Dimension® Cyclosporine (CSA) Assay - Medcorp
Dimension® Cyclosporine (CSA) Assay - Medcorp
Dimension® Cyclosporine (CSA) Assay - Medcorp
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Dimension® <strong>Cyclosporine</strong> (<strong>CSA</strong>) <strong>Assay</strong>The Dimension® <strong>Cyclosporine</strong> (<strong>CSA</strong>) <strong>Assay</strong> combines the equivalent specificityof the Syva® EMIT® 2000 <strong>Assay</strong> with fully automated processing requiring no samplepre-treatment on the Dimension® RxL HM, Xpand TM HM and AR clinical chemistryanalyzers.Key attributes● accurate results, excellentcorrelation with HPLC method● monospecific assay, employsEMIT® antibody● fully automated processing,no sample pre-treatment● high volume throughputon Dimension® RxL HM,Xpand TM HM and ARPerformancecharacteristics● quantitative measurement of<strong>CSA</strong> in EDTA whole blood● low <strong>CSA</strong> metabolitecross-reactivity● assay range: 25-500 ng/mL● calibration interval: 30 days● time to first result:
Method comparison500500Dimension® <strong>Cyclosporine</strong> <strong>Assay</strong> (ng/ml)400300200100y = 1.08 - 0.5n = 241r = 0.985Dimension® <strong>Cyclosporine</strong> <strong>Assay</strong> (ng/ml)400300200100y = 1.04 - 2.9n = 182r = 0.9600 100 200 300 400 50000 100 200 300 400 500HPLC (ng/ml)Emit® 2000 <strong>Cyclosporine</strong> <strong>Assay</strong> (ng/ml)Dimension® <strong>Cyclosporine</strong> <strong>Assay</strong> vs. HPLCTransplant categories: heart & kidneyDimension® <strong>Cyclosporine</strong> <strong>Assay</strong> vs. Emit® 2000<strong>Cyclosporine</strong> <strong>Assay</strong>Transplant categories: liver & kidneyReproducibilityTotal n QC 1 QC 2 QC 3precision mean CV mean CV mean CV(ng/mL) (%) (ng/mL) (%) (ng/mL) (%)Lab 1 20 103.3 9.5 204.3 6.8 287.3 6.2Lab 2 20 97.8 6.7 208.3 5.3 300.9 4.6Lab 3 20 98.0 9.1 209.3 6.9 304.4 4.9Lab 4 20 92.5 8.1 193.9 5.5 274.5 7.1Ordering & technical informationDimension® <strong>Cyclosporine</strong> Flex® Catalogue number: DF89Reagent Cartridge Packaging: 80 tests per cartonDimension® <strong>Cyclosporine</strong> Calibrator Catalogue number: DC89Packaging:2 x 2.5 mL (0), 4 x 2 mLDimension ® , Syva ® , EMIT ® and Flex ® are registered trademarksof Dade Behring Inc. in Germany and other countries. Xpand TM is atrademark of Dade Behring Inc. Information given in this brochureis accurate at the time of going to press. Details in the packageinsert are binding in each individual case. This brochure is for useoutside the USA. 131 296 E 02/07DADE BEHRINGHoechster Strasse 7065835 Liederbach, Germanywww.dadebehring.com
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