â Realizing the potential of IonWorks screening in a drug discovery ...
â Realizing the potential of IonWorks screening in a drug discovery ...
â Realizing the potential of IonWorks screening in a drug discovery ...
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<strong>IonWorks</strong> can resolve differential pharmacology1 st Pulse Compound Concentration Response25 th Pulse Compound Concentration Response10010080Compound 1Compound 280Compound 1Compound 26060% Inhibition40200IC 50= 0.569µMIC 50= 121µM% Inhibition40200IC 50= 0.148µMIC 50= 50µM-20-20-400.01 0.1 1 10 100 1000Concentration (µM)0.01 0.1 1 10 100 1000 10000Concentration (µM)Two compounds with differential pharmacology, but similar use-dependency ratiosCompound 1 use-dependence ratio is 3.8Compound 2 use-dependence ratio is 2.5
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