility group nucleosomal binding domain 22378 0.09157 2.38 up Mm.21882 Cd84 94028_f_at AI642245 CD84 antigen2379 0.09167 1.53 up Mm.2424 Rpl10a 161327_f_at AV104703 ribosomal protein L10A2380 0.09168 1.73 down Mm.3380 Kif5b 160417_at U86090 kinesin family member 5B2381 0.09170 3.04 up Mm.35692 Il1rl1 98501_at Y07519 interleukin 1 receptor-like 12382 0.09182 1.77 up Mm.24720 Fkbp7 104746_at AF040252 FK506 binding protein 7 (23 kDa)2383 0.09185 3.83 up Mm.28362 AI326478 101744_i_at X94422 expressed sequence AI3264782384 0.09186 1.48 down Mm.22597 2310042E05Rik 94299_at AI839731 RIKEN cDNA 2310042E05 gene2385 0.09191 1.50 down Mm.22530 Exo70 104345_at AF014461 exocyst component protein 70 kDa homolog (S. cerevisiae)2386 0.09200 1.63 up Mm.482 Jun 100130_at X12761 Jun oncogene2387 0.09203 1.36 up Mm.28256 Narg1-pending 96152_at AI645561 NMDA receptor-regulated gene 12388 0.09210 2.47 up Mm.569 Vdac2 161255_at AV282090 voltage-dependent anion channel 22389 0.09212 1.88 up Mm.10563 Mtf2 103657_i_at AI836552 metal response element binding transcription factor 22390 0.09218 1.79 up Mm.70127 Rpl12 101049_at L04280 ribosomal protein L122391 0.09219 1.62 down Mm.3705 P4ha2 162188_f_at AV370017 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), a2392 0.09219 1.54 down Mm.675 Oaz2 101000_at D78643 ornithine decarboxylase antizyme 22393 0.09222 4.57 up Mm.104644 Mm.104644 160478_r_at AV216394 EST2394 0.09222 2.26 up Mm.4491 Prpmp5-pending 98382_f_at X63004 proline-rich protein MP52395 0.09222 3.93 up Mm.28767 Crp 96229_at X13588 C-reactive protein, petaxin related2396 0.09226 3.11 up Mm.34257 1190008A14Rik 160419_r_at AA866869 RIKEN cDNA 1190008A14 gene2397 0.09233 4.36 up Mm.42037 Odz1 101714_at AB025410 odd Oz/ten-m homolog 1 (Drosophila)2398 0.09234 1.37 up Mm.26069 Trfr 103958_g_at X57349 transferrin receptor2399 0.09240 4.48 up Mm.30083 2510015F01Rik 96886_at AW060556 RIKEN cDNA 2510015F01 gene2400 0.09242 1.44 down Mm.1963 Srrm1 93521_at AW049194 serine/arginine repetitive matrix 12401 0.09246 2.18 up Mm.88831 Siat7f 100369_at AB035174 sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acet2402 0.09246 2.83 up Mm.12885 Dach1 94180_s_at AF090437 dachshund 1 (Drosophila)2403 0.09253 2.02 up Mm.4475 Btk 92668_at L10627 Bruton agammaglobulinemia tyrosine kinase2404 0.09253 3.51 up Mm.218846 Lbp 96123_at X99347 lipopolysaccharide binding protein2405 0.09253 3.83 up Mm.24741 Slc1a1 104748_s_at D43797 solute carrier family 1, member 12406 0.09260 2.12 up Mm.6461 Hrb 100954_at AF057287 HIV-1 Rev binding protein2407 0.09269 2.76 up Mm.3322 H2-DMb1 98034_at U35330 histocompatibility 2, class II, locus Mb12408 0.09284 2.80 up Mm.4091 Hcls1 99461_at X84797 hematopoietic cell specific Lyn substrate 12409 0.09287 3.33 up Mm.18527 Dab1 161291_at AV039198 disabled homolog 1 (Drosophila)2410 0.09289 1.27 down Mm.193096 Scd2 162077_f_at AV327760 stearoyl-Coenzyme A desaturase 22411 0.09289 2.22 down Mm.13168 AA516738 94683_at AA516738 expressed sequence AA5167382412 0.09290 1.81 down Mm.21458 1810009A16Rik 104041_at AW122255 RIKEN cDNA 1810009A16 gene2413 0.09291 1.47 down Mm.195451 Gosr2 94072_g_at AI847904 golgi SNAP receptor complex member 22414 0.09298 1.89 up Mm.180455 Slc38a4 104286_at AA795541 solute carrier family 38, member 42415 0.09311 1.84 up Mm.1548 Ggta1 102993_at M85153 glycoprotein galactosyltransferase alpha 1, 32416 0.09311 2.38 up Mm.157012 Tcrb-V13 93105_s_at M26056 T-cell receptor beta, variable 132417 0.09321 1.81 down Mm.4470 Ar 92667_at M37890 androgen receptor2418 0.09321 2.46 up Mm.19379 Lst1 103571_at U72644 leucocyte specific transcript 12419 0.09330 1.66 up Mm.24059 Schip1 160708_at AI840446 schwannomin interacting protein 12420 0.09333 2.15 up Mm.24214 Foxk1 160969_at L26507 forkhead box K12421 0.09336 1.57 up Mm.2339 Ptgis 104538_at AB001607 prostaglandin I2 (prostacyclin) synthase2422 0.09340 2.20 up Mm.22494 Urod 161328_i_at AV106467 uroporphyrinogen decarboxylase2423 0.09349 3.12 up Mm.14897 Cdh2 102852_at M31131 cadherin 22424 0.09355 5.02 up Mm.2679 Agtr2 161212_r_at AV247006 angiotensin II receptor, type 22425 0.09356 1.69 up Mm.5045 Slc16a2 100491_at AF045692 solute carrier family 16 (monocarboxylic acid transporters), member 22426 0.09356 2.26 up Mm.5309 Gabrg2 93163_at M62374 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 22427 0.09356 3.02 up Mm.26835 Spint2 96101_at AI847090 serine protease inhibitor, Kunitz type 22428 0.09370 1.95 up Mm.18635 Rgs10 161765_f_at AV335997 regulator of G-protein signalling 102429 0.09376 3.62 up Mm.23938 Mm.23938 95882_at AI592102 EST2430 0.09377 2.56 up 94090_at X53493Page 27 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2431 0.09379 1.53 down Mm.6635 Ivd 104153_at AW047743 isovaleryl coenzyme A dehydrogenase2432 0.09390 1.79 up Mm.4681 Mm.4681 98778_at AI837543 ESTs2433 0.09410 3.18 up Mm.30266 Hbb-b1 160560_at AV107330 hemoglobin, beta adult major chain2434 0.09411 1.70 up Mm.5041 Acvr2 98841_at M65287 activin receptor IIA2435 0.09415 1.18 down Mm.29170 Fbxw5 96797_s_at AW122681 f-box and WD-40 domain protein 52436 0.09417 1.46 down Mm.28999 0610033H09Rik 94518_at AW121749 RIKEN cDNA 0610033H09 gene2437 0.09425 1.44 up Mm.6055 C81234 160907_at AI592789 expressed sequence C812342438 0.09427 1.65 up Mm.12881 Lhx6 94176_at AB031040 LIM homeobox protein 62439 0.09438 1.48 up Mm.3921 Casp2 99049_at D28492 caspase 22440 0.09441 1.57 up Mm.18759 Acads 161469_r_at AV354445 acetyl-Coenzyme A dehydrogenase, short chain2441 0.09442 1.71 down Mm.8911 Psmb5 101558_s_at AB003304 proteasome (prosome, macropain) subunit, beta type 52442 0.09450 1.64 up Mm.7103 Pbx2 98426_at AF030001 pre B-cell leukemia transcription factor 22443 0.09452 3.24 up 100387_f_at AF0281232444 0.09456 2.89 up Mm.142731 Reg1 162312_f_at AV053434 regenerating islet-derived 12445 0.09456 1.95 up Mm.21082 Mm.21082 161741_r_at AV316991 Mus musculus, Similar to hypothetical protein MGC2555, clone MGC:290182446 0.09459 3.40 up Mm.943 Mm.943 100765_at AI592747 ESTs2447 0.09459 2.47 up Mm.18923 Mcmd7 162293_r_at AV377480 mini chromosome maintenance deficient 7 (S. cerevisiae)2448 0.09472 1.58 down Mm.27373 Vps26 96665_at AW211618 vacuolar protein sorting 26 (yeast)2449 0.09475 1.84 up Mm.20446 Fish 95327_at AJ007012 five SH3 domains2450 0.09477 2.09 up Mm.21503 B3gnt1 98291_at AF092050 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 12451 0.09484 1.62 up Mm.6743 Nfe2l1 101757_at AF015881 nuclear factor, erythroid derived 2,-like 12452 0.09489 2.21 up Mm.28178 Krt1-3 162106_f_at AV292406 keratin complex 1, acidic, gene 32453 0.09497 1.70 up Mm.5126 Fadd 100500_at U50406 Fas (TNFRSF6)-associated via death domain2454 0.09498 1.44 down Mm.29651 1110030L07Rik 95690_at AW047363 RIKEN cDNA 1110030L07 gene2455 0.09504 1.41 down Mm.29377 1100001D10Rik 160338_at AW121792 RIKEN cDNA 1100001D10 gene2456 0.09504 2.12 up Mm.4676 Slc7a2 92736_at L03290 solute carrier family 7 (cationic amino acid transporter, y+ system), member 22457 0.09514 3.13 up Mm.5196 Cmklr1 101199_at U79525 chemokine-like receptor 12458 0.09522 1.73 up Mm.29580 Scgn10 95669_g_at AI840972 superiorcervical ganglia, neural specific 102459 0.09531 2.54 up Mm.14277 Saa3 102712_at X03505 serum amyloid A 32460 0.09540 2.85 up Mm.681 Ly68 93454_at AF081789 lymphocyte antigen 682461 0.09555 1.47 down Mm.171292 2010200I23Rik 94882_at AA684506 RIKEN cDNA 2010200I23 gene2462 0.09558 1.63 up Mm.34319 Ywhab 98053_at AF058797 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,2463 0.09562 1.73 down Mm.2237 Ap1m1 94248_at M62419 adaptor-related protein complex AP-1, mu subunit 12464 0.09570 1.78 down Mm.142363 2810036L13Rik 103525_at AA981725 RIKEN cDNA 2810036L13 gene2465 0.09575 1.53 down Mm.29873 AI463719 96284_at AW121446 expressed sequence AI4637192466 0.09576 2.60 up Mm.12246 Ier5 92773_at AF079528 immediate early response 52467 0.09585 3.17 up Mm.20443 Pscd1 95325_at AF051337 pleckstrin homology, Sec7 and coiled/coil domains 12468 0.09585 1.62 down Mm.16537 Acta2 93100_at X13297 actin, alpha 2, smooth muscle, aorta2469 0.09595 1.68 up Mm.4498 Ptpn14 98385_at D31842 protein tyrosine phosphatase, non-receptor type 142470 0.09600 1.51 up Mm.1865 Mm.1865 103388_at AW047050 Mus musculus Myb protein P42POP mRNA, complete cds2471 0.09603 1.45 down Mm.30110 1110025H24Rik 97436_at AA869653 RIKEN cDNA 1110025H24 gene2472 0.09605 1.41 down Mm.88827 Mllt7 96987_at AB032770 myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog (Dro2473 0.09607 1.94 up Mm.870 Msx1 101526_at X14759 homeo box, msh-like 12474 0.09613 2.24 down Mm.6205 Mja1l-pending 101621_at AF008595 major allergen 1-like2475 0.09616 1.94 down Mm.26743 Apoa1 101528_at D00925 apolipoprotein A-I2476 0.09620 1.63 down Mm.29769 2310050K10Rik 95743_at AI846078 RIKEN cDNA 2310050K10 gene2477 0.09630 1.89 up Mm.4622 Serpinb5 100034_at U54705 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 52478 0.09634 1.60 up Mm.4140 Gm2a 99141_at U09816 GM2 ganglioside activator protein2479 0.09654 1.72 up Mm.29257 6530405F15Rik 104435_at AI644072 RIKEN cDNA 6530405F15 gene2480 0.09657 2.50 up Mm.1541 Snta1 162147_f_at AV356394 syntrophin, acidic 12481 0.09658 1.83 up Mm.28585 Thrsp 160306_at X95279 thyroid hormone responsive SPOT14 homolog (Rattus)2482 0.09660 2.57 up Mm.35020 Kat2 98123_at AW226961 kynurenine aminotransferase II2483 0.09665 3.22 up Mm.24365 0610042A05Rik 161975_r_at AV372191 RIKEN cDNA 0610042A05 gene2484 0.09673 1.82 up Mm.205578 AA408451 160777_at AI851515 expressed sequence AA4084512485 0.09676 1.57 up Mm.25722 P2rx1 103971_at X84896 purinergic receptor P2X, ligand-gated ion channel, 12486 0.09680 1.72 down Mm.205883 AI323986 102360_at AW214225 expressed sequence AI3239862487 0.09684 1.54 down Mm.193432 ORF18 95477_at AW125185 open reading frame 182488 0.09686 1.30 down Mm.21714 2410003A14Rik 93986_at AA939576 RIKEN cDNA 2410003A14 gene2489 0.09691 2.39 up Mm.1777 Hsp60 161140_r_at AV159556 heat shock protein, 60 kDa2490 0.09707 1.43 up Mm.3012 2900091E11Rik 96902_at AW121847 RIKEN cDNA 2900091E11 gene2491 0.09712 2.95 up Mm.56895 D17H6S56E-3 103719_at AF109905 DNA segment, Chr 17, human D6S56E 32492 0.09734 1.81 up Mm.21878 Pomc1 94026_at J00612 pro-opiomelanocortin-alpha2493 0.09768 2.03 up Mm.10188 Gprk5 102217_at AI639925 G protein-coupled receptor kinase 52494 0.09774 3.15 up Mm.196666 Hsd17b5 92556_at D45850 hydroxysteroid (17-beta) dehydrogenase 52495 0.09784 1.53 up Mm.29738 Apoa5 95728_g_at AI785422 apolipoprotein A-V2496 0.09787 1.37 down Mm.930 Ctsl 101963_at X06086 cathepsin L2497 0.09790 2.66 up Mm.21806 Elovl3 103469_at U97107 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like2498 0.09791 1.61 up Mm.23526 2610036L13Rik 161332_f_at AV114755 RIKEN cDNA 2610036L13 gene2499 0.09795 1.90 down Mm.23335 Yme1l1 104535_at AF090430 YME1-like 1 (S. cerevisiae)2500 0.09801 1.89 up Mm.21289 Rps12 162317_r_at AV064697 ribosomal protein S122501 0.09809 1.55 down Mm.6926 AI852726 93467_at AI852734 expressed sequence AI8527262502 0.09825 10.07 down Mm.24663 Angl 95228_f_at U72672 angiogenin-like2503 0.09826 1.89 up Mm.25035 C79468 95984_at AI586160 expressed sequence C794682504 0.09834 2.31 up Mm.22673 Fcer1g 160692_at J05020 Fc receptor, IgE, high affinity I, gamma polypeptide2505 0.09847 1.30 down Mm.197518 Laptm4b 100571_at AW123934 lysosomal-associated protein transmembrane 4B2506 0.09863 2.63 up Mm.906 Mdk 160561_at M34094 midkine2507 0.09868 2.19 up Mm.44249 Nos1 98365_at D14552 nitric oxide synthase 1, neuronal2508 0.09868 1.30 down Mm.18494 Map2k3 93315_at AI852636 mitogen activated protein kinase kinase 32509 0.09876 2.41 up Mm.5001 Dnmt3a 100479_at AA756653 DNA methyltransferase 3A2510 0.09889 1.48 up Mm.195916 D18Wsu154e 161990_f_at AV238605 DNA segment, Chr 18, Wayne State University 154, expressed2511 0.09892 1.37 down Mm.144420 0610038P07Rik 96007_at AI835359 RIKEN cDNA 0610038P07 gene2512 0.09898 1.30 down Mm.43822 Cs 99666_at AW125431 citrate synthase2513 0.09899 1.83 up Mm.3941 Eif4e 99097_at M61731 eukaryotic translation initiation factor 4E2514 0.09909 1.64 down Mm.1104 Ube1x 92616_at D10576 ubiquitin-activating enzyme E1, Chr X2515 0.09913 3.01 down Mm.8245 Timp 162107_r_at AV363716 tissue inhibitor of metalloproteinase2516 0.09917 1.71 up Mm.3095 Nr1h4 97969_at U09416 nuclear receptor subfamily 1, group H, member 42517 0.09921 1.76 up Mm.1813 Cct5 161514_at AV170770 chaperonin subunit 5 (epsilon)2518 0.09929 3.56 up Mm.29357 1300017C10Rik 162401_f_at AV278137 RIKEN cDNA 1300017C10 gene2519 0.09941 2.08 up Mm.4545 Tbxa2r 92685_at D10849 thromboxane A2 receptor2520 0.09952 2.34 up Mm.203935 D16Bwg1543e 104055_at AI153645 DNA segment, Chr 16, Brigham & Women's Genetics 1543 expressedPage 28 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2521 0.09967 2.04 up Mm.8540 1700062C23Rik 101520_at AF032967 RIKEN cDNA 1700062C23 gene2522 0.09969 2.73 up Mm.5244 Crem 160526_s_at M60285 cAMP responsive element modulator2523 0.09971 1.72 down Mm.5128 Htf9c 100525_at X05830 HpaII tiny fragments locus 9c2524 0.09977 3.41 up Mm.5266 Fcer1a 101209_at J05018 Fc receptor, IgE, high affinity I, alpha polypeptide2525 0.09980 1.88 up Mm.2981 Vrk1 97393_at AF080253 vaccinia related kinase 12526 0.09981 1.48 down Mm.8940 Acvr2b 93903_at M84120 activin receptor IIB2527 0.09986 1.52 down Mm.28790 Cpsf3 96234_at AI849311 cleavage and polyadenylation specificity factor 32528 0.09986 1.88 up Mm.19039 Got1 93489_at X07302 glutamate oxaloacetate transaminase 1, soluble2529 0.09995 1.22 down Mm.197493 1300003F06Rik 99636_at AI848033 RIKEN cDNA 1300003F06 gene2530 0.10008 2.04 up Mm.8249 Stat1 101465_at U06924 signal transducer and activator of transcription 12531 0.10019 1.55 up Mm.154979 Plac1 104201_at AA718649 placental specific protein 12532 0.10029 4.09 up Mm.4912 Fgfr4 92937_at X59927 fibroblast growth factor receptor 42533 0.10032 1.67 up Mm.34869 Ndufa1 92330_r_at AA517665 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12534 0.10034 1.29 down Mm.4261 Kai1 99584_at D14883 kangai 1 (suppression of tumorigenicity 6, prostate)2535 0.10041 3.37 up Mm.3807 Mm.3807 97708_at AA438122 ESTs, Weakly similar to I49130 reverse transcriptase - mouse [M.musculus]2536 0.10041 3.16 up Mm.24608 Fbxl12 161098_at AA930049 f-box and leucine-rich repeat protein 122537 0.10049 1.34 down Mm.58771 Rab14 97301_at AW124187 RAB14, member RAS oncogene family2538 0.10049 1.50 down Mm.27061 0610011I04Rik 96605_at AI787183 RIKEN cDNA 0610011I04 gene2539 0.10053 2.08 up Mm.212146 Mm.212146 97645_f_at AA420397 ESTs2540 0.10057 3.84 up Mm.196054 Klra3 93894_f_at U49866 killer cell lectin-like receptor, subfamily A, member 32541 0.10073 1.66 up Mm.30246 Cd151 161823_r_at AV379735 CD151 antigen2542 0.10073 2.16 up Mm.23869 2510006M18Rik 161891_r_at AV372372 RIKEN cDNA 2510006M18 gene2543 0.10082 4.39 up Mm.189064 Mm.189064 161362_at AV215734 EST2544 0.10094 1.46 up Mm.179650 Prkcabp 161638_f_at AV056986 protein kinase C, alpha binding protein2545 0.10094 2.39 up Mm.34216 Ulk1 92209_at AF053756 Unc-51 like kinase 1 (C. elegans)2546 0.10095 1.87 up Mm.88837 Chrna6 96996_at AJ245706 cholinergic receptor, nicotinic, alpha polypeptide 62547 0.10100 1.75 up Mm.3797 Nap1l1 98587_at X61449 nucleosome assembly protein 1-like 12548 0.10107 1.41 up Mm.214 1110007H17Rik 103439_at AW045417 RIKEN cDNA 1110007H17 gene2549 0.10111 2.84 up Mm.9500 Zpbp 161922_r_at AV140661 zona pellucida binding protein2550 0.10121 1.85 up Mm.42829 Sepw1 99595_at AF015284 selenoprotein W, muscle 12551 0.10129 1.47 down Mm.180290 1500032L24Rik 95076_at AI848476 RIKEN cDNA 1500032L24 gene2552 0.10141 3.06 up Mm.2044 Serpinf1 93574_at AF036164 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigme2553 0.10142 1.56 down Mm.206206 Ncdn-pending 99633_at AB017608 neurochondrin2554 0.10146 1.57 down Mm.33815 Mm.33815 97554_at AI838889 Mus musculus, Similar to hepatocellular carcinoma-associated antigen 59, c2555 0.10151 2.18 up Mm.157783 AI893585 101321_r_at L28059 expressed sequence AI8935852556 0.10153 1.59 down Mm.9945 2610024N01Rik 102199_at AW047322 RIKEN cDNA 2610024N01 gene2557 0.10156 2.34 up Mm.171374 1110032A03Rik 104314_r_at AI851206 RIKEN cDNA 1110032A03 gene2558 0.10163 2.59 up Mm.200916 Ugt1a6 161844_at AV003213 UDP glycosyltransferase 1 family, polypeptide A62559 0.10166 1.59 up Mm.3205 Scyd1 98008_at U92565 small inducible cytokine subfamily D, 12560 0.10180 1.26 down Mm.8392 Bet3-pending 101514_at AF041433 Bet3 homolog (S. cerevisiae)2561 0.10186 2.23 up Mm.1415 Epas1 102698_at AF045160 endothelial PAS domain protein 12562 0.10191 1.29 down Mm.138725 2510001K09Rik 97722_at AA879709 RIKEN cDNA 2510001K09 gene2563 0.10194 1.51 up Mm.5934 Ard1 100575_at AI841645 N-acetyltransferase ARD1 homolog (S. cerevisiae)2564 0.10197 2.50 up Mm.111845 Eln 92836_at AA919594 elastin2565 0.10199 1.70 up Mm.156895 1110020E07Rik 162269_at AV363431 RIKEN cDNA 1110020E07 gene2566 0.10203 1.31 down Mm.21444 1110003H09Rik 93805_at AW121164 RIKEN cDNA 1110003H09 gene2567 0.10205 2.90 up Mm.902 Mm.902 101912_at AI019679 ESTs2568 0.10224 1.36 down Mm.179189 2410038A03Rik 102098_at AI415065 RIKEN cDNA 2410038A03 gene2569 0.10224 1.61 down Mm.4860 Ptprl 100454_at D88187 protein tyrosine phosphatase, receptor type, L2570 0.10226 2.09 up Mm.41189 Freq 92416_at AF020184 frequenin homolog (Drosophila)2571 0.10230 1.87 up Mm.4414 Cdc2l2 161457_at AV297156 cell division cycle 2 homolog (S. pombe)-like 22572 0.10245 1.47 down Mm.28765 1810049E02Rik 160936_at AA763937 RIKEN cDNA 1810049E02 gene2573 0.10245 2.03 up Mm.21776 Cnn2 94004_at Z19543 calponin 22574 0.10247 1.88 up Mm.89474 Cd80 93906_s_at D16220 CD80 antigen2575 0.10251 3.51 up Mm.200437 AA408156 100745_r_at AA408156 expressed sequence AA4081562576 0.10264 2.07 up Mm.5281 Rps7 101212_at AF043285 ribosomal protein S72577 0.10275 1.73 up Mm.4845 Tcfap2a 92923_g_at U17291 transcription factor AP-2, alpha2578 0.10278 3.15 up Mm.37491 C77405 101691_s_at C77405 expressed sequence C774052579 0.10296 2.10 up Mm.30290 Capn6 97942_g_at Y12582 calpain 62580 0.10301 3.74 up Mm.24660 2610528A11Rik 104737_at AA689670 RIKEN cDNA 2610528A11 gene2581 0.10304 1.50 up Mm.36088 Gtf2e2 98515_at AI844392 general transcription factor IIE, polypeptide 2 (beta subunit, 34kD)2582 0.10304 1.64 up Mm.218576 1700009P03Rik 160600_at AA608168 RIKEN cDNA 1700009P03 gene2583 0.10305 1.70 up Mm.194 Flt3 95295_s_at X59398 FMS-like tyrosine kinase 32584 0.10310 3.57 up 95281_at AA5896232585 0.10319 2.63 up Mm.1892 Crhr 95290_at X72305 corticotropin releasing hormone receptor2586 0.10321 1.80 down Mm.14286 U2af1-rs1 102817_at S69507 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related s2587 0.10323 2.15 up Mm.4375 Smstr2 98352_r_at AF008914 somatostatin receptor 22588 0.10328 2.24 up Mm.1251 Mag 102405_at M31811 myelin-associated glycoprotein2589 0.10331 2.16 up Mm.1940 Csf2rb2 103210_at M29855 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macroph2590 0.10335 4.66 up Mm.195085 Tyms-ps 100396_i_at M30774 thymidylate synthase, pseudogene2591 0.10335 2.08 up Mm.196558 Selenbp2 162030_r_at AV366872 selenium binding protein 22592 0.10338 1.78 up Mm.30198 2810025O06Rik 96946_at AW123507 RIKEN cDNA 2810025O06 gene2593 0.10344 1.77 up Mm.27673 D6Wsu176e 97771_r_at AA733372 DNA segment, Chr 6, Wayne State University 176, expressed2594 0.10345 1.52 up Mm.42578 Rpl13 102109_at U28917 ribosomal protein L132595 0.10347 1.48 down Mm.28793 Snap25bp 160792_at AI853318 synaptosomal-associated protein, 25 kDa, binding protein2596 0.10348 3.84 up Mm.203896 Lman1 161622_f_at AV356315 lectin, mannose-binding, 12597 0.10349 1.33 down Mm.22593 Gtf2i 94295_at AF017085 general transcription factor II I2598 0.10352 2.99 up Mm.98916 Vip 100393_at X74297 vasoactive intestinal polypeptide2599 0.10354 1.57 up Mm.28618 2410004D02Rik 98916_at AI854289 RIKEN cDNA 2410004D02 gene2600 0.10355 1.52 down Mm.29213 1200015F23Rik 95078_at AI841400 RIKEN cDNA 1200015F23 gene2601 0.10360 1.36 down Mm.18561 Cyhr1 104209_at AI847016 cysteine and histidine rich 12602 0.10365 1.90 up Mm.22216 Gilz 94212_at AI843911 glucocorticoid-induced leucine zipper2603 0.10366 2.57 up Mm.878 Ly6d 162216_i_at AV089967 lymphocyte antigen 6 complex, locus D2604 0.10371 1.33 down Mm.29821 Prdx3 96256_at M28723 peroxiredoxin 32605 0.10373 3.15 up Mm.25097 4930579C15Rik 160985_at AV279590 RIKEN cDNA 4930579C15 gene2606 0.10385 1.97 up Mm.196216 D6Ertd746e 104168_at AA791742 DNA segment, Chr 6, ERATO Doi 746, expressed2607 0.10407 1.36 down Mm.57192 Cyp21a1 97428_at AF049850 cytochrome P450, 21, steroid 21 hydroxylase2608 0.10408 1.39 up Mm.22514 0610008F14Rik 162343_f_at AV149071 RIKEN cDNA 0610008F14 gene2609 0.10422 1.37 down Mm.154985 PAL31 96891_at AI842771 proliferation related acidic leucine rich protein PAL312610 0.10425 2.10 up Mm.2992 Mbp 96311_at M11533 myelin basic proteinPage 29 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2611 