DQ8-villin-IL-15tg

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IL-15 promotes a weak T H 17 anti-gluten T cell responseafter oral ingestion of gliadinCeliac DiseaseCrohn’s diseaseHunt, K. A. et al. Nat. Genet., 2008Franke A. et al., Nat. Genet., 2010
Perspectives: Blocking IL-15 signaling prevents theinduction of inflammatory T cell responses to fed antigenDQ8/ DQ8-D d -IL-15tg miceanti-IL-15TMβ-1 (anti-IL-2Rβ)anti-IL-12i.p.PBS (sham)gliadini.g.10 daysRe-stimulation of Lp and MLN cellsW/gliadinAnalysis of IFN-γ production
Page 1 and 2: SYNERGISTIC ROLE OF IL-15IN THE EPI
Page 3 and 4: Intestinal HomeostasisDefault respo
Page 5 and 6: Is there a link between dysregulate
Page 7: IL-15 induces an inflammatory IFN-
Page 11 and 12: DQ8-D d -IL-15tg mice fed gluten ph
Page 13 and 14: Effector intraepithelial CTL killst
Page 15 and 16: INNATE IMMUNE ACTIVATION“CD4 anti
Page 17 and 18: SHAMDQ8 DQ8-D d -IL-15tg DQ8-villin
Page 19 and 20: DQ8-D d -villin-IL-15tg mice fed gl
Page 21 and 22: In absence of DQ8D d -villin-IL-15t
Page 23 and 24: AcknowledgmentsValerie AbadieWillia

DQ8-villin-IL-15tg

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