DQ8-villin-IL-15tg

INNATE IMMUNE ACTIVATION“CD4 anti-gluten T cell responses are requiredbut not sufficient to induce intestinal damage”Adaptive immune response(anti-TG2 antibodies)Innate epithelial response(IL-15, epithelial stress markers)Kaukinen et al. Scand J Gastroenterol, 2005Marietta et al. JCI, 2004de Kauwe et al., J Immunol, 2009IEL activation↓Inhibitory NKG2A↑Activatory NKR (CD94+NKG2A-, NKG2D+)Jabri et al., Gastroenterology 2001Meresse et al., Immunity 2004Hue et al., Immunity 2004Meresse et al., J.Exp.Med. 2006VILLOUS ATROPHYInhibitory NK receptorsActivatory NK receptorsActivatory NK receptorsSetty M. et al., in preparation