0.10425 3.62 up Mm.8015 Stk22s1 94624_at AF025310 serine/threonine kinase 22 substrate 12612 0.10438 3.69 up Mm.22248 Igfbp4 101571_g_at X76066 insulin-like growth factor binding protein 42613 0.10442 1.87 down Mm.22139 AA409373 103485_at AA795415 expressed sequence AA4093732614 0.10443 1.85 up Mm.29722 Usmg5 95718_f_at AW060158 upregulated during skeletal muscle growth 52615 0.10455 1.20 up Mm.848 Tex261 101517_at X81058 testis expressed gene 2612616 0.10456 2.42 up Mm.153899 Adar 102741_at AW046250 adenosine deaminase, RNA-specific2617 0.10473 1.36 down Mm.21976 0610031J06Rik 94047_at AW122935 RIKEN cDNA 0610031J06 gene2618 0.10477 1.58 up Mm.10233 Cpx2-pending 102227_g_at AF017639 metallocarboxypeptidase 22619 0.10481 2.00 up Mm.23018 2810423O19Rik 161992_at AV241638 RIKEN cDNA 2810423O19 gene2620 0.10491 2.43 up Mm.1100 Inha 102266_at X55957 inhibin alpha2621 0.10492 4.31 up Mm.196617 Gp49a 100325_at M65027 glycoprotein 49 A2622 0.10497 1.45 down Mm.21356 1010001C05Rik 93787_f_at AI837302 RIKEN cDNA 1010001C05 gene2623 0.10500 1.55 down Mm.8385 Mapk3 101834_at Z14249 mitogen activated protein kinase 32624 0.10501 1.58 down Mm.203950 AI195141 93983_at AI846382 expressed sequence AI1951412625 0.10507 1.93 down Mm.22831 AW049671 103523_at AI851703 expressed sequence AW0496712626 0.10507 3.71 up Mm.83250 Mm.83250 161179_at AV233149 EST2627 0.10513 1.92 up Mm.28107 Enpp2 161350_f_at AV153319 ectonucleotide pyrophosphatase/phosphodiesterase 22628 0.10514 1.81 down Mm.15928 Preb 161430_at AV305295 prolactin regulatory element binding2629 0.10521 1.96 up Mm.56971 Tnfaip3 99392_at U19463 tumor necrosis factor, alpha-induced protein 32630 0.10524 3.72 up Mm.27256 Dlgh4 104175_at D50621 discs, large homolog 4 (Drosophila)2631 0.10524 1.61 down Mm.27809 AA415431 95573_at AW122821 expressed sequence AA4154312632 0.10526 1.83 up Mm.32357 AA420392 104670_at AI315698 expressed sequence AA4203922633 0.10533 1.55 down Mm.33851 Mm.33851 92182_at AI836877 ESTs, Weakly similar to Rap2 interacting protein 8 [M.musculus]2634 0.10534 1.59 up Mm.41433 Dffa 99485_at AB009376 DNA fragmentation factor, alpha subunit2635 0.10541 2.42 up Mm.14274 Spi2-rs1 102816_at X69832 serine protease inhibitor-2 related sequence 12636 0.10544 4.05 up Mm.1059 Map2k1 162082_r_at AV332058 mitogen activated protein kinase kinase 12637 0.10547 2.53 up Mm.28529 Ptch2 96557_at AB010833 patched homolog 22638 0.10554 1.99 up Mm.2474 Nhlh1 95929_at M97506 nescient helix loop helix 12639 0.10556 2.63 up Mm.157063 Mm.157063 161136_r_at AV327032 ESTs2640 0.10560 2.07 up Mm.4379 Pcnt 99664_at U05823 pericentrin2641 0.10565 1.91 up Mm.36666 Ceacam11 160441_at AI156095 CEA-related cell adhesion molecule 112642 0.10576 1.74 up 97571_r_at AF0596152643 0.10577 2.62 up Mm.1905 Mm.1905 95291_r_at AI627121 ESTs2644 0.10580 2.18 up Mm.18742 Nupr1 160108_at AI852641 nuclear protein 12645 0.10582 1.77 down Mm.35687 Casp7 98499_s_at U67321 caspase 72646 0.10602 1.53 up Mm.3616 Polg 160439_at U53584 polymerase, gamma2647 0.10604 1.74 up Mm.27665 2010015J01Rik 95538_at AI844812 RIKEN cDNA 2010015J01 gene2648 0.10605 2.54 up Mm.2578 F10 96501_at AI506285 coagulation factor X2649 0.10607 1.50 up Mm.200415 Fbs 161951_f_at AV360914 fibrosin2650 0.10609 3.89 up Mm.142714 ank 100948_at AW049351 progressive ankylosis2651 0.10614 1.58 up Mm.1265 Akp2 92796_at J02980 alkaline phosphatase 2, liver2652 0.10643 3.44 up Mm.3999 Mpeg1 99071_at L20315 macrophage expressed gene 12653 0.10652 1.64 down Mm.19726 Dnahc11 103212_at AI314784 dynein, axon, heavy chain 112654 0.10656 1.62 up Mm.21362 Zfp57 103437_at D21850 zinc finger protein 572655 0.10668 1.53 up Mm.1627 Mm.1627 161882_f_at AV366849 ESTs2656 0.10670 1.28 up Mm.4272 Snai2 99552_at U79550 snail homolog 2 (Drosophila)2657 0.10675 2.07 up 100371_at U653162658 0.10683 1.65 down Mm.3466 Atf2 98455_at U46026 activating transcription factor 22659 0.10691 3.38 up Mm.41535 2310035M22Rik 99149_at AI851230 RIKEN cDNA 2310035M22 gene2660 0.10692 3.79 up Mm.5112 Npy1r 93007_at Z18280 neuropeptide Y receptor Y12661 0.10697 1.74 up Mm.6306 Atp2a3 93403_at U49393 ATPase, Ca++ transporting, ubiquitous2662 0.10699 2.58 up Mm.4915 Gabra6 92940_s_at AJ222970 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 62663 0.10714 1.56 down Mm.26091 Fosb 104607_at AF093624 FBJ osteosarcoma oncogene B2664 0.10714 2.26 up Mm.30149 Sdf4 160390_at U45977 stromal cell derived factor 42665 0.10715 1.74 up Mm.29898 2410015N17Rik 96293_at AI842600 RIKEN cDNA 2410015N17 gene2666 0.10718 2.62 up Mm.49441 Zik1 101193_at U69133 zinc finger protein interacting with K protein 12667 0.10727 2.86 up Mm.196290 4930434H03Rik 95655_at AA717740 RIKEN cDNA 4930434H03 gene2668 0.10732 1.75 up Mm.3229 Rpl26 100729_at X80699 ribosomal protein L262669 0.10737 2.68 up Mm.155608 D2Ertd127e 100763_at C77022 DNA segment, Chr 2, ERATO Doi 127, expressed2670 0.10746 1.38 down Mm.10735 Cask 102248_f_at Y17138 calcium/calmodulin-dependent serine protein kinase2671 0.10751 2.08 up Mm.29623 Ddb1 95684_at AA033408 damage specific DNA binding protein 1 (127 kDa)2672 0.10759 1.84 down Mm.849 Ppm1b 101837_g_at D45859 protein phosphatase 1B, magnesium dependent, beta isoform2673 0.10760 1.82 up Mm.5083 Rab3a 160524_at X72966 RAB3A, member RAS oncogene family2674 0.10762 1.49 down Mm.196201 Mem3 92640_at U47024 maternal embryonic message 32675 0.10762 2.27 up Mm.1925 Mm.1925 95293_at AI450171 ESTs2676 0.10763 1.47 down Mm.29909 1810005K14Rik 96299_at AI847298 RIKEN cDNA 1810005K14 gene2677 0.10771 2.58 up Mm.2423 Col2a1 95410_s_at M63709 procollagen, type II, alpha 12678 0.10775 7.71 up Mm.42240 Zfp162 99567_at X80159 zinc finger protein 1622679 0.10781 1.95 up Mm.25703 D3Ertd330e 160988_r_at AA709728 DNA segment, Chr 3, ERATO Doi 330, expressed2680 0.10784 1.41 up Mm.196457 Samhd1 103080_at U15635 SAM domain and HD domain, 12681 0.10785 1.98 up Mm.202781 Spi13 161115_r_at AA408234 serine protease inhibitor 132682 0.10787 1.74 down Mm.4976 Krt1-5 161052_r_at X65506 keratin complex 1, acidic, gene 52683 0.10790 2.91 up Mm.57175 Cd83 99434_at AF001036 CD83 antigen2684 0.10793 1.42 down Mm.686 Actc1 101029_f_at M15501 actin, alpha, cardiac2685 0.10794 2.42 up Mm.200660 AA408606 162427_r_at AV292780 expressed sequence AA4086062686 0.10797 2.10 up Mm.7248 Slc4a1 161972_r_at AV227914 solute carrier family 4 (anion exchanger), member 12687 0.10798 3.12 up Mm.84043 Igbp1b-pending 100287_at AJ010637 immunoglobulin (CD79A) binding protein 1b2688 0.10810 2.62 up Mm.86361 Sh2d2a 100292_at AI646422 SH2 domain protein 2A2689 0.10814 1.81 up Mm.4509 Runx2 92677_s_at AF010284 runt related transcription factor 22690 0.10818 2.44 up Mm.25122 AA408985 161868_r_at AV358218 expressed sequence AA4089852691 0.10823 1.62 up Mm.30066 Rpl8 96575_at U67771 ribosomal protein L82692 0.10831 1.60 down Mm.3420 Nfkb1 98427_s_at M57999 nuclear factor of kappa light chain gene enhancer in B-cells 1, p1052693 0.10832 1.55 up Mm.491 3110043O21Rik 100464_at AI840585 RIKEN cDNA 3110043O21 gene2694 0.10841 1.73 up Mm.181216 Mpg 94857_at U10420 N-methylpurine-DNA glycosylase2695 0.10843 1.77 down Mm.27057 C77863 104035_at AW123795 expressed sequence C778632696 0.10845 2.49 up Mm.14135 Mcpt1 94729_r_at X68803 mast cell protease 12697 0.10847 1.54 up Mm.24353 Ykt6-pending 104400_at AF076956 prenylated SNARE protein2698 0.10847 2.62 up Mm.22711 Ccni 161527_r_at AV226645 cyclin I2699 0.10847 1.72 down Mm.175302 2610313E07Rik 98491_at AI286904 RIKEN cDNA 2610313E07 gene2700 0.10871 1.45 down Mm.20943 Fkbp9 93731_at AF090334 FK506 binding protein 9Page 30 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2701 0.10878 2.33 up Mm.17715 Mm.17715 102568_at U65067 Mus musculus newborn ovary homeodomain protein (Nobox) mRNA, comple2702 0.10879 1.38 down Mm.28000 Ubxdc2 97285_f_at AW120609 UBX domain-containing 22703 0.10898 3.99 up Mm.200527 2410197A17Rik 161521_at AV218044 RIKEN cDNA 2410197A17 gene2704 0.10904 1.65 up Mm.200929 C76746 101221_at C76746 expressed sequence C767462705 0.10914 1.65 up Mm.27560 Uble1b 96700_r_at AW060594 ubiquitin-like 1 (sentrin) activating enzyme E1B2706 0.10914 1.40 up Mm.28057 1110064N10Rik 160266_r_at AW124599 RIKEN cDNA 1110064N10 gene2707 0.10920 1.56 down Mm.196452 AI462175 160196_at AI843662 expressed sequence AI4621752708 0.10927 1.50 down Mm.32580 1200014O24Rik 94397_at AA690091 RIKEN cDNA 1200014O24 gene2709 0.10933 1.44 up Mm.1012 Krt1-19 102121_f_at AU040563 keratin complex 1, acidic, gene 192710 0.10934 1.35 down Mm.182912 Ghitm 160530_at AW120976 growth hormone inducible transmembrane protein2711 0.10935 1.64 down Mm.3035 3110006P09Rik 97464_at AI844416 RIKEN cDNA 3110006P09 gene2712 0.10936 1.70 down Mm.28143 EIG180 96132_at AB023957 ethanol induced gene product EIG1802713 0.10939 2.31 down Mm.140243 2010012D11Rik 161851_r_at AV053298 RIKEN cDNA 2010012D11 gene2714 0.10947 1.96 up Mm.30824 Ch25h 104509_at AF059213 cholesterol 25-hydroxylase2715 0.10948 1.98 up Mm.29739 W64236 160817_at AA727424 EST W642362716 0.10954 1.58 down Mm.1486 Arf4 160082_s_at D87901 ADP-ribosylation factor 42717 0.10955 3.19 up Mm.65610 Mm.65610 161128_r_at AV212851 ESTs2718 0.10960 2.68 up Mm.5145 Pde1c 100502_at L76947 phosphodiesterase 1C2719 0.10968 3.36 up Mm.202804 AI255215 96207_at AW046449 expressed sequence AI2552152720 0.10985 2.16 up Mm.8681 Ptpn11 102874_at D84372 protein tyrosine phosphatase, non-receptor type 112721 0.10986 2.42 up Mm.57025 Ear5 101716_at AF017260 eosinophil-associated ribonuclease 52722 0.10986 1.79 up Mm.213000 Mm.213000 99998_at Y07611 ESTs, Highly similar to PC4220 protein kinase [M.musculus]2723 0.10988 3.17 up Mm.464 4921531G14Rik 161570_r_at AV113481 RIKEN cDNA 4921531G14 gene2724 0.10990 2.27 down Mm.7549 Ddit3 101429_at X67083 DNA-damage inducible transcript 32725 0.10994 2.97 up 97177_at D005702726 0.11004 1.49 up Mm.6105 Pltp 100927_at U28960 phospholipid transfer protein2727 0.11013 1.31 down Mm.30849 1200015P13Rik 97485_at AI850953 RIKEN cDNA 1200015P13 gene2728 0.11014 1.56 up Mm.181287 Mm.181287 102120_f_at C80148 ESTs, Moderately similar to VIS3 MOUSE VISININ-LIKE PROTEIN 3 [M.mus2729 0.11015 2.07 up Mm.18527 Dab1 102972_s_at Y08380 disabled homolog 1 (Drosophila)2730 0.11016 2.81 up Mm.57059 Ppyr1 101736_at U40189 pancreatic polypeptide receptor 12731 0.11025 2.15 up Mm.4746 Hand1 161468_f_at AV353710 heart and neural crest derivatives expressed transcript 12732 0.11026 2.48 up Mm.57207 Gja3 102552_at U44955 gap junction membrane channel protein alpha 32733 0.11033 1.96 up Mm.153405 Mm.153405 161101_r_at AV339278 Mus musculus, Similar to KIAA0952 protein, clone MGC:25591 IMAGE:40112734 0.11037 1.50 down Mm.31353 Vps16 160410_at AI847040 vacuolar protein sorting 16 (yeast homolog)2735 0.11037 1.59 up Mm.14089 Cyp1a1 94715_at K02588 cytochrome P450, 1a1, aromatic compound inducible2736 0.11043 2.08 down Mm.222 Trp53 101617_s_at U59758 transformation related protein 532737 0.11044 1.44 up Mm.41776 Oc90 92439_at AF091847 otoconin 902738 0.11046 1.31 down Mm.142369 Rbm8 97254_at AA690061 RNA binding motif protein2739 0.11050 1.83 up Mm.1560 AI851258 160947_at AI851258 expressed sequence AI8512582740 0.11057 1.59 down Mm.26002 Mm.26002 103988_at AA692921 Mus musculus, clone IMAGE:4219507, mRNA, partial cds2741 0.11070 1.72 down Mm.30016 C87222 101929_at AI836322 expressed sequence C872222742 0.11087 2.06 up Mm.23547 Mm.23547 103541_at U46151 Mus musculus male meiosis specific protein Tcte2 (Tcte2) mRNA, complete2743 0.11092 1.57 up Mm.5903 Gpaa1 161682_f_at AV161234 GPI anchor attachment protein 12744 0.11097 4.44 up Mm.143141 Eif1a 94745_f_at U28419 eukaryotic translation initiation factor 1A2745 0.11097 1.39 down Mm.12677 Atp5c1 92800_i_at AI836694 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypepti2746 0.11100 1.94 down Mm.12184 2610209L14Rik 102384_at AI842968 RIKEN cDNA 2610209L14 gene2747 0.11102 1.76 up Mm.3156 Mor2 97508_at M29462 malate dehydrogenase, soluble2748 0.11104 1.64 down Mm.28652 Coro1b 98928_at AW122820 coronin, actin binding protein 1B2749 0.11109 2.76 up Mm.5024 Pdcd1 98836_at X67914 programmed cell death 12750 0.11115 2.13 up Mm.14099 Hzf-pending 102691_at AI848518 hematopoietic zinc finger2751 0.11117 3.48 up Mm.153999 Prlpf 97946_at AF020524 prolactin-like protein F2752 0.11120 1.28 up Mm.182350 Parn 160515_at AW048715 poly(A)-specific ribonuclease (deadenylation nuclease)2753 0.11126 1.49 down Mm.1427 Anxa11 102815_at U65986 annexin A112754 0.11132 1.56 up Mm.5349 1700018F16Rik 161474_r_at AV043191 RIKEN cDNA 1700018F16 gene2755 0.11143 2.53 up Mm.20462 Rgs6 94568_at AF061933 regulator of G-protein signaling 62756 0.11143 1.74 down Mm.29852 Mm.29852 96270_at AI847092 Mus musculus, clone IMAGE:5102170, mRNA, partial cds2757 0.11151 1.68 up Mm.5772 1700056O17Rik 100905_at AI849361 RIKEN cDNA 1700056O17 gene2758 0.11152 1.80 up Mm.10723 Per3 102242_at AF050182 period homolog 3 (Drosophila)2759 0.11153 2.12 up Mm.4502 Mcmd 100062_at X62154 mini chromosome maintenance deficient (S. cerevisiae)2760 0.11156 3.03 up 93414_at M603482761 0.11156 1.75 up Mm.153684 1110032C13Rik 160834_at AI847051 RIKEN cDNA 1110032C13 gene2762 0.11157 1.41 down Mm.16596 Btg1 93104_at Z16410 B-cell translocation gene 1, anti-proliferative2763 0.11159 1.75 up Mm.24643 Cetn2 104733_at AW047001 centrin 22764 0.11168 1.61 down Mm.3757 Prp8 98574_at AI835685 pre-mRNA processing 82765 0.11176 2.93 up Mm.181290 Mrpl49 161597_r_at AV292964 mitochondrial ribosomal protein L492766 0.11179 2.59 up Mm.4170 Ptgfr 161713_f_at AV248803 prostaglandin F receptor2767 0.11190 1.39 down Mm.12665 Cul3 92797_at AI840051 cullin 32768 0.11190 1.73 down Mm.1719 AI414429 102941_at AA644978 expressed sequence AI4144292769 0.11204 3.78 up Mm.67919 Mafb 102205_at L36434 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)2770 0.11221 2.80 up 97175_at AI3271692771 0.11223 1.95 up Mm.180150 Ube2v2 160247_at AW060527 ubiquitin-conjugating enzyme E2 variant 22772 0.11228 2.10 up Mm.15383 Tnfrsf11b 102887_at U94331 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)2773 0.11233 2.17 up Mm.7445 AW491150 161665_at AV134205 expressed sequence AW4911502774 0.11239 1.46 up Mm.27288 Gfm 160226_at AW046879 G elongation factor2775 0.11243 2.07 up Mm.780 Igl-V1 99429_at X04770 immunoglobulin lambda chain, variable 12776 0.11252 1.49 up Mm.205096 AI462491 103443_at AA711704 expressed sequence AI4624912777 0.11256 1.30 down Mm.4578 Foxa1 92697_at U44752 forkhead box A12778 0.11257 1.75 up Mm.5025 Pea3 92979_at X63190 polyomavirus enhancer activator 32779 0.11262 6.27 up Mm.46301 Tyrobp 100397_at AF024637 TYRO protein tyrosine kinase binding protein2780 0.11262 3.47 up Mm.14438 AU044919 102825_at U62650 expressed sequence AU0449192781 0.11270 1.79 up Mm.24996 C78651 95875_at C78651 expressed sequence C786512782 0.11272 2.63 up Mm.7409 Mcpt6 92711_at M57625 mast cell protease 62783 0.11278 1.24 down Mm.196536 1500001M02Rik 94537_at AI838859 RIKEN cDNA 1500001M02 gene2784 0.11288 1.63 up Mm.22173 Selpl 103488_at X91144 selectin, platelet (p-selectin) ligand2785 0.11289 1.25 up Mm.20946 Psmc3 100225_f_at AA409481 proteasome (prosome, macropain) 26S subunit, ATPase 32786 0.11290 1.66 up Mm.2740 Nppb 104184_at D16497 natriuretic peptide precursor type B2787 0.11294 4.94 up Mm.88761 Tbx14 100354_at AF013282 T-box 142788 0.11299 1.66 up Mm.6146 4933403M19Rik 99827_at AA673238 RIKEN cDNA 4933403M19 gene2789 0.11310 1.87 up Mm.26608 Mm.26608 96524_at AI157060 ESTs2790 0.11319 1.54 down Mm.24778 Capn7 160718_at AJ012475 calpain 7Page 31 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2791 0.11322 2.78 up Mm.28693 Mm.28693 98940_at AI849493 Mus musculus, Similar to aspartyl-tRNA synthetase, clone MGC:6719 IMAG2792 0.11324 2.49 up Mm.8013 Itgb3 99904_at AF026509 integrin beta 32793 0.11331 2.30 up Mm.3519 Gp5 161585_at AV318587 glycoprotein 5 (platelet)2794 0.11337 3.31 up Mm.46724 Pvrl3 161415_r_at AV318045 poliovirus receptor-related 32795 0.11338 1.45 up Mm.4419 Rpl5 101129_at X83590 ribosomal protein L52796 0.11339 1.51 down Mm.27171 Ap3s1 160734_at AF084575 adaptor-related protein complex AP-3, sigma 1 subunit2797 0.11340 1.44 down Mm.24433 Smt3h1 95424_at AW120986 SMT3 (supressor of mif two, 3) homolog 1 (S. cerevisiae)2798 0.11346 2.03 up Mm.42023 Mds1 101711_at AJ010015 myelodysplasia syndrome 1 homolog (human)2799 0.11349 3.32 up Mm.34367 Ctsw 92214_at AF014941 cathepsin W2800 0.11349 1.90 up Mm.143795 ORF11 96093_at AI842705 open reading frame 112801 0.11349 4.32 up Mm.14271 Defcr-rs2 94738_s_at M33227 defensin related cryptdin, related sequence 22802 0.11378 1.85 down Mm.6888 Plcb3 101358_at U43144 phospholipase C, beta 32803 0.11379 1.63 up Mm.4257 Aldh3a1 162331_f_at AV089850 aldehyde dehydrogenase family 3, subfamily A12804 0.11394 2.40 up Mm.21062 C87860 93741_at AA693066 expressed sequence C878602805 0.11398 2.36 up Mm.10805 Col13a1 102261_f_at U30292 procollagen, type XIII, alpha 12806 0.11398 1.25 down Mm.3350 Aclp7 98402_at AI843799 actin-crosslinking protein 72807 0.11406 1.77 up Mm.143768 Fbxo3 161491_r_at AV083174 f-box only protein 32808 0.11416 1.30 down Mm.16340 Fgfr2 93090_at M23362 fibroblast growth factor receptor 22809 0.11417 1.94 up Mm.213458 Mm.213458 101824_at X03669 Mouse T-cell receptor rearranged alpha-chain mRNA V-J-C region, 3' end2810 0.11418 1.28 up Mm.10314 Atp5g2 102134_f_at AI461702 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subuni2811 0.11420 2.77 up Mm.23845 1600017K21Rik 161549_f_at AV246051 RIKEN cDNA 1600017K21 gene2812 0.11439 1.56 up Mm.29301 D0H8S2298E 160803_at D88447 DNA segment, Human S2298E2813 0.11450 3.63 up Mm.195874 Xlr 92665_f_at X07967 X-linked lymphocyte-regulated complex2814 0.11454 1.33 up Mm.30097 Psma1 96892_at AI836804 proteasome (prosome, macropain) subunit, alpha type 12815 0.11458 3.37 up Mm.5069 Lcn4 101176_at D38581 lipocalin 42816 0.11473 2.13 up Mm.4550 Atp1b1 160500_at X61433 ATPase, Na+/K+ transporting, beta 1 polypeptide2817 0.11474 3.34 up Mm.42368 4921513E08Rik 98326_f_at AV254726 RIKEN cDNA 4921513E08 gene2818 0.11484 1.89 up Mm.20911 Stc 103292_at U47815 stanniocalcin2819 0.11488 1.34 up Mm.57095 Gpr50 101763_at AF065145 G-protein-coupled receptor 502820 0.11490 1.78 up Mm.987 Map4k4 161295_r_at AV012076 mitogen-activated protein kinase kinase kinase kinase 42821 0.11492 2.06 up Mm.23934 BB079060 160965_at AA163960 expressed sequence BB0790602822 0.11493 1.53 down Mm.28842 Clcn3 94465_g_at AF029347 chloride channel 32823 0.11509 1.81 up Mm.1323 Snrpb2 92839_f_at X63020 U2 small nuclear ribonucleoprotein B2824 0.11521 3.29 up Mm.56994 Nkx2-3 101334_at Y11117 NK2 transcription factor related, locus 3 (Drosophila)2825 0.11527 1.43 up Mm.4655 Gal 100407_at L38580 galanin2826 0.11531 2.67 up Mm.34614 Enc1 97729_at U65079 ectodermal-neural cortex 12827 0.11536 2.95 up Mm.2553 Pap 161890_f_at AV371861 pancreatitis-associated protein2828 0.11537 1.35 down Mm.3259 Nfyb 98024_at X55316 nuclear transcription factor-Y beta2829 0.11540 2.32 up Mm.116 H2-Oa 100898_r_at AF100956 histocompatibility 2, O region alpha locus2830 0.11542 2.15 up Mm.6194 Ifna8 96419_f_at X01972 interferon alpha family, gene 82831 0.11546 2.03 down Mm.14777 Stk22b 102846_at AF019926 serine/threonine kinase 22B (spermiogenesis associated)2832 0.11551 1.15 down Mm.21094 D9Wsu138e 93748_at AW123901 DNA segment, Chr 9, Wayne State University 138, expressed2833 0.11553 1.41 up Mm.10745 Tccr 102250_at AF053005 T cell cytokine receptor2834 0.11553 1.23 down Mm.7091 1500032E05Rik 101061_at AI845293 RIKEN cDNA 1500032E05 gene2835 0.11576 1.56 down Mm.7247 Stxbp2 101398_at U19520 syntaxin binding protein 22836 0.11578 2.11 up Mm.5972 2410080P20Rik 100917_at AA795841 RIKEN cDNA 2410080P20 gene2837 0.11579 2.61 up Mm.35830 Hbb-y 103535_at X14061 hemoglobin Y, beta-like embryonic chain2838 0.11584 1.52 up Mm.2635 Pk3 162032_f_at AV368209 pyruvate kinase 32839 0.11585 1.71 up Mm.22632 Tagln2 160162_at AI852545 transgelin 22840 0.11588 1.45 up Mm.30239 4933419D20Rik 97442_at AW124340 RIKEN cDNA 4933419D20 gene2841 0.11590 1.95 up Mm.6461 Hrb 103397_at AA795486 HIV-1 Rev binding protein2842 0.11594 2.43 up Mm.21549 Cryac 162448_f_at AV354094 crystallin, alpha C2843 0.11607 2.74 up Mm.42125 Slfn3 98299_s_at AF099974 schlafen 32844 0.11615 1.45 down Mm.157105 Psmc1 160152_at U39302 protease (prosome, macropain) 26S subunit, ATPase 12845 0.11621 1.30 down Mm.12921 Birc6 102754_at Y17267 baculoviral IAP repeat-containing 62846 0.11627 1.62 down Mm.24573 Gab1 160714_at AI046826 growth factor receptor bound protein 2-associated protein 12847 0.11629 6.26 up Mm.46395 Psca 160508_at AW209486 prostate stem cell antigen2848 0.11636 1.44 down Mm.25719 0710001C05Rik 96021_at AI854264 RIKEN cDNA 0710001C05 gene2849 0.11637 2.53 up Mm.57175 Cd83 103040_at AI837100 CD83 antigen2850 0.11641 1.29 down Mm.619 Anxa4 100584_at