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MALDI- Matrix AssistedLaser Desorption IonizationIncorporation of sample molecules into the matrixirradiation with short-pulse UV-Laser in high vacuumMatrices : small organic compounds with high absorption coeff.at laser-N 2 -Laser : = 337 nm, = 3 nsFokus- 200 µm
MALDI sample preparation"Dried droplet"analyte:protein/peptidematrix:DHBsolve10 -5 -10 -7 Min H 2 O/ACN0.1% TFA5-50 g/LinH 2 O/ACN0.1% TFAdripsolutionslet dry<strong>MS</strong>
Page 1 and 2: From Small-Molecule Drugs to Proteo
Page 5 and 6: Relative AbundanceTandemMSorMS/MSM
Page 8 and 9: 5000400030002000conferenceuntil 200
Page 12: nevertheless a difficult start
Page 16: can an exact protein molecular mass
Page 20 and 21: % Intensity% IntensityNative MALDI
Page 22 and 23: ESI and today also MALDI solved an
Page 24 and 25: Small-molecule MALDIQuantification
Page 26: Analyte/IS*ConcAnalyte/IS*Conc10.90
Page 32 and 33: in order to analyze a proteome key
Page 34: 1-the conventional way :"MALDI pept
Page 37: Protein Identifizierung : ESI or MA
Page 40 and 41: in order to analyze a proteome key
Page 44 and 45: Remaining problems :• possibly lo
Page 46 and 47: (self)critical discussion about pro
Page 48 and 49: ut with large efforts and investmen
Page 51: the alternative.....back to hypothe
Page 55 and 56: A new tool MALDI imaging mass spect
Page 57: AK KarasU. Bahr, Ph.DB. Meyer, Ph.D

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