DQ8-villin-IL-15tg
DQ8-villin-IL-15tg
DQ8-villin-IL-15tg
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<strong>DQ8</strong>-D d -<strong>IL</strong>-<strong>15tg</strong> mice fed gluten phenocopythe early stages of Celiac Disease characterized by the inductionof an adaptive anti-gluten immunity in the absence of villous atrophy(Potential Celiac Disease)• IFN-γ + and <strong>IL</strong>-21 + anti-gluten CD4 + T cell responses• Anti-gliadin antibodies•Autoantibodies: Anti-transglutaminases•Infiltration of intraepithelial lymphocytesMarsh 1Marsh 1DePaolo R.W. & Abadie V.et al., Nature, 2011
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