U72941 annexin A42851 0.11644 2.10 up Mm.157460 Krt2-10 93555_at M92088 keratin complex 2, basic, gene 102852 0.11647 2.94 up Mm.4503 Np220 162409_r_at AV315224 nuclear protein 2202853 0.11647 2.65 up Mm.3635 D7Wsu130e 97187_at AI480533 DNA segment, Chr 7, Wayne State University 130, expressed2854 0.11654 2.07 up Mm.1196 AW536703 161502_r_at AV116571 expressed sequence AW5367032855 0.11663 2.53 up Mm.35492 2600013N14Rik 98135_r_at AI851008 RIKEN cDNA 2600013N14 gene2856 0.11667 3.13 up Mm.89727 Bop 101903_at U76371 CD8beta opposite strand2857 0.11668 2.25 up Mm.104363 Cyp2d9 94539_f_at M27168 cytochrome P450, 2d92858 0.11680 1.60 up Mm.22028 0610006A11Rik 104124_at AW123135 RIKEN cDNA 0610006A11 gene2859 0.11688 1.96 up Mm.16959 C77140 94787_at AA914517 expressed sequence C771402860 0.11700 2.85 up Mm.4914 Gabra1 92938_at X61430 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 12861 0.11701 1.50 down Mm.29609 5830466O21Rik 95679_at AI835912 RIKEN cDNA 5830466O21 gene2862 0.11710 2.40 up Mm.146332 C87808 161878_r_at AV363881 expressed sequence C878082863 0.11715 1.88 up Mm.13849 Hsp25 92853_at L07577 heat shock protein, 25 kDa2864 0.11716 1.65 up Mm.176927 2610301I15Rik 94009_at AI848888 RIKEN cDNA 2610301I15 gene2865 0.11723 1.91 up Mm.30045 Mbl2 97427_at U09016 mannose binding lectin, serum (C)2866 0.11731 2.01 up Mm.53203 Mm.53203 162474_f_at AV087499 EST, Moderately similar to A57474 extracellular matrix protein 1 precursor -2867 0.11745 2.48 up Mm.42201 Hus1 92503_at Y16894 Hus1 homolog (S. pombe)2868 0.11749 1.26 down Mm.27396 Cox17 160230_at AI852363 cytochrome c oxidase, subunit XVII assembly protein homolog (yeast)2869 0.11753 2.39 up Mm.2108 Ttr 95350_at D00073 transthyretin2870 0.11761 2.56 up Mm.2941 Mttp 104448_at L47970 microsomal triglyceride transfer protein2871 0.11761 4.45 up Mm.24219 1810037I17Rik 161955_f_at AV362937 RIKEN cDNA 1810037I17 gene2872 0.11763 1.77 up Mm.197850 C77789 98245_at C77789 expressed sequence C777892873 0.11767 6.05 up Mm.22479 Krt1-18 162191_at AV053495 keratin complex 1, acidic, gene 182874 0.11769 1.77 down Mm.157900 1300007C21Rik 160799_at AW060549 RIKEN cDNA 1300007C21 gene2875 0.11770 2.08 up Mm.6642 Mm.6642 93441_at AI595322 Mus musculus, Similar to highly expressed in cancer, rich in leucine heptad r2876 0.11770 2.50 up Mm.4701 Nkx2-2 92747_at U31566 NK2 transcription factor related, locus 2 (Drosophila)2877 0.11774 2.01 up Mm.1536 Mt4 102989_at U07808 metallothionein 42878 0.11780 3.42 up Mm.6218 Kcns2 101625_at AF008574 K+ voltage-gated channel, subfamily S, 22879 0.11788 2.28 up Mm.18628 Cd36 93332_at L23108 CD36 antigen2880 0.11799 2.35 up Mm.16366 Mtcp1 103045_at U32332 mature T-cell proliferation 1Page 32 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2881 0.11823 1.74 down Mm.29194 1700094M07Rik 95071_at AW060448 RIKEN cDNA 1700094M07 gene2882 0.11826 1.81 down Mm.13799 Gpr56 102787_at AI841654 G protein-coupled receptor 562883 0.11830 1.66 down Mm.28421 2410071B14Rik 97896_r_at AW125218 RIKEN cDNA 2410071B14 gene2884 0.11830 1.97 up Mm.17031 Pou5f1 161159_r_at AV214633 POU domain, class 5, transcription factor 12885 0.11830 2.27 up Mm.41726 Siat8c 99504_at X80502 sialyltransferase 8 (alpha-2, 8-sialytransferase) C2886 0.11831 1.33 down Mm.25293 Pcmt1 94348_f_at AW124044 protein-L-isoaspartate (D-aspartate) O-methyltransferase 12887 0.11831 3.17 up Mm.200692 C77258 103532_at AW120579 expressed sequence C772582888 0.11836 3.75 up Mm.1009 Il4ra 102021_at M27960 interleukin 4 receptor, alpha2889 0.11841 1.53 up Mm.88829 Casp9 100367_g_at AB019600 caspase 92890 0.11843 4.01 up Mm.29522 2410090P21Rik 97328_at AA034874 RIKEN cDNA 2410090P21 gene2891 0.11848 2.00 up Mm.44199 2610101M19Rik 161038_at AA120675 RIKEN cDNA 2610101M19 gene2892 0.11852 1.39 up Mm.29131 1110049F12Rik 161424_f_at AV294837 RIKEN cDNA 1110049F12 gene2893 0.11854 2.23 up Mm.1338 Fgr 94697_at X52191 Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog2894 0.11857 3.46 up Mm.10865 Uox 92606_at M27695 urate oxidase2895 0.11869 1.69 up Mm.3458 Rpo1-1 161347_r_at AV148041 RNA polymerase 1-1 (40 kDa subunit)2896 0.11883 3.20 up Mm.10222 Wisp1 102044_at AF100777 WNT1 inducible signaling pathway protein 12897 0.11884 1.60 up Mm.214583 Prosc 101567_at AB018567 proline synthetase co-transcribed2898 0.11885 1.59 up Mm.8042 Inhba 100277_at X69619 inhibin beta-A2899 0.11887 1.56 up Mm.16009 Itk 103028_at D14042 IL2-inducible T-cell kinase2900 0.11889 2.76 up Mm.587 Ptpra 161811_f_at AV354090 protein tyrosine phosphatase, receptor type, A2901 0.11890 4.86 up Mm.93826 Mm.93826 162012_r_at AV337324 ESTs2902 0.11895 1.32 down Mm.22330 Nisch 94236_at AI838152 nischarin2903 0.11900 1.30 down Mm.29830 4930524H12Rik 96263_at AW124933 RIKEN cDNA 4930524H12 gene2904 0.11908 5.32 up Mm.6751 Mm.6751 161586_f_at AV320778 ESTs, Weakly similar to S28261 centromere protein E [H.sapiens]2905 0.11917 2.75 up Mm.6130 Mm.6130 99826_at AI506695 ESTs2906 0.11917 1.93 up Mm.104747 Igk-V28 97567_f_at AF045026 immunoglobulin kappa chain variable 28 (V28)2907 0.11921 1.35 down Mm.24350 H1f0 95419_at M29260 H1 histone family, member 02908 0.11921 3.00 up Mm.31625 Mip 98796_at U27502 major intrinsic protein of eye lens fiber2909 0.11922 3.05 up Mm.42201 Hus1 92505_g_at AF076845 Hus1 homolog (S. pombe)2910 0.11928 3.83 up 94726_at M212032911 0.11947 3.47 down Mm.212716 Mm.212716 100362_f_at X02463 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6672912 0.11948 3.18 up Mm.22073 Mm.22073 94065_at AW122753 Mus musculus, clone MGC:18741 IMAGE:3992341, mRNA, complete cds2913 0.11953 1.83 up Mm.1453 Adam1 102832_at U22056 a disintegrin and metalloproteinase domain 1a (fertilin alpha)2914 0.11959 2.26 up Mm.24770 4933411H20Rik 103768_at AW209561 RIKEN cDNA 4933411H20 gene2915 0.11971 1.46 down Mm.21846 Ubl3 94018_at AW120725 ubiquitin-like 32916 0.11975 1.76 up Mm.4290 1110020G17Rik 160484_at AI840118 RIKEN cDNA 1110020G17 gene2917 0.11987 1.74 up Mm.27744 Unc119h 95555_at AF030169 unc119 homolog (C. elegans)2918 0.12005 3.58 up 95183_i_at AA4196842919 0.12016 1.37 down Mm.28474 AJ237586 97908_at AW120676 hypothetical protein, clone MTA.D02.0902920 0.12022 1.52 up Mm.4379 Pcnt 99662_at AI194767 pericentrin2921 0.12029 4.44 up Mm.2254 Emr1 103507_at X93328 EGF-like module containing, mucin-like, hormone receptor-like sequence 12922 0.12033 2.94 up Mm.12800 Tgn 94154_at AF076186 thyroglobulin2923 0.12040 2.90 up Mm.28044 LOC192176 97300_at AW045218 filamin-like protein2924 0.12044 1.66 up Mm.42156 Myh1 98308_at AJ002522 myosin, heavy polypeptide 1, skeletal muscle, adult2925 0.12051 3.60 up Mm.42028 Sema7a 97794_at AB017532 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (sem2926 0.12052 1.71 down Mm.6379 Slc1a4 100943_at U75215 solute carrier family 1 (glutamate/neutral amino acid transporter), member 42927 0.12055 1.65 up Mm.29012 Fbxw4 102478_f_at AW122990 f-box and WD-40 domain protein 42928 0.12055 2.92 up Mm.10663 Ascl1 102238_at M95603 achaete-scute complex homolog-like 1 (Drosophila)2929 0.12061 3.04 up Mm.42227 Pmx2b 98317_at Y14493 paired mesoderm homeobox 2b2930 0.12064 1.55 down Mm.34216 Ulk1 102332_at AI850194 Unc-51 like kinase 1 (C. elegans)2931 0.12076 2.31 up Mm.56967 Smstr1 101318_at M81831 somatostatin receptor 12932 0.12082 3.51 up Mm.141984 Mm.141984 160975_at AI504338 ESTs2933 0.12086 2.66 up Mm.2655 qk 160726_at U44940 quaking2934 0.12086 1.52 down Mm.4980 Chrne 92967_r_at AI326288 cholinergic receptor, nicotinic, epsilon polypeptide2935 0.12101 2.42 up Mm.1927 Srpx 162156_f_at AV021449 sushi-repeat-containing protein2936 0.12106 1.27 down Mm.27804 Ierepo4-pending 160251_at AW125150 immediate early response, erythropoietin 42937 0.12116 1.46 up Mm.4719 Fdxr 162122_f_at AV374384 ferredoxin reductase2938 0.12119 2.58 up Mm.35867 Ccne2 97182_at AF091432 cyclin E22939 0.12135 1.30 down Mm.2871 AU020082 160203_at AA840409 expressed sequence AU0200822940 0.12140 2.55 up Mm.41766 Tfam 99172_at L07107 transcription factor A, mitochondrial2941 0.12141 1.28 up Mm.2947 AF006998 104453_at AW046336 EST AF0069982942 0.12147 1.27 up Mm.56990 Ercc2 92278_at AI843631 excision repair cross-complementing rodent repair deficiency, complementat2943 0.12153 3.39 up Mm.20861 Lrp6 103271_at AF074265 low density lipoprotein receptor-related protein 62944 0.12155 1.19 up Mm.28528 2610002D06Rik 160299_at AA879590 RIKEN cDNA 2610002D06 gene2945 0.12165 2.44 up Mm.8019 Ptpn20 93658_at D64141 protein tyrosine phosphatase, non-receptor type 202946 0.12166 1.48 up Mm.2136 Cox4a 102124_f_at AI836879 cytochrome c oxidase, subunit IVa2947 0.12169 1.65 up Mm.214762 Mm.214762 97700_at AI326621 Mus musculus, Similar to histocompatibility 2, D region locus 1, clone MGC:22948 0.12176 2.22 up Mm.4660 Scyb5 98772_at U27267 small inducible cytokine B subfamily, member 52949 0.12185 2.85 up Mm.143877 5530600P05Rik 99367_at AA434661 RIKEN cDNA 5530600P05 gene2950 0.12188 1.54 down Mm.3991 Slc25a10 99112_at AA683883 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocato2951 0.12190 2.50 up Mm.28950 Acp6 162336_r_at AV099657 acid phosphatase 6, lysophosphatidic2952 0.12196 1.23 down Mm.205266 D9Ertd25e 160482_at AI841705 DNA segment, Chr 9, ERATO Doi 25, expressed2953 0.12200 1.78 up Mm.22226 Mm.22226 160682_at AI851770 Mus musculus, clone MGC:7054 IMAGE:3156506, mRNA, complete cds2954 0.12221 2.12 up Mm.41274 AI987948 93719_at AA050273 expressed sequence AI9879482955 0.12239 1.80 up Mm.42125 Slfn3 92315_at AF099977 schlafen 32956 0.12242 1.92 down 93651_r_at M232362957 0.12252 1.39 down Mm.133404 Rnf8 99028_at AI788534 ring finger protein 82958 0.12256 1.99 up Mm.87834 V2r1 95797_f_at AF011411 vomeronasal 2, receptor, 12959 0.12259 2.97 up 101799_at AF0781122960 0.12285 1.51 up Mm.181709 Rgs16 94378_at U94828 regulator of G-protein signaling 162961 0.12285 2.07 up Mm.772 AI666264 93636_at AA146482 expressed sequence AI6662642962 0.12286 2.34 up Mm.132309 Kcnd2 99339_r_at AI839615 potassium voltage-gated channel, Shal-related family, member 22963 0.12295 1.79 up Mm.218877 Igfbp5 100566_at L12447 insulin-like growth factor binding protein 52964 0.12297 2.94 up Mm.65528 Mm.65528 161475_f_at AV044731 ESTs2965 0.12303 1.78 up Mm.29357 1300017C10Rik 160337_at AI847162 RIKEN cDNA 1300017C10 gene2966 0.12317 1.50 up Mm.30098 Mcm3ap 97433_at AJ006590 minichromosome maintenance deficient (S. cerevisiae) 3-associated protein2967 0.12343 1.25 down Mm.4885 Yap 160520_at X80508 yes-associated protein, 65 kDa2968 0.12359 1.52 up Mm.24862 AI852829 103779_at AI852829 expressed sequence AI8528292969 0.12370 3.72 up Mm.219663 Fbln1 94307_at X70854 fibulin 12970 0.12375 1.68 up Mm.195953 Nore1-pending 102028_at AF053959 novel ras effector 1Page 33 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2971 0.12377 1.39 down Mm.486 Lamp2 100136_at M32017 lysosomal membrane glycoprotein 22972 0.12377 2.52 up Mm.183126 2210409B01Rik 162285_r_at AV373266 RIKEN cDNA 2210409B01 gene2973 0.12381 3.20 down Mm.73172 Serpina5 101187_at U67878 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, anti2974 0.12392 3.50 up Mm.43778 Rps14 99657_at Y08307 ribosomal protein S142975 0.12398 1.47 up Mm.154890 Sars2-pending 95630_at AW122852 seryl-aminoacyl-tRNA synthetase 22976 0.12403 2.52 up Mm.955 Vpreb3 93957_at D13208 pre-B lymphocyte gene 32977 0.12404 1.76 up Mm.23322 AI181996 95386_at AI847050 expressed sequence AI1819962978 0.12418 3.48 up Mm.42016 Aldh1a2 101707_at X99273 aldehyde dehydrogenase family 1, subfamily A22979 0.12419 1.47 up Mm.4538 AI505894 160890_at AW214587 expressed sequence AI5058942980 0.12419 1.78 up Mm.4709 Wnt10b 92751_i_at U61970 wingless related MMTV integration site 10b2981 0.12425 1.92 up Mm.89341 Hsp70-4 101562_at U08215 heat shock protein, 70 kDa 42982 0.12431 1.31 up Mm.156616 Rnf42 95155_at AI853875 ring finger protein 422983 0.12440 1.34 up Mm.29908 Dnclc1 96298_f_at AF020185 dynein, cytoplasmic, light chain 12984 0.12440 3.81 up Mm.28081 Tead1 104233_at L13853 TEA domain family member 12985 0.12446 1.45 up 99478_at X972682986 0.12450 1.48 down Mm.8903 Bckdk 101557_at AF043070 branched chain ketoacid dehydrogenase kinase2987 0.12452 2.38 up Mm.20945 Rgs19ip1 101683_at AF089818 regulator of G-protein signaling 19 interacting protein 12988 0.12457 1.40 down Mm.24254 Pdcd6 95412_at U49112 programmed cell death 62989 0.12464 2.88 up Mm.3288 Trim30 162086_r_at AV316033 tripartite motif protein 302990 0.12464 2.16 up Mm.4837 Col10a1 92921_at X67348 procollagen, type X, alpha 12991 0.12465 1.36 down Mm.23692 Csnk2a1-rs4 160690_at AW050240 casein kinase II, alpha 1 related sequence 42992 0.12467 2.89 up Mm.28924 1810008A14Rik 94495_at AI854801 RIKEN cDNA 1810008A14 gene2993 0.12481 1.24 up Mm.4053 Tln 162089_r_at AV336639 talin2994 0.12505 2.07 up Mm.183266 Tnxb 161907_s_at AV375788 tenascin XB2995 0.12513 1.71 down Mm.89572 Mm.89572 97257_at AW122766 Mus musculus, clone MGC:7674 IMAGE:3496398, mRNA, complete cds2996 0.12532 2.07 up Mm.8070 Gdi2 94642_at U07951 guanosine diphosphate (GDP) dissociation inhibitor 22997 0.12533 2.80 up Mm.27768 6330403K07Rik 161354_f_at AV161034 RIKEN cDNA 6330403K07 gene2998 0.12533 1.74 up Mm.56954 Smstr3 101309_at M91000 somatostatin receptor 32999 0.12534 1.47 up Mm.213003 Myd88 102430_at X51397 myeloid differentiation primary response gene 883000 0.12536 2.10 up Mm.35121 AI467481 97154_f_at AA413015 expressed sequence AI4674813001 0.12541 1.38 down Mm.20864 Tpbg 95345_at AJ012160 trophoblast glycoprotein3002 0.12542 2.08 down Mm.5794 C79158 161070_at AI851250 expressed sequence C791583003 0.12543 1.82 down Mm.34533 Ephb4 98446_s_at U06834 Eph receptor B43004 0.12543 3.79 up Mm.3510 Inhbe 97153_at U96386 inhibin beta E3005 0.12568 1.31 down Mm.28594 Mm.28594 98910_at AI846118 ESTs3006 0.12570 2.03 up Mm.951 Ifit3 93956_at U43086 interferon-induced protein with tetratricopeptide repeats 33007 0.12574 2.26 up Mm.56907 Gja8 101286_at M91243 gap junction membrane channel protein alpha 83008 0.12581 1.53 down Mm.29744 Slc29a1 95733_at AI838274 solute carrier family 29 (nucleoside transporters), member 13009 0.12583 1.73 up Mm.23808 D12Wsu95e 161471_f_at AV356223 DNA segment, Chr 12, Wayne State University 95, expressed3010 0.12591 1.44 down Mm.21109 Gsn 93750_at J04953 gelsolin3011 0.12596 2.74 up Mm.23909 Mm.23909 95399_at AI592745 ESTs3012 0.12598 1.96 up Mm.73273 Mm.73273 161736_r_at AV312182 EST3013 0.12601 2.50 up Mm.3735 Mm.3735 100746_at AA408891 ESTs3014 0.12606 1.91 up Mm.206164 Mm.206164 162370_r_at AV239591 Mus musculus, clone IMAGE:3484208, mRNA, partial cds3015 0.12613 3.18 up Mm.24261 AI848335 161262_r_at AV312779 expressed sequence AI8483353016 0.12624 1.86 up Mm.3028 1110054G21Rik 104491_at AI509330 RIKEN cDNA 1110054G21 gene3017 0.12626 1.97 down Mm.2879 Grik5 104409_at D10011 glutamate receptor, ionotropic, kainate 5 (gamma 2)3018 0.12632 2.48 up Mm.20066 2210013M04Rik 103601_at AW046150 RIKEN cDNA 2210013M04 gene3019 0.12633 1.99 up Mm.5518 Mm.5518 101220_at C76628 EST3020 0.12639 2.82 up Mm.104747 Igk-V28 102156_f_at M80423 immunoglobulin kappa chain variable 28 (V28)3021 0.12642 2.81 down Mm.116721 Cab140 101125_at AA536953 calcium binding protein, 140 kDa3022 0.12643 1.55 down Mm.9075 Ephx1 101587_at U89491 epoxide hydrolase 1, microsomal3023 0.12646 1.22 up Mm.3981 Cops6 99106_at AF071315 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thal3024 0.12655 4.90 up Mm.104747 Igk-V28 93086_at M18237 immunoglobulin kappa chain variable 28 (V28)3025 0.12656 2.97 up Mm.215223 AA416453 101689_at AA416453 expressed sequence AA4164533026 0.12661 3.98 up Mm.856 Tm4sf1 161315_i_at AV087000 transmembrane 4 superfamily member 13027 0.12663 1.59 up Mm.21370 Ltbp3 160133_at L40459 latent transforming growth factor beta binding protein 33028 0.12671 3.13 up Mm.778 2610107G07Rik 162162_f_at AV356864 RIKEN cDNA 2610107G07 gene3029 0.12672 1.99 up Mm.2416 Scin 161977_r_at AV372912 scinderin3030 0.12676 3.36 up Mm.3311 1100001H23Rik 98033_at AA710132 RIKEN cDNA 1100001H23 gene3031 0.12679 2.52 up Mm.1395 Slpi 162329_r_at AV087239 secretory leukocyte protease inhibitor3032 0.12687 1.60 up Mm.57026 Smstr4 101717_at U26176 somatostatin receptor 43033 0.12687 3.94 up Mm.1498 Akap4 102857_at U10341 A kinase anchor protein 43034 0.12693 2.13 up Mm.30438 Tyrp1 97955_at X59513 tyrosinase-related protein 13035 0.12703 5.69 up Mm.22621 Col1a1 103709_at AA763466 procollagen, type I, alpha 13036 0.12704 1.51 up Mm.27546 8430408O15Rik 95034_f_at AW212243 RIKEN cDNA 8430408O15 gene3037 0.12712 1.68 up Mm.27757 Bmp1 92701_at AA518586 bone morphogenetic protein 13038 0.12715 1.58 up Mm.196749 5830417I10Rik 95580_at AI834960 RIKEN cDNA 5830417I10 gene3039 0.12716 1.42 up Mm.27194 D7Rp2e 96629_at X04097 DNA segment, Chr 7, Roswell Park 2 complex, expressed3040 0.12719 1.56 up Mm.205855 D13Wsu123e 94451_at AI787627 DNA segment, Chr 13, Wayne State University 123, expressed3041 0.12720 2.48 up Mm.29034 AI413782 94527_at AI842152 expressed sequence AI4137823042 0.12723 3.73 up Mm.6559 Asgr1 93433_s_at D13517 asialoglycoprotein receptor 13043 0.12725 1.99 up Mm.24960 D15Ertd55e 95861_at C77618 DNA segment, Chr 15, ERATO Doi 55, expressed3044 0.12727 1.47 down Mm.2706 Atf3 104156_r_at U19118 activating transcription factor 33045 0.12739 1.95 up Mm.5055 Fgf5 98845_at M37823 fibroblast growth factor 53046 0.12741 1.83 up Mm.9334 Prkar1b 101927_at M20473 protein kinase, cAMP dependent regulatory, type I beta3047 0.12743 1.36 down Mm.3317 Gus-s 97538_at M19279 beta-glucuronidase structural3048 0.12743 2.56 up Mm.39472 Mm.39472 162281_at AV371705 Mus musculus farnesyl pyrophosphate synthase (Fpps) mRNA, complete cd3049 0.12755 1.45 down Mm.27539 Mm.27539 104202_at AI850624 ESTs, Weakly similar to I38919 probable transmembrane protein [H.sapiens3050 0.12756 2.04 up Mm.4793 Gaa 162441_i_at AV348065 glucosidase, alpha, acid3051 0.12770 1.51 up Mm.213275 Mm.213275 95305_at AA756275 ESTs, Highly similar to A30583 T-cell receptor delta chain precursor V region3052 0.12786 1.94 down Mm.175310 H2-Aa 104429_at AF027865 histocompatibility 2, class II antigen A, alpha3053 0.12793 2.20 down Mm.21735 2310043O08Rik 104079_at AW124678 RIKEN cDNA 2310043O08 gene3054 0.12793 2.28 up Mm.23965 Efnb3 103692_at AW121468 ephrin B33055 0.12795 1.91 up Mm.2415 Mm.2415 104610_at AW050015 Mus musculus, clone MGC:12121 IMAGE:3710295, mRNA, complete cds3056 0.12804 1.45 down Mm.2662 Gsta4 96085_at L06047 glutathione S-transferase, alpha 43057 0.12806 1.77 down Mm.12931 Rbm6 102758_at AJ006486 RNA binding motif protein 63058 0.12809 3.32 up Mm.28587 Map3k4 161568_f_at AV270901 mitogen activated protein kinase kinase kinase 43059 0.12809 2.06 up Mm.57050 Cmkbr3 99412_at U29677 chemokine (C-C) receptor 33060 0.12818 1.96 down Mm.2917 Mm.2917 161009_at AW123037 ESTsPage 34 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3061 0.12820 2.50 up Mm.1395 Slpi 92858_at AF002719 secretory leukocyte protease inhibitor3062 0.12823 1.35 down Mm.41583 Mm.41583 99154_s_at AW122625 Mus musculus, Similar to PTD015 protein, clone MGC:36240 IMAGE:5027463063 0.12830 1.97 up Mm.6254 Ucp3 93392_at AB010742 uncoupling protein 3, mitochondrial3064 0.12840 2.79 up Mm.42179 Anxa10 92494_at AJ238978 annexin A103065 0.12841 1.60 up Mm.2766 Pva 96719_i_at X59382 parvalbumin3066 0.12856 1.66 up Mm.25165 Af1q-pending 95503_at U95498 ALL1-fused gene from chromosome 1q3067 0.12857 1.30 up Mm.29725 Mapkapk2 95721_at AW120722 MAP kinase-activated protein kinase 23068 0.12865 2.66 up Mm.195072 Pcdha10 101773_r_at AB008183 protocadherin alpha 103069 0.12878 1.74 up Mm.27313 AW046661 94991_at AW046661 expressed sequence AW0466613070 0.12881 2.33 up Mm.24691 Mm.24691 95926_at AA517021 ESTs3071 0.12883 1.53 down Mm.196531 AI428202 103551_at AW124208 EST AI4282023072 0.12885 1.24 down Mm.6743 Nfe2l1 160535_at X78709 nuclear factor, erythroid derived 2,-like 13073 0.12892 1.25 up Mm.1258 Tnfrsf1a 92793_at X57796 tumor necrosis factor receptor superfamily, member 1a3074 0.12894 1.86 down Mm.140548 2510001I10Rik 95139_at AW122075 RIKEN cDNA 2510001I10 gene3075 0.12896 1.54 down Mm.29561 Ctsf 97336_at AJ131851 cathepsin F3076 0.12910 1.61 down Mm.140192 Itln 102755_at AB016496 intelectin3077 0.12910 2.54 up Mm.27095 2610511O17Rik 160223_at AW047172 RIKEN cDNA 2610511O17 gene3078 0.12914 1.49 down Mm.24118 Gstt2 104603_at X98056 glutathione S-transferase, theta 23079 0.12922 1.69 down Mm.4940 AI413214 100471_at AW048916 expressed sequence AI4132143080 0.12960 2.02 up Mm.3202 Mm.3202 97099_at AI415109 ESTs3081 0.12965 6.33 up Mm.35784 Sox3 161276_i_at AV324911 SRY-box containing gene 33082 0.12970 2.09 up Mm.30478 2810465O16Rik 94844_at AI648758 RIKEN cDNA 2810465O16 gene3083 0.12974 2.00 up Mm.141021 1110004C05Rik 160253_at AW125390 RIKEN cDNA 1110004C05 gene3084 0.12982 1.44 up Mm.3213 Ldlr 160832_at Z19521 low density lipoprotein receptor3085 