â Realizing the potential of IonWorks screening in a drug discovery ...
â Realizing the potential of IonWorks screening in a drug discovery ...
â Realizing the potential of IonWorks screening in a drug discovery ...
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Assay format• S<strong>in</strong>gle hole HT mode• Pulse to -10mV from -55mV 25times @ 10Hz• First run <strong>of</strong> day from -100mV– Keep track <strong>of</strong> relative current– Provides estimate <strong>of</strong> voltagecontrol• 6 compounds/plate• Full 7-pt IC 50 ’s• One row vehicle control• Four plates/day – 24cmpds/day• 96 cmpds/week