Meridian Life Science, Inc. - Antibodies, Antigens, Blocking agents ...

®Life Science, Inc.Meridian Life Science, Inc. (MLS) is a leading large scalemanufacturer of antibodies, viral antigens, recombinantproteins, and critical assay reagents. We provide contractR&D, process development, and manufacturing servicesto the biopharmaceutical and in vitro diagnostic marketsalong with cGMP biologics manufacturing for Phase I/IIclinical trials.With the acquisition of Bioline, MLS has addedPCR capabilities and products to complement MLS’expanding life science product line sold to the research,pharmaceutical and diagnostic manufacturer markets.Bioline adds proprietary know-how in the manufacturingof high quality, high volume nucleotides and PCRenzymes.MLS has been providing innovative life science solutionsand building trusted partnerships for almost thirty years.Our focus is to offer products and services that helpto advance the development of diagnostic assays andvaccine development.• Extensive scientific expertise in viral antigenexpression, production and contract R&D services• Large scale manufacturing of nativeand recombinant antigens• Commercial manufacturing of mouse IgG,TRU Block® and other HAMA blockers• Highly efficient ascites and cell cultureantibody production services• Protein purification expertise• Custom designed products percustomers’ specifications• Antibodies, Antigens and Immunoassay reagents• Dedicated R&D and Manufacturing Teams• Technical Support with assay development experience• Reagents for molecular assays• Robust and Mature Quality SystemISO 9001 Certified & cGMP Compliant- 1 -

CapabilitiesOVERVIEW OF CAPABILITIESMeridian Life Science, Inc. is an industry leader in the commercial manufacturing of critical raw materials for the in vitrodiagnostic market. With a proven track record in cell culture, ascites, viral propagation, and protein purification, weinvite you to leverage our experience to design and develop manufacturing processes that are the right fit for you.PRODUCTION SYSTEMSTissue culture flasksSpinner flasksRoller bottles (smooth and ribbed)Cell factoriesWAVE Bioreactors TMFermentorsEXPRESSION SYSTEMSMammalian (CHO, Vero, NS0, etc.)Bacterial (E.coli)Yeast (P. pastoris, S. cerevisiae, H. polymorpha)Baculovirus in Sf9Egg-based Virus ProductionVaccinia & AdenoIN VIVO / ASCITES CAPABILITIESDedicated facility with 55,000 mice capacityUp to 5,000 mice per lotMultiple strains availablePURIFICATION METHODSProtein A/GUltrafiltrationDiafiltrationTFF (plate or hollow fiber)Centrifugation/ultracentrifugationÄKTA FPLC systems for SEC, Affinity, Ion exchange, HICDialysis, ultracentrifugation, tangential flowExpanded bed chromatographyCentrifugation, gradient centrifugationMicrofluidization, freeze/thaw, chemical lysisQUALITY CONTROL AND ANALYTICAL TESTINGISO 9001cGMPMonthly customer auditsIn-house testing:Protein concentration (UV/Vis, BCA)Cell density/viabilitySDS-PAGESterilitySilver stainingELISAHPLCWestern blotCustom assay development and testingWAVE is a trademark of GE Healthcare- 3 -

servicesContract R&D and cGMP MANUFACTURING ServicesMeridian Life Science, Inc. (MLS) provides contract R&D, process development, scale-up, and downstreamprocessing services to support IVD and biopharmaceutical production and has produced over 20 clinical gradebiotherapeutics and vaccines in our cGMP facility in Memphis, TN. MLS possesses a mature Quality System withexperience supporting clinical products manufactured in our validated cleanroom facility in accordance with cGMP(21 CFR 210/211). Services include clinical cGMP biomanufacturing for vaccines, viral challenge materials, virus-likeparticles, vectored gene therapies, and recombinant proteins in all expression systems.Biopharmaceutical ExperienceInfluenza Challenge StockRSV Challenge StockRhinovirus Challenge StockNIAID Experimental Vaccines- 2 Dengue- 4 RSV- 1 PIV3Rotavirus VaccineDivalent VLP Norovirus VaccineLentivirus Vector for Preclinical and ClinicalParvovirus B19 VLP VaccineVaccinia ProductionCell-based Specialty AssaysClinical Phase I /II ProductionViral VaccinesRecombinant, Live, Attenuated, ChallengeVLPs, Oncolytic, & Therapeutic VaccinesGene Therapy VectorsRecombinant Proteins (BEVS)SERVICESVirus generationCell & Viral BankingProcess development- Upstream and downstreamPilot studiesYield optimizationValidation lotsAnalytical methods development & testingFormulation & FillSub-cloning into new expression vectorClone developmentTransient expression and evaluationCell line rescue and subcloningStable cell line developmentImmunization & hybridoma fusionConversion from ascites to cell culture- 5 -

servicesCustom Antibody Development and ManufacturingCLONAL DEVELOPMENT, SELECTION, AND ADAPTATIONImmunogenImmunization /Hybridoma fusionClonal selection /screeningPROJECT CAN BEGIN AT ANY STAGEEvaluation / Adaptation of Candidate ClonesOPTION: Conversion toserum free mediaAnalytical TestingSelection of lead candidatesfor pilot studyHybridoma Cell BankOPTION: Sub-cloningNext Step:Optimization or Pilot RunEstablishedHybridomaCell LineTech Transfer /Optimization /Feasibility StudyANALYTICAL TESTING• UV/Vis • ELISA• SDS-PAGE • HPLC• Silver• Cell density/viability• Western blotTesting / AnalyticalGo / No-Go PointOPTIMIZATION STUDIESUPSTREAM OPTIMIZATIONCell Density& ViabilityMediaSelectionDOWNSTREAM OPTIMIZATIONMaster andWorkingCell BankPhysiologicalConditionsProductionSystemMouseStrain(In Vivo only)FeedingScheduleHarvestConditionsInjectionConcentration(In Vivo only)ElutionMethodsFinal BufferConditionsFiltrationMethodsColumnParametersNext Step:ProductionPILOT AND COMMERCIAL MANUFACTURINGPilot Run(1L - 20L scaleor 20+ mice)Testing & Batch Record(e.g.; yield, PTMs, purity)Optional: Validation Runs(increasing in scale or atscale)CommercialProduction- 7 -

servicesRecombinant Protein CUSTOM SERVICESE. coli and Yeast ServicesSub-cloning into appropriate expression vector, analysisby sequence, restriction digest and plasmid maxi-prepExpression and Evaluation - Transform into appropriate host strain(S. cerevisiae or P. pastoris for yeast)Pilot Study and Optimization - Small scale culture and purification,QC by SDS-PAGE and Western BlotBaculovirus/Insect Cell ServicesSub-cloning into appropriate expression vector, analysisby sequence and restriction digest and plasmid maxi-prepExpression and Evaluation - Transformation into appropriate host strainVirus Generation - Generation of recombinant bacmidTransfection of insect cell with recombinant bacmid DNAGeneration and titration of high titer viral stocksPilot Study and Optimization - Infection of insect cells with P3 stockExpression optimization and detection:MOI, time course, cell linesSmall scale culture and purification,QC by SDS-PAGE and Western BlotMammalian ServicesSub-cloning into appropriate expression vector, analysisby sequence and restriction digest and plasmid maxi-prepExpression and Evaluation - Transient transfection into appropriate host strain(CHO, HEK-293, etc.)OPTIONAL: Stable cell line developmentProtein expression level determinedby ELISA or Western BlotPilot Study and Optimization - Small scale culture and purification,QC by SDS-PAGE and Western Blot- 8 - www.MeridianLifeScience.com

servicesR&D to Commercial Scale ManufacturingPRODUCTION SYSTEMSTissue Culture Flasks | Spinner Flasks | Roller Bottles | Cell Factories | WAVE Bioreactors TM | FermentorsCELL BANKINGMCB & WCB | CharacterizationCULTURE CONDITION ANALYSIS - Variable matrix analysisCell density | Media optimization | Production system | Feed vs. batch mode | Physiological conditionsANALYTICAL TESTINGSDS-PAGE (Variety of Stains) | Western Blot | UV-Vis Spectrophotometry | BCA/BradfordHPLC Methods (RP, SEC, Other) | LAL Endotoxin | ELISA or other activity assay (Fluorescent Capabilities)UPSTREAM OPTIMIZATION DOWNSTREAM OPTIMIZATION PRODUCTIONPURIFICATION METHODSSEC, IEC, HIC, HyAP | Affinity columnsCentrifugation, UltracentrifugationUltrafiltration, Diafiltration, TFF (Plate or Hollow Fiber)Formulation, Fill/FinishEQUIPMENTÄKTAprime | ÄKTAexplorer | ÄKTApilot | ÄKTAreadyPURIFICATION PROCESS DESIGN - Variable matrix analysisHarvest conditions | Lysis conditionsClarification (Centrifugation / Filtration)UF / DF | Chromatography | PrecipitationVALIDATION LOTSValidate at scaleRegulatory requirementsPILOT STUDYFixed-fee 1L, 5L, and 10L pilot studiesROUTINE PRODUCTIONFlexible schedulingQuotes on a per mg or gram basisANALYTICAL TESTINGSDS-PAGE (Variety of Stains) | Western Blot |UV-Vis Spectrophotometry | BCA/BradfordHPLC Methods (RP, SEC, Other) | LAL EndotoxinELISA or other activity assay (Fluorescent Capabilities)- 9 -

