DQ8-villin-IL-15tg
DQ8-villin-IL-15tg DQ8-villin-IL-15tg
IL-15 promotes a weak T H 17 anti-gluten T cell responseafter oral ingestion of gliadinCeliac DiseaseCrohn’s diseaseHunt, K. A. et al. Nat. Genet., 2008Franke A. et al., Nat. Genet., 2010
Perspectives: Blocking IL-15 signaling prevents theinduction of inflammatory T cell responses to fed antigenDQ8/ DQ8-D d -IL-15tg miceanti-IL-15TMβ-1 (anti-IL-2Rβ)anti-IL-12i.p.PBS (sham)gliadini.g.10 daysRe-stimulation of Lp and MLN cellsW/gliadinAnalysis of IFN-γ production
- Page 1 and 2: SYNERGISTIC ROLE OF IL-15IN THE EPI
- Page 3 and 4: Intestinal HomeostasisDefault respo
- Page 5 and 6: Is there a link between dysregulate
- Page 7: IL-15 induces an inflammatory IFN-
- Page 11 and 12: DQ8-D d -IL-15tg mice fed gluten ph
- Page 13 and 14: Effector intraepithelial CTL killst
- Page 15 and 16: INNATE IMMUNE ACTIVATION“CD4 anti
- Page 17 and 18: SHAMDQ8 DQ8-D d -IL-15tg DQ8-villin
- Page 19 and 20: DQ8-D d -villin-IL-15tg mice fed gl
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- Page 23 and 24: AcknowledgmentsValerie AbadieWillia
<strong>IL</strong>-15 promotes a weak T H 17 anti-gluten T cell responseafter oral ingestion of gliadinCeliac DiseaseCrohn’s diseaseHunt, K. A. et al. Nat. Genet., 2008Franke A. et al., Nat. Genet., 2010
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