0.12987 5.35 up Mm.4767 Gast 161639_f_at AV062425 gastrin3086 0.12991 1.55 up Mm.56990 Ercc2 99397_at U97572 excision repair cross-complementing rodent repair deficiency, complementat3087 0.12998 2.00 up Mm.29473 Copz1 161319_at AV091858 coatomer protein complex, subunit zeta 13088 0.13003 2.61 up Mm.24537 AI661031 95923_at AI661031 expressed sequence AI6610313089 0.13006 1.65 down Mm.1898 AI848576 103198_at AI838229 expressed sequence AI8485763090 0.13013 1.53 down Mm.27039 1110032N12Rik 96604_at AW125827 RIKEN cDNA 1110032N12 gene3091 0.13017 2.58 up Mm.4783 Klra2 98801_at U10304 killer cell lectin-like receptor, subfamily A, member 23092 0.13020 1.25 down Mm.3526 Ank3 98476_at L40631 ankyrin 3, epithelial3093 0.13029 2.02 down Mm.5264 Mm.5264 100876_at AI841076 ESTs, Highly similar to FEZ1_RAT FASCICULATION AND ELONGATION P3094 0.13029 1.84 up Mm.90109 Mm.90109 99849_at C85523 EST3095 0.13031 1.81 down Mm.22440 AL033346 94262_at AI172920 expressed sequence AL0333463096 0.13044 3.39 up Mm.4628 Smpd1 161789_r_at AV347445 sphingomyelin phosphodiesterase 1, acid lysosomal3097 0.13049 3.04 up Mm.196320 5830405F06Rik 93107_r_at M20878 RIKEN cDNA 5830405F06 gene3098 0.13055 2.64 up Mm.12880 T2 94175_at AF072546 brachyury 23099 0.13057 1.31 up Mm.2935 4631408O11Rik 104445_at AW046694 RIKEN cDNA 4631408O11 gene3100 0.13068 1.94 down Mm.1332 Gpx5 94692_at X53780 glutathione peroxidase 53101 0.13072 3.71 up Mm.20289 Car6 160647_at AF079834 carbonic anhydrase 63102 0.13075 2.23 up Mm.24627 4833432B22Rik 104730_at AW046889 RIKEN cDNA 4833432B22 gene3103 0.13082 1.56 up Mm.2635 Pk3 96066_s_at X97047 pyruvate kinase 33104 0.13083 1.75 up Mm.5260 Gabt1 161059_at M92378 gamma-aminobutyric acid (GABA-A) transporter 13105 0.13089 2.28 up Mm.7563 Rdh5 101431_at AF033195 retinol dehydrogenase type 53106 0.13092 1.57 up Mm.66013 Mm.66013 161535_at AV234882 EST3107 0.13102 1.49 up Mm.6973 Krtap6-1 101376_at D86419 keratin associated protein 6-13108 0.13108 1.34 down Mm.20543 Pum2 93580_at AI837010 pumilio 2 (Drosophila)3109 0.13127 1.23 down Mm.21961 Atp6s1 94043_at AB031290 ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 13110 0.13127 1.55 down Mm.918 Hspa5 101955_at AJ002387 heat shock 70kD protein 5 (glucose-regulated protein, 78kD)3111 0.13154 1.94 up Mm.2718 Eef1b2 102107_at AI325544 eukaryotic translation elongation factor 1 beta 23112 0.13157 2.02 up Mm.31646 Actl6 104654_at AI847687 actin-like 63113 0.13157 1.22 down Mm.4009 Rit 92376_at U71205 RAS-like protein expressed in many tissues3114 0.13166 4.33 up Mm.30184 2700086I23Rik 96937_at AI853247 RIKEN cDNA 2700086I23 gene3115 0.13178 1.39 down Mm.140804 Mm.140804 94042_f_at AI843937 Mus musculus, guanine nucleotide binding protein (G protein), gamma 5, clo3116 0.13186 1.77 down Mm.12790 1600025I13Rik 102423_at AI649125 RIKEN cDNA 1600025I13 gene3117 0.13197 2.40 up Mm.28587 Map3k4 161007_at U11548 mitogen activated protein kinase kinase kinase 43118 0.13210 1.80 up Mm.42245 Ndst1 92516_at AF074926 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 13119 0.13217 1.91 up Mm.6960 Trip13 101372_at AI852645 thyroid hormone receptor interactor 133120 0.13220 2.52 up Mm.29976 5-Sep 96337_at AF033350 septin 53121 0.13222 2.42 up Mm.56941 Olfr15 101303_at M84005 olfactory receptor 153122 0.13225 1.91 up Mm.15252 Srpk1 102985_at AB012290 serine/arginine-rich protein specific kinase 13123 0.13225 3.64 up Mm.23905 Pf4 104571_at AB017491 platelet factor 43124 0.13235 4.94 up Mm.34441 Mid1 92219_s_at Y14848 midline 13125 0.13236 1.93 up Mm.41772 Tmeff1 160472_r_at AI837838 transmembrane protein with EGF-like and two follistatin-like domains 13126 0.13240 2.77 up Mm.107441 Zfp26 161717_i_at AV252842 zinc finger protein 263127 0.13245 2.81 up Mm.4979 Scyb2 101160_at X53798 small inducible cytokine subfamily, member 23128 0.13248 1.81 up Mm.24464 Mm.24464 95914_at AA177382 ESTs, Weakly similar to E29149 proline-rich protein - mouse [M.musculus]3129 0.13250 2.27 down Mm.3726 Slc2a3 92292_at M75135 solute carrier family 2 (facilitated glucose transporter), member 33130 0.13261 1.47 down Mm.153183 Zap3-pending 100413_at AB033168 ZAP3 protein3131 0.13262 2.78 up Mm.6523 S100a13 100959_at X99921 S100 calcium binding protein A133132 0.13263 1.58 down Mm.310 Zfp103 97972_at AB012161 zinc finger protein 1033133 0.13265 2.22 up Mm.89933 Cacnb2 100757_at L20343 calcium channel, voltage-dependent, beta 2 subunit3134 0.13267 2.24 up Mm.4716 Htr1a 101140_at U39391 5-hydroxytryptamine (serotonin) receptor 1A3135 0.13270 1.76 down Mm.2877 Alcam 104407_at L25274 activated leukocyte cell adhesion molecule3136 0.13271 3.06 up Mm.24119 2210415F13Rik 94914_at AW121391 RIKEN cDNA 2210415F13 gene3137 0.13276 1.70 up Mm.29898 2410015N17Rik 96294_s_at AI854235 RIKEN cDNA 2410015N17 gene3138 0.13281 2.06 up Mm.204 2610042L04Rik 93568_i_at AI853444 RIKEN cDNA 2610042L04 gene3139 0.13283 1.55 down Mm.18555 AU019331 103370_at AI848367 expressed sequence AU0193313140 0.13292 1.61 up Mm.29302 AA409087 104442_at AI605538 expressed sequence AA4090873141 0.13294 1.95 up Mm.2453 Smst 95436_at X51468 somatostatin3142 0.13310 1.58 up Mm.35774 5930436K22Rik 98502_at AW060461 RIKEN cDNA 5930436K22 gene3143 0.13311 1.65 up Mm.2797 Mm.2797 96543_at AA960345 ESTs3144 0.13321 2.68 up Mm.23793 Cncg 95389_at M84742 cyclic nucleotide gated channel, cGMP gated3145 0.13323 2.54 up Mm.2899 Penk1 161164_r_at AV218397 preproenkephalin 13146 0.13328 1.45 down Mm.20873 Tnrc11 103277_s_at AF071310 trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit3147 0.13331 3.27 up Mm.859 Polg2 162277_r_at AV368016 polymerase, gamma 23148 0.13332 1.33 up Mm.16802 D16Wsu73e 94780_at AI987985 DNA segment, Chr 16, Wayne State University 73, expressed3149 0.13336 1.94 up Mm.658 Slc25a5 100619_r_at AA062013 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocato3150 0.13362 1.49 up Mm.32884 Tuba8 104682_at AI848983 tubulin alpha 8Page 35 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3151 0.13369 4.92 up Mm.25855 AI118496 103984_at AI043040 expressed sequence AI1184963152 0.13371 2.36 up Mm.2104 Apeg1 103298_at U57098 aortic preferentially expressed gene 13153 0.13375 1.74 up Mm.6932 1810060K07Rik 101036_at AW047047 RIKEN cDNA 1810060K07 gene3154 0.13376 2.82 up Mm.30314 Nrp2 104493_at AF022856 neuropilin 23155 0.13377 1.57 down Mm.10721 Dnajc4 102324_at AF036875 DnaJ (Hsp40) homolog, subfamily C, member 43156 0.13379 2.42 up 96967_at M210003157 0.13384 1.80 up Mm.703 S100a3 101051_at AF004941 S100 calcium binding protein A33158 0.13392 2.35 up Mm.684 Ctsc 101020_at AI842667 cathepsin C3159 0.13393 2.14 up Mm.116 H2-Oa 102274_at M95514 histocompatibility 2, O region alpha locus3160 0.13400 1.44 down Mm.37216 Zhx1 160848_at Z54200 zinc fingers and homeoboxes protein 13161 0.13403 1.74 up Mm.27673 D6Wsu176e 95541_at AW125506 DNA segment, Chr 6, Wayne State University 176, expressed3162 0.13416 3.50 up Mm.1213 Masp1 102284_at D16492 mannan-binding lectin serine protease 13163 0.13429 1.79 up Mm.196085 Igh-4 102152_f_at M16724 immunoglobulin heavy chain 4 (serum IgG1)3164 0.13443 2.87 up Mm.38540 Mm.38540 101693_f_at C80919 ESTs3165 0.13448 1.37 down Mm.22619 Anxa6 94304_at X13460 annexin A63166 0.13452 1.46 up Mm.6375 Gyg1 162262_f_at AV357306 glycogenin 13167 0.13460 1.99 down Mm.196149 1110008E19Rik 93268_at AI852001 RIKEN cDNA 1110008E19 gene3168 0.13460 2.39 up Mm.4358 Map3k12 160881_at U14636 mitogen activated protein kinase kinase kinase 123169 0.13461 1.66 up Mm.43213 9030402K04Rik 99621_s_at AA690583 RIKEN cDNA 9030402K04 gene3170 0.13469 1.55 down Mm.45312 Anapc5 95100_at AI847314 anaphase-promoting complex subunit 53171 0.13469 2.20 up Mm.35670 Abcc9 97172_s_at D86037 ATP-binding cassette, sub-family C (CFTR/MRP), member 93172 0.13473 1.49 down Mm.6919 Dctn1 101367_at U60312 dynactin 13173 0.13481 1.51 down Mm.22679 1300019P08Rik 94807_at AI848354 RIKEN cDNA 1300019P08 gene3174 0.13488 2.76 up Mm.1062 Tnfsf10 94112_at U37522 tumor necrosis factor (ligand) superfamily, member 103175 0.13489 2.65 up Mm.28394 Apoc2 97887_at Z22216 apolipoprotein CII3176 0.13509 3.32 up Mm.3301 Mcpt7 97109_at L00653 mast cell protease 73177 0.13511 1.37 up Mm.21814 6720474K14Rik 104091_at AW122563 RIKEN cDNA 6720474K14 gene3178 0.13511 1.98 up Mm.35788 Pold2 98155_r_at Z72486 polymerase (DNA directed), delta 2, regulatory subunit (50 kDa)3179 0.13514 2.33 up Mm.1089 Mest 92607_at AF017994 mesoderm specific transcript3180 0.13517 1.34 up Mm.153159 Cct6a 162279_f_at AV370410 chaperonin subunit 6a (zeta)3181 0.13518 5.86 up Mm.22621 Col1a1 94305_at U03419 procollagen, type I, alpha 13182 0.13518 1.58 down Mm.41268 Zac1 99469_at AW121865 zinc finger protein regulator of apoptosis and cell cycle arrest3183 0.13522 5.41 up Mm.980 Tnc 162362_f_at AV230686 tenascin C3184 0.13530 1.44 up Mm.37835 Rpl7 97695_s_at M29015 ribosomal protein L73185 0.13533 2.44 up Mm.4756 Lepr 100430_at Y10298 leptin receptor3186 0.13535 1.92 up Mm.111845 Eln 92207_at U08210 elastin3187 0.13538 2.10 up Mm.176946 Lrg-pending 97420_at AW230891 leucine-rich alpha-2-glycoprotein3188 0.13540 3.34 up Mm.10167 1110055A02Rik 160060_at AI851492 RIKEN cDNA 1110055A02 gene3189 0.13546 1.50 down Mm.2734 Sat 96657_at L10244 spermidine/spermine N1-acetyl transferase3190 0.13556 3.38 up Mm.89962 Pfp 93931_at X12760 pore forming protein3191 0.13557 1.80 up Mm.57004 H2-M9 101341_at AF016308 histocompatibility 2, M region locus 93192 0.13564 1.63 up Mm.741 Fabp5 160544_at AJ223066 fatty acid binding protein 5, epidermal3193 0.13569 3.43 down Mm.12832 Zfp61 102304_f_at L28167 zinc finger protein 613194 0.13572 1.85 up Mm.6594 Clca3 162287_r_at AV373378 chloride channel calcium activated 33195 0.13581 1.26 down Mm.27842 Slc9a3r1 97243_at U74079 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 13196 0.13583 1.61 down Mm.24492 AA408380 95920_at AA408838 expressed sequence AA4083803197 0.13591 1.82 up Mm.21146 Gata6 160662_r_at AA667100 GATA binding protein 63198 0.13593 1.48 down Mm.12194 Psmd3 92769_at M25149 proteasome (prosome, macropain) 26S subunit, non-ATPase, 33199 0.13597 2.07 up Mm.56941 Olfr15 92715_at AL078630 olfactory receptor 153200 0.13601 1.36 up Mm.13080 AA536815 102767_at AW121700 EST AA5368153201 0.13602 1.79 up Mm.44453 Mm.44453 102144_f_at AW048189 EST3202 0.13627 1.68 down Mm.18048 Mm.18048 102964_at AW122326 Mus musculus, Similar to zinc finger protein ANC_2H01, clone MGC:7348 IM3203 0.13643 1.46 up Mm.29544 Capn10 97331_at AW049679 calpain 103204 0.13650 2.29 up Mm.69061 Gnat1 99860_at M25513 guanine nucleotide binding protein, alpha transducing 13205 0.13654 3.32 up Mm.7996 Fgf12 93654_at U66201 fibroblast growth factor 123206 0.13654 1.94 up Mm.86686 H2-M10.1 100303_at AF016309 histocompatibility 2, M region locus 10.13207 0.13659 1.95 up Mm.188567 Mm.188567 96424_at C80016 EST3208 0.13661 2.91 up Mm.4993 Mmp3 98833_at X66402 matrix metalloproteinase 33209 0.13664 2.08 up Mm.90003 Gjb3 104232_at X63099 gap junction membrane channel protein beta 33210 0.13670 2.97 up Mm.29751 Pycs 161391_r_at AV256849 pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthet3211 0.13671 2.53 up Mm.14599 Smr1 102739_s_at X71629 submaxillary gland androgen regulated protein 13212 0.13671 1.77 up Mm.566 Orc5 161256_at AV321113 origin recognition complex, subunit 5 homolog (S. cerevisiae)3213 0.13673 1.70 up Mm.76983 M6a-pending 104456_at AA863742 m6a methyltransferase3214 0.13685 2.16 up Mm.15534 Il1a 94755_at M14639 interleukin 1 alpha3215 0.13688 2.22 up Mm.196032 H2-Q5 95773_at X16423 histocompatibility 2, Q region locus 53216 0.13692 1.17 down Mm.28952 Mel 94503_at AI842492 cell line NK14 derived transforming oncogene3217 0.13694 1.54 down Mm.22616 Mm.22616 104366_at AW047831 ESTs, Weakly similar to Zinc finger protein s11-6 [M.musculus]3218 0.13701 1.81 up Mm.3969 Acrp30 99104_at U49915 adipocyte complement related protein of 30 kDa3219 0.13702 1.32 up Mm.10353 Oasis-pending 102231_at AB017614 old astrocyte specifically induced substance3220 0.13703 3.22 up Mm.5105 Ptgdr 98856_at D29765 prostaglandin D receptor3221 0.13706 1.79 up Mm.202361 AW045841 95575_r_at AI641995 expressed sequence AW0458413222 0.13706 2.66 up Mm.17009 Rip1 98954_f_at AA793671 Ral-interacting protein 13223 0.13710 3.17 up Mm.4379 Pcnt 162431_at AV295664 pericentrin3224 0.13712 1.78 up Mm.29580 Scgn10 95670_at AI839868 superiorcervical ganglia, neural specific 103225 0.13713 3.44 up Mm.182921 2310061B02Rik 162213_i_at AV084836 RIKEN cDNA 2310061B02 gene3226 0.13714 2.63 up Mm.27096 Ceacam9 104159_at L49180 CEA-related cell adhesion molecule 93227 0.13745 2.28 up Mm.28738 C330027I04Rik 102100_f_at AI845835 RIKEN cDNA C330027I04 gene3228 0.13749 1.93 up Mm.18974 Gabpa 102981_at M74515 GA repeat binding protein, alpha3229 0.13761 1.76 up Mm.7214 Anxa3 101393_at AJ001633 annexin A33230 0.13769 1.86 up Mm.2035 Fnbp1 98729_at U40751 formin binding protein 13231 0.13788 2.10 up Mm.2407 Sod3 94902_at U38261 superoxide dismutase 3, extracellular3232 0.13792 2.15 up Mm.203910 AI467555 96528_at D18912 expressed sequence AI4675553233 0.13803 4.03 up Mm.597 Pafah1b3 161218_r_at AV249855 platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit3234 0.13804 1.35 up Mm.18808 Pcolce 93349_at X57337 procollagen C-proteinase enhancer protein3235 0.13816 2.45 up Mm.212870 Ifi204 98465_f_at M31419 interferon activated gene 2043236 0.13817 1.88 up Mm.43904 C78893 102135_at C78893 expressed sequence C788933237 0.13819 2.17 up Mm.143889 Adam5 99474_at U22059 a disintegrin and metalloprotease domain 53238 0.13819 2.36 up Mm.42246 Pck1 160481_at AF009605 phosphoenolpyruvate carboxykinase 1, cytosolic3239 0.13819 1.47 up Mm.24474 Mm.24474 104713_at AA863717 ESTs, Weakly similar to D1054.14.p [Caenorhabditis elegans] [C.elegans]3240 0.13843 5.79 up Mm.25115 Mm.25115 96489_at C81612 ESTsPage 36 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3241 0.13844 2.74 up Mm.41842 Cacna1a 100337_at L29346 calcium channel, voltage-dependent, P/Q type, alpha 1A3242 0.13844 1.27 down Mm.30245 2310047I15Rik 97448_at AI845165 RIKEN cDNA 2310047I15 gene3243 0.13850 1.55 down Mm.28039 1810030E18Rik 97296_at AW124918 RIKEN cDNA 1810030E18 gene3244 0.13865 1.81 up Mm.23869 2510006M18Rik 104566_at AI845009 RIKEN cDNA 2510006M18 gene3245 0.13870 1.27 down Mm.24786 D1Ertd654e 101914_at AI846484 DNA segment, Chr 1, ERATO Doi 654, expressed3246 0.13871 1.35 up Mm.183016 Tdg 101540_at AF069519 thymine DNA glycosylase3247 0.13898 1.57 up Mm.27964 2010110I09Rik 160258_at AI853190 RIKEN cDNA 2010110I09 gene3248 0.13909 1.49 up Mm.2859 Baat 104273_at U95215 bile acid-Coenzyme A: amino acid N-acyltransferase3249 0.13912 3.14 up Mm.12907 Cox7a1 102749_at AF037370 cytochrome c oxidase, subunit VIIa 13250 0.13940 1.56 down Mm.19133 Aplp2 93498_s_at M97216 amyloid beta (A4) precursor-like protein 23251 0.13942 2.89 up Mm.42017 Neurog2 97792_at Y07621 neurogenin 23252 0.13946 1.70 up Mm.12872 Itgb2l 94171_at AF051367 integrin beta 2-like3253 0.13950 3.66 up Mm.9086 Slc16a1 101588_at AF058055 solute carrier family 16 (monocarboxylic acid transporters), member 13254 0.13967 1.70 down Mm.127171 Bfsp1 100390_s_at AB003147 beaded filament structural protein in lens-CP943255 0.13976 3.46 up 160143_r_at Y084863256 0.13990 1.23 down Mm.42197 Psmb1 98113_at U60824 proteasome (prosome, macropain) subunit, beta type 13257 0.13996 1.35 down Mm.27443 D10Wsu93e 104187_at AI847110 DNA segment, Chr 10, Wayne State University 93, expressed3258 0.13998 2.73 up Mm.206794 Mcpt9 94735_s_at M57401 mast cell protease 93259 0.14003 1.59 down Mm.3820 Cmas 98593_at AJ006215 cytidine monophospho-N-acetylneuraminic acid synthetase3260 0.14013 4.90 up Mm.214981 Hist1 94638_at U62675 histone gene complex 13261 0.14015 1.96 up Mm.6456 Pftk1 93421_at AF033655 PFTAIRE protein kinase 13262 0.14033 1.42 up Mm.90115 Lypla1 161774_f_at AV358770 lysophospholipase 13263 0.14038 2.04 up Mm.8186 Klrd1 93677_at AF030311 killer cell lectin-like receptor, subfamily D, member 13264 0.14041 1.50 down Mm.46224 Mm.46224 93169_at AW212708 Mus musculus, clone IMAGE:4503739, mRNA, partial cds3265 0.14042 4.69 up Mm.175310 H2-Aa 92866_at X52643 histocompatibility 2, class II antigen A, alpha3266 0.14044 1.50 up Mm.22575 Maged2 94289_r_at AI851574 melanoma antigen, family D, 23267 0.14046 1.94 up Mm.584 Anxa2 100569_at M14044 annexin A23268 0.14049 1.66 up Mm.667 Gstm5 100631_r_at AA241764 glutathione S-transferase, mu 53269 0.14054 3.62 up Mm.3317 Gus-s 162128_i_at AV376939 beta-glucuronidase structural3270 0.14070 1.58 down Mm.1410 Il18 102802_at D49949 interleukin 183271 0.14077 3.64 up Mm.1858 Cd8a 102975_at U34881 CD8 antigen, alpha chain3272 0.14089 1.58 down Mm.20794 Anxa7 93587_at L13129 annexin A73273 0.14096 1.58 down Mm.193088 Clcn4-2 99672_at Z49916 chloride channel 4-23274 0.14099 2.75 up Mm.3275 Map3k8 161768_r_at AV341985 mitogen activated protein kinase kinase kinase 83275 0.14102 4.11 up Mm.8037 Camk2a 93660_at X87142 calcium/calmodulin-dependent protein kinase II alpha3276 0.14110 2.70 down Mm.56941 Olfr15 102168_at AL078630 olfactory receptor 153277 0.14122 1.65 up Mm.7141 Pcna 101065_at X57800 proliferating cell nuclear antigen3278 0.14122 1.88 up Mm.27997 Rfc5 104001_at AA959940 replication factor C (activator 1) 5 (36.5 kDa)3279 0.14126 1.51 up Mm.20354 Klc1 93565_at AF055665 kinesin light chain 13280 0.14129 2.03 down Mm.28994 Mm.28994 96759_r_at AW061265 Mus musculus, clone MGC:6302 IMAGE:2655022, mRNA, complete cds3281 0.14133 2.55 up Mm.156919 Ctsz 92633_at AJ242663 cathepsin Z3282 0.14133 2.27 up Mm.1715 Ltb 102940_at U16985 lymphotoxin B3283 0.14154 1.42 up 101165_at W917623284 0.14165 1.61 down Mm.28088 Mvk 95632_f_at AW122653 mevalonate kinase3285 0.14172 3.46 up Mm.5255 Slc7a1 101208_at M26687 solute carrier family 7 (cationic amino acid transporter, y+ system), member3286 0.14190 2.59 up Mm.30435 Tsc2 97952_at U39818 tuberous sclerosis 23287 0.14193 1.99 up Mm.19987 Dct 103597_at X63349 dopachrome tautomerase3288 0.14203 2.09 up Mm.821 Snrpa1 161929_at AV170107 U2 small nuclear ribonucleoprotein polypeptide A'3289 0.14205 2.64 up Mm.4421 Tph 161385_r_at AV250738 tryptophan hydroxylase3290 0.14212 1.80 up Mm.29755 Incenp 93758_at AA823653 inner centromere protein3291 0.14213 1.38 down Mm.5856 Nyren18-pending 100570_at U27462 NY-REN-18 antigen3292 0.14214 1.60 up Mm.57247 Apc2 102582_at AJ130783 adenomatosis polyposis coli 23293 0.14217 2.22 up Mm.4778 Cspg3 98798_at X84727 chondroitin sulfate proteoglycan 33294 0.14217 1.37 down Mm.12915 Nit1 160075_at AF069988 nitrilase 13295 0.14225 1.45 down Mm.18706 AA414968 93339_at AI846243 expressed sequence AA4149683296 0.14226 1.29 up Mm.1776 Fth 161913_r_at AV378014 ferritin heavy chain3297 0.14231 2.75 up Mm.154660 Plat 93981_at J03520 plasminogen activator, tissue3298 0.14241 1.28 up Mm.142095 1200011K09Rik 96884_at AI847631 RIKEN cDNA 1200011K09 gene3299 0.14247 1.54 down Mm.15185 Madh1 102984_g_at U58992 MAD homolog 1 (Drosophila)3300 0.14251 1.48 down Mm.144337 1110059H15Rik 95031_at AW060212 RIKEN cDNA 1110059H15 gene3301 0.14257 3.21 up Mm.2719 Zic1 104169_at D32167 zinc finger protein of the cerebellum 13302 0.14260 1.32 down Mm.3931 Max 99095_at M63903 Max protein3303 0.14268 3.23 down Mm.22682 Pip5k2c 161763_r_at AV303514 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma3304 0.14269 1.22 down Mm.4597 Pctk1 100093_at X69025 PCTAIRE-motif protein kinase 13305 0.14270 2.35 up Mm.4078 Mki67 161931_r_at AV309347 antigen identified by monoclonal antibody Ki 673306 0.14270 3.97 up Mm.32207 Wnt5a 99390_at M89798 wingless-related MMTV integration site 5A3307 0.14278 1.88 up Mm.4829 Etsrp71 101150_at L10427 ets related protein 713308 0.14281 2.07 up Mm.143742 Aig1-pending 103543_at AW208098 acupuncture induced gene 13309 0.14281 1.50 down Mm.24782 Naf1-pending 104755_at AJ242778 Nef-associated factor 13310 0.14291 2.08 up Mm.6898 Birc1a 93461_at AF007769 baculoviral IAP repeat-containing 1a3311 0.14300 1.37 up Mm.23990 AW558298 95886_g_at AA177826 expressed sequence AW5582983312 0.14301 1.65 down Mm.197555 MGC6664 101485_at AW124859 hypothetical protein MGC66643313 0.14301 2.69 up Mm.18658 Adcy7 103392_at U12919 adenylate cyclase 73314 0.14302 2.00 down Mm.3626 2600001J17Rik 160845_at AW214617 RIKEN cDNA 2600001J17 gene3315 0.14304 1.91 up Mm.58 Itgb7 100906_at M68903 integrin beta 73316 0.14304 3.71 up Mm.663 Odf2 100626_at AF034105 outer dense fiber of sperm tails 23317 0.14305 2.94 up Mm.779 Cd5 93637_at M15177 CD5 antigen3318 0.14307 1.51 up Mm.29383 Mm.29383 160804_at AI836524 ESTs, Highly similar to E2BE RAT TRANSLATION INITIATION FACTOR EIF3319 0.14310 2.02 up Mm.2856 Il6ra 104268_at X51975 interleukin 6 receptor, alpha3320 0.14313 1.63 down Mm.29910 Rps6ka1 161419_r_at AV321321 ribosomal protein S6 kinase polypeptide 13321 0.14315 1.26 up Mm.44225 Mrpl17 100040_at AI843081 