productsPRODUCT RANGEINFECTIOUS DISEASERubellaToxoHepatitisCMVEBVVZVMumpsRubeolaHIV-1, 2HSV-1, 2HBsAg (ad & ay)HCVNorovirusAdenovirusRSVInfluenza A,BDengueChikungunyaMalariaChagasCampylobacterChlamydiaC. difficileE. coliLegionellaMycoplasmaMycobacteriumH. pyloriSalmonellaTUMOR MARKERSAFPCA 125CA 15-3CA 19-9CA 72-4CA 50CEACyfra 21-1erbB-2/HER2Muc1NSEOsteopontinp53PSAS-100CARDIAC MARKERSCK-MB, CK-MM, CK-BBTroponin I, TMyoglobinBNPpro-BNPCRPMPOD-DimerGalectin - 3Cystatin - CIMMUNOGLOBULINSAnimal IgG –bovine, chicken, goat, mouseHuman IgA, IgG, IgM, IgE,Kappa light chain,Lambda light chainGoat anti-human IgG, IgM, IgAGoat anti-mouse IgGHORMONESLH, FSH, hCG, hGHCortisol, EstradiolInsulin, C-peptideProlactinProgesteronePTHPAPP-ATSH, T4, T3, ACTHThyroglobulinFor a complete list please visit us at www.MeridianLifeScience.comOther Product Categories availble• Drugs of Abuse• Food & Water Safety• Genetic, CNS & Autoimmune• Clinical Chemistry• Blood Banking- 10 - www.MeridianLifeScience.com

productsINFECTIOUS DISEASEMost Popular Products - for a complete listing please visit www.MeridianLifeScience.com.ANTIGENSSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeChagasChagas Antigen 1F8, Recomb. R01436 E. coli N/A N Purified 0.25mg N/A Proclin 300Chagas Multiantigen, Recomb. R01364 E. coli N/A EIA,LF N Purified 1mg N/A NaN3Trypanosoma cruzi B13, Recomb. R01499 E. coli N/A EIA Y Purified 1mg N/A NoneTrypanosoma cruzi FRA, Recomb. R01500 E. coli N/A EIA Y Purified 1mg N/A NoneTrypanosoma cruzi IF8, Recomb. R01498 E. coli N/A EIA Y Purified 1mg N/A NoneCytomegalovirus (CMV)CMV, 90% Viral Protein 8180 P3H3 or P3HR-1 N/A EIA Y Aff.Pur. 1mL N/A NoneEBV, Nuclear Antigen-1 (EBNA-1)RecombinantR01522 E.coli N/A EIA,WB Y Purified 1mg N/A NoneEBV, p18 (VP26), Recombinant R01519 E.coli N/A EIA N Purified 1mg N/A NoneEBV, p18 (VP26), Recombinant R01516 E.coli N/A EIA,LF,WB Y Purified 1mg N/A NoneEBV (HHV-4) Early Antigen D (EA-D)RecombinantR18740 E. coli N/A EIA,WB N Purified 1mg N/A NoneEBV, Nuclear Antigen-1 (EBNA-1)(a.a. 1-90, 408-498), RecombinantR01520 E.coli N/A EIA N Purified 1mg N/A NoneHelicobacter pylori (H. pylori)H. pylori (Strain 43504) R92101 H. pylori Culture N/A EIA Y Lysate 1mg N/A NaN3Hepatitis (HAV / HBcAg / HBeAg / HBsAg / HCV)HAV, >60% Viral Protein 8198 FRhK-4 Cells N/A EIA,WB Y Partially Purified 1mL N/A NaN3HAV, Concentrate, >60% Viral Protein 8505 FRhK-4 Cells N/A EIA,WB Y Partially Purified 1mL N/A NaN3HBcAg (183 a.a.) Recombinant VTI610 Pichia pastoris N/A WB Y Purified 1mg N/A NoneHBcAg (a.a. 1-183) 18kDa, Recombinant R8A120 E. coli N/A EIA,LF,WB N Purified 0.5mg N/A NoneHBeAg, Recombinant R01401 E. coli N/A EIA N Purified 1mg N/A NoneHBsAg (ad) R01289 S. cerevisiae N/A EIA,WB N Purified 100ug N/A NoneHBsAg (ad) R36100 Human Plasma N/A N Purified 1mg N/A NaN3HBsAg (adw) Recombinant R18560 Pichia pastoris N/A EIA,WB N Purified 0.5mg N/A NoneHBsAg (adw) Recombinant R86872 S. cerevisiae N/A EIA N Purified 0.5mg N/A NoneHBsAg (adw) Recombinant R01403 Pichia pastoris N/A EIA N Purified 1mg N/A NoneHBsAg (ay) R01290 S. cerevisiae N/A EIA,WB N Purified 100ug N/A NoneHBsAg (ay) R36200 Human Plasma N/A N Purified 1mg N/A NaN3HBsAg (ayw) Recombinant R86870 S. cerevisiae N/A EIA N Purified 0.5mg N/A NoneHCV, Core Antigen (a.a. 1-120)16kDa, RecombinantVTI710 Pichia pastoris N/A WB Y Purified 1mg N/A NoneHCV, NS-3 c33c (a.a. 1192-1459)Genotype 1a, RecombinantR01518 E.coli N/A EIA N Purified 1mg N/A NoneINFECTIOUS DISEASE- 11 -

productsINFECTIOUS DISEASEANTIGENSSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeHerpes Simplex Virus (HSV)HSV, Grade II EV9287 Vero Cells N/A EIA Y Purified 1mL N/A NoneHSV-1, Antigen (Strain F)

productsANTIGENSSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeMycoplasma pneumoniaeMycoplasma pneumoniae (Strain FH) R01494 Culture N/A EIA Y Purified 1mg N/A NoneMycoplasma pneumoniae (Strain FH) R02102 Culture N/A Y Purified 1mL N/A NonePlasmodiumPlasmodium falciparum (Malaria) Histidine-Rich Protein 2 (HRP-2), RecombinantR01478 E. coli N/A EIA N Purified 1mg N/A NaN3Plasmodium vivax CSP protein,Recombinant (Malaria CSP pv)R01440 E. coli N/A EIA N Purified 1mg N/A NaN3Plasmodium vivax MSP-1 protein,Recombinant (Malaria MSP-1, pv)R01439 E. coli N/A EIA N Purified 1mg N/A NaN3Respiratory Syncytial Virus (RSV)RSV (Strain Long) 60% Viral Protein6075 Vero Cells N/A EIA Y Purified 1mL N/A NoneRubella Grade IV Antigen (Strain HPV77)>90% Viral Protein6076 Vero Cells N/A EIA Y Purified 1mg N/A NoneRubella Grade IV Antigen (Strain HPV77)>90% Viral Protein, PBS6123 Vero Cells N/A EIA,WB Y Purified 1mg N/A NoneRubella RSVP (TM) (Strain HPV77)>90% Viral Protein, Capsid-Free6200 Vero Cells N/A EIA,WB Y Purified 1mg N/A NoneRubeola (Measles)Rubeola (Measles) Edmonston Strain R14120 Vero Cells N/A EIA Y Partially Purified 1mg N/A NoneRubeola (Measles) Nuclear Protein,RecombinantEV9298 Sf9 Cells N/A EIA,WB Y Purified 1mL N/A NoneToxoplasma gondiiToxoplasma gondii Antigens 8122 HeLa/Tachyzoites N/A EIA Y Partially Purified 1mg N/A NoneToxoplasma gondii Antigen,Grade III,

productsINFECTIOUS DISEASEMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeAdenovirusAdenovirus C65431M Mouse 143EIA,IFA,LF,PrN Purified 100ug IgG1 NaN3Adenovirus C11994M Mouse B209M N Purified 1mg IgG NaN3Adenovirus hexon C86804M Mouse 8C4 EIA,Pr N Purified 1mg IgG2a NaN3Adenovirus hexon C01296M Mouse B315M N Purified 1mg IgG NaN3Campylobacter jejuniCampylobacter jejuni C65727M Mouse BDI727 EIA,WB N Purified 100ug IgG1 NaN3Campylobacter jejuni C65717M Mouse BDI717 EIA,WB N Purified 100ug IgG1 NaN3Chikungunya VirusChikungunya Virus C01642M Mouse B1414M EIA,IFA N Purified 100ug IgG2b NaN3Chikungunya Virus C01640M Mouse B1412M EIA,IFA N Purified 100ug IgG1 NaN3Chikungunya Virus C01641M Mouse B1413M EIA,IFA N Purified 100ug IgG1 NaN3Chikungunya Virus EV9522 Mouse B1421M EIA N Purified 1mg IgG2a NaN3Chlamydia species LPSChlamydia species LPS C01365M Mouse B352M EIA,Pr N Purified 100ug IgG2b NaN3Chlamydia species LPS C01364M Mouse B351M EIA,Pr N Purified 100ug IgG2b NaN3Chlamydia species LPS C01367M Mouse B353M EIA,Pr N Purified 100ug IgG2b NaN3Chlamydia species LPS C01368M Mouse B354M EIA,Pr N Purified 100ug IgG2b NaN3Chlamydia species LPS MAV07-347 Mouse 027-10347 N Purified 1mg IgG2b,k NaN3Chlamydia trachomatisChlamydia trachomatis C66435M Mouse K14.67 N Purified 1mg IgG3,k NaN3Chlamydia trachomatis andChlamydophila psittaciC66436M Mouse A21-65 IFA,IHC(p) N Purified 1mg IgG3,l NaN3Chlamydia trachomatis LPS C01566M Mouse B1214M LF,Pr N Purified 1mg IgG NaN3Chlamydia trachomatis LPS C01235M Mouse 111-15174 EIA N Purified 0.2mg IgG2a NaN3Chlamydia trachomatis LPS C01565M Mouse B1215M LF,Pr N Purified 1mg IgG NaN3Clostridium difficileClostridium difficile Toxin A C70517M Mouse PCG4.1 EIA Y Purified 1mg IgG2a NaN3Clostridium difficile Toxin B C65429M Mouse B428M EIA N Purified 100ug IgG1 NaN3Clostridium difficile Toxin B C65427M Mouse B427M EIA N Purified 100ug IgG1 NaN3Clostridium difficile Toxin B C65426M Mouse B426M EIA N Purified 100ug IgG1 NaN3Clostridium difficile Toxin B C65424M Mouse B424M EIA N Purified 100ug IgG1 NaN3Clostridium difficile Toxin B C65423M Mouse B423M EIA N Purified 100ug IgG1 NaN3Clostridium difficile Toxin B C70885M Mouse 5A8-E11 Y Ascites 1mL IgG1,k NaN3Clostridium difficile Toxin B C70888M Mouse 5A8-E11 Y Purified 1mg IgG1,k None- 14 - www.MeridianLifeScience.com

productsMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeCytomegalovirus (CMV)CMV, Glycoprotein B C8A024M Mouse 1-M-12 EIA,IFA,WB N Purified 100ug IgG1 NaN3DengueDengue Types 1,2,3,4 C03045M Mouse BDI419 DB,EIA,IFA N Purified 1mg IgG2a,k NaN3Dengue Type 2, envelope C01551M Mouse B932M IFA N Purified 0.5mg IgG1 NoneE. coli O157E. coli O157 C01536M Mouse B838M EIA,IFA,Pr N Purified 100ug IgG1 NaN3E. coli O157 C01535M Mouse B837M EIA,IFA,Pr N Purified 100ug IgG1 NaN3E. coli O157 C01537M Mouse B839M EIA,IFA,Pr N Purified 100ug IgG3 NaN3E. coli O157 C01534M Mouse B836M EIA,IFA,Pr N Purified 100ug IgG2b NaN3E. coli O157 C01533M Mouse B835M EIA,IFA,Pr N Purified 100ug IgG1 NaN3E. coli O157 C65310M Mouse 3011 IFA N Purified 100ug IgG3 NaN3Epstein-Barr Virus (EBV)EBV, Viral Capsid Antigen gp125 C66405M Mouse 2E08 N Purified 1mg IgG1,k NaN3Helicobacter pylori (H. pylori)H. pylori, 54kDa (flagellin) C65516M Mouse BDI516 EIA,IFA,WB N Purified 100ug IgG1 NaN3H. pylori, 54kDa (flagellin) C65461M Mouse BDI461 EIA,IFA,WB N Purified 100ug IgG1 NaN3H. pylori, CagA Protein C01529M Mouse B818M EIA,WB,Pr N Purified 1mg IgG NaN3H. pylori, CagA Protein C86548M Mouse B237H EIA,WB,Pr N Purified 1mg IgG NaN3H. pylori, CagA Protein C86547M Mouse B236H EIA,Pr N Purified 1mg IgG NaN3HepatitisHepatitis A Virus (HAV) C65868M Mouse BDI868 EIA,IHC N Purified 100ug IgG3 NaN3Hepatitis A Virus (HAV) C65885M Mouse 581 EIA N Purified 100ug IgG2a NaN3Hepatitis B Core Antigen (HBcAg) C86317M Mouse H6F5 EIA,Pr,WB N Purified 1mg IgG2a NaN3Hepatitis B Core Antigen (HBcAg) C86340M Mouse H3A4 EIA,Pr,WB N Purified 1mg IgG2a NaN3Hepatitis B 'e' Antigen (HBeAg) C31170M Mouse 773 EIA,Pr N Purified 1mg IgG2a NaN3Hepatitis B Surface Antigen (HBsAg) MAV18-511 Mouse 090-18511 EIA,Pr N Purified 1mg IgG1,k NaN3Hepatitis B Surface Antigen (HBsAg) C86303M Mouse Hs33 EIA,Pr N Purified 1mg IgG2a NaN3Hepatitis B Surface Antigen (HBsAg) C86401M Mouse Hs41 EIA,Pr N Purified 1mg IgG1 NaN3Hepatitis B Surface Antigen (HBsAg) (ad/ay) C01248M Mouse B117M EIA, Pr N Purified 100ug IgG2a NaN3Hepatitis B Surface Antigen (HBsAg) (ad/ay) C01247M Mouse B118M EIA, Pr N Purified 100ug IgG2a NaN3Hepatitis B Surface Antigen (HBsAg) (ad/ay) C01250M Mouse B116M EIA, Pr N Purified 100ug IgG1 NaN3Hepatitis B Surface Antigen (HBsAg) (ad/ay) C01249M Mouse B121M EIA,Pr N Purified 100ug IgG2a NaN3Hepatitis B Surface Antigen (HBsAg) (ad/ay) C01246M Mouse B119M EIA,Pr N Purified 100ug IgG2a NaN3Hepatitis B Surface Antigen (HBsAg) (ay) C01600M Mouse B1264M EIA,WB N Purified 1mg IgG2a NaN3Hepatitis B Surface Antigen (HBsAg) (ay) MAV18-004 Mouse 057-17004 EIA,Pr N Purified 1mg IgG2a,k NaN3Hepatitis C Virus (HCV) Core Antigen C01251M Mouse B055M EIA,Pr N Purified 100ug IgG2a NaN3Hepatitis C Virus (HCV) Core Antigen C01252M Mouse B056M EIA,IFA,Pr N Purified 100ug IgG1 NaN3Hepatitis C Virus (HCV) Core Antigen C01253M Mouse B057MEIA,WB,IFA,PrN Purified 100ug IgG1 NaN3Hepatitis C Virus (HCV) Core Antigen(a.a. 33-38)C65317M Mouse B317MEIA,IFA,IHC,Pr,WBN Purified 100ug IgG1 NaN3INFECTIOUS DISEASE- 15 -

productsINFECTIOUS DISEASEMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeHerpes Simplex Virus (HSV)HSV-1, Glycoprotein G-1 C66150M Mouse H1379 WB,IFA N Purified 0.5mg IgG2a NaN3HSV 1 & 2, Glycoprotein D C01294M Mouse B287M EIA,Pr N Purified 1mg IgG2a NaN3HSV 1 & 2, Glycoprotein D C01293M Mouse B286M EIA,Pr N Purified 1mg IgG NaN3HSV 1 & 2, Envelope gp C65171M Mouse 017 IFA,WB N Purified 100ug IgG2a NaN3HSV 2, Glycoprotein G-2 C66501M Mouse H1206 Y Ascites 1mL IgG1 NoneHSV 2, Glycoprotein G-2 C66500M Mouse H1206 N Purified 0.5mg IgG1 NaN3HIVHIV-1 p24 C65690M Mouse BDI690 EIA,Pr N Purified 100ug IgG1 NaN3HIV-1 p24 C65499M Mouse BDI499 EIA,Pr N Purified 100ug IgG1 NaN3HIV-1 p24 C65941M Mouse 491EIA,IFA,IHC(f), N Purified 100ug IgG1 NaN3Pr,WBInfluenzaInfluenza A (Nucleoprotein) C65331M Mouse 1331 EIA,IFA,Pr N Purified 100ug IgG2a NaN3Influenza A (Nucleoprotein) C01321M Mouse B247M EIA,WB,Pr N Purified 1mg IgG1 NaN3Influenza A Hemagglutinin H1 C01278M Mouse B213M EIA,WB N Purified 1mg IgG1 NaN3Influenza A Hemagglutinin H1 C01281M Mouse B217M EIA,WB,Pr N Purified 1mg IgG1 NaN3Influenza A Hemagglutinin H1 C01282M Mouse B218M EIA,WB,Pr N Purified 1mg IgG1 NaN3Influenza A Hemagglutinin H1 C01283M Mouse B219M EIA,WB N Purified 1mg IgG1 NaN3Influenza A Hemagglutinin H1 C86304M Mouse IVC102 EIA,ICC,IFA N Purified 1mg IgG1 NaN3Influenza A Hemagglutinin H5 (Avian H5N1) C01309M Mouse B253M EIA,Pr N Purified 1mg IgG2a NaN3Influenza A Hemagglutinin H5 (Avian H5N1) C86280M Mouse B515MDB,EIA,HI,PrN Purified 1mg IgG2a NaN3Influenza A Hemagglutinin H5 (Avian H5N1) C86240M Mouse B519MDB,EIA,HI,PrN Purified 100ug IgG2a NaN3Influenza A Hemagglutinin H5 (Avian H5N1) C86490M Mouse B513M DB,EIA,HI N Purified 1mg IgG2a NaN3Influenza A Hemagglutinin H5 (Avian H5N1) C01310M Mouse B254M EIA,Pr,HI N Purified 1mg IgG2a NaN3Influenza B (Nucleoprotein) C65131M Mouse 1131 IFA,LF,Pr N Purified 100ug IgG2b NaN3Influenza B (Nucleoprotein) C01326M Mouse B265M EIA,WB,Pr N Purified 1mg IgG2b NaN3Influenza B (Nucleoprotein) C01328M Mouse B268M EIA,WB,Pr N Purified 1mg IgG1 NaN3Influenza B (Nucleoprotein) C01327M Mouse B267M EIA,WB,Pr N Purified 1mg IgG1 NaN3Influenza B (Nucleoprotein) C01329M Mouse B269M EIA,WB,Pr N Purified 1mg IgG1 NaN3Influenza B (Nucleoprotein) C65016M Mouse BDI016 IFA,LF,Pr N Purified 100ug IgG2b NaN3- 16 - www.MeridianLifeScience.com

productsMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeLegionella pneumophila LPSLegionella pneumophila LPS C01590M Mouse B1252M EIA,IFA,Pr N Purified 100ug IgG3 NaN3Legionella pneumophila LPS C01591M Mouse B1254M EIA,IFA,Pr N Purified 100ug IgG3 NaN3Legionella pneumophila LPSPhiladelphia 1 strainC86135M Mouse 2F10 DB,Pr N Purified 1mg IgG3 NaN3Legionella pneumophila LPSPhiladelphia 1 strainC86515M Mouse 5F4 EIA,Pr N Purified 1mg IgG3 NaN3MalariaMalaria - pLDH C66509M Mouse B1423M N Purified 1mg IgG2b,k NaN3Malaria - Plasmodium falciparumHistidine-Rich Protein 2 (HRP-2)C01585M Mouse B1245M EIA,Pr,LF N Purified 1mg IgG1 NaN3Malaria - Plasmodium falciparumHistidine-Rich Protein 2 (HRP-2)C01584M Mouse B1242M EIA,Pr,LF N Purified 1mg IgG1 NaN3Malaria - Plasmodium falciparumHistidine-Rich Protein 2 (HRP-2)C01586M Mouse B1243M EIA,Pr,LF N Purified 1mg IgG1 NaN3MumpsMumps Virus C65605M Mouse 6005 N Purified 100ug IgG1 NaN3Mumps Virus C65003M Mouse 6003 N FITC 100ug IgG1 NaN3Mumps Virus C65001M Mouse 6001 N Purified 100ug IgG1 NaN3Mycobacterium tuberculosisMycobacterium tuberculosis CFP10(10kDa culture filtrate protein)C01398M Mouse B386M EIA,Pr N Purified 1mg IgG1 NaN3Mycobacterium tuberculosis CFP10(10kDa culture filtrate protein)C01400M Mouse B391M EIA,Pr N Purified 1mg IgG2b NaN3NorovirusNorovirus, capsid protein C01257M Mouse B113M EIA,Pr N Purified 100ug IgG1 NaN3Norovirus, capsid protein C01258M Mouse B114M EIA,Pr N Purified 100ug IgG1 NaN3INFECTIOUS DISEASE- 17 -

productsINFECTIOUS DISEASEMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeRespiratory Syncytial Virus (RSV)RSV, Fusion Protein C65063M Mouse 631 EIA,IFA,Pr N Purified 100ug IgG2a NaN3RSV, Fusion Protein C65064M Mouse BDI064EIA,IFA,Neut,PrN Purified 100ug IgG1 NaN3RSV, Fusion Protein C65065M Mouse BDI065EIA,IFA,Neut,PrN Purified 100ug IgG2a NaN3RubellaRubella (E1) 10190 Mouse 26-24 WB Y Ascites 1ml IgG1,k NaN3Rubella (E1) 10191 Mouse 26-24 WB N Purified 1mg IgG1,k NaN3Rubella (E1) 10194 Mouse 2-36 WB Y Ascites 1ml IgG1,k NaN3Rubella (E1) 10195 Mouse 2-36 WB N Purified 1mg IgG1,k NaN3Rubella (E1) 10196 Mouse Ru6 WB N Purified 1mg IgG2a NaN3Rubella (E1) C66499M Mouse B456M EIA,WB N Purified 1mg IgG1 NaN3Rubella (E1) C66503M Mouse B146M EIA,WB N Purified 100ug IgG2b NaN3Rubella (E2) 10193 Mouse B147M WB N Purified 100ug IgG3 NaN3Rubella (E2) C66497M Mouse B148M EIA,WB N Purified 100ug IgG2a NaN3Rubella Capsid (C) Protein 10192 Mouse TP3 WB N Purified 1mg IgG2a NaN3Rubella Capsid (C) Protein C66496M Mouse 626 EIA,IFA,WB N Purified 100ug IgG1 NaN3Rubella Virus (E1) C86323M Mouse B1247M EIA,WB N Purified 1mg IgG1 NaN3Rubella Virus Core Protein C01430M Mouse B1241M EIA,WB N Purified 1mg IgG1 NaN3- 18 - www.MeridianLifeScience.com

productsMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeRubeola (measles)Rubeola (measles) C65011M Mouse 161 N Purified 100ug IgG1 NaN3Rubeola (measles) C65013F Mouse 161 N FITC 100ug IgG1 NaN3Rubeola (measles) C65610M Mouse 166 EIA,IFA N Purified 100ug IgG NaN3SalmonellaSalmonella species (A,B,C,D,E,F & G Groups) C01361M Mouse B347M EIA,IFA,Pr N Purified 100ug IgG2b NaN3Salmonella species (A,B,C,D,E,F & G Groups) C01358M Mouse B343M EIA,Pr N Purified 100ug IgG2a NaN3Salmonella species (A,B,C,D,E,F & G Groups) C01359M Mouse B345M EIA,IFA,Pr N Purified 100ug IgG2a NaN3Salmonella species (A,B,C,D,E,F & G Groups) C01360M Mouse B346M EIA,IFA,Pr N Purified 100ug IgG3 NaN3Salmonella typhimurium-LPS C86309M Mouse 1E6 EIA N Purified 1mg IgG1 NaN3ToxoplasmaToxoplasma gondii C86319M Mouse TP3 EIA,IFA,WB N Purified 1mg IgG2a NaN3Toxoplasma gondii, MIC3 C01587M Mouse B1241M EIA,WB,IFA N Purified 1mg IgG1 NaN3Toxoplasma gondii, p30 (SAG 1) C65620M Mouse 203 EIA,IFA,WB N Purified 100ug IgG2 NaN3Toxoplasma gondii, SAG1 C01523M Mouse B754M EIA,WB,IFA N Purified 100ug IgG2a NaN3Varicella-Zoster Virus (VZV)VZV, (Mixed) C05108MA Mouse MixedIFA,IHC(p),IP,WBY Purified 0.7mg Mixed NoneVZV, (155kDa) C05106MA Mouse NCP-1 Y Purified 0.5mg IgG1 NoneVZV, (gpI & IV) (VZVgE & gI) C05100MA Mouse SG1EIA,IFA,IP,WBY Purified 0.5mg IgG2b,k NoneVZV, (gpI & IV) (VZVgE & gI) C05101MA Mouse SG1-1 Y Purified 0.5mg IgG1 NoneVZV, (gpII) (VZVgB) C05102MA Mouse SG2-2E6 Y Purified 0.5mg IgG1 NoneVZV, (gpIII) (VZVgH) C05104MA Mouse SG3 Y Purified 0.5mg IgG1 NoneVZV, (gpIV) (VZVgI) C05105MA Mouse SG4 Y Purified 0.5mg IgG1 NoneVZV, 175kDa, gene 62 C05107MA Mouse IE(62) Y Purified 0.5mg IgG1 NoneINFECTIOUS DISEASEFor a complete list of Polyclonal Antibodiesvisit www.MeridianLifeScience.com- 19 -

productsCancerMost Popular Products - for a complete listing please visit www.MeridianLifeScience.com.CANCERANTIGENSSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeAlpha Fetoprotein (AFP)AFP Antigen Grade A32260H Culture N/A WB N Aff.Pur. 1mg N/A NaN3Cancer Antigen (CA)CA15-3 Antigen Grade A86153H Human Fluids N/A EIA N Purified 250 KU N/A NaN3CA15-3 Antigen Grade A32000H Culture N/A RIA,WB N Purified 50 KU N/A NaN3CA15-3 Antigen Grade A32231H Culture N/A N Calibrator 50 KU N/A NaN3CA19-9 Antigen Grade A97185H Human N/A N Purified 50 KU N/A NaN3CA19-9 Calibrator Grade A97184H Human N/A N Purified 50 KU N/A NaN3CA19-9 Antigen Grade A32502H Culture N/A N Purified 50 KU N/A NaN3CA50 Calibrator Grade A01264H Culture N/A N Calibrator 50KU N/A NaN3CA72-4 Antigen Grade A32400H Human Fluids N/A Y Purified 20 KU N/A NaN3CA125 Antigen Grade A97180H Human N/A RIA,WB N Purified 50 KU N/A NaN3CA125 Calibrator Grade LCR A32180H Human N/A N Purified 50 KU N/A NaN3CA125 Calibrator Grade LCR A32303H Human N/A N Calibrator 50 KU N/A NaN3CA125 Calibrator Grade LCR A86928H Human N/A N Purified 250 KU N/A NaN3Carcinoembryonic Antigen (CEA)CEA Antigen Grade A32321H Culture N/A N Aff.Pur. 1mg N/A NaN3CEA Antigen GradeA38151HHumanMetastatic LiverN/A Y Purified 100ug N/A NaN3CEA Calibrator Grade A32030H Culture N/A N Calibrator 1mg N/A NaN3Cyfra-21-1Cyfra-21-1 Antigen A32340H Human N/A N Calibrator 50ug N/A NoneNeuron Specific Enolase (NSE)Neuron Specific Enolase (NSE) A86803H Human Brain N/A EIA,WB Y Purified 100ug N/A NoneNon-Neuronal Enolase (NNE) A86584H Human Brain N/A Y Purified 100ug N/A NoneProstate Specific Antigen (PSA)PSA >95% Pure A01238H Human Fluids N/A N Purified 100ug N/A NaN3PSA >98% PureA86878HHumanSeminal FluidsN/A EIA N Purified 1mg N/A NonePSA ACT Complex A75029H Human Fluids N/A EIA Y Purified 50ug N/A NaN3S-100S-100, ProteinA86809HHumanBrain TissueN/A N Purified 1mg N/A NoneS-100B, Protein (beta-beta)A86289HHumanBrain TissueN/A N Purified 1mg N/A None- 20 - www.MeridianLifeScience.com

productsMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeAlpha Fetoprotein (AFP)AFP M01286M Mouse B821M EIA,WB N Purified 1mg IgG1 NaN3AFP MAM01-210 Mouse131-12210(TB- EIA,IHC,Pr N Purified 1mg IgG2b,k NaN34B2-10)AFP MAM01-301 Mouse 057-11301 EIA,Pr N Purified 1mg IgG1,k NaN3AFP M86304M Mouse 4A3 EIA,Pr N Purified 1mg IgG2a NaN3AFP M86641M Mouse 5H7 EIA,Pr N Purified 1mg IgG1 NaN3Cancer Antigen (CA)CA19-9 M66106M Mouse 106-3A3 EIA,Pr N Purified 1mg IgG1 NaN3CA19-9 M66107M Mouse 106-3E11 EIA,Pr N Purified 1mg IgG1 NaN3CA19-9 M66108M Mouse 106-2F6 EIA,Pr N Purified 1mg IgG1 NaN3CA19-9 M01237M Mouse B384M IHC N Purified 1mg IgM NaN3CA125, Group A M86306M Mouse X306 EIA,Pr,WB N Purified 1mg IgG1 NaN3CA125, Group B M86429M Mouse X75 EIA,Pr,WB N Purified 1mg IgG1 NaN3CA125, Group B M86924M Mouse X325EIA, IHC(p),Pr,WBN Purified 1mg IgG1 NaN3Carcinoembryonic Antigen (CEA)CEA MAM02-007 Mouse 057-10007 EIA,Pr N Purified 1mg IgG1 NaN3CEA MAM02-008 Mouse 057-10008 EIA,Pr N Purified 1mg IgG1,k NaN3CEA MAM02-009 Mouse 057-10009 EIA,Pr N Purified 1mg IgG1,k NaN3CEA MAM02-881 Mouse131-13881(TF3H8-1-6)EIA,Pr N Purified 1mg IgG1,k NaN3Cyfra-21-1Cyfra-21-1 M01300M Mouse B974M EIA,WB N Purified 1mg IgG1 NaN3erB-2/HER2erbB-2, HER2/neu M01296M Mouse B979M EIA N Purified 1mg IgG2a NaN3erbB-2, HER2/neu M01297M Mouse B978M EIA N Purified 1mg IgM NaN3erbB-2, HER2/neu M01298M Mouse B976M EIA N Purified 1mg IgG2a NaN3erbB-2, HER2/neu M01299M Mouse B975M EIA N Purified 1mg IgG2a NaN3Muc1 (CA15-3)Muc1 M01288M Mouse M2E104EIA,IHC(f,p),PrN Purified 1mg IgG NaN3Muc1 M01289M Mouse M2F1EIA,IHC(f,p),PrN Purified 1mg IgG NaN3Muc1 M01291M Mouse M10H6EIA,IHC(f),PrN Purified 1mg IgG NaN3Muc1 M01292M Mouse M8C9EIA,IHC(f),PrN Purified 1mg IgG NaN3Muc1 M01294M Mouse M9E7EIA,IHC(f),PrN Purified 1mg IgG NaN3Muc1 M86205M Mouse M2C5EIA,IHC(f,p),PrN Purified 1mg IgG NaN3Muc1 M86240M Mouse M4H2EIA,IHC(f,p),PrN Purified 1mg IgG NaN3Muc1 M86410M Mouse M10G4 EIA,Pr N Purified 1mg IgG NaN3CANCER- 21 -

productsCANCERMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #Tested AppsDryIceFormat U/M Isotype PreservativeOsteopontinOsteopontin (CT) M66105M Mouse 1F11 EIA,WB,Pr N Purified 1mg IgG1 NaN3Osteopontin (NT) M66101M Mouse 2E11 EIA,WB N Purified 1mg IgG1 NaN3Osteopontin (NT) M66102M Mouse 2C5 EIA,WB N Purified 1mg IgG1 NaN3Osteopontin (NT) M66103M Mouse 2F10 EIA,WB,Pr N Purified 1mg IgG1 NaN3Osteopontin (NT) M66104M Mouse 2H9 EIA,WB N Purified 1mg IgG1 NaN3p53p53 (a.a. 32-79) MAM42-801 Mouse289-11801(PAb1801)N Purified 0.2mg IgG1,k NaN3p53 (a.a. 306-393) MAM45-802 Mouse289-11802(PAb1802)N Purified 0.2mg IgG1,k NaN3Prostate Specific Antigen (PSA)PSA, Total M66276M Mouse B727M EIA,Pr N Purified 1mg IgG1,kPSA, Total M66278M Mouse B729M EIA,Pr N Purified 1mg IgG2b,k NaN3PSA, Total M66279M Mouse B731M EIA,Pr N Purified 1mg IgG1,k NaN3PSA, Total M66280M Mouse B728M EIA,Pr N Purified 1mg IgG1,k NaN3PSA, Total M66281M Mouse B732M EIA,Pr N Purified 1mg IgG2b,k NaN3PSA, Total M86209M Mouse 2H9 EIA,Pr N Purified 1mg IgG2a NaN3PSA, Total M86506M Mouse 5A6 EIA,Pr N Purified 1mg IgG2a NaN3PSA, Total M86599M Mouse 5G6 EIA,Pr N Purified 1mg IgG1 NaN3PSA, Free M86343M Mouse PS1 EIA,LF,Pr N Purified 1mg IgG1 NaN3PSA, Free M86806M Mouse 8A6 EIA,Pr N Purified 1mg IgG2a NaN3S-100MAb to S-100 MEM24-211 Mouse131-12211(KJ22-1-1)N Purified 100ug IgM,k NaN3MAb to S-100 (alpha-beta) Q86003M Mouse 3B10 EIA,WB N Purified 1mg IgG2a NaN3MAb to S-100 (beta-beta) Q86006M Mouse 8B10 EIA,Pr,WB N Purified 1mg IgG1 NaN3MAb to S-100 (beta-beta) Q86403M Mouse 4B3 WB N Purified 1mg IgG2a NaN3MAb to S-100 (beta-beta) Q86610M Mouse 6G1 EIA,Pr,WB N Purified 1mg IgG1 NaN3Neuron Specific EnolaseNeuron Specific Enolase (NSE) gamma M86101M Mouse 1C1 EIA,Pr,WB N Purified 1mg IgG2a NaN3Neuron Specific Enolase (NSE) gamma M86141M Mouse H11 EIA, IHC(p), Pr N Purified 1mg IgG2a NaN3Neuron Specific Enolase (NSE) gamma M86201M Mouse 2F1 EIA, IHC(p) ,Pr N Purified 1mg IgG2a NaN3Neuron Specific Enolase (NSE) gamma M86406M Mouse 5A4 EIA, IHC(p), Pr N Purified 1mg IgG2a NaN3Neuron Specific Enolase (NSE) gamma M86416M Mouse 5G10 EIA, IHC(p), Pr N Purified 1mg IgG2b NaN3Neuron Specific Enolase (NSE) gamma M86520M Mouse 5E2EIA, IHC(p),Pr,WBN Purified 1mg IgG2a NaN3- 22 - www.MeridianLifeScience.com

productsCardiacMost Popular Products - for a complete listing please visit www.MeridianLifeScience.com.ANTIGENSSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeBrain Natriuretic Peptide (BNP)BNP and NT-proBNP Free Plasma N86583H Human Plasma N/A Y Aff.Pur. 50mL N/A Nonepro-Brain Natriuretic Peptide (proBNP)(a.a. 1-108) RecombinantA24108H E. coli N/A N Purified 10ug N/A Nonepro-Brain Natriuretic Peptide (proBNP)glycosylated, RecombinantA01243HHuman embryonickidney epithelialcellsN/A N Aff.Pur. 50ug N/A Nonepro-Brain Natriuretic Peptide,C-terminal (proBNP) (a.a. 77-108)A24810H Synthetic N/A N Purified 100ug N/A Nonepro-Brain Natriuretic Peptide,N-terminal (NT-proBNP) (a.a. 1-76)A24607H Synthetic N/A N Purified 10ug N/A Nonepro-Brain Natriuretic Peptide, N-terminal(NT-proBNP) (a.a. 1-76) RecombinantA24760H E. coli N/A N Purified 10ug N/A NoneCreatine KinaseCK-BB H6C01-323 Human Brain N/A N Purified 100ug N/A NoneCK-BB, Recombinant VTI830 Pichia pastoris N/A Y Purified 1mg N/A NoneCK-MM >95% Pure A38925H Human Heart N/A N Purified 100 Units N/A NoneCK-MB Type I, Recombinant VTI840 Pichia pastoris N/A Y Purified 1mg N/A NoneCK-MB Type II, Recombinant VTI810 Pichia pastoris N/A Y Purified 1mg N/A NoneCK-MM Type I, Recombinant VTI850 Pichia pastoris N/A Y Purified 1mg N/A NoneCK-MM Type III, Recombinant VTI820 Pichia pastoris N/A Y Purified 1KU N/A NoneC-Reactive Protein (CRP)CRP, Antigen GradeA97201HHumanPleural FluidN/A IEP,RID N Purified 5mg N/A NaN3CRP, Recombinant A01250H E. coli N/A N Purified 1mg N/A NaN3CRP Free Serum N86802H Human Serum N/A EIA Y Aff.Pur. 50ml N/A NoneCystatin CCystatin C A01259H Human Urine N/A N Purified 1mg N/A NaN3Cystatin C, Recombinant A01258H E. coli N/A EIA N Aff.Pur. 1mg N/A NoneCystatin C, Free Serum A86123H Human Serum N/A Y Aff.Pur. 50ml N/A NoneD-DimerD-Dimer A86870H Human Plasma N/A N Purified 100ug N/A NoneMyeloperoxidase (MPO)MPO A38104H Human Neutrophil N/A N Purified 1mg N/A NoneMyoglobinMyoglobin A38131H Human Heart N/A N Purified 1mg N/A NaN3Myoglobin (Antigen grade) A86850H Human Heart N/A EIA,WB N Purified 1mg N/A NoneTroponin ITroponin I, Free Serum N86002H Human Serum N/A Y Aff.Pur. 50mL N/A NoneTroponin I-Cardiac, Calibrator Set(NHS base)A86860H Human Heart N/A EIA N Calibrator 1 set N/A NoneTroponin I-Cardiac >95% Pure A86853H Human Heart N/A EIA,WB N Purified 0.5mg N/A NoneTroponin I-Cardiac >98% Pure A38150H Human Heart N/A N Purified 100ug N/A NoneTroponin TTroponin T-Cardiac >98% Pure A86813H Human Heart N/A EIA,WB N Purified 0.5mg N/A NoneCARDIAC- 23 -

productsCARdiacMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeBrain Natriuretic Peptide (BNP)BNP H86051M Mouse 50E1 EIA,Pr N Purified 1mg IgG1 NaN3BNP H86245M Mouse 24C5 EIA,Pr N Purified 1mg IgG1 NaN3BNP H86262M Mouse 26E2 EIA,Pr N Purified 1mg IgG1 NaN3BNP H86573M Mouse 57H3 EIA,Pr N Purified 1mg IgG2a NaN3BNP H86507M Mouse 50B7 EIA,Pr N Purified 1mg IgG2a NaN3C-Reactive Protein (CRP)CRP M01239M Mouse CRP135 EIA,Pr N Purified 1mg IgG1 NaN3CRP M86005M Mouse C5 EIA,Pr N Purified 1mg IgG2a NaN3CRP M86007M Mouse C7EIA,IHC(p),PrN Purified 1mg IgG1 NaN3CRP M86284M Mouse C6 EIA,Pr N Purified 1mg IgG2a NaN3CRP M86842M Mouse C2 EIA,Pr N Purified 1mg IgG1 NaN3Creatine KinaseCK-BB MAC01-288 Mouse 027-11288 N Purified 1mg IgG1,k NaN3CK-MB H01298M Mouse B927M EIA,LF N Purified 1mg IgG1 NaN3CK-MB H01299M Mouse B928M EIA,LF N Purified 1mg IgG1 NaN3CK-MM MAC02-186 Mouse 027-17186 N Purified 1mg IgG2b,k NaN3CK-MM MAC02-512 Mouse131-11512(A12E3-15-N Purified 1mg IgG1,k NaN312)Cystatin CCystatin C H86218M Mouse Cyst-10 EIA,Pr N Purified 1mg IgG3 NaN3Cystatin C H01304M Mouse Cyst-11 EIA,Pr N Purified 1mg IgG1 NaN3Cystatin C H86013M Mouse Cyst-13 EIA,Pr N Purified 1mg IgG1 NaN3Cystatin C H86217M Mouse Cyst-16 EIA N Purified 1mg IgG1 NaN3Cystatin C H86018M Mouse Cyst-18 EIA N Purified 1mg IgG1 NaN3Cystatin C H86216M Mouse Cyst-19 EIA,Pr N Purified 1mg IgG1 NaN3Cystatin C H01303M Mouse Cyst-20 EIA,Pr N Purified 1mg IgG1 NaN3Cystatin C H86023M Mouse Cyst-23 EIA,Pr N Purified 1mg IgG1 NaN3Cystatin C H86212M Mouse Cyst-24 EIA,Pr N Purified 1mg IgG1 NaN3Cystatin C H86219M Mouse Cyst-28 EIA,Pr N Purified 1mg IgG1 NaN3D-DimerD-Dimer (Fibrin Degradation Product) N01252M Mouse DD22 EIA,WB N Purified 1mg IgG2a NaN3D-Dimer (Fibrin Degradation Product) N01253M Mouse DD46 EIA,WB N Purified 1mg IgG2a NaN3D-Dimer (Fibrin Degradation Product) N01254M Mouse DD93 EIA,WB N Purified 1mg IgG1 NaN3D-Dimer (Fibrin Degradation Product) N01264M Mouse 8D3 EIA N Purified 1mg IgG1,k NaN3D-Dimer (Fibrin Degradation Product) N01265M Mouse 15C5 EIA N Purified 1mg IgG1,k NaN3D-Dimer (Fibrin Degradation Product) N86352M Mouse DD44 EIA,Pr,WB N Purified 1mg IgG2b NaN3D-Dimer (Fibrin Degradation Product) N86925M Mouse DD41 EIA,Pr,WB N Purified 1mg IgG2a NaN3- 24 - www.MeridianLifeScience.com

productsMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeMyeloperoxidase (MPO)MPO K86005M Mouse 4A4 EIA N Purified 1mg IgG2b NaN3MPO K86006M Mouse 2A11 EIA N Purified 1mg IgG2a NaN3MPO K86016M Mouse 16G6 EIA,WB N Purified 1mg IgG1 NaN3MPO K86018M Mouse 18B7 EIA,Pr N Purified 1mg IgG1 NaN3MPO K86163M Mouse 16E3 EIA,Pr N Purified 1mg IgG1 NaN3MPO H87207M Mouse 2C7EIA,FC,IHC(fp), N Purified 0.2mg IgG1 NaN3WBMyoglobinMyoglobin H86142M Mouse 4E2 EIA,Pr N Purified 1mg IgG1 NaN3Myoglobin H86703M Mouse 7C3 EIA,Pr N Purified 1mg IgG1 NaN3pro-Brain Natriuretic Peptide (N-terminal)BNP, N-terminal (NT-proBNP) (a.a. 1-12) H86056M Mouse 5B6 EIA,WB N Purified 1mg IgG1 NaN3BNP, N-terminal (NT-proBNP) (a.a. 1-12) H86912M Mouse B912M EIA,Pr,WB N Purified 1mg IgG2a NaN3BNP, N-terminal (NT-proBNP) (a.a. 13-27) H86511M Mouse 15F11 EIA,Pr N Purified 1mg IgG2b NaN3BNP, N-terminal (NT-proBNP) (a.a. 13-27) H86915M Mouse B915M EIA,Pr,WB N Purified 1mg IgG1 NaN3BNP, N-terminal (NT-proBNP) (a.a. 13-27) H86132M Mouse 13G12 EIA,Pr,WB N Purified 1mg IgG2a NaN3BNP, N-terminal (NT-proBNP) (a.a. 28-45) H86010M Mouse 11D1 EIA,WB N Purified 1mg IgG1 NaN3BNP, N-terminal (NT-proBNP) (a.a. 61-76) H86214M Mouse 24E11 EIA,Pr,WB N Purified 1mg IgG2a NaN3BNP, N-terminal (NT-proBNP) (a.a. 61-76) H86451M Mouse 15C4 EIA,Pr,WB N Purified 1mg IgG2b NaN3Troponin ITroponin I-Cardiac (41-49 Region) H86207M Mouse 284(19C7)EIA,LF,Pr,WBN Purified 1mg IgG2b NaN3Troponin I-Cardiac (83-93 Region) H86465M Mouse 560EIA,LF,Pr,WBN Purified 1mg IgG1 NaN3Troponin I-Cardiac (85-92 Region) H86286M Mouse 16A12 EIA,WB N Purified 1mg IgG1 NaN3Troponin I-Cardiac (87-91 Region) H86285M Mouse 285(16A11)EIA,LF,Pr,WBN Purified 1mg IgG1 NaN3Troponin I-Cardiac (148-158 Region) H01247M Mouse B159MEIA,WB,IHC,IPN Purified 1mg IgG1 NaN3Troponin I-Cardiac (169-178 Region) H86596M Mouse 596 EIA,WB N Purified 1mg IgG1 NaN3Troponin I-Cardiac (169-178 Region) H86625M Mouse 625 EIA,Pr,WB N Purified 1mg IgG1 NaN3Troponin TTroponin T-Cardiac H86519M Mouse 2F3 EIA,Pr,WB N Purified 1mg IgG2b NaN3Troponin T-Cardiac H86707M Mouse 7E7 EIA,Pr,WB N Purified 1mg IgG NaN3Troponin T-Cardiac (1-60 Region) H86906M Mouse 9G6 EIA,Pr,WB N Purified 1mg IgG1 NaN3Troponin T-Cardiac (60-70 Region) H86102M Mouse 1F2 EIA,WB N Purified 1mg IgG1 NaN3Troponin T-Cardiac (60-70 Region) H86429M Mouse 7G7 EIA,Pr,WB N Purified 1mg IgG1 NaN3Troponin T-Cardiac (70-94 Region) H86306M Mouse 3D6 EIA,WB N Purified 1mg IgG1 NaN3Troponin T-Cardiac (95-181 Region) H86111M Mouse 1C11 EIA,Pr,WB N Purified 1mg IgG1 NaN3Troponin T-Cardiac (146-160 Region) H86914M Mouse 1A11 EIA,WB N Purified 1mg IgG2b NaN3Troponin T-Cardiac (180-287 Region) H86215M Mouse 7A9 EIA,WB N Purified 1mg IgG1 NaN3CARdiac- 25 -

