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Chromatin modification induced by DNAmethylation Histone H3 Inactive = Methylation ↔ Active = Acetylation Methylation of histone H3 increases the nucleosome’sstability.1. MeCP2 binds to methylated regions of DNA andhistone deacetylase.2. EZH2 binds to DNA methyltransferase which wouldmethylate DNA and histone.3. Histone H1 binds to methylated regions of DNA.4. Heterochromatin.
Chromatin decompactionMechanical and chemical modificationson the chromatin regulate geneexpressions.4• Dosage compensation• Methylation• Insulator
Page 3 and 4: An integrated account of gene expre
Page 9 and 10: Nucleosome and chromatin structureC
Page 11 and 12: Inactivation of a single X chromoso
Page 13 and 14: X chromosome inactivation in mammal
Page 15 and 16: Chromatin decompactionMechanical an
Page 17: Methylation of globin genes in huma
Page 21 and 22: Insulators on folate/-globin genesp
Page 23 and 24: Basic anatomy of the genePromoter r
Page 25 and 26: Formation of the active eukaryotic
Page 27 and 28: Transcription factor DNA-binding do
Page 29 and 30: Summary of the steps involved in th
Page 31 and 32: Coupled transcription and mRNA proc
Page 33 and 34: Regulation of ectoderm-specific gen
Page 35 and 36: Alternative RNA splicing FgfR2 & Bc
Page 37 and 38: 5.39 An integrated account of gene
Page 39 and 40: Differential mRNA longevity The lon
Page 41 and 42: Control of gene expression at the l
Page 43 and 44: Translational regulation in oocytes
Page 45 and 46: Current model for the formation and
Page 47 and 48: The dsRNA-mediated gene silencing p
Page 49: Next Class on Sep-15 Chapter 7, Fer

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