mitochondrial ribosomal protein L173322 0.14319 1.75 up Mm.24313 Mm.24313 103732_at AI850079 ESTs, Moderately similar to similar to phosphatidylinositol [H.sapiens]3323 0.14330 1.27 up Mm.28470 0910001B06Rik 97907_at AW049564 RIKEN cDNA 0910001B06 gene3324 0.14359 1.81 up Mm.982 Edg1 161788_f_at AV347228 endothelial differentiation sphingolipid G-protein-coupled receptor 13325 0.14361 1.42 up Mm.30150 1010001M12Rik 102097_f_at AI323980 RIKEN cDNA 1010001M12 gene3326 0.14362 2.43 up Mm.1202 Myb 92644_s_at M12848 myeloblastosis oncogene3327 0.14365 2.38 up Mm.88645 Tes 101550_at X78990 testis derived transcript3328 0.14377 1.25 down Mm.21149 Cript-pending 93760_at AI838759 postsynaptic protein Cript3329 0.14387 2.08 up Mm.1682 Ptpns1 95804_g_at D85785 protein tyrosine phosphatase, non-receptor type substrate 13330 0.14388 1.69 up Mm.30805 AI463083 104508_at AA756506 expressed sequence AI463083Page 37 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3331 0.14391 1.25 up Mm.28986 Sqrdl 94515_at AW208628 sulfide quinone reductase-like (yeast)3332 0.14391 2.19 up Mm.6923 Pem 101368_at M32484 placentae and embryos oncofetal gene3333 0.14391 1.47 down Mm.23702 AW495846 104549_at AI844761 expressed sequence AW4958463334 0.14398 1.42 down Mm.144083 0610006I08Rik 96017_at AA710907 RIKEN cDNA 0610006I08 gene3335 0.14407 2.63 up Mm.23845 1600017K21Rik 162349_i_at AV173028 RIKEN cDNA 1600017K21 gene3336 0.14414 2.35 up Mm.24680 Dnpep 95455_at AF005051 aspartyl aminopeptidase3337 0.14424 3.66 up Mm.200430 AW125581 99331_at AW125581 expressed sequence AW1255813338 0.14425 1.63 up Mm.27872 2810411G23Rik 97253_at AI854343 RIKEN cDNA 2810411G23 gene3339 0.14439 1.17 down Mm.38241 Il1rak 98595_at U56773 interleukin 1 receptor-associated kinase3340 0.14441 1.71 down Mm.13264 Rgs11 102650_at AF061934 regulator of G-protein signaling 113341 0.14453 1.18 up Mm.57192 Cyp21a1 103414_at AF049850 cytochrome P450, 21, steroid 21 hydroxylase3342 0.14453 3.28 up Mm.3722 Faf1 98987_at U39643 Fas-associated factor 13343 0.14460 7.00 up Mm.2570 C1qb 96020_at M22531 complement component 1, q subcomponent, beta polypeptide3344 0.14460 1.31 up Mm.4050 Fxc1 99123_s_at AW061280 fractured callus expressed transcript 13345 0.14461 2.67 up Mm.1021 Vcam1 92558_at M84487 vascular cell adhesion molecule 13346 0.14466 1.28 up Mm.6660 Scya27 100972_s_at AW124975 small inducible cytokine A273347 0.14469 2.05 up Mm.153891 Ptp4a3 160862_at AF035645 protein tyrosine phosphatase 4a33348 0.14488 2.16 up Mm.21919 C80248 160677_at AI843114 expressed sequence C802483349 0.14488 2.01 up Mm.20240 Ckmt2 161876_r_at AV082931 creatine kinase, mitochondrial 23350 0.14497 2.03 up Mm.1084 Mm.1084 94131_at AI451173 ESTs3351 0.14512 1.47 up Mm.196310 AU043625 94403_at AW121330 expressed sequence AU0436253352 0.14520 1.99 up Mm.39533 Adam23 92357_at AB009673 a disintegrin and metalloprotease domain 233353 0.14527 2.71 up Mm.1567 Ppp3cc 160948_at M81475 protein phosphatase 3, catalytic subunit, gamma isoform3354 0.14529 1.84 up Mm.215524 AA409442 100774_at AI851233 expressed sequence AA4094423355 0.14554 1.71 up Mm.945 Ptpre 101932_at D83484 protein tyrosine phosphatase, receptor type, E3356 0.14558 2.02 up Mm.21899 C86609 160147_r_at AA422224 expressed sequence C866093357 0.14561 2.01 up Mm.213148 AW492292 161374_f_at AV242583 expressed sequence AW4922923358 0.14574 2.09 up Mm.200513 AI323512 104417_at AW048779 expressed sequence AI3235123359 0.14580 1.29 down Mm.20935 Ilf3 160657_at AI835460 interleukin enhancer binding factor 33360 0.14582 2.12 up Mm.5342 AI853648 99344_at AI853648 expressed sequence AI8536483361 0.14583 1.35 down Mm.34580 Tbk1 98087_at AW048562 TANK-binding kinase 13362 0.14587 1.45 down Mm.19111 Prkaca 103559_at M12303 protein kinase, cAMP dependent, catalytic, alpha3363 0.14619 3.33 up Mm.2658 Mm.2658 162146_r_at AV355197 ESTs3364 0.14623 1.30 down Mm.181538 2610007K22Rik 101962_at AI854884 RIKEN cDNA 2610007K22 gene3365 0.14626 1.88 up Mm.38248 Siat9 98596_s_at Y15003 sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase3366 0.14626 3.33 up Mm.4198 Mm.4198 97780_at AA517845 ESTs3367 0.14634 1.54 up Mm.3727 AA408731 92294_at AW060793 expressed sequence AA4087313368 0.14638 1.93 up Mm.4682 Hoxb3 98780_at U02278 homeo box B33369 0.14640 1.51 down Mm.6402 Terf2 93413_at AF003000 telomeric repeat binding factor 23370 0.14645 1.83 up Mm.5177 Kcnq1 161796_r_at AV367240 potassium voltage-gated channel, subfamily Q, member 13371 0.14647 2.12 up Mm.43017 0610040D20Rik 99615_at AI616209 RIKEN cDNA 0610040D20 gene3372 0.14649 1.69 up Mm.80532 Labh1-pending 160087_at AW060262 lung alpha/beta hydrolase 13373 0.14663 1.95 down Mm.86595 Shc1 93713_at U15784 src homology 2 domain-containing transforming protein C13374 0.14669 2.35 up Mm.3411 Orc2 160838_at U27457 origin recognition complex, subunit 2 homolog (S. cerevisiae)3375 0.14676 2.94 up Mm.4504 Gja1 100064_f_at M63801 gap junction membrane channel protein alpha 13376 0.14687 2.87 up Mm.212716 Mm.212716 97576_f_at AF036738 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6673377 0.14690 2.36 up Mm.8056 Hoxa13 94636_at U59322 homeo box A133378 0.14691 2.90 up Mm.137 Scya6 162198_f_at AV373027 small inducible cytokine A63379 0.14697 1.90 up Mm.42040 Ak4 99521_at AB020239 adenylate kinase 43380 0.14714 1.82 up Mm.196825 5430416A05Rik 102782_at AI172819 RIKEN cDNA 5430416A05 gene3381 0.14717 1.87 up Mm.5002 2210012L08Rik 92971_at AW125849 RIKEN cDNA 2210012L08 gene3382 0.14724 1.76 up Mm.218230 Spi1-1 101572_f_at M75721 serine protease inhibitor 1-13383 0.14726 2.76 up Mm.57144 Fpr-rs4 101802_at AF071182 formyl peptide receptor, related sequence 43384 0.14727 1.61 up Mm.41926 Ndufa4 160477_at AW046205 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 43385 0.14744 1.65 down Mm.42138 Nfe2l3 99527_at AB013852 nuclear factor, erythroid derived 2, like 33386 0.14752 1.29 down Mm.76278 2610203K23Rik 160177_at AW123805 RIKEN cDNA 2610203K23 gene3387 0.14754 2.01 up Mm.7612 Ltf 101115_at J03298 lactotransferrin3388 0.14763 2.68 up Mm.5012 Sh3bp2 162373_r_at AV241207 SH3-domain binding protein 23389 0.14765 1.46 up Mm.21401 Nedd4b 103907_at AW108492 neural precursor cell expressed, developmentally down-regulated gene 4b3390 0.14772 1.73 down Mm.133919 Tcfl1 160363_at D43643 transcription factor-like 13391 0.14773 2.18 up Mm.6256 Fzd9 99844_at Y17709 frizzled homolog 9 (Drosophila)3392 0.14778 1.33 down Mm.29784 4733401P19Rik 95752_at AI837369 RIKEN cDNA 4733401P19 gene3393 0.14786 1.51 down Mm.22560 Dia1 94284_at AW122731 diaphorase 1 (NADH)3394 0.14789 2.09 up Mm.24985 D6Ertd160e 95870_at C78187 DNA segment, Chr 6, ERATO Doi 160, expressed3395 0.14800 1.69 up Mm.57250 Hic1 96994_at AJ132691 hypermethylated in cancer 13396 0.14807 2.33 up Mm.385 2810454G14Rik 99018_at AA874446 RIKEN cDNA 2810454G14 gene3397 0.14816 2.02 up 99589_f_at X076253398 0.14816 1.61 down Mm.4608 Pvt1 92706_at Z12002 plasmacytoma variant translocation 13399 0.14817 1.73 up Mm.27983 Mln64-pending 162228_f_at AV126703 steroidogenic acute regulatory protein related3400 0.14833 5.64 up Mm.196640 2610511G02Rik 161165_f_at AV221664 RIKEN cDNA 2610511G02 gene3401 0.14836 4.13 up Mm.14485 Tex9 102735_at AB000619 testis expressed gene 93402 0.14837 2.25 up Mm.28256 Narg1-pending 103791_at AW048763 NMDA receptor-regulated gene 13403 0.14845 1.87 up Mm.5356 AU016588 161166_i_at AV222721 expressed sequence AU0165883404 0.14854 1.29 up Mm.21553 Mm.21553 104059_at AI851751 ESTs, Weakly similar to KIAA0308 [H.sapiens]3405 0.14860 1.91 down Mm.2485 C1d-pending 95479_at X95591 nuclear DNA binding protein3406 0.14894 1.32 up Mm.24950 D16Ertd36e 103790_at AI846632 DNA segment, Chr 16, ERATO Doi 36, expressed3407 0.14896 1.71 up Mm.27840 D2Wsu23e 100706_f_at AA407367 DNA segment, Chr 2, Wayne State University 23, expressed3408 0.14896 2.49 up Mm.3917 Rrh 100752_at AF012271 retinal pigment epithelium derived rhodopsin homolog3409 0.14908 2.46 up Mm.415 Iapp 99488_at M25389 islet amyloid polypeptide3410 0.14918 2.35 up Mm.4345 Tie1 161184_f_at AV235418 tyrosine kinase receptor 13411 0.14919 3.16 up Mm.7491 Nmi 101424_at AF019249 N-myc (and STAT) interactor3412 0.14923 2.31 up Mm.42022 Gria4 101710_at AB022913 glutamate receptor, ionotropic, AMPA4 (alpha 4)3413 0.14923 2.69 up Mm.36335 D1Wsu40e 162197_at AV372369 DNA segment, Chr 1, Wayne State University 40, expressed3414 0.14926 1.40 down Mm.88212 Tuba6 101543_f_at M13441 tubulin alpha 63415 0.14929 1.78 up Mm.5269 R75531 162109_f_at AV365046 expressed sequence R755313416 0.14933 1.54 down Mm.24642 AW146242 160715_at AI852398 expressed sequence AW1462423417 0.14951 2.13 up Mm.2913 Slc11a1 96562_at L13732 solute carrier family 11 (proton-coupled divalent metal ion transporters), mem3418 0.14955 2.02 up Mm.28508 Mm.28508 98878_r_at AW050141 Mus musculus, Similar to aladin, clone MGC:25579 IMAGE:3994248, mRNA3419 0.14956 1.41 down Mm.20806 Lysal1 93589_at AI851172 lysosomal apyrase-like 13420 0.14959 1.75 up Mm.807 Eif2ak2 93672_at U09928 eukaryotic translation initiation factor 2 alpha kinase 2Page 38 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3421 0.14970 1.66 up Mm.156895 1110020E07Rik 160794_at AI847158 RIKEN cDNA 1110020E07 gene3422 0.14980 1.40 down Mm.201095 C76432 99598_g_at AI841629 expressed sequence C764323423 0.14985 1.71 up Mm.42229 Dsg2 98319_at AJ000328 desmoglein 23424 0.14990 1.76 up Mm.27364 Surf6 96663_at X92842 surfeit gene 63425 0.14996 3.35 up Mm.88822 Or28 96982_g_at AB030892 gene for odorant receptor MOR283426 0.15016 2.62 up Mm.4276 Kcnj6 92524_at U51123 potassium inwardly-rectifying channel, subfamily J, member 63427 0.15018 2.33 up Mm.24295 Mm.24295 103728_at AA183875 ESTs3428 0.15029 2.36 up Mm.27450 Akl3l-pending 92492_at AB020203 adenylate kinase 3 alpha like3429 0.15044 4.55 up Mm.4825 Mmp7 162318_r_at AV069212 matrix metalloproteinase 73430 0.15052 1.72 up Mm.15105 Inpp5d 161678_at AV172408 inositol polyphosphate-5-phosphatase, 145 kDa3431 0.15070 1.71 up Mm.46801 Mm.46801 101720_f_at U30629 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain3432 0.15070 1.74 up Mm.29759 Maz 160355_at L04649 MYC-associated zinc finger protein (purine-binding transcription factor)3433 0.15078 1.27 down Mm.6370 Miz1 100941_at AF039567 Msx-interacting-zinc finger3434 0.15084 1.92 up Mm.29582 Psmc4 95672_at L76223 proteasome (prosome, macropain) 26S subunit, ATPase, 43435 0.15085 2.04 up Mm.14595 Csf2rb1 94747_at M34397 colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macroph3436 0.15087 1.62 up Mm.27997 Rfc5 95612_at AA667128 replication factor C (activator 1) 5 (36.5 kDa)3437 0.15094 2.72 up Mm.42133 Cacna2d3 98300_at AJ010949 calcium channel, voltage dependent, alpha2/delta subunit 33438 0.15094 1.52 down Mm.28052 Ubp1 97304_at AI836100 upstream binding protein 13439 0.15098 1.52 down Mm.32827 Mm.32827 161109_at AV335391 ESTs3440 0.15105 1.39 up Mm.20893 Dncic1 103809_r_at AF063229 dynein, cytoplasmic, intermediate chain 13441 0.15113 1.66 up Mm.8362 Nnmt 101473_at U86108 nicotinamide N-methyltransferase3442 0.15118 2.33 up Mm.1432 Trrp1 94739_at U73625 transient receptor protein 13443 0.15120 1.27 down Mm.27065 Chp-pending 96607_at AW124902 calcium binding protein P223444 0.15123 2.06 up Mm.22220 Fabp3 94214_at X14961 fatty acid binding protein 3, muscle and heart3445 0.15127 1.53 up Mm.150472 Dlx6as 98867_at AI848793 distal-less homeobox 6, antisense3446 0.15128 1.98 up Mm.56966 Ifnab 101317_f_at L38698 interferon alpha family, gene B3447 0.15130 1.40 down Mm.29842 Ndufv1 96267_at AI846127 NADH dehydrogenase flavoprotein 13448 0.15134 1.93 up Mm.3962 Blk 95893_at AA204265 B lymphoid kinase3449 0.15137 3.40 up Mm.4306 Terf1 160879_at AA692742 telomeric repeat binding factor 13450 0.15139 2.14 up Mm.29795 Epcs3-pending 162115_i_at AV368637 ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm3451 0.15151 2.84 up Mm.2547 Dad1 162175_at AV007196 defender against cell death 13452 0.15157 1.83 up Mm.196544 Kars 96324_at AA756724 lysyl-tRNA synthetase3453 0.15161 2.16 up Mm.4609 Pex14 100028_r_at AI881987 peroxisomal biogenesis factor 143454 0.15162 1.31 up Mm.18516 H3f3b 101781_f_at V00754 H3 histone, family 3B3455 0.15164 1.63 up Mm.21798 2810026P18Rik 104089_at AW045664 RIKEN cDNA 2810026P18 gene3456 0.15168 1.48 up Mm.11376 Rpl36 92628_at X75895 ribosomal protein L363457 0.15169 1.36 down Mm.1493 Sox10 102856_at AF047389 SRY-box containing gene 103458 0.15184 2.29 up Mm.3924 Cav3 162297_s_at AV023068 caveolin 33459 0.15190 1.85 up Mm.23742 Nes 103549_at AW061260 nestin3460 0.15191 1.50 up Mm.731 Il12rb1 162408_f_at AV314524 interleukin 12 receptor, beta 13461 0.15204 3.01 down Mm.175302 2610313E07Rik 98490_at AA822412 RIKEN cDNA 2610313E07 gene3462 0.15224 2.48 up Mm.149115 Birc4 93402_i_at U36842 baculoviral IAP repeat-containing 43463 0.15225 2.30 up Mm.4746 Hand1 92766_at U21226 heart and neural crest derivatives expressed transcript 13464 0.15229 2.28 up Mm.16479 2310076D10Rik 162065_r_at AV225351 RIKEN cDNA 2310076D10 gene3465 0.15233 1.30 down Mm.28330 Dnaja3 97868_at AW060270 DnaJ (Hsp40) homolog, subfamily A, member 33466 0.15261 2.26 up Mm.23871 Mm.23871 95396_at AF071754 Mus musculus DNA cytosine methyltransferase mRNA3467 0.15263 2.32 up Mm.56935 Kcnd1 101302_at M64226 potassium voltage-gated channel, Shal-related family, member 13468 0.15274 1.75 up Mm.3300 Ly78 100730_at D37797 lymphocyte antigen 783469 0.15280 1.38 down Mm.5274 Sod1 100538_at M35725 superoxide dismutase 1, soluble3470 0.15283 2.50 up Mm.14191 Klkbp 102707_f_at X61597 kallikrein binding protein3471 0.15287 1.79 up Mm.121 Tnfrsf7 102282_g_at L24495 tumor necrosis factor receptor superfamily, member 73472 0.15295 1.89 up Mm.29420 Mm.29420 96833_at AW048468 ESTs, Highly similar to nuclear ubiquitous casein kinase 2; cyclin-dependen3473 0.15302 3.41 up Mm.1593 Lcat 103023_at J05154 lecithin cholesterol acyltransferase3474 0.15305 2.13 up Mm.57065 Gpr66 99417_at AF044602 G protein-coupled receptor 663475 0.15317 1.35 up Mm.37952 Krt1-24 98998_r_at AF020790 keratin complex 1, acidic, gene 243476 0.15324 1.99 up Mm.35784 Sox3 103301_i_at AA866668 SRY-box containing gene 33477 0.15329 1.38 down Mm.157648 5730403B10Rik 100587_f_at AI843959 RIKEN cDNA 5730403B10 gene3478 0.15332 1.32 up Mm.13437 AW544820 102776_at AI155095 expressed sequence AW5448203479 0.15334 1.96 up Mm.2533 Pax8 96504_at X57487 paired box gene 83480 0.15343 1.27 down Mm.18965 AI854251 160636_at AI854251 expressed sequence AI8542513481 0.15347 2.29 up Mm.56914 Fut10-pending 99375_at Y09882 fucosyltransferase 103482 0.15363 1.60 down Mm.1500 Mcmd4 93041_at D26089 mini chromosome maintenance deficient 4 homolog (S. cerevisiae)3483 0.15375 2.43 up Mm.7995 Fgf13 99893_at AF020737 fibroblast growth factor 133484 0.15379 1.75 down Mm.218091 Mm.218091 97197_r_at C78850 Mouse endogenous murine leukemia virus mRNA, clone L5103485 0.15389 1.22 down Mm.111 Pcbp2 92621_at X97982 poly(rC) binding protein 23486 0.15410 1.20 down Mm.196444 Ubc 162125_f_at AV305832 ubiquitin C3487 0.15410 1.44 down Mm.2931 Flot1 95095_at U90435 flotillin 13488 0.15433 1.60 up Mm.28003 Cbx5 95614_at AI852086 chromobox homolog 5 (Drosophila HP1a)3489 0.15445 2.54 up Mm.93826 Mm.93826 101667_at AA571393 ESTs3490 0.15461 2.63 up Mm.7361 4432411E13Rik 101413_at AI847142 RIKEN cDNA 4432411E13 gene3491 0.15467 1.53 up Mm.27796 5730427N09Rik 97229_at AW061042 RIKEN cDNA 5730427N09 gene3492 0.15468 1.72 up Mm.30264 Mm.30264 162446_at AV351896 ESTs, Moderately similar to T46399 hypothetical protein DKFZp434N2420.13493 0.15473 2.60 up Mm.2549 Hk2 102651_at L41631 hexokinase 23494 0.15476 1.29 down Mm.628 Tcfl4 100935_at U43548 transcription factor-like 43495 0.15483 1.25 down Mm.24108 Mrps21 94912_at AI835592 mitochondrial ribosomal protein S213496 0.15500 2.17 up Mm.21300 Igfbp1 103896_f_at X81579 insulin-like growth factor binding protein 13497 0.15504 1.42 down Mm.30191 2600013G09Rik 102117_at AI844445 RIKEN cDNA 2600013G09 gene3498 0.15506 2.13 up Mm.22360 1200016D08Rik 162092_f_at AV337815 RIKEN cDNA 1200016D08 gene3499 0.15506 1.50 up Mm.212712 Iap 98254_f_at AW209004 intracisternal A particles3500 0.15507 1.36 down Mm.114116 GU2 92226_at AA866971 nucleolar protein GU23501 0.15508 1.38 up Mm.1125 Nme2 92625_at X68193 expressed in non-metastatic cells 2, protein (NM23B) (nucleoside diphospha3502 0.15515 1.74 down Mm.1239 Gfap 94144_g_at X02801 glial fibrillary acidic protein3503 0.15530 1.34 down Mm.218574 6330416C07Rik 95594_at AI847486 RIKEN cDNA 6330416C07 gene3504 0.15533 2.29 up Mm.2326 Mif 94849_at AI848170 macrophage migration inhibitory factor3505 0.15546 2.16 down Mm.14926 Atp7a 102854_s_at U03434 ATPase, Cu++ transporting, alpha polypeptide3506 0.15546 1.50 up Mm.192736 Mm.192736 99585_at AI894122 ESTs, Highly similar to CD82 MOUSE CD82 ANTIGEN [M.musculus]3507 0.15552 1.50 up Mm.29758 Tcp11 97381_s_at X52128 t-complex protein 113508 0.15560 1.87 up Mm.193478 Klra7 97762_f_at U12890 killer cell lectin-like receptor, subfamily A, member 73509 0.15565 1.40 down Mm.24452 Echs1 95426_at AW048512 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial3510 0.15565 1.28 up Mm.259 B3Gat3 94407_at AI835481 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)Page 39 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3511 0.15566 1.84 up Mm.25145 AI847581 96490_at AI847581 expressed sequence AI8475813512 0.15570 1.43 down Mm.6775 Oazi 101002_at AF032128 ornithine decarboxylase antizyme inhibitor3513 0.15579 1.38 down Mm.426 Gstp2 99583_at X53451 glutathione S-transferase, pi 23514 0.15584 1.83 up Mm.27402 2010001P08Rik 162205_f_at AV374357 RIKEN cDNA 2010001P08 gene3515 0.15585 1.77 up Mm.24507 Mm.24507 95164_at AA409213 ESTs3516 0.15585 1.30 down Mm.18946 Ap2m1 93362_at U27106 adaptor protein complex AP-2, mu13517 0.15591 1.63 down Mm.18113 3110038K10Rik 103338_at AW120504 RIKEN cDNA 3110038K10 gene3518 0.15598 1.54 up Mm.29409 4933428G09Rik 104446_f_at AI595812 RIKEN cDNA 4933428G09 gene3519 0.15601 2.53 up Mm.2821 6530401N04Rik 104243_r_at AI835622 RIKEN cDNA 6530401N04 gene3520 0.15601 1.87 up Mm.4641 Tff3 100106_at D38410 trefoil factor 3, intestinal3521 0.15608 3.05 up Mm.5058 Cadps 92989_f_at D86214 Cadependent activator protein for secretion3522 0.15619 2.65 up Mm.4128 Axl 99136_at X63535 AXL receptor tyrosine kinase3523 0.15629 1.99 up Mm.3645 Myo5a 98968_at X57377 myosin Va3524 0.15631 2.09 up 102932_at M813853525 0.15633 1.93 up Mm.27529 D7Ertd348e 95032_at AA856349 DNA segment, Chr 7, ERATO Doi 348, expressed3526 0.15639 1.42 down Mm.8294 Vbp1 101509_at U96760 von Hippel-Lindau binding protein 13527 0.15644 3.16 up Mm.4836 Sgne1 100131_at X15830 secretory granule neuroendocrine protein 1, 7B2 protein3528 0.15646 2.31 down Mm.28774 Mm.28774 96230_at AA790936 ESTs3529 0.15651 2.97 up Mm.87839 Zfy1 98343_s_at AF074549 zinc finger protein 1, Y linked3530 0.15667 1.35 down Mm.200982 AA410023 97551_at AI846182 expressed sequence AA4100233531 0.15669 1.83 up Mm.2338 Glns 99498_at M60803 glutamine synthetase3532 0.15673 1.89 up Mm.8048 H1f3 100280_at X72805 H1 histone family, member 33533 0.15674 2.34 up Mm.23704 Fosl2 103546_at X83971 fos-like antigen 23534 0.15676 1.65 down Mm.2135 Folr1 93785_at M64782 folate receptor 1 (adult)3535 0.15681 2.32 up Mm.7861 Hnrpdl 161372_f_at AV240182 heterogeneous nuclear ribonucleoprotein D-like3536 0.15699 4.78 up Mm.1365 Tyr 102666_at M26729 tyrosinase3537 0.15709 1.44 down Mm.18522 Cpt1a 93320_at AF017175 carnitine palmitoyltransferase 1, liver3538 0.15712 2.56 up Mm.22126 Fabp1 162342_at AV139831 fatty acid binding protein 1, liver3539 0.15733 1.82 down Mm.7800 Itpr5 101442_f_at AF031127 inositol 1,4,5-triphosphate receptor 53540 0.15735 2.13 up Mm.35851 Sap18 161303_at AV054196 Sin3-associated polypeptide 183541 0.15735 1.53 up Mm.34289 H2-Bl 101300_at M26156 histocompatibility 2, blastocyst3542 0.15740 1.29 up Mm.873 Snrp116-pending 101530_at U97079 U5 small nuclear ribonucleoprotein 116 kDa3543 0.15745 2.36 up Mm.17031 Pou5f1 103075_at M34381 POU domain, class 5, transcription factor 13544 0.15752 2.38 up Mm.2523 Myt1l 96497_s_at AI848062 myelin transcription factor 1-like3545 0.15752 1.26 down Mm.1838 Vamp8 93305_f_at AF053724 vesicle-associated membrane protein 83546 0.15758 1.62 up Mm.30020 C77652 160378_at AI853127 expressed sequence C776523547 0.15769 5.65 up Mm.10747 Aif1 102330_at D86382 allograft inflammatory factor 13548 0.15771 1.31 down Mm.5710 2610017J04Rik 93217_at AW049642 RIKEN cDNA 2610017J04 gene3549 0.15781 1.62 up Mm.30282 Ebf3 104492_at U92702 early B-cell factor 33550 0.15782 3.79 up Mm.15528 Pcdha4 160610_at D86916 protocadherin alpha 43551 0.15787 2.17 up Mm.4394 Kit 99956_at Y00864 kit oncogene3552 0.15788 2.90 up Mm.10826 Umod 92605_at L33406 uromodulin3553 0.15793 1.78 up Mm.10693 Sprr2h 94121_at AJ005566 small proline-rich protein 2H3554 0.15795 