productsHormoneMost Popular Products - for a complete listing please visit www.MeridianLifeScience.com.HORMONEANTIGENSSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeCortisolCortisol A82601P Synthetic N/A EIA N HRP 1mL N/A ThimerosalEstradiolEstradiol A82604P N/A N/A N HRP 1mL N/A ThimerosalFollicle Stimulating Hormone (FSH)FSH >98% Pure H6F02-323 Human Pituitary N/A N Purified 100ug N/A NoneHuman Chorionic Gonadotropin (hCG)hCG, USP GradeA01322HHumanPregnancy UrineN/A N Purified 5mg N/A NonehCG-b >= 98% Pure A01376H Human Urine N/A N Purified 100ug N/A NonehCG-b >=98% PureA01278HHumanPregnancy UrineN/A EIA,WB N Purified 100ug N/A NoneHuman Growth Hormone (hGH)hGH >=70% Pure, Human A75714H Human Pituitary N/A N Purified 1mg N/A NoneLuteinizing Hormone (LH) >=95% PureLH >=95% Pure A01370H Human Pituitary N/A EIA N Purified 100ug N/A NonePregnancy Associated Plasma Protein A (PAPP-A)PAPP-AA86864HRetroplacentalBloodN/A EIA N Purified 100ug N/A NoneThyroglobulinThyroglobulin H6T08-275 Human N/A N Purified 1mg N/A NoneThyroglobulin >98% Pure A86852H Human Thyroid N/A N Purified 1mg N/A NoneThyroid Stimulating Hormone (TSH)TSH 98% Pure H6T04-323 Human Pituitary N/A N Purified 100ug N/A NoneMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeAdrenocorticotropic Hormone (ACTH)ACTH, N-terminal E54057M Mouse 57 EIA,IHC(p) N Purified 1mg IgG1 NaN3ACTH, Middle Region E01302M Mouse B951M EIA N Purified 1mg IgG2a NaN3CortisolCortisol MAS01-501 Mouse 057-11501 N Purified 1mg IgG1,k NaN3Cortisol E82294M Mouse BDI410 N Purified 1mg IgG NaN3Cortisol E86232M Mouse CORT-2 EIA N Purified 1mg IgG3 NaN3Cortisol E86322M Mouse CORT-1 EIA N Purified 1mg IgG1 NaN3Cortisol E86220M Mouse XM210 EIA N Purified 1mg IgG2a NaN3C-peptideC-peptide MHP18-601 Mouse 236-15601 N Purified 100ug IgG1 NaN3C-peptide E86710M Mouse 7E10 EIA,RIA N Purified 1mg IgG1 NaN3C-peptide (Proinsulin) E54094M Mouse C-PEP-01 IHC(f) N Purified 0.25mg IgG1 NaN3C-peptide (Proinsulin) E86018M Mouse 1H8 EIA N Purified 1mg IgG1,k NaN3C-peptide (Proinsulin) E86408M Mouse 4H8 EIA,RIA N Purified 1mg IgG1,k NaN3C-peptide (Proinsulin) E86588M Mouse 5B8 EIA,RIA N Purified 1mg IgG1 NaN3- 26 - www.MeridianLifeScience.com

productsMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeEstradiolEstradiol MAS04-267 Mouse 027-11267 N Purified 1mg IgG2a,k NaN3Follicle Stimulating Hormone (FSH)FSH MAF02-243 Mouse 090-10243 EIA,Pr N Purified 1mg IgG1,k NaN3FSH MAF02-264 Mouse 090-10264 EIA,Pr N Purified 1mg IgG2a,k NaN3FSH MAF02-155 Mouse 090-14155 EIA,Pr N Purified 1mg IgG1,k NaN3FSH, beta E86123M Mouse B251M EIA,Pr,WB N Purified 1mg IgG NaN3Human Chorionic Gonadotropin (hCG) betahCG, beta MAF05-019 Mouse 057-10019 EIA,Pr N Purified 1mg IgG1,k NaN3hCG, beta MAF05-020 Mouse 057-10020 N Purified 1mg IgG1,k NaN3hCG, beta MAF05-022 Mouse 057-10022 N Purified 1mg IgG1,k NaN3hCG, beta MAF05-528 Mouse 322-10528 EIA N Purified 1mg IgG1 NaN3hCG, beta MAF05-023 Mouse 057-10023 N Purified 1mg IgG1,k NaN3hCG, beta MAF05-043 Mouse 057-10043 EIA,Pr N Purified 1mg IgG1,k NaN3hCG, beta MAF05-627 Mouse 094-10627 EIA,Pr N Purified 1mg IgG1,k NaN3hCG, beta MAF05-018 Mouse 057-10018 EIA N Purified 1mg IgG1,k NaN3hCG, beta MAF05-025 Mouse 057-10025 EIA,Pr N Purified 1mg IgG1,k NaN3hCG, beta MKF05-148 Mouse 218-10148 N Purified 1mg IgG NaN3Human Growth Hormone (hGH)hGH MAF06-154 Mouse 090-10154 EIA N Purified 1mg IgG1,k NaN3hGH MAF06-210 Mouse 090-12210 EIA,Pr N Purified 1mg IgG1,k NaN3hGH MAF06-610 Mouse 090-12610 EIA,Pr N Purified 1mg IgG1,k NaN3hGH MAF06-212 Mouse 090-11212 EIA,Pr N Purified 1mg IgG1,k NaN3InsulinInsulin E86201M Mouse D4B8EIA,IHC(f),Pr,RIAN Purified 1mg IgG1,k NaN3Insulin E86102M Mouse 7F8 EIA,Pr,RIA N Purified 1mg IgG1,k NaN3Insulin E86306M Mouse 3A6 EIA,Pr,RIA N Purified 1mg IgG1,k NaN3Insulin E86802M Mouse 8E2 EIA,Pr,RIA N Purified 1mg IgG1,k NaN3Luteinizing Hormone (LH)LH MAF07-412 Mouse 090-11412 EIA,Pr N Purified 1mg IgG1,k NaN3LH MAF07-226 Mouse 090-10226 EIA,Pr N Purified 1mg IgG1,k NaN3LH MAF07-036 Mouse 057-10036 EIA,Pr N Purified 1mg IgG2a,k NaN3Pregnancy Associated Plasma Protein A (PAPP-A)PAPP-A E86910M Mouse 10H9 EIA,Pr N Purified 1mg IgG2a NaN3PAPP-A E86120M Mouse 10E2 EIA,Pr N Purified 1mg IgG2b NaN3PAPP-A E86101M Mouse 10E1 EIA,Pr N Purified 1mg IgG2b NaN3Parathyroid Hormone (PTH)Parathyroid Hormone (PTH) N-terminal,a.a.1-34Parathyroid Hormone (PTH) N-terminal,a.a.1-34E01277M Mouse B638M EIA,IHC(p),RIAN Purified 1mg IgG1 NaN3E01278M Mouse B639M EIA,RIA N Purified 1mg IgG2b NaN3Parathyroid Hormone (PTH) (a.a. 1-34) E01314M Mouse B1284M EIA N Purified 1mg IgG2a NaN3Parathyroid Hormone (PTH) (a.a. 1-34) E01315M Mouse B1285M EIA N Purified 1mg IgG1 NaN3Parathyroid Hormone (PTH) (a.a. 44-68) E01312M Mouse B1281M EIA N Purified 1mg IgG2b NaN3Parathyroid Hormone (PTH) (a.a. 44-68) E01313M Mouse B1283M EIA N Purified 1mg IgG2a NaN3ProgesteroneProgesterone E86222M Mouse HPRO-2 EIA N Purified 1mg IgG2b NaN3Progesterone E86702M Mouse XM207 EIA N Purified 1mg IgG2b NaN3HORMONE- 27 -

productsHORMONEMONOCLONAL ANTIBODIESSpecificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M Isotype PreservativeProinsulinProinsulin E86104M Mouse 1G4EIA,IHC(f),PrN Purified 1mg IgG1,k NaN3Proinsulin E86209M Mouse 3A1EIA,IHC,Pr,RIAN Purified 1mg IgG1,k NaN3ProlactinProlactin MAF10-710 Mouse 090-11710 EIA,Pr N Purified 1mg IgG2a,k NaN3Prolactin MAF10-111 Mouse 090-18111 EIA,Pr N Purified 1mg IgG1,k NaN3Prolactin MAF10-145 Mouse 090-10145 EIA,Pr N Purified 1mg IgG1,k NaN3Prolactin MAF10-245 Mouse 090-10245 EIA,Pr N Purified 1mg IgG1,k NaN3ThyroglobulinThyroglobulin E86212M Mouse 24TG/5E6 EIA,Pr N Purified 1mg IgG2b NaN3Thyroglobulin E86059M Mouse 24TG/5F9 EIA,Pr N Purified 1mg IgG2a NaN3Thyroid Stimulating Hormone (TSH)TSH MAT04-006 Mouse 057-11006 EIA,Pr N Purified 1mg IgG1,k NaN3TSH MAT04-003 Mouse 057-11003 EIA,Pr N Purified 1mg IgG1,k NaN3TSH MAT04-252 Mouse 204-12252 EIA,Pr N Purified 1mg IgG1,k NaN3TSH MAT04-410 Mouse 204-12410 EIA,Pr N Purified 1mg IgG1,k NaN3TSH, Intact & beta MAT04-001 Mouse 057-11001 EIA,Pr N Purified 1mg IgG1,k NaN3Thyroxine (T4)Thyroxine (T4) MAT02-525 Mouse 204-14525 N Purified 1mg IgG1,k NaN3Thyroxine (T4) MKT02-007 Mouse 057-11007 N Purified 10mg IgG2b,k NaN3Thyroxine (T4) E86206M Mouse 1H1 EIA N Purified 1mg IgG1 NaN3Thyroxine Binding Globulin (TBG)Thyroxine Binding Globulin (TBG) MAT03-439 Mouse 027-10439 N Purified 1mg IgG2a,k NoneThyroxine Binding Globulin (TBG) MAT03-612 Mouse 027-10612 N Purified 1mg IgG2a,k NaN3Triiodothyronine (T3)Triiodothyronine (T3) MAT01-121 Mouse 291-13121 N Purified 1mg IgG1,k NaN3Triiodothyronine (T3) MAT01-237 Mouse 027-10237 N Purified 1mg IgG1,k NaN3- 28 - www.MeridianLifeScience.com

