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5000400030002000conferenceuntil 2004 1990 continous but slow growth•• • ••6-6500 att.Major limitations: Ionization techniques only forsmall, thermally stabile compounds= widespread use of GC-<strong>MS</strong> no robust and universal couplingbetween HPLC and <strong>MS</strong>1000•1950 1960 1970 1980 1990 2000
500040003000•• • ••20046-7000 att.starting at 1984/85....breakthrough bytwo newionization techniques :20001000•ESI(Electrospray-Ionization)&MALDI(Matrix-Assisted LaserDesorption Ionization)1950 1960 1970 1980 1990 2000
Page 1 and 2: From Small-Molecule Drugs to Proteo
Page 5 and 6: Relative AbundanceTandemMSorMS/MSM
Page 10 and 11: MALDI- Matrix AssistedLaser Desorpt
Page 12: nevertheless a difficult start
Page 16: can an exact protein molecular mass
Page 20 and 21: % Intensity% IntensityNative MALDI
Page 22 and 23: ESI and today also MALDI solved an
Page 24 and 25: Small-molecule MALDIQuantification
Page 26: Analyte/IS*ConcAnalyte/IS*Conc10.90
Page 32 and 33: in order to analyze a proteome key
Page 34: 1-the conventional way :"MALDI pept
Page 37: Protein Identifizierung : ESI or MA
Page 40 and 41: in order to analyze a proteome key
Page 44 and 45: Remaining problems :• possibly lo
Page 46 and 47: (self)critical discussion about pro
Page 48 and 49: ut with large efforts and investmen
Page 51: the alternative.....back to hypothe
Page 55 and 56: A new tool MALDI imaging mass spect
Page 57:
AK KarasU. Bahr, Ph.DB. Meyer, Ph.D
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