2.00 down Mm.21712 AW558171 93985_at AW120868 expressed sequence AW5581713555 0.15796 1.86 up Mm.45765 2810417H13Rik 100116_at AI122538 RIKEN cDNA 2810417H13 gene3556 0.15797 3.17 up Mm.10760 Osmr 102255_at AB015978 oncostatin receptor3557 0.15801 1.49 down Mm.11360 AU018154 102352_at AW121380 expressed sequence AU0181543558 0.15801 1.51 down Mm.204698 Mm.204698 97400_at AW122420 Mus musculus, clone MGC:37879 IMAGE:5101205, mRNA, complete cds3559 0.15804 5.02 up Mm.3771 Ptprr 162209_r_at AV378081 protein tyrosine phosphatase, receptor type, R3560 0.15809 3.04 up Mm.57069 LOC56544 101742_at AF053986 tissue-type vomeronasal neurons putative pheromone receptor V2R23561 0.15821 1.36 down Mm.18892 Emd 103420_at U79753 emerin3562 0.15821 1.32 down Mm.24772 Mmrp19-pending 104752_at AB028863 monocyte macrophage 193563 0.15823 1.58 down Mm.1405 Wbp2 92863_at U40826 WW domain binding protein 23564 0.15827 2.85 up Mm.26791 Gnrhr 104013_at L28757 gonadotropin releasing hormone receptor3565 0.15846 1.53 up Mm.10124 Chkl 102026_s_at AB011000 choline kinase-like3566 0.15848 1.26 down Mm.6505 Sptlc1 100608_at X95641 serine palmitoyltransferase, long chain base subunit 13567 0.15853 1.69 up Mm.24868 Mm.24868 160719_at AW049760 Mus musculus, Similar to CGI-147 protein, clone MGC:25743 IMAGE:399003568 0.15859 1.40 down Mm.30071 Laptm4a 96876_at U34259 lysosomal-associated protein transmembrane 4A3569 0.15873 1.45 up Mm.3135 Igfals 97987_at U66900 insulin-like growth factor binding protein, acid labile subunit3570 0.15887 1.79 down Mm.3979 Mm.3979 104019_at AI851068 Mus musculus, Similar to ubiquitin-like 4, clone MGC:19132 IMAGE:42156993571 0.15889 1.33 up Mm.45151 1700043E15Rik 98077_at AA796831 RIKEN cDNA 1700043E15 gene3572 0.15911 1.93 up Mm.21789 1200014D15Rik 104086_at AI787269 RIKEN cDNA 1200014D15 gene3573 0.15920 1.57 down Mm.2862 5730414C17Rik 98917_at AA823202 RIKEN cDNA 5730414C17 gene3574 0.15921 1.26 up Mm.178550 2410026K10Rik 101047_at AW123697 RIKEN cDNA 2410026K10 gene3575 0.15924 2.23 up Mm.278 Guca2b 95569_at U95182 guanylate cyclase activator 2b (retina)3576 0.15925 1.64 down Mm.1532 Mm.1532 162049_f_at AV379304 Mus musculus, clone MGC:31332 IMAGE:4224574, mRNA, complete cds3577 0.15926 1.62 down Mm.201095 C76432 99597_at AI841629 expressed sequence C764323578 0.15927 5.71 up Mm.197 Hoxa1 95297_at M22115 homeo box A13579 0.15933 2.47 up Mm.16148 Musk 94763_at U37709 muscle, skeletal, receptor tyrosine kinase3580 0.15934 1.45 down 96949_at AI8535423581 0.15959 1.65 up Mm.1685 Plxn3 102933_at D86950 plexin 33582 0.15961 2.76 up Mm.59652 Mm.59652 94792_at AI447305 ESTs3583 0.15964 2.05 up Mm.45025 6330409N04Rik 161055_r_at AW047521 RIKEN cDNA 6330409N04 gene3584 0.15967 3.00 up Mm.2608 Bgn 96049_at X53928 biglycan3585 0.15971 1.47 up Mm.88847 Olfr70 97005_at AJ133430 olfactory receptor 703586 0.15976 2.64 up Mm.24169 Cebpa-rs1 94467_at U19892 CCAAT/enhancer binding protein alpha (C/EBP), related sequence 13587 0.15981 1.38 down Mm.28237 AU041521 160277_at AW125618 expressed sequence AU0415213588 0.16004 1.88 up Mm.88850 Zirtl 100373_at AJ243651 zinc-iron transporter-like3589 0.16007 2.23 up Mm.103336 Rara 92901_at M60909 retinoic acid receptor, alpha3590 0.16009 1.59 down Mm.24105 Nude-pending 94910_at AW120739 nuclear distribution gene E homolog (Aspergillus)3591 0.16011 2.75 up Mm.2381 Aplp1 94874_at L04538 amyloid beta (A4) precursor-like protein 13592 0.16035 1.41 down Mm.22485 2610311I19Rik 94273_at AI849067 RIKEN cDNA 2610311I19 gene3593 0.16036 2.14 up Mm.1791 Dusp6 93285_at AI845584 dual specificity phosphatase 63594 0.16042 1.60 down Mm.5242 2900086B20Rik 161057_at AI662504 RIKEN cDNA 2900086B20 gene3595 0.16043 1.69 up Mm.27681 Adam17 160241_at AB021709 a disintegrin and metalloproteinase domain 173596 0.16046 2.88 up Mm.202775 2610007A16Rik 162367_f_at AV233977 RIKEN cDNA 2610007A16 gene3597 0.16050 1.24 down Mm.28145 2700061N24Rik 104237_at AI838071 RIKEN cDNA 2700061N24 gene3598 0.16060 1.32 up Mm.2209 Cd4 98147_at AC002397 CD4 antigen3599 0.16063 4.13 up Mm.93201 Mm.93201 161764_r_at AV334462 ESTs3600 0.16084 1.37 down Mm.21773 Mm.21773 94003_at AI848510 ESTs, Highly similar to AF227741 1 protein kinase WNK1 [R.norvegicus]Page 40 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3601 0.16099 5.31 up Mm.1120 Ebaf 162480_f_at AV101751 endometrial bleeding associated factor3602 0.16107 1.32 up Mm.3785 Ppp2r5c 98993_at U59418 protein phosphatase 2, regulatory subunit B (B56), gamma isoform3603 0.16115 1.96 up Mm.715 Hck 93483_at J03023 hemopoietic cell kinase3604 0.16116 1.47 up Mm.4702 Gnb5 100122_at L34290 guanine nucleotide binding protein, beta 53605 0.16121 2.61 up Mm.1160 AI597080 161168_at AV237606 expressed sequence AI5970803606 0.16121 1.32 down Mm.155 2610204K14Rik 93059_at AI854841 RIKEN cDNA 2610204K14 gene3607 0.16136 1.38 down Mm.100399 Madh4 160440_at U79748 MAD homolog 4 (Drosophila)3608 0.16157 3.47 up Mm.25788 4633402D15Rik 160992_at AI035432 RIKEN cDNA 4633402D15 gene3609 0.16159 1.29 up Mm.3760 Fasn 98575_at X13135 fatty acid synthase3610 0.16160 1.52 down Mm.30435 Tsc2 97951_s_at U37775 tuberous sclerosis 23611 0.16162 1.73 up Mm.3499 Rax 97149_at U73177 retina and anterior neural fold homeobox3612 0.16168 1.52 up Mm.21545 Tdo2 93827_at U24493 tryptophan 2,3-dioxygenase3613 0.16170 1.45 up Mm.4824 Syt3 92916_at D45858 synaptotagmin 33614 0.16178 2.00 up Mm.263 Reg3g 96064_at D63362 regenerating islet-derived 3 gamma3615 0.16183 2.96 up Mm.157101 C330007P06Rik 103696_r_at AW047329 RIKEN cDNA C330007P06 gene3616 0.16187 2.88 up Mm.25046 Mm.25046 95987_at C80377 ESTs3617 0.16188 1.65 up Mm.1834 Lyn 103349_at M57696 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog3618 0.16205 1.99 up Mm.1302 Sfpi1 102641_at L03215 SFFV proviral integration 13619 0.16247 1.54 up Mm.14198 Edr2 92867_at AF060076 early development regulator 2 (homolog of polyhomeotic 2)3620 0.16249 2.07 up Mm.29065 0610006N12Rik 94541_at AI839549 RIKEN cDNA 0610006N12 gene3621 0.16255 1.80 up Mm.43612 Ogg1 160882_at AF012916 8-oxoguanine DNA-glycosylase 13622 0.16261 3.03 up Mm.2535 Mata2-pending 96505_at U88401 metastasis associated 23623 0.16263 1.34 up Mm.21184 D2Wsu58e 162311_f_at AV050648 DNA segment, Chr 2, Wayne State University 58, expressed3624 0.16272 1.39 down Mm.2566 Ang 94392_f_at U22516 angiogenin3625 0.16282 1.58 down Mm.88793 Fga 101553_at AI876446 fibrinogen, alpha polypeptide3626 0.16284 1.85 up Mm.3730 Sema3e 96097_at AI847973 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se3627 0.16288 1.66 up Mm.12860 D0Kist8 102305_at AB016602 DNA segment, KIST 83628 0.16290 1.63 down Mm.9901 Nucb2 102197_at AJ222586 nucleobindin 23629 0.16291 1.16 down Mm.196635 2010005E08Rik 101067_at AW124711 RIKEN cDNA 2010005E08 gene3630 0.16307 1.81 down Mm.29088 0610013D04Rik 96785_at AF110520 RIKEN cDNA 0610013D04 gene3631 0.16307 2.27 up Mm.4421 Tph 99972_at J04758 tryptophan hydroxylase3632 0.16312 1.22 down Mm.18561 Cyhr1 103467_g_at AA790056 cysteine and histidine rich 13633 0.16316 5.94 up Mm.1722 2810012G08Rik 102942_at AA683785 RIKEN cDNA 2810012G08 gene3634 0.16323 1.36 down Mm.30270 Psma4 97459_at AI851441 proteasome (prosome, macropain) subunit, alpha type 43635 0.16331 1.92 up Mm.28280 Renbp 161153_r_at AV211623 renin binding protein3636 0.16334 1.89 down Mm.173818 Mm.173818 102133_at AI158971 ESTs, Weakly similar to ZINC FINGER PROTEIN ZFP-90 [M.musculus]3637 0.16358 1.37 up Mm.90115 Lypla1 101944_at U89352 lysophospholipase 13638 0.16367 1.39 down Mm.196484 Csrp 160065_s_at AI837625 cysteine rich protein3639 0.16380 1.31 up Mm.25785 Ldb2 93682_at U89489 LIM domain binding 23640 0.16387 1.72 up Mm.130322 Paf53-pending 98021_at D14336 RNA polymerase I associated factor, 53 kD3641 0.16402 3.04 up Mm.24301 2310067L16Rik 103730_at AI414756 RIKEN cDNA 2310067L16 gene3642 0.16402 2.87 up Mm.969 Mm.969 93963_at AA200748 ESTs3643 0.16420 3.22 up Mm.104747 Igk-V28 102553_at Z70662 immunoglobulin kappa chain variable 28 (V28)3644 0.16424 3.67 up Mm.22519 5230400M11Rik 104336_at AI843273 RIKEN cDNA 5230400M11 gene3645 0.16424 1.31 down Mm.29398 D19Wsu162e 96829_at AW047083 DNA segment, Chr 19, Wayne State University 162, expressed3646 0.16437 7.03 up Mm.34927 Mm.34927 97135_at C76313 ESTs3647 0.16438 2.80 up Mm.18921 Vcp 161550_r_at AV246219 valosin containing protein3648 0.16445 1.88 up Mm.28483 D530048A03Rik 95883_at AW048355 RIKEN cDNA D530048A03 gene3649 0.16451 1.84 up Mm.218862 Mm.218862 101532_g_at AI527354 Mus musculus, clone MGC:25455 IMAGE:4241025, mRNA, complete cds3650 0.16462 1.88 up Mm.5398 Mm.5398 97598_at AW209139 EST3651 0.16480 1.45 down Mm.215 Hoxb6 103445_at M18401 homeo box B63652 0.16481 2.75 up Mm.18 1-Sep 102962_at M37030 septin 13653 0.16484 2.90 up Mm.140155 Tlbp 94927_at U96149 testis lipid binding protein3654 0.16484 3.06 up Mm.4784 Gad2 92899_at D42051 glutamic acid decarboxylase 23655 0.16501 1.74 down Mm.4040 Myo6 92382_at U49739 myosin VI3656 0.16504 1.53 up 101445_at AF0360083657 0.16505 1.52 up Mm.5510 Mm.5510 93187_at AW048347 Mus musculus, Similar to gene overexpressed in astrocytoma, clone IMAGE3658 0.16508 1.39 down Mm.197479 Foxp1 96183_at AW122985 forkhead box P13659 0.16511 1.62 up Mm.3929 Zfhx1a 99052_at D76432 zinc finger homeobox 1a3660 0.16521 1.66 up Mm.203041 AW215585 102920_at AW215585 expressed sequence AW2155853661 0.16526 1.24 up Mm.871 Rfng 101858_at AF015770 radical fringe gene homolog, (Drosophila)3662 0.16553 1.69 up Mm.180561 Rbpsuh 101902_at X17459 recombining binding protein suppressor of hairless (Drosophila)3663 0.16561 1.92 up Mm.5875 Prss8 100909_at AA760364 protease, serine, 8 (prostasin)3664 0.16566 1.73 down Mm.19353 LOC56304 97563_f_at AF042798 recombinant antineuraminidase single chain Ig VH and VL domains3665 0.16568 1.56 down Mm.10088 Dtnb 102210_at AJ003007 dystrobrevin, beta3666 0.16571 2.17 up Mm.15617 Il11ra1 93065_at U14412 interleukin 11 receptor, alpha chain 13667 0.16578 2.20 up Mm.21458 1810009A16Rik 161314_r_at AV086272 RIKEN cDNA 1810009A16 gene3668 0.16583 1.97 up Mm.20323 5830400A04Rik 103231_at AA739233 RIKEN cDNA 5830400A04 gene3669 0.16594 1.55 down Mm.3766 Ppm1a 98580_at D28117 protein phosphatase 1A, magnesium dependent, alpha isoform3670 0.16597 1.52 down Mm.14352 Sel1h 92870_at AF063095 Sel1 (suppressor of lin-12) 1 homolog (C. elegans)3671 0.16600 1.64 up Mm.37369 1110037N09Rik 160824_at AI852741 RIKEN cDNA 1110037N09 gene3672 0.16605 1.66 up Mm.1291 Tgfb3 102751_at M32745 transforming growth factor, beta 33673 0.16614 2.40 up Mm.3899 Hcngp-pending 161662_f_at AV124076 transcriptional regulator protein3674 0.16615 1.58 down Mm.34790 AA407033 160432_at AI853062 expressed sequence AA4070333675 0.16617 1.31 down Mm.3965 Stam 92360_at U43900 signal transducing adaptor molecule (SH3 domain and ITAM motif) 13676 0.16622 3.04 up Mm.3246 Frzb 104672_at U68058 frizzled-related protein3677 0.16623 1.79 up Mm.16251 Psmb9 93085_at D44456 proteosome (prosome, macropain) subunit, beta type 9 (large multifunctiona3678 0.16625 1.35 down Mm.3126 Fhl1 97500_g_at AI839950 four and a half LIM domains 13679 0.16629 2.13 up Mm.3085 6230425C21Rik 97967_at AA881438 RIKEN cDNA 6230425C21 gene3680 0.16630 1.85 up Mm.27571 1110007C05Rik 95041_at AI846165 RIKEN cDNA 1110007C05 gene3681 0.16634 1.41 down Mm.29186 Dnaja2 95068_at AA763945 DnaJ (Hsp40) homolog, subfamily A, member 23682 0.16638 2.27 up Mm.9277 Pla2g7 101923_at U34277 phospholipase A2 group VII (platelet-activating factor acetylhydrolase, plasm3683 0.16648 2.25 up Mm.46754 AI316867 162233_r_at AV325582 expressed sequence AI3168673684 0.16649 1.86 up Mm.2419 Cdh4 95898_at X69966 cadherin 43685 0.16657 1.55 up Mm.44501 2500002G23Rik 104353_at AW047921 RIKEN cDNA 2500002G23 gene3686 0.16664 1.62 up Mm.28050 Cd2bp2 160766_at AA733868 CD2 antigen (cytoplasmic tail) binding protein 23687 0.16666 1.63 down Mm.3344 2600001M11Rik 104693_at AA260145 RIKEN cDNA 2600001M11 gene3688 0.16679 3.75 up Mm.2185 Bub1 162264_s_at AV359014 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)3689 0.16690 1.16 down Mm.4896 Rpo2-4 100461_at D85818 RNA polymerase II 4 (14 kDa subunit)3690 0.16697 2.09 up Mm.3514 Gdf8 97155_at U84005 growth differentiation factor 8Page 41 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3691 0.16699 1.26 down Mm.27087 2010012C24Rik 96611_at AI843074 RIKEN cDNA 2010012C24 gene3692 0.16700 1.67 up Mm.212716 Mm.212716 100360_f_at X02466 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6673693 0.16716 1.41 up Mm.45712 Mm.45712 161670_f_at AV140884 ESTs3694 0.16724 1.68 up Mm.5777 C78986 101599_at C78986 expressed sequence C789863695 0.16750 1.27 down Mm.27656 Asb6 160748_at AW124849 ankyrin repeat and SOCS box-containing protein 63696 0.16757 1.66 up Mm.5400 Brd7 100544_at AW125534 bromodomain-containing 73697 0.16757 1.69 up Mm.133447 Smarca5 93701_at AA982124 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,3698 0.16761 1.64 up Mm.6378 AW122246 93410_at AW120840 expressed sequence AW1222463699 0.16771 1.82 up Mm.5286 Arbp 162353_at AV157339 acidic ribosomal phosphoprotein PO3700 0.16778 2.28 down Mm.27982 Mm.27982 97283_at AI606389 Mus musculus stella mRNA, complete cds3701 0.16782 1.46 down Mm.28842 Clcn3 94464_at AF029347 chloride channel 33702 0.16788 1.17 down Mm.22001 Dpm2 94052_at AB013360 dolichol-phosphate (beta-D) mannosyltransferase 23703 0.16799 1.71 up Mm.4994 Tnfsf4 101164_at U12763 tumor necrosis factor (ligand) superfamily, member 43704 0.16812 2.44 up Mm.12834 Lfng 160601_at AF015768 lunatic fringe gene homolog (Drosophila)3705 0.16813 1.37 up Mm.4712 Itgb1 100124_r_at X15202 integrin beta 1 (fibronectin receptor beta)3706 0.16817 2.04 up Mm.4733 Cdkn2a 98789_at AF044336 cyclin-dependent kinase inhibitor 2A3707 0.16818 3.12 up Mm.27086 2410012A13Rik 161748_r_at AV322550 RIKEN cDNA 2410012A13 gene3708 0.16820 1.91 up Mm.3022 Mm.3022 96579_at AA267568 ESTs3709 0.16820 1.42 up Mm.19126 4930534K13Rik 103563_at AW125713 RIKEN cDNA 4930534K13 gene3710 0.16831 2.22 up Mm.23172 4930472G13Rik 92230_at AI642033 RIKEN cDNA 4930472G13 gene3711 0.16834 1.92 down Mm.41456 Pcp2 162452_at AV028792 Purkinje cell protein 2 (L7)3712 0.16836 1.59 down Mm.4913 Fst 98817_at Z29532 follistatin3713 0.16840 1.41 down Mm.21932 2700060E02Rik 94038_at AA675468 RIKEN cDNA 2700060E02 gene3714 0.16846 2.31 up Mm.4611 Chrna7 101131_at L37663 cholinergic receptor, nicotinic, alpha polypeptide 73715 0.16855 1.45 down Mm.29500 Mm.29500 95648_at AA655507 Mus musculus, hypothetical protein FLJ10788, clone MGC:6884 IMAGE:2653716 0.16856 1.36 up Mm.44218 2610042O14Rik 99677_at AI849559 RIKEN cDNA 2610042O14 gene3717 0.16862 1.56 up Mm.18228 5430432M24Rik 103343_at AI845815 RIKEN cDNA 5430432M24 gene3718 0.16864 1.98 up Mm.10758 Mm.10758 102254_f_at AA289585 Mus musculus clone L2 uniform group of 2-cell-stage gene family mRNA, co3719 0.16878 1.16 up Mm.29743 Mm.29743 95732_at AW047746 Mus musculus, Similar to hypothetical protein MGC3133, clone MGC:115963720 0.16900 2.12 up Mm.14437 H2-M3 102730_at AA163474 histocompatibility 2, M region locus 33721 0.16902 1.61 up Mm.7973 Ids 99883_g_at L07921 iduronate 2-sulfatase3722 0.16908 1.44 down Mm.34778 Fto 98460_at AJ237917 fatso3723 0.16912 1.71 up Mm.73650 Mm.73650 162366_r_at AV233144 ESTs3724 0.16925 2.36 up Mm.154890 Sars2-pending 161339_f_at AV126830 seryl-aminoacyl-tRNA synthetase 23725 0.16942 1.67 up Mm.41523 6330416G13Rik 161029_at AI849583 RIKEN cDNA 6330416G13 gene3726 0.16950 1.76 up Mm.18843 Tgm2 93352_at M55154 transglutaminase 2, C polypeptide3727 0.16951 1.60 down Mm.28278 Cav 160280_at AI747654 caveolin, caveolae protein, 22 kDa3728 0.16956 1.74 up Mm.27915 Nxn 97270_at X92750 nucleoredoxin3729 0.16961 4.49 up Mm.1810 Ctgf 93294_at M70642 connective tissue growth factor3730 0.16976 1.90 up Mm.1662 Fxyd3 103059_at X93038 FXYD domain-containing ion transport regulator 33731 0.16978 2.07 up Mm.14135 Mcpt1 94728_f_at X68803 mast cell protease 13732 0.16980 2.34 up Mm.32990 Pigm 162405_at AV283870 phosphatidylinositol glycan, class M3733 0.16984 2.37 up Mm.29351 Tiaf1 102080_at AF104984 TGF-beta1-induced anti-apoptotic factor 13734 0.16989 1.86 up Mm.2235 Rpl29 94240_i_at L08651 ribosomal protein L293735 0.16990 3.32 up Mm.54162 Kcnb1 101308_at M64228 potassium voltage gated channel, Shab-related subfamily, member 13736 0.16992 3.51 up Mm.29923 Smt3h2 96316_at AI839289 SMT3 (supressor of mif two, 3) homolog 2 (S. cerevisiae)3737 0.16999 1.84 up Mm.12903 Sema3f 102623_at AF080090 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se3738 0.17009 1.37 down Mm.1458 Pps 102836_at U96724 putative phosphatase3739 0.17011 1.55 down Mm.103605 Dnajb10 98451_at AI843164 DnaJ (Hsp40) homolog, subfamily B, member 103740 0.17028 2.40 up Mm.30502 2210039B01Rik 160906_i_at AA184423 RIKEN cDNA 2210039B01 gene3741 0.17033 1.82 up Mm.1032 Hspa4 100352_at AA919208 heat shock 70 kDa protein 43742 0.17040 2.07 up Mm.73777 2810405I11Rik 161513_r_at AV164757 RIKEN cDNA 2810405I11 gene3743 0.17041 1.38 up Mm.24208 AI882074 103723_at AA608387 expressed sequence AI8820743744 0.17050 2.07 up Mm.1764 Gabpb1 161341_f_at AV135160 GA repeat binding protein, beta 13745 0.17050 1.63 up Mm.28308 Nkx6-2 93182_at L08074 NK6 transcription factor related, locus 2 (Drosophila)3746 0.17068 1.65 up Mm.174295 Mm.174295 102103_f_at AI482454 ESTs3747 0.17073 2.01 up Mm.1291 Tgfb3 161382_at AV246832 transforming growth factor, beta 33748 0.17074 1.65 up Mm.43167 AI451582 99924_at AW121845 expressed sequence AI4515823749 0.17079 1.96 up Mm.4265 Zic3 98330_at D70849 zinc finger protein of the cerebellum 33750 0.17080 2.32 up Mm.57138 Six6 101797_at AJ011787 sine oculis-related homeobox 6 homolog (Drosophila)3751 0.17083 1.31 down Mm.188 Pgk1 93346_at M15668 phosphoglycerate kinase 13752 0.17085 1.30 down Mm.214594 2410112O06Rik 93859_at AI875598 RIKEN cDNA 2410112O06 gene3753 0.17088 1.33 down Mm.89579 Mpdu1 101901_at AB024713 mannose-P-dolichol utilization defect 13754 0.17091 1.30 up Mm.2831 Nap1l4 97860_at AJ002198 nucleosome assembly protein 1-like 43755 0.17100 1.98 up Mm.4369 Adrb3 92536_at X72862 adrenergic receptor, beta 33756 0.17106 2.28 up Mm.142717 Itmap1 162196_f_at AV059956 integral membrane-associated protein 13757 0.17110 1.57 down Mm.17932 Pnp 93290_at U35374 purine-nucleoside phosphorylase3758 0.17123 1.42 down Mm.3476 Catnb 160430_at M90364 catenin beta3759 0.17128 1.78 down Mm.206799 D9Wsu18e 103789_at AI854614 DNA segment, Chr 9, Wayne State University 18, expressed3760 0.17150 1.39 down Mm.7051 Rdx 101056_at X60672 radixin3761 0.17161 1.45 up Mm.7454 AI662457 101102_at AJ223156 expressed sequence AI6624573762 0.17164 1.57 down Mm.26743 Apoa1 101529_g_at D00925 apolipoprotein A-I3763 0.17165 1.78 up Mm.41791 Gpm6b 99178_at AI845652 glycoprotein m6b3764 0.17165 2.37 up Mm.42148 Foxm1 98305_at Y11245 forkhead box M13765 0.17176 1.39 down Mm.18249 2610027H02Rik 103345_at AW046708 RIKEN cDNA 2610027H02 gene3766 0.17179 2.12 up Mm.22635 AA415817 97713_at AW214336 expressed sequence AA4158173767 0.17180 1.32 down Mm.30116 5730494N06Rik 97916_at AI116222 RIKEN cDNA 5730494N06 gene3768 0.17183 2.04 up Mm.5109 Hsd17b3 101184_at U66827 hydroxysteroid 17-beta dehydrogenase 33769 0.17184 2.24 up Mm.1741 Relb 162372_f_at AV240218 avian reticuloendotheliosis viral (v-rel) oncogene related B3770 0.17188 2.22 up Mm.34556 Car14 161434_r_at AV308641 carbonic anhydrase 143771 0.17194 2.64 up Mm.20286 4632419J12Rik 160951_at AI645694 RIKEN cDNA 4632419J12 gene3772 0.17196 2.85 up Mm.16091 Scya7 94761_at X70058 small inducible cytokine A73773 0.17206 1.48 down Mm.25157 2410001C21Rik 95501_at AW122970 RIKEN cDNA 2410001C21 gene3774 0.17210 1.36 up Mm.21761 Ifrg15-pending 93997_at AI853475 interferon alpha responsive gene, 15 kDa3775 0.17211 2.66 up Mm.4656 Sox6 161211_r_at AV246999 SRY-box containing gene 63776 0.17212 3.10 up Mm.6272 Cmkbr2 93397_at U56819 chemokine (C-C) receptor 23777 0.17216 1.88 up Mm.33240 Eva 94125_at AF030454 epithelial V-like antigen3778 0.17217 2.22 up Mm.197554 Ahsg 99862_at AF025821 alpha-2-HS-glycoprotein3779 0.17220 3.22 up Mm.3686 AA408251 97194_at AA408251 expressed sequence AA4082513780 0.17221 1.91 up Mm.2605 Rbp4 96047_at U63146 retinol binding protein 4, plasmaPage 42 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3781 0.17224 1.85 up Mm.4902 AA517023 101154_at AA517023 expressed sequence AA5170233782 0.17224 1.30 down Mm.25311 1810015C04Rik 95518_at AW122893 RIKEN cDNA 1810015C04 gene3783 0.17232 1.30 up Mm.27933 Poh1-pending 97274_at Y13071 26S proteasome-associated pad1 homolog3784 0.17234 1.50 down Mm.27074 2610019N13Rik 96609_at AW122195 RIKEN cDNA 2610019N13 gene3785 0.17240 1.55 up Mm.41307 2610014F08Rik 92421_at AI846645 RIKEN cDNA 2610014F08 gene3786 0.17270 1.88 up Mm.87312 Gmfb 101860_at AA756568 glia maturation factor, beta3787 0.17273 2.52 up Mm.135 Cln3 161643_i_at