productsImmunoglobulinMost Popular Products - for a complete listing please visit www.MeridianLifeScience.com.Specificity Catalog #Host Species /SourceClone #TestedAppsDryIceFormat U/M PreservativeAnimal Igs, PurifiedGamma Globulin, Bovine A51300B Bovine Serum N/A N Purified 10g NoneIgY, Chicken A01302C Chicken N/A N Purified 50mg NoneIgG, Goat - Differential ppt A66200H Goat Serum N/A N Purified 20mg NaN3TRU Block, Heterophilic Antibody Interference,Active BlockerA66800H Mouse Based N/A N Purified 100mg NaN3IgG, Mouse - Protein A (9-13 mg/mL) A66186M Mouse Serum N/A N Purified 20mg NaN3IgG, Mouse - Protein A (45-55 mg/mL) A66189M Mouse Serum N/A N Purified 1 gram ProClinIgG, Mouse - Protein A (50-55 mg/mL) A66185M Mouse Serum N/A N Purified 20mg NaN3IgG, Rabbit - Differential ppt A66100H Rabbit Serum N/A Y Purified 50mg NaN3IgG, Rabbit - Differential ppt A66105R Rabbit Serum N/A N Purified 50mg NaN3IgG, Sheep, >70mg/mL A66400S Sheep Serum N/A Y Purified 1 gram ProClinHuman Igs, PurifiedKappa Light Chain A09628H Human N/A N Purified 1mg NaN3Lambda Light Chain A09287H Human N/A N Purified 1mg NaN3IgE, kappa A01235H Human Myeloma N/A N Purified 1mg NaN3IgE, kappa H6G69-163 Human Myeloma N/A N Purified 100ug NaN3IgE, lambda A50796H Human Myeloma N/A N Purified 1mg NaN3IgG1, kappa A50183H Human Myeloma N/A EIA,IEP N Purified 1mg NaN3IgG2, kappa A50184H Human Myeloma N/A IEP N Purified 1mg NaN3IgG4, kappa A01241H Human Myeloma N/A N Purified 1mg NaN3IgM, Fc5u A50591H Human Myeloma N/A IEP Y Purified 1mg NoneIgA1, kappa A50166H Human Myeloma N/A IEP Y Purified 5mg NaN3IgA1, lambda A50165H Human Myeloma N/A IEP N Purified 5mg NaN3IgA A50167H Human Plasma N/A N Purified 1mg NaN3IgE A50384H Human Plasma N/A None Y Purified 100ug NaN3IgG A50170H Human Plasma N/A IEP N Purified 5x10mg NaN3IgG (Fc) A50175H Human Plasma N/A N Purified 10mg NaN3Goat Anti-Human IgsIgA L66605G Goat N/A TIA N TIA 10mL NaN3IgG (Fc) W66040G Goat N/A Y Aff.Pur. 5mg NoneIgG (Fc) L15406G Goat N/A N Monospecific 10mL NaN3IgM (Fcu) L66607G Goat N/A TIA N TIA 10mL NaN3Goat Anti-MouseIgG (H&L) W41502G Goat N/A N Aff.Pur. 5mg NaN3immunoglobulin- 29 -

productsBlocking agentsTRU BLOCKActive Blocker – uses a proprietary active mechanism to bind Human Anti-Mouse Antibodies (HAMA)Blocks HAMA, other types of Heterophilic Antibodies (HA) and Rheumatoid Factor (RF)High potency blocking: Use 5 – 20x less than Mouse IgGFunctional testing performed on each lotOutperforms competitive productsUsing a commercial CA19-9 Sandwich Assay, TRU Block, Mouse IgG and a competitor’sactive blocker were tested for effectiveness in blocking HAMA and RF.HAMARF2.5Blockers vs. BRH56382 on CA19-9Unblocked HAMA Signal4.54Blockers vs. SD386-15 on CA19-9Unblocked RF SignalCorrected Absorbance21.510.5Corrected Absorbance3.532.521.510.50HAMATRU BLOCKCOMPETITORMOUSE lgG0RFTRU BLOCKCOMPETITORMOUSE lgGHAMA, no blocker5 μg/mL2.5 μg/mL1.25 μg/mL0.625 μg/mLRF, no blocker5 μg/mL2.5 μg/mL1.25 μg/mL0.625 μg/mLTesting Protocol• Buffer without mouse IgG or other blockers was used in place ofkit buffer which contained mouse IgG as blocker• Blockers were added in sample diluent buffer• HAMA/RF activity was measured initially in the absence ofblockers to determine 100% signal• HAMA/RF activity was then tested in the presence of blocker tomeasure suppression of signal• A lower absorbance indicates a greater suppression of HAMA/RFHeterophilic antibodies (HA) to other animals may also cause false results.MLS has available the following animal IgG’s for HA blocking:Sheep (HASA) | Goat (HAGA) | Rabbit (HARA)- 30 - www.MeridianLifeScience.com

productsMouse iggMeridian Life Science, Inc. (MLS) manufactures commercial scale Mouse IgG in a variety of formulations foruse as a Human Anti-Mouse Antibody (HAMA) blocker in immunoassays:• A66186M (concentration range 9-13 mg/mL, Protein A Purified)• A66185M (concentration range 50-55 mg/mL, Protein A Purified)• A66187M Mouse IgG (Caprylic Acid)• Customized product upon requestThe blocking mechanism of HAMA Blocker Mouse IgG is illustrated below:NORMAL SIGNAL(HAMA not present)FALSE SIGNAL(HAMA binds to assay MAb)TRUE SIGNAL(MLS Mouse lgG blocks HAMA)FALSEFALSETRUETRUEPOSITIVENEGATIVEPOSITIVENEGATIVEPOSITIVENEGATIVEAntigenCapture MAbDetection MAbHAMAMouse IgGigM diluentMLS IgM Diluent (Product # 8120) is intended for use in the development of qualitative and quantitative assays for thedetection of IgM antibodies. The diluent is formulated to reduce assay interference from IgG antibodies, rheumatoidfactor, heterophilic antibodies, and other non-specific proteins which may affect assay results. The addition of MLSIgM Diluent can aid in the determination of current or recent viral infections.MLS IgM Diluent is designed to remove specific IgG interference from serum samples. It also contains proteins toreduce non-specific interaction commonly found with polystyrene plates and low affinity interactions to proteinsbound on the plates.Number of Patient Samples6050403020100Rubella IgM Population Study(Diluent Comparison)Rubella IgM Negative SamplesPositive Cutoff @ 0.5 OD0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1O.D. Range (low limit)Heterophilic and low-affinity antibodies mayaffect serum reactivity and could cause falsepositive results. The graph demonstrates variousformulations of commercially available samplediluent against 100 negative human serumsamples in an in-house Rubella IgM ELISA.The RED bars demonstrate the ELISA responsewhen a heterophilic blocking reagent is addedto the sample. The GREEN bars were generatedwith a standard sample diluent. The BLUE barsindicate the ELISA response when the sample isdiluted using the MLS IgM Diluent. The YELLOWbars display the results with a competing diluent.Heterophile Ab Removal Standard Diluent MLS IgM Diluent Commercial Diluent- 31 -

productsMolecular ReagentsMyTaq DNA Polymerase• New generation Taq with highest specificityand superior performance• Robust high yields across a full range oftemplates, including complex genomic DNA• Novel optimized buffer system with ultrapuredNTPs and MgCl 2MyTaq TM HS DNA Polymerase• New generation of antibody-basedhot-start polymerase• Specifically designed for fast, highlyspecific, hot-start PCR• Highest specificity and superior performance• Validated for a full range of genomic DNA templates• Novel optimized buffer system with ultrapuredNTPs and MgCl 2SensiFast for Real-Time PCR• Highly optimized qPCR mix for unparalleledperformance in real-time PCR• Faster results - under 30 minutes• Unmatched sensitivity – earliest Ct detection• Universal – compatible with all standardand fast cycling instrumentsUltra-pure dNTPs• Ultra-pure: >99.9% triphosphate by HPLC• Enzymatically synthesized• Free from PCR inhibitors• DNase, RNase, and Nickase free• Functionally tested in a wide range of assays• Custom, bulk and OEM nucleotide serviceMyTaq and SensiFast are trademarks of Bioline, Inc.- 32 - www.MeridianLifeScience.comFor more information about molecular reagents visit www.bioline.com

WHY PARTNER WITH MLS?• Unparalleled experience and proventrack record (almost 30 yrs)• Core expertise in cell culture, ascites,protein production and purification• Flexibility in scale and production systems• Complete R&D and Process Developmentservices• Robust quality system• Dedicated project management• All manufacturing conductedunder ISO 9001 and cGMP• Continuous improvement throughLean Six-Sigma• Complete confidentiality

®Life Science, Inc.Innovative Solutions. Trusted Partner. ®Meridian Life Science, Inc.5171 Wilfong Road | Memphis, TN 38134901.382.8716 • 800.327.6299June 2012