DQ8-villin-IL-15tg

IngestedglutenEnvironmentalfactorsgliadinVRVPVPQLQPQNPSQQQPQEQVPLVQQQQFLGQQQPFPPQQPYPQPQPFPSQQPYLQLQPFPQPQLPYSQPQPFRPQQPYGluten is not digested(proline-rich)protease-resistantlong gliadinpeptidesShan et al., Science, 2002(glutamine-rich)Tissue Transglutaminase (TG2)LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPFVader et al., J exp Med, 2002Molberg et al., Nat Med, 1998Van de Wal et al., J immunol, 1998TG2QQYPSGQGSFQPSQQNPQPQPELPYPQPPFPQPELPYPimmunogenic gliadin peptidesEGSFQPSQETCRHLA-DQ2CD4CD4TCRHLA-DQ8Vader et al., J exp Med, 2002Molberg et al., Nat Med, 1998Van de Wal et al., J immunol, 1998anti-gluten T cell responseNilsen et al., Gut, 1995Molberg et al., Scand.J.Immunol., 1997Nilsen et al., Gastroenterology, 1998