AV076916 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)3788 0.17277 2.96 up Mm.42226 Matn3 102089_at Y10521 matrilin 33789 0.17287 1.77 up Mm.14418 Tesp2 94741_at AB008911 testicular serine protease 23790 0.17288 1.42 up Mm.2240 1110013B16Rik 104312_at AW123271 RIKEN cDNA 1110013B16 gene3791 0.17293 1.63 down Mm.24965 D2Ertd63e 95862_at C77692 DNA segment, Chr 2, ERATO Doi 63, expressed3792 0.17293 1.66 up Mm.25806 AA986477 160212_at AW050205 expressed sequence AA9864773793 0.17294 1.88 up Mm.4745 Ksr 92764_at U43585 kinase suppressor of ras3794 0.17307 1.68 up Mm.21353 Mm.21353 103903_at AW122472 ESTs, Weakly similar to DnaJ (Hsp40) homolog, subfamily B, member 6; ma3795 0.17309 1.60 up Mm.29550 Mm.29550 97335_at AA795198 Mus musculus, clone MGC:36283 IMAGE:4158605, mRNA, complete cds3796 0.17315 1.55 down Mm.18941 1190006E07Rik 160112_at AI852865 RIKEN cDNA 1190006E07 gene3797 0.17316 2.35 up Mm.27857 2410088E07Rik 95584_at AA794108 RIKEN cDNA 2410088E07 gene3798 0.17323 1.90 up Mm.42823 6530413N01Rik 99553_f_at AI842002 RIKEN cDNA 6530413N01 gene3799 0.17325 1.44 down Mm.182232 1110018N24Rik 94868_at AW049812 RIKEN cDNA 1110018N24 gene3800 0.17338 2.46 up Mm.46754 AI316867 161954_r_at AV362664 expressed sequence AI3168673801 0.17338 6.57 up Mm.4482 Col1a2 101130_at X58251 procollagen, type I, alpha 23802 0.17348 1.26 down Mm.22362 H47 94245_at AW125865 histocompatibility 473803 0.17354 2.18 up Mm.9154 Tgfb1 101918_at AJ009862 transforming growth factor, beta 13804 0.17364 1.37 up Mm.3285 3110056O03Rik 98029_at AW060459 RIKEN cDNA 3110056O03 gene3805 0.17377 1.38 up Mm.30266 Hbb-b1 162457_f_at AV003378 hemoglobin, beta adult major chain3806 0.17380 1.42 down Mm.41 Atp5o 99128_at AI849767 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit3807 0.17382 1.87 up Mm.4139 Rtkn 160864_at U54638 rhotekin3808 0.17384 1.70 up Mm.6251 Tnfrsf11a 101632_at AF019046 tumor necrosis factor receptor superfamily, member 11a3809 0.17387 1.22 down Mm.28202 D16Ertd269e 97823_g_at AW122689 DNA segment, Chr 16, ERATO Doi 269, expressed3810 0.17389 1.90 up Mm.200941 Saa2 103465_f_at U60438 serum amyloid A 23811 0.17390 4.01 up Mm.219554 Pcdha13 101770_i_at AB008180 protocadherin alpha 133812 0.17397 1.83 down Mm.28551 Sudd 161551_f_at AV247682 sudD, suppressor of bimD6 homolog (Aspergillus nidulans)3813 0.17397 2.00 up Mm.27491 Map2k4 99960_at U18310 mitogen activated protein kinase kinase 43814 0.17406 1.52 up Mm.4215 Cas1 160479_at M29394 catalase 13815 0.17410 1.60 down Mm.28626 2410018G23Rik 98920_g_at AA867773 RIKEN cDNA 2410018G23 gene3816 0.17416 2.48 up Mm.30290 Capn6 97941_at Y12582 calpain 63817 0.17428 2.63 up Mm.213198 Mm.213198 99342_at M60596 Mus musculus gamma-aminobutyric acid (GABA-A) receptor, subunit delta (G3818 0.17431 1.44 up Mm.22279 Casp8ap2 104290_at AI847837 caspase 8 associated protein 23819 0.17432 1.41 up Mm.56903 Gpr44 101282_at AF054507 G protein-coupled receptor 443820 0.17435 1.63 up Mm.179747 Itga7 93061_at L23423 integrin alpha 73821 0.17443 1.18 down Mm.27220 Nfyc 94968_at AW048793 nuclear transcription factor-Y gamma3822 0.17444 1.48 down Mm.9248 Adprt1 101957_f_at X14206 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 13823 0.17444 1.22 down Mm.4222 Tpi 99566_at L31777 triosephosphate isomerase3824 0.17445 1.90 up Mm.19946 S100a5 95301_at AF087469 S100 calcium binding protein A53825 0.17446 1.39 up Mm.29717 Ywhag 95716_at AW125041 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma po3826 0.17454 1.86 up Mm.28050 Cd2bp2 162099_f_at AV360307 CD2 antigen (cytoplasmic tail) binding protein 23827 0.17456 3.43 up Mm.29170 Fbxw5 96798_r_at AW122681 f-box and WD-40 domain protein 53828 0.17464 2.16 up Mm.20424 Fgf18 95316_at AB004639 fibroblast growth factor 183829 0.17477 1.95 up Mm.79266 Mm.79266 162084_i_at AV314213 EST3830 0.17481 1.30 down Mm.21251 Dp1 96115_at U28168 deleted in polyposis 13831 0.17485 1.63 up Mm.156 Dok1 102896_at U78818 downstream of tyrosine kinase 13832 0.17488 1.23 up Mm.23868 Mm.23868 160964_at AI838494 Mus musculus brain cDNA, clone MNCb-41373833 0.17498 1.71 up Mm.17306 Tpm3 93265_at X53753 tropomyosin 3, gamma3834 0.17498 2.21 up Mm.38548 Rgs9 99907_at AF011358 regulator of G-protein signaling 93835 0.17502 1.22 up Mm.21880 Prss25 161446_r_at AV353694 protease, serine, 253836 0.17508 2.37 up Mm.182913 Csnk1d 97264_r_at AI846289 casein kinase 1, delta3837 0.17520 1.73 up Mm.1262 Cyp17 102416_at M64863 cytochrome P450, 173838 0.17524 1.44 down Mm.36769 Slap 98553_at AW124175 sarcolemmal-associated protein3839 0.17526 1.64 up Mm.12967 Ikbkg 94196_at AF069542 inhibitor of kappaB kinase gamma3840 0.17533 2.44 up Mm.1296 Tpx1 92825_at M25533 testis specific gene 13841 0.17535 1.33 up Mm.2973 Pkd1 97375_at U70209 polycystic kidney disease 1 homolog3842 0.17541 2.51 up Mm.360 Cox5a 160438_at X15963 cytochrome c oxidase, subunit Va3843 0.17566 2.14 down Mm.27816 Hexb 97232_at U07049 hexosaminidase B3844 0.17570 1.54 down Mm.6259 Slc4a1ap 93396_at AF035526 solute carrier family 4 (anion exchanger), member 1, adaptor protein3845 0.17576 1.86 up Mm.196574 Grhpr 95085_r_at AI844995 glyoxylate reductase/hydroxypyruvate reductase3846 0.17589 1.65 down Mm.2304 AI646383 95382_at AI646383 expressed sequence AI6463833847 0.17593 1.68 up Mm.16898 Phgdh 162168_r_at AV361953 3-phosphoglycerate dehydrogenase3848 0.17593 1.74 up Mm.12809 Gucy2e 98727_at L41933 guanylate cyclase 2e3849 0.17597 1.60 up Mm.24462 AA407619 95913_at AI661057 expressed sequence AA4076193850 0.17599 1.77 up Mm.8029 Sema6b 99911_at AF036585 sema domain, transmembrane domain (TM), and cytoplasmic domain, (sema3851 0.17604 1.64 down Mm.142364 Star 92213_at L36062 steroidogenic acute regulatory protein3852 0.17604 2.21 up Mm.153729 2210010C04Rik 101839_at AE000663 RIKEN cDNA 2210010C04 gene3853 0.17608 2.73 up Mm.4949 Pdx1 98821_at X74342 pancreatic and duodenal homeobox gene 13854 0.17615 2.41 up Mm.79380 Lhx9 93643_at AJ243851 LIM homeobox protein 93855 0.17626 1.27 down Mm.34609 D5Wsu111e 98092_at AA790307 DNA segment, Chr 5, Wayne State University 111, expressed3856 0.17630 1.79 up Mm.5181 Rnf19 161814_f_at AV355427 ring finger protein (C3HC4 type) 193857 0.17635 1.81 up Mm.40323 Mm.40323 160860_at AI853332 Mus musculus, clone IMAGE:4224368, mRNA, partial cds3858 0.17642 2.16 up Mm.2144 Evl 160667_at U72519 Ena-vasodilator stimulated phosphoprotein3859 0.17646 2.47 up Mm.10658 Gsta1 160063_i_at M19256 glutathione S-transferase, alpha 1 (Ya)3860 0.17655 2.02 up 101731_at M123743861 0.17660 1.27 down Mm.26940 Cbr1 96110_at U31966 carbonyl reductase 13862 0.17663 1.28 up Mm.10125 Cdv1 102215_at Y10495 carnitine deficiency-associated gene expressed in ventricle 13863 0.17666 1.34 down Mm.6407 D9Ertd280e 161075_at AI226337 DNA segment, Chr 9, ERATO Doi 280, expressed3864 0.17669 2.26 up Mm.46207 Mm.46207 161843_at AV003017 ESTs3865 0.17671 1.76 up Mm.25012 C79130 95880_s_at C79086 expressed sequence C791303866 0.17680 1.29 down Mm.2204 Mm.2204 160679_at AW121381 Mus musculus, clone MGC:28766 IMAGE:4485843, mRNA, complete cds3867 0.17688 2.80 up Mm.197552 Tgfbr1 92427_at D25540 transforming growth factor, beta receptor I3868 0.17691 1.72 up Mm.12440 Rnasep2-pending 160071_at U95123 ribonuclease P23869 0.17696 1.66 up Mm.2923 Il2rg 96807_at X75337 interleukin 2 receptor, gamma chain3870 0.17719 1.54 up Mm.7984 Zan 99888_at U83190 zonadhesinPage 43 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3871 0.17736 2.16 down Mm.5277 R74640 93159_at AW122995 expressed sequence R746403872 0.17737 2.11 up Mm.20304 Bat2 95311_at AF073932 HLA-B associated transcript 23873 0.17740 2.68 up Mm.4486 Klk6 100060_i_at M13500 kallikrein 63874 0.17742 1.51 up Mm.21075 Calm4 93744_at AI119347 calmodulin 43875 0.17742 1.75 up Mm.29811 1190002H23Rik 160359_at AI854358 RIKEN cDNA 1190002H23 gene3876 0.17743 4.02 up Mm.2639 Ly86 94425_at AB007599 lymphocyte antigen 863877 0.17743 1.71 up Mm.21129 2210409E12Rik 103867_at AA822813 RIKEN cDNA 2210409E12 gene3878 0.17748 3.31 up Mm.2254 Emr1 161377_at AV244683 EGF-like module containing, mucin-like, hormone receptor-like sequence 13879 0.17754 2.79 up Mm.4073 Acrbp 99456_at D17573 proacrosin binding protein3880 0.17763 1.28 down Mm.196365 4833416I09Rik 98908_at AW125510 RIKEN cDNA 4833416I09 gene3881 0.17765 1.86 up Mm.20455 G2a-pending 94566_at AF083442 G protein-coupled receptor G2A3882 0.17773 1.62 up Mm.6332 Alox15b 99848_at Y14696 arachidonate 15-lipoxygenase, second type3883 0.17780 2.34 up Mm.2209 Cd4 99238_at AC002397 CD4 antigen3884 0.17786 1.22 up Mm.38173 6030457N17Rik 160448_at AI646750 RIKEN cDNA 6030457N17 gene3885 0.17790 1.33 down Mm.28984 D10Jhu81e 96757_at AI852165 DNA segment, Chr 10, Johns Hopkins University 81 expressed3886 0.17792 1.58 up Mm.5056 Psg17 98846_f_at M83344 pregnancy specific glycoprotein 173887 0.17799 1.48 up Mm.5650 Mm.5650 101226_at C77776 ESTs3888 0.17803 1.90 up Mm.3944 Prss18 92353_at Y18723 protease, serine, 183889 0.17807 1.83 up Mm.21193 Cyp3a11 93770_at X60452 cytochrome P450, steroid inducible 3a113890 0.17815 1.49 down Mm.3986 Ghr 99107_at M31680 growth hormone receptor3891 0.17823 1.76 up Mm.38756 Pcaf 161116_at AA756076 p300/CBP-associated factor3892 0.17828 2.14 up Mm.10298 Nmt2 102229_at AF043327 N-myristoyltransferase 23893 0.17841 1.34 down Mm.205569 Mm.205569 93826_at AI956230 Mus musculus, clone MGC:38798 IMAGE:5359803, mRNA, complete cds3894 0.17852 2.44 up Mm.4662 Irg1 98774_at L38281 immunoresponsive gene 13895 0.17854 1.62 down Mm.21966 4930421J07Rik 104117_at AI836641 RIKEN cDNA 4930421J07 gene3896 0.17869 1.53 up Mm.18910 Sdfr2 103421_at D50464 stromal cell derived factor receptor 23897 0.17882 3.44 up Mm.18509 Ptger4 103362_at D13458 prostaglandin E receptor 4 (subtype EP4)3898 0.17883 1.75 up Mm.35677 Eps15-rs 98497_at U29156 epidermal growth factor receptor pathway substrate 15, related sequence3899 0.17886 4.40 up Mm.20471 V1ra1 94571_at Y12725 vomeronasal 1 receptor, A13900 0.17891 2.11 up Mm.57242 Pax5 102578_at M97013 paired box gene 53901 0.17893 2.65 up Mm.1233 Fcer2a 94141_at X64224 Fc receptor, IgE, low affinity II, alpha polypeptide3902 0.17898 1.74 up Mm.42260 Foxa3 98324_at X74938 forkhead box A33903 0.17907 1.27 down Mm.30255 H2afy 97452_at AI853078 H2A histone family, member Y3904 0.17914 1.82 up Mm.21281 Rnf4 161809_r_at AV372357 ring finger protein 43905 0.17917 1.72 up Mm.2372 Tpbpa 100709_at X17071 trophoblast specific protein alpha3906 0.17918 2.41 up Mm.11526 Cd160 102272_at AF060982 CD160 antigen3907 0.17920 2.03 up Mm.30115 2310061P20Rik 97438_r_at AW122483 RIKEN cDNA 2310061P20 gene3908 0.17926 1.57 up Mm.180052 Ube2d2 162499_f_at AV171056 ubiquitin-conjugating enzyme E2D 23909 0.17928 1.50 up Mm.3601 Tfpi 98514_at AF004833 tissue factor pathway inhibitor3910 0.17933 1.61 up Mm.28541 1700012G19Rik 98890_at AI848173 RIKEN cDNA 1700012G19 gene3911 0.17934 1.60 up Mm.6479 Irf5 93425_at AF028725 interferon regulatory factor 53912 0.17948 2.56 up Mm.2924 Pdgfra 161202_r_at AV242260 platelet derived growth factor receptor, alpha polypeptide3913 0.17953 2.20 up Mm.30066 Rpl8 162476_r_at AV092840 ribosomal protein L83914 0.17953 1.38 down Mm.10226 Igf1r 102224_at AF056187 insulin-like growth factor I receptor3915 0.17961 2.51 up Mm.21671 D5Wsu45e 161743_i_at AV317706 DNA segment, Chr 5, Wayne State University 45, expressed3916 0.17975 1.71 down Mm.182944 3110001I17Rik 101507_at AI836274 RIKEN cDNA 3110001I17 gene3917 0.17986 1.78 up Mm.2816 Art5 104238_at U60881 ADP-ribosyltransferase 53918 0.17997 2.55 up Mm.4146 Pdgfrb 161154_at AV230288 platelet derived growth factor receptor, beta polypeptide3919 0.18001 1.31 down Mm.25539 Cryl1 103955_at AW050325 crystallin, lamda 13920 0.18010 2.33 up Mm.31255 Notch1 162204_r_at AV374287 Notch gene homolog 1, (Drosophila)3921 0.18012 1.45 down Mm.28660 2310004I03Rik 96211_at AI846896 RIKEN cDNA 2310004I03 gene3922 0.18012 2.31 up Mm.4496 Foxn1 92674_at X81593 forkhead box N13923 0.18018 1.89 up Mm.1167 Junb 102362_i_at U20735 Jun-B oncogene3924 0.18026 1.54 up Mm.25154 Wtap 94346_at AI853721 Wilms' tumour 1-associating protein3925 0.18033 2.79 up Mm.87487 Mm.87487 161084_at AI603944 Mus musculus, clone IMAGE:3586510, mRNA, partial cds3926 0.18038 1.65 up Mm.2210 Abca2 104137_at X75927 ATP-binding cassette, sub-family A (ABC1), member 23927 0.18041 1.40 up Mm.21739 Fus1-pending 160142_at AW122983 fusion 13928 0.18052 1.44 up Mm.5089 Sall3 98852_at X97581 sal-like 3 (Drosophila)3929 0.18053 2.07 up Mm.30 4930422J18Rik 161817_f_at AV376312 RIKEN cDNA 4930422J18 gene3930 0.18055 1.48 up Mm.5915 2410012M04Rik 100912_at AI182009 RIKEN cDNA 2410012M04 gene3931 0.18060 1.68 up Mm.148721 Atp5f1 96898_at U29530 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform3932 0.18065 2.26 up Mm.14302 Cmkbr5 102718_at AF022990 chemokine (C-C) receptor 53933 0.18079 1.97 up Mm.41814 Mm.41814 161096_at AA209597 ESTs, Weakly similar to Y211_HUMAN Hypothetical zinc finger protein KIAA3934 0.18084 1.28 up Mm.3199 1500001N04Rik 97517_at AW061222 RIKEN cDNA 1500001N04 gene3935 0.18084 4.99 up Mm.157783 AI893585 161486_f_at AV080003 expressed sequence AI8935853936 0.18095 1.37 down Mm.154153 1110034O07Rik 160245_at AW045564 RIKEN cDNA 1110034O07 gene3937 0.18096 1.95 up Mm.2958 AI843786 161010_r_at AI843786 expressed sequence AI8437863938 0.18096 1.72 up Mm.282 Gsto1 97819_at AI843119 glutathione S-transferase omega 13939 0.18098 1.79 up Mm.1360 Gadd45b 102779_at X54149 growth arrest and DNA-damage-inducible 45 beta3940 0.18101 1.68 down Mm.27649 4930588A18Rik 96717_at AW122643 RIKEN cDNA 4930588A18 gene3941 0.18107 2.16 up Mm.849 Ppm1b 101838_r_at AB007798 protein phosphatase 1B, magnesium dependent, beta isoform3942 0.18116 1.22 down Mm.27862 Mm.27862 95587_at AI837204 ESTs, Weakly similar to T16757 hypothetical protein R144.3 - Caenorhabditi3943 0.18118 1.20 up Mm.29822 Hp1bp3 96257_at AW124376 heterochromatin protein 2, binding protein 33944 0.18119 1.59 down Mm.22369 4930533O14Rik 104306_at AI847886 RIKEN cDNA 4930533O14 gene3945 0.18125 2.33 up Mm.1019 Il6 102218_at X54542 interleukin 63946 0.18126 5.53 up Mm.1405 Wbp2 161991_at AV325341 WW domain binding protein 23947 0.18127 1.37 down Mm.29187 Lmo4 98122_at AF074600 LIM only 43948 0.18129 1.43 down Mm.16562 Actg2 93102_f_at U20365 actin, gamma 2, smooth muscle, enteric3949 0.18133 2.36 up Mm.4679 Gdnf 161598_at AV296394 glial cell line derived neurotrophic factor3950 0.18136 1.65 up Mm.4742 Pa2g4 100125_at U43918 proliferation-associated 2G4, 38kD3951 0.18137 1.61 up 99798_at X032783952 0.18137 1.39 up Mm.151329 Mm.151329 161757_f_at AV298789 Mus musculus Ran binding protein 5 mRNA, partial cds3953 0.18141 2.76 up Mm.20880 Sh2d1a 103279_at AF097632 SH2 domain protein 1A3954 0.18151 1.39 down Mm.44202 5330422J23Rik 99675_at AI839766 RIKEN cDNA 5330422J23 gene3955 0.18159 3.02 up Mm.21123 Retnlb 93755_at AA611740 resistin like beta3956 0.18159 1.60 up Mm.20901 Pex11b 103815_at AI852311 peroxisomal biogenesis factor 11b3957 0.18161 1.87 up Mm.7634 Lbcl1 93632_g_at X95761 lymphoid blast crisis-like 13958 0.18162 1.38 down Mm.29382 1110038D17Rik 95119_at AA866888 RIKEN cDNA 1110038D17 gene3959 0.18164 1.31 up Mm.988 1500004O06Rik 102000_f_at AI842835 RIKEN cDNA 1500004O06 gene3960 0.18170 2.03 up Mm.34209 Nr0b2 97123_at L76567 nuclear receptor subfamily 0, group B, member 2Page 44 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3961 0.18181 2.47 up Mm.4519 Ryr1 100003_at D38216 ryanodine receptor 1, skeletal muscle3962 0.18192 2.54 up Mm.5074 Lalba 92994_at M87863 lactalbumin, alpha3963 0.18194 1.79 up Mm.625 Sprr1a 161312_r_at AV085264 small proline-rich protein 1A3964 0.18211 1.32 up Mm.880 Int6 160554_at AI839363 mammary tumor integration site 63965 0.18214 2.45 up Mm.27830 Slc7a8 104214_at AW122706 solute carrier family 7 (cationic amino acid transporter, y+ system), member3966 0.18218 2.51 up Mm.28178 Krt1-3 97814_at X75650 keratin complex 1, acidic, gene 33967 0.18219 1.92 up Mm.22152 2610025P08Rik 104146_at AI853551 RIKEN cDNA 2610025P08 gene3968 0.18220 1.31 up Mm.29714 1200009C21Rik 95715_at AW125739 RIKEN cDNA 1200009C21 gene3969 0.18222 1.59 up Mm.1428 Gata4 102713_at M98339 GATA binding protein 43970 0.18233 2.44 up Mm.21545 Tdo2 99269_g_at AI194855 tryptophan 2,3-dioxygenase3971 0.18235 1.14 up Mm.1144 2410117E06Rik 102271_at AW125462 RIKEN cDNA 2410117E06 gene3972 0.18239 1.84 up Mm.153833 Cdk5r2 101335_at U90267 cyclin-dependent kinase 5, regulatory subunit 2 (p39)3973 0.18265 1.21 up Mm.148348 1500005G05Rik 103921_i_at AI839690 RIKEN cDNA 1500005G05 gene3974 0.18273 1.87 up Mm.41038 Mm.41038 93707_f_at AA646859 ESTs, Weakly similar to ZINC FINGER PROTEIN MLZ-4 [M.musculus]3975 0.18280 1.58 up Mm.76694 1110067D22Rik 160704_at AW121603 RIKEN cDNA 1110067D22 gene3976 0.18281 1.90 up Mm.5824 D3Ertd246e 101605_at C79364 DNA segment, Chr 3, ERATO Doi 246, expressed3977 0.18310 3.72 up Mm.200919 AI450287 161089_r_at AV367756 expressed sequence AI4502873978 0.18314 1.27 up Mm.4723 Sct 92756_r_at X73580 secretin3979 0.18316 1.30 down Mm.1538 Btf3 93057_at AW122989 basic transcription factor 33980 0.18317 1.61 up Mm.182962 Eif3s5 160541_at AW124660 eukaryotic translation initiation factor 3, subunit 5 (epsilon)3981 0.18322 4.48 up Mm.86813 Col8a1 100308_at X66976 procollagen, type VIII, alpha 13982 0.18325 1.29 down Mm.21963 AA409398 104115_at AA867340 expressed sequence AA4093983983 0.18342 1.58 up Mm.57155 Fshr 101810_at AF095642 follicle stimulating hormone receptor3984 0.18345 2.27 up Mm.89940 Adam19 103554_at AA726223 a disintegrin and metalloproteinase domain 19 (meltrin beta)3985 0.18346 1.49 up Mm.23793 Cncg 101706_at AJ238239 cyclic nucleotide gated channel, cGMP gated3986 0.18352 1.29 down Mm.23943 Vapa 94889_at AW121235 vesicle-associated membrane protein, associated protein A (33 kDa)3987 0.18360 1.57 up Mm.80325 AA407874 92279_at AW121320 EST AA4078743988 0.18361 1.59 up Mm.3797 Nap1l1 98586_at AW107230 nucleosome assembly protein 1-like 13989 0.18362 2.30 up Mm.2576 Brp44l 96028_at AW125628 brain protein 44-like3990 0.18370 1.68 up Mm.12255 2310042P20Rik 160595_at AI842450 RIKEN cDNA 2310042P20 gene3991 0.18377 1.27 down Mm.1989 Sca2 162399_f_at AV276058 spinocerebellar ataxia 2 homolog (human)3992 0.18377 1.91 up Mm.2811 Chrnd 96549_at L10076 cholinergic receptor, nicotinic, delta polypeptide3993 0.18379 2.96 up Mm.41988 Scya17 97783_at AJ242587 small inducible cytokine subfamily A173994 0.18379 1.48 down Mm.16528 Myog 103053_at X15784 myogenin3995 0.18383 1.32 down Mm.22668 Hmgcl 94324_f_at U49878 3-hydroxy-3-methylglutaryl-Coenzyme A lyase3996 0.18387 1.88 up Mm.41939 1110018D06Rik 99195_at AW120734 RIKEN cDNA 1110018D06 gene3997 0.18396 1.88 up Mm.9020 Mrc2 100759_at U56734 mannose receptor, C type 23998 0.18397 1.97 up Mm.153446 Pla2g5 94665_at AA408341 phospholipase A2, group V3999 0.18402 1.89 up Mm.22194 Prg 94085_at M34603 proteoglycan, secretory granule4000 0.18403 1.58 down Mm.196000 Col18a1 101882_s_at U03715 procollagen, type XVIII, alpha 14001 0.18405 2.84 up Mm.3532 Tmsb10 98129_at AI852553 thymosin, beta 104002 0.18406 1.30 down Mm.28463 Ap3d 96185_at AB004305 adaptor-related protein complex AP-3, delta subunit4003 0.18408 2.01 up Mm.231 Rad51 104527_at D13803 RAD51 homolog (S. cerevisiae)4004 0.18416 2.68 up Mm.194940 AI194696 94994_at M29007 expressed sequence AI1946964005 0.18417 2.41 up Mm.42044 Icos 98282_at AB023132 inducible T-cell co-stimulator4006 0.18423 2.25 up Mm.44184 AA408776 99966_at AA274528 expressed sequence AA4087764007 0.18442 2.78 up Mm.217538 Mm.217538 95246_at AA516958 EST, Weakly similar to TYROSINE-PROTEIN KINASE JAK3 [M.musculus]4008 0.18455 1.45 down Mm.77432 Txnip 160547_s_at AI839138 thioredoxin interacting protein4009 0.18465 1.29 up Mm.42083 Plcb1 92466_at U85714 phospholipase C, beta 14010 0.18465 1.34 up Mm.20445 Tspyl 95326_at AF042180 testis-specific protein, Y-encoded-like4011 0.18468 1.33 down Mm.179650 Prkcabp 97684_at Z46720 protein kinase C, alpha binding protein4012 0.18468 2.22 up Mm.108242 Dnahc8 95299_at AA144987 dynein, axon, heavy chain 84013 0.18475 1.60 down Mm.41979 Mcpt8 97779_at X78545 mast cell protease 84014 0.18477 2.20 up Mm.33972 D7Ertd59e 97120_at C77679 DNA segment, Chr 7, ERATO Doi 59, expressed4015 0.18480 2.15 up Mm.10656 Mm.10656 97073_at L17305 Mouse granuloma associated factor mRNA, complete cds4016 0.18484 1.23 up Mm.1616 Ctf1 103037_at U18366 cardiotrophin 14017 0.18488 1.68 down Mm.12947 Mona 102633_at AF053405 monocytic adaptor4018 0.18492 1.35 down Mm.22711 Ccni 94819_f_at AF005886 cyclin I4019 0.18496 1.30 down Mm.24116 5730589N07Rik 103713_at AW124533 RIKEN cDNA 5730589N07 gene4020 0.18498 1.84 up Mm.108678 Cyp11a 96228_at AW121619 cytochrome P450, 11a, cholesterol side chain cleavage4021 0.18499 1.52 down Mm.7013 0610038L10Rik 97104_g_at AF031380 RIKEN cDNA 0610038L10 gene4022 0.18501 1.63 down Mm.24395 Decr1 160711_at AI844846 2,4-dienoyl CoA reductase 1, mitochondrial4023 0.18513 1.49 up Mm.30927 3300001P08Rik 160791_at AW049254 RIKEN cDNA 3300001P08 gene4024 0.18520 2.00 up Mm.38347 1500005I02Rik 161082_r_at AA016517 RIKEN cDNA 1500005I02 gene4025 0.18525 3.00 up Mm.100109 Siat10 102208_at AI153959 sialyltransferase 10 (alpha-2,3-sialyltransferase VI)4026 0.18531 2.29 up Mm.2527 Gata5 96500_at U84725 GATA binding protein 54027 0.18541 1.82 up Mm.141666 Krt1-c29 93800_f_at AB013607 keratin complex-1, acidic, gene C294028 0.18579 2.01 down Mm.67919 Mafb 102204_at L36435 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)4029 0.18598 1.43 down Mm.21173 2310015N07Rik 103873_i_at AA684456 RIKEN cDNA 2310015N07 gene4030 0.18610 2.64 up Mm.1371 Pax3 100697_at X59358 paired box gene 34031 0.18613 1.92 up Mm.181021 Col4a2 101039_at X04647 procollagen, type IV, alpha 24032 0.18614 1.52 down Mm.28207 D4Wsu132e 160773_at AI846285 DNA segment, Chr 4, Wayne State University 132, expressed4033 0.18621 1.75 up Mm.19016 Dbn1 103430_at AW124952 drebrin 14034 0.18623 1.60 up Mm.28406 Mm.28406 160781_r_at AW215456 Mus musculus, Similar to unc93 (C.elegans) homolog B, clone MGC:25627 I4035 0.18632 3.18 up Mm.6258 Eda 93394_at AF004435 ectodysplasin-A4036 0.18636 1.45 down Mm.27363 1110003O22Rik 96662_at AI847054 RIKEN cDNA 1110003O22 gene4037 0.18638 1.52 up Mm.7997 Foxd2 94621_at AF023915 forkhead box D24038 0.18639 2.31 up Mm.57128 Ifna4 101790_f_at X01973 interferon alpha family, gene 44039 0.18639 2.30 up Mm.25620 Dntt 103961_s_at X68670 deoxynucleotidyltransferase, terminal4040 0.18657 3.22 up Mm.4554 Laptm5 161819_f_at AV356071 lysosomal-associated protein transmembrane 54041 0.18668 1.20 down Mm.1147 Calm3 92631_f_at M19380 calmodulin 34042 0.18672 2.15 up Mm.25070 Mm.25070 95998_at C79930 ESTs4043 0.18690 1.37 down Mm.23044 AA409679 160963_at AI551141 expressed sequence AA4096794044 0.18699 2.98 up Mm.27880 Cugbp2 93892_at Y18298 CUG triplet repeat,RNA binding protein 24045 0.18702 2.02 up Mm.4938 Fmn 92953_at U60969 formin4046 0.18711 2.14 down Mm.14825 Idh3g 162478_r_at AV097887 isocitrate dehydrogenase 3 (NAD+), gamma4047 0.18714 1.58 up Mm.196640 2610511G02Rik 96806_at AI843802 RIKEN cDNA 2610511G02 gene4048 0.18719 1.22 up Mm.21092 AW742319 93747_at AW122599 expressed sequence AW7423194049 0.18720 1.46 up Mm.141936 Igfbp2 98627_at X81580 insulin-like growth factor binding protein 24050 0.18730 1.79 up Mm.30355 Kif5a 96583_s_at AF053473 kinesin family member 5APage 45 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4051 0.18731 1.36 down Mm.141276 Sdbcag84 96345_at AI837012 serologically defined breast cancer antigen 844052 0.18745 1.61 up Mm.6471 Mm.6471 93423_at AI844772 Mus musculus, clone MGC:38821 IMAGE:5360322, mRNA, complete cds4053 0.18760 3.61 up Mm.4640 Lrrn1 161959_f_at AV221593 leucine rich repeat protein 1, neuronal4054 0.18769 2.48 up Mm.4237 Top2a 99578_at U01915 topoisomerase (DNA) II alpha4055 0.18770 1.45 up Mm.28018 1500006O09Rik 160260_at AI836346 RIKEN cDNA 1500006O09 gene4056 0.18774 2.10 up Mm.14487 Map2k6 102829_s_at X97052 mitogen activated protein kinase kinase 64057 0.18781 1.41 down Mm.34556 Car14 98079_at AB005450 carbonic anhydrase 144058 0.18784 1.22 down Mm.30006 1500035H01Rik 97423_at AI839819 RIKEN cDNA 1500035H01 gene4059 0.18787 2.56 up Mm.141197 Wbp11 161582_r_at AV317102 WW domain binding protein 114060 0.18788 1.94 up Mm.4722 Kcnj11 98787_at D50581 potassium inwardly rectifying channel, subfamily J, member 114061 0.18789 1.64 up Mm.56986 Has3 99394_at U86408 hyaluronan synthase 34062 0.18790 1.86 up Mm.2582 Vps45 94404_at U66865 vacuolar protein sorting 45 (yeast)4063 0.18794 1.32 down Mm.2006 Tagln 93541_at Z68618 transgelin4064 0.18808 2.25 up Mm.8217 D6H12S2489E 93678_s_at AF054819 DNA Segment, Chr 6, human D12S2489E4065 0.18814 1.87 up Mm.1287 Mapt 102743_at M18776 microtubule-associated protein tau4066 0.18825 2.09 up Mm.14526 Mylpf 92881_at U77943 myosin light chain, phosphorylatable, fast skeletal muscle4067 0.18845 2.51 up Mm.8012 Mm.8012 93657_at U87620 Mus musculus Ets transcription factor Spi-B, partial cds4068 0.18845 1.53 down Mm.3129 Stxbp1 97983_s_at D45903 syntaxin binding protein 14069 0.18847 1.62 up Mm.686 Actc1 101028_i_at M15501 actin, alpha, cardiac4070 0.18851 1.96 down Mm.29735 0610006H10Rik 95725_at AI314227 RIKEN cDNA 0610006H10 gene4071 0.18852 1.38 up Mm.28088 Mvk 95633_r_at AW122653 mevalonate kinase4072 0.18852 1.29 down Mm.181430 Dnchc1 97333_at AW121185 dynein, cytoplasmic, heavy chain 14073 0.18857 1.54 up Mm.4142 Ttgn1 99144_s_at D50031 trans-golgi network protein 14074 0.18861 2.24 up Mm.34324 5830461H18Rik 92212_at AI849862 RIKEN cDNA 5830461H18 gene4075 0.18861 3.54 up Mm.37854 Ptprm 92309_i_at X58287 protein tyrosine phosphatase, receptor-type, M4076 0.18868 1.55 up Mm.4631 2310079H06Rik 162203_r_at AV373867 RIKEN cDNA 2310079H06 gene4077 0.18875 1.83 up Mm.4983 Mc1r 101161_at X65635 melanocortin 1 receptor4078 0.18882 1.65 down Mm.4219 Man2b1 99562_at U87240 mannosidase 2, alpha B14079 0.18896 1.53 up Mm.20872 Large 103276_at AJ006278 like-glycosyltransferase4080 0.18903 1.66 up Mm.26939 Rap2b 104020_at AI837726 RAP2B, member of RAS oncogene family4081 0.18903 2.93 up Mm.42233 Aanat 92511_at AF004108 arylalkylamine N-acetyltransferase4082 0.18925 2.32 up Mm.3970 Elavl4 92361_at D31953 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)4083 0.18927 1.88 up Mm.1370 Pde6a 100696_at X60664 phosphodiesterase 6A, cGMP-specific, rod, alpha4084 0.18936 1.67 up Mm.2509 Col6a1 162459_f_at AV010209 procollagen, type VI, alpha 14085 0.18944 1.23 up Mm.177451 5730544L10Rik 96674_at AW123553 RIKEN cDNA 5730544L10 gene4086 0.18944 2.04 up Mm.27740 AA987150 160246_at AI839109 expressed sequence AA9871504087 0.18951 1.48 up Mm.9002 Ube3a 101581_at U82122 ubiquitin protein ligase E3A4088 0.18959 2.49 up Mm.24187 AI415282 94921_i_at AA220757 expressed sequence AI4152824089 0.18961 2.65 up Mm.3765 1700094D03Rik 98578_at AA692915 RIKEN cDNA 1700094D03 gene4090 0.18970 1.25 down Mm.21743 Mor1 93991_at X07295 malate dehydrogenase, mitochondrial4091 0.18970 2.43 up Mm.3460 Cd14 98088_at X13333 CD14 antigen4092 0.18974 1.77 up Mm.218865 Tnfrsf9 97683_at U02567 tumor necrosis factor receptor superfamily, member 94093 0.18986 2.23 up Mm.46795 Ifna7 102149_f_at M13710 interferon alpha family, gene 74094 0.18993 2.27 up Mm.28805 Set 161182_r_at AV234941 SET translocation4095 0.19004 3.26 up Mm.28687 Msn 160308_at AI839417 moesin4096 0.19010 2.00 up Mm.42020 Ahrr 101709_at AB015140 aryl-hydrocarbon receptor repressor4097 0.19020 3.14 up Mm.4353 Cdx4 98347_at L08061 caudal type homeo box 44098 0.19025 2.58 up Mm.5022 Mmp13 100484_at X66473 matrix metalloproteinase 134099 0.19028 3.03 up Mm.3040 Fgl2 162289_at AV374876 fibrinogen-like protein 24100 0.19036 2.19 up Mm.381 Adfp 98589_at M93275 adipose differentiation related protein4101 0.19036 1.54 up Mm.40447 Cegf1 101732_at M12039 CUB domain and EGF-like repeat containing 14102 0.19037 2.73 up Mm.5171 Stra8 101194_at Z75287 stimulated by retinoic acid gene 84103 0.19047 1.65 up Mm.1255 Scya4 94146_at X62502 small inducible cytokine A44104 0.19047 2.38 up Mm.5348 1700010P14Rik 161213_r_at AV264887 RIKEN cDNA 1700010P14 gene4105 0.19052 1.66 up Mm.27738 1700020M16Rik 161751_f_at AV324916 RIKEN cDNA 1700020M16 gene4106 0.19058 1.70 up Mm.5353 AI845814 93173_at AI845814 expressed sequence AI8458144107 0.19061 1.64 up Mm.2817 Ppfibp2 160771_r_at U79024 protein tyrosine phosphatase, receptor-type, F interacting protein, binding pro4108 0.19061 2.06 down Mm.203556 BC003494 161677_r_at AV171666 hypothetical protein, MGC:69434109 0.19072 1.35 down Mm.1056 Slc1a7 92582_at L42115 solute carrier family 1, member 74110 0.19098 1.42 down Mm.25125 5730409F23Rik 95496_at AI848866 RIKEN cDNA 5730409F23 gene4111 0.19111 1.55 up Mm.2573 Ahcy 96025_g_at L32836 S-adenosylhomocysteine hydrolase4112 0.19134 1.22 down Mm.38994 2600001N01Rik 99087_at AW060179 RIKEN cDNA 2600001N01 gene4113 0.19148 1.44 down Mm.29571 1200017E04Rik 95665_at AI852087 RIKEN cDNA 1200017E04 gene4114 0.19149 1.83 up Mm.19353 LOC56304 100722_r_at U10410 recombinant antineuraminidase single chain Ig VH and VL domains4115 0.19153 2.51 up Mm.8073 Bche 94644_at M99492 butyrylcholinesterase4116 0.19160 1.33 down Mm.3131 Dld 97502_at U73445 dihydrolipoamide dehydrogenase4117 0.19164 1.99 up Mm.57212 Adra2a 102556_at M99377 adrenergic receptor, alpha 2a4118 0.19169 1.92 up Mm.192181 Abcd4 93867_at AJ001166 ATP-binding cassette, sub-family D (ALD), member 44119 0.19173 12.32 up Mm.42029 Scya8 92459_at AB023418 small inducible cytokine A84120 0.19173 1.92 up Mm.3819 Col12a1 92313_at AI844066 procollagen, type XII, alpha 14121 0.19174 2.05 up Mm.135092 Mm.135092 162040_r_at AV374320 ESTs, Weakly similar to T14031 sodium bicarbonate cotransporter, pancreat4122 0.19178 1.33 down Mm.28596 C85108 104274_at AW124843 expressed sequence C851084123 0.19178 1.78 up Mm.14860 Anxa1 161703_f_at AV003419 annexin A14124 0.19179 2.55 up Mm.10116 Scyb13 102025_at AF030636 small inducible cytokine subfamily B (Cys-X-Cys), member 134125 0.19182 3.56 up Mm.3266 Evi2 98025_at M34896 ecotropic viral integration site 24126 0.19186 1.48 up Mm.2424 Rpl10a 100711_at U12403 ribosomal protein L10A4127 0.19189 1.61 down Mm.20947 Rad17 103840_at AJ011923 RAD17 homolog (S. pombe)4128 0.19193 1.85 up Mm.37832 2310022L06Rik 97694_at AU040601 RIKEN cDNA 2310022L06 gene4129 0.19193 4.52 up Mm.4389 Man1b 92650_at U03458 mannosidase 1, beta4130 0.19194 1.48 up Mm.6765 Siah1a 100985_at Z19579 seven in absentia 1A4131 0.19204 1.51 up Mm.200422 AU020206 104252_at AW123823 expressed sequence AU0202064132 0.19206 2.06 up Mm.5507 C76554 99355_r_at C76554 expressed sequence C765544133 0.19232 1.85 up Mm.34447 V2r15 97127_f_at AF011425 vomeronasal 2, receptor, 154134 0.19234 1.73 up Mm.134988 AI605202 102211_r_at U66835 expressed sequence AI6052024135 0.19237 1.45 up Mm.1703 Tubb5 94789_r_at X04663 tubulin, beta 54136 0.19237 1.60 down Mm.135092 Mm.135092 93471_at AI594427 ESTs, Weakly similar to T14031 sodium bicarbonate cotransporter, pancreat4137 0.19244 1.52 up Mm.28176 C81205 96550_at C81401 expressed sequence C812054138 0.19245 2.46 up Mm.30211 Scyb14 96953_at AW120786 small inducible cytokine subfamily B (Cys-X-Cys), member 144139 0.19246 1.34 up Mm.14569 AI256776 160079_i_at AI845773 expressed sequence AI2567764140 0.19246 2.84 up Mm.21974 Csk 162504_at AV160784 c-src tyrosine kinasePage 46 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4141 0.19249 2.90 up Mm.17336 Hemt1 102948_at AJ242830 hematopoietic cell transcript 14142 0.19250 1.63 up Mm.5184 Prss7 99324_at U73378 protease, serine, 7 (enterokinase)4143 0.19263 1.58 up Mm.4595 Fbl 160503_at Z22593 fibrillarin4144 0.19265 2.13 up 160375_at AJ0064744145 0.19282 1.77 up Mm.1736 Chl1 161239_r_at AV281386 close homolog of L14146 0.19284 1.80 down Mm.4312 Slc9a1 99922_at U51112 solute carrier family 9 (sodium/hydrogen exchanger), member 14147 0.19284 1.78 up Mm.28427 Lt1 162111_r_at AV295836 lurcher transcript 14148 0.19285 3.16 up Mm.3941 Eif4e 162222_r_at AV115237 eukaryotic translation initiation factor 4E4149 0.19297 2.34 up Mm.10725 Tesp1 102244_at AB008910 testicular serine protease 14150 0.19310 1.61 down Mm.12898 Traf1 94186_at L35302 Tnf receptor-associated factor 14151 0.19315 1.34 down Mm.18485 2700059C12Rik 93312_at AW124623 RIKEN cDNA 2700059C12 gene4152 0.19318 2.17 up Mm.4054 Tbxas1 162136_r_at AV380691 thromboxane A synthase 1, platelet4153 0.19328 1.96 up Mm.27949 Posh-pending 100707_at AF030131 plenty of SH3 domains4154 0.19328 2.07 up Mm.24810 Mm.24810 95936_at AI594426 ESTs4155 0.19329 2.27 up Mm.12826 Siat8a 94164_at X84235 sialyltransferase 8 (alpha-2, 8-sialytransferase) A4156 0.19334 1.83 up Mm.24801 AV001382 160978_at AW261569 expressed sequence AV0013824157 0.19335 1.62 up Mm.1423 Lyst 94736_at U52461 lysosomal trafficking regulator4158 0.19344 1.46 up Mm.141054 5530600A18Rik 98464_at AW124196 RIKEN cDNA 5530600A18 gene4159 0.19361 1.38 down Mm.24984 4930560O18Rik 103916_at AI850713 RIKEN cDNA 4930560O18 gene4160 0.19365 1.64 up Mm.88843 Olfr37c 97001_r_at AJ133426 olfactory receptor 37c4161 0.19375 1.61 up Mm.5300 Tp120a-pending 99338_at AA674798 TBP-interacting protein4162 0.19375 1.65 up Mm.22378 Itgax 104308_at AI035495 integrin alpha X4163 0.19380 1.81 up Mm.21096 Eral1 103859_at AA863768 Era (G-protein)-like 1 (E. coli)4164 0.19388 1.75 up Mm.4642 Calcr 101135_at U18542 calcitonin receptor4165 0.19400 2.46 up Mm.12806 Ptafr 94157_i_at AF004858 platelet-activating factor receptor4166 0.19402 1.57 up Mm.19961 Mm.19961 103593_at K02781 ESTs, Highly similar to ANF MOUSE ATRIAL NATRIURETIC FACTOR PRE4167 0.19416 2.24 up Mm.4664 Tnfsf8 101136_at L09754 tumor necrosis factor (ligand) superfamily, member 84168 0.19439 2.26 up Mm.42224 F12 92509_at X99571 coagulation factor XII (Hageman factor)4169 0.19442 1.92 up Mm.4539 Psp 100080_at X01697 parotid secretory protein4170 0.19443 1.43 up Mm.30249 Galnt1 97934_at U73820 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra4171 0.19456 1.58 up Mm.326 1110038L14Rik 97527_at AA681998 RIKEN cDNA 1110038L14 gene4172 0.19465 1.40 down Mm.29985 2310010I22Rik 97419_at AW060956 RIKEN cDNA 2310010I22 gene4173 0.19473 1.88 up Mm.3322 H2-DMb1 98035_g_at U35330 histocompatibility 2, class II, locus Mb14174 0.19474 1.42 down Mm.202841 AL024279 95128_at AI849611 expressed sequence AL0242794175 0.19476 1.61 up Mm.21551 9130009C22Rik 103446_at AA959954 RIKEN cDNA 9130009C22 gene4176 0.19485 2.01 down Mm.38211 Mm.38211 98594_at AW125453 ESTs4177 0.19489 3.07 up Mm.29010 Mbc2 162079_at AV331295 membrane bound C2 domain containing protein4178 0.19494 1.50 down Mm.9440 Ptdss1 101931_at AF042731 phosphatidylserine synthase 14179 0.19494 1.49 up Mm.56995 Agrp 99399_at U89486 agouti related protein4180 0.19498 2.94 up Mm.42208 Hoxa3 102087_at Y11717 homeo box A34181 0.19514 2.11 up Mm.27777 1700013H19Rik 95561_at AW120867 RIKEN cDNA 1700013H19 gene4182 0.19526 1.68 down Mm.19821 Mm.19821 160644_at AI314106 ESTs, Weakly similar to UBP4 MOUSE UBIQUITIN CARBOXYL-TERMINAL4183 0.19531 1.78 up Mm.57043 Nfkbie 101727_at AF030896 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, e4184 0.19539 1.90 up Mm.22815 Sgcd 103522_at AB024923 sarcoglycan, delta (35kD dystrophin-associated glycoprotein)4185 0.19543 1.63 up Mm.5796 C79709 99819_at C79709 expressed sequence C797094186 0.19546 1.76 up Mm.7548 AA408554 99874_at AA959291 expressed sequence AA4085544187 0.19550 3.55 up Mm.30144 Ctla2a 96912_s_at X15591 cytotoxic T lymphocyte-associated protein 2 alpha4188 0.19550 1.50 down Mm.31051 2610003J05Rik 97491_at AW123032 RIKEN cDNA 2610003J05 gene4189 0.19552 1.80 up Mm.21961 Atp6s1 103700_r_at AI646638 ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 14190 0.19557 1.28 up Mm.139675 Tssc4 160557_at AI848914 tumor-suppressing subchromosomal transferable fragment 44191 0.19564 1.99 up Mm.1259 Ngfb 102298_at M17298 nerve growth factor, beta4192 0.19574 2.26 up Mm.30322 V2r11 101645_f_at AF011421 vomeronasal 2, receptor, 114193 0.19578 1.63 up Mm.1845 Pcx 93308_s_at M97957 pyruvate decarboxylase4194 0.19581 1.34 down Mm.27493 C78303 104193_at AW047583 expressed sequence C783034195 0.19581 1.70 up Mm.56895 D17H6S56E-3 101083_s_at AF109905 DNA segment, Chr 17, human D6S56E 34196 0.19592 1.35 down Mm.200461 2010012F07Rik 97429_at AW048113 RIKEN cDNA 2010012F07 gene4197 0.19597 1.26 up Mm.86933 2900008M13Rik 102099_f_at AI843637 RIKEN cDNA 2900008M13 gene4198 0.19597 2.46 up Mm.29189 Ak1 96801_at AJ010108 adenylate kinase 14199 0.19605 1.21 down Mm.42805 AI256693 99593_at AI852355 expressed sequence AI2566934200 0.19608 1.28 up Mm.24148 AI465155 104609_at AA644817 expressed sequence AI4651554201 0.19610 2.00 up Mm.15406 Skir 94752_s_at U10531 ski/sno related4202 0.19615 1.34 down Mm.9860 4833420G17Rik 101998_at AW125086 RIKEN cDNA 4833420G17 gene4203 0.19622 2.19 up Mm.1411 Lig3 162060_r_at AV273892 ligase III, DNA, ATP-dependent4204 0.19624 1.53 down Mm.5185 Mm.5185 93143_at AI844196 ESTs4205 0.19630 1.87 up Mm.219663 Fbln1 161628_r_at AV035226 fibulin 14206 0.19635 1.66 down Mm.21868 Araf 102286_at M13071 raf-related oncogene4207 0.19637 1.75 down Mm.4103 Myom1 92407_at AJ012072 myomesin 14208 0.19640 2.01 up Mm.8367 Mbl1 101474_at U09010 mannose binding lectin, liver (A)4209 0.19650 1.71 up Mm.29390 2400007P05Rik 95122_g_at AW060791 RIKEN cDNA 2400007P05 gene4210 0.19656 2.86 up Mm.57116 Drd3 101779_at X67274 dopamine receptor 34211 0.19658 2.02 up Mm.29581 Hey1 95671_at AJ243895 hairy/enhancer-of-split related with YRPW motif 14212 0.19660 5.10 up Mm.3619 Ctss 98543_at AJ223208 cathepsin S4213 0.19663 1.53 up Mm.3908 Cbx2 97723_at X62537 chromobox homolog 2 (Drosophila Pc class)4214 0.19672 2.12 up Mm.354 Calb1 98133_at D26352 calbindin-28K4215 0.19691 2.13 up Mm.14438 AU044919 100583_at J00475 expressed sequence AU0449194216 0.19707 2.35 down Mm.57219 Npr3 99806_at D78175 natriuretic peptide receptor 34217 0.19712 1.78 up Mm.21884 Mm.21884 160961_at AI853347 ESTs, Weakly similar to T14106 probable GTPase-activating protein SPA-14218 0.19712 1.61 up Mm.154651 Purb 101395_at AW120626 purine rich element binding protein B4219 0.19718 3.66 up Mm.231 Rad51 162232_r_at AV311591 RAD51 homolog (S. cerevisiae)4220 0.19738 1.58 up Mm.22318 AU022703 103497_at AA592351 expressed sequence AU0227034221 0.19740 2.77 up Mm.9114 Crym 160937_at AF039391 crystallin, mu4222 0.19745 3.76 up Mm.42948 Prdx2 100330_at AF032714 peroxiredoxin 24223 0.19752 1.34 up Mm.1384 Trim21 92942_at AA138192 tripartite motif protein 214224 0.19758 1.43 down Mm.28637 4930569O04Rik 98924_at Y08027 RIKEN cDNA 4930569O04 gene4225 0.19770 1.31 down Mm.7198 Mkrn1 101069_g_at AA656621 makorin, ring finger protein, 14226 0.19774 1.19 down Mm.28144 0610007C21Rik 160271_at AW121255 RIKEN cDNA 0610007C21 gene4227 0.19782 1.50 down Mm.28063 AA409091 97308_at AI835409 expressed sequence AA4090914228 0.19782 1.73 up Mm.1644 Lhcgr 100705_at M81310 luteinizing hormone/choriogonadotropin receptor4229 0.19798 2.58 up Mm.4946 Ins2 161849_r_at AV051765 insulin II4230 0.19817 1.82 down Mm.27790 2610510E10Rik 95567_at AW123947 RIKEN cDNA 2610510E10 genePage 47 of 48

Supplementary InformationRank Prob (t-test) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4231 0.19826 1.78 up Mm.1397 Smr2 102685_at U82380 submaxillary gland androgen regulated protein 24232 0.19831 1.20 up Mm.100113 Rpl10 161657_f_at AV105022 ribosomal protein 104233 0.19839 2.16 up Mm.39200 Pde6g 97732_at Y00746 phosphodiesterase 6G, cGMP-specific, rod, gamma4234 0.19842 1.92 down Mm.23697 Tssc3 104548_at Y15443 tumor-suppressing subchromosomal transferable fragment 34235 0.19849 1.52 up Mm.28252 1110018O12Rik 96151_at AA839813 RIKEN cDNA 1110018O12 gene4236 0.19852 1.17 down Mm.28202 D16Ertd269e 97821_at AI646056 DNA segment, Chr 16, ERATO Doi 269, expressed4237 0.19858 1.33 up Mm.4024 Cfl1 99119_at D00472 cofilin 1, non-muscle4238 0.19859 1.37 down Mm.7401 Hax1-pending 101096_s_at AF023482 HS1 binding protein4239 0.19861 2.23 up Mm.3509 Tnfip6 98474_r_at U83903 tumor necrosis factor induced protein 64240 0.19875 3.35 up Mm.5026 Phxr3 101167_at X12807 per-hexamer repeat gene 34241 0.19893 1.25 down Mm.2472 Cops5 95460_at U70736 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thal4242 0.19901 3.91 up Mm.29800 Cdc25a 161412_r_at AV315419 cell division cycle 25 homolog A (S. cerevisiae)4243 0.19904 1.99 up Mm.14046 Krt1-17 92861_i_at M13805 keratin complex 1, acidic, gene 174244 0.19921 2.50 up Mm.6215 Fosl1 99835_at AF017128 fos-like antigen 14245 0.19924 1.31 up Mm.20805 2410141M05Rik 103672_at AW122572 RIKEN cDNA 2410141M05 gene4246 0.19952 2.63 up Mm.40678 Pde1a 99453_at U56649 phosphodiesterase 1A, calmodulin-dependent4247 0.19953 1.42 down Mm.28892 AA959742 94486_at AW125178 expressed sequence AA9597424248 0.19960 2.26 down Mm.203911 AA407887 161892_r_at AV372708 expressed sequence AA4078874249 0.19974 2.22 up Mm.28721 Brd3 98947_at AW121208 bromodomain-containing 34250 0.19977 1.54 up Mm.195525 D2Bwg0891e 99641_at AW121364 DNA segment, Chr 2, Brigham & Women's Genetics 0891 expressed4251 0.19980 2.10 up Mm.5366 Mm.5366 99348_r_at AA116459 EST4252 0.19981 3.28 up Mm.1155 Tuba4 161592_at AV291613 tubulin alpha 44253 0.19989 8.36 up Mm.147387 Col3a1 98331_at X52046 procollagen, type III, alpha 14254 0.19991 1.98 up Mm.196085 Igh-4 99850_at X01857 immunoglobulin heavy chain 4 (serum IgG1)4255 0.19994 3.03 up Mm.140768 G6pc-rs 95330_at Z47787 glucose-6-phosphatase, catalytic, related sequence4256 0.19996 1.75 down Mm.22453 1190002A23Rik 104324_at AA940036 RIKEN cDNA 1190002A23 gene4257 0.19998 1.73 up Mm.30670 Spnr 103329_at X84692 spermatid perinuclear RNA binding proteinPage 48 of 48