NobelGuide, the planning and surgical concept from Nobel Biocare

MEDIA RELEASEChicago, Illinois, USA – 23 February, 2006NobelGuide, the planning and surgical concept from NobelBiocare, enables dentists to place an implant and fully functioningtooth in one patient visitNobelGuide from Nobel Biocare, the world leader in innovative esthetic dentalsolutions, makes it possible for dentists to safely place a dental implant and fullyfunctioning tooth within one patient visit. NobelGuide takes advantage of NobelBiocare’s Procera® surgical planning software and the surgical technique calledFlapless Surgery, which is comparable to “keyhole surgery”. Heliane Canepa,President and CEO for Nobel Biocare said, “If dentists can do crowns and bridges,then with Procera® and NobelGuide, they plan the exact placement of a patient’simplants and can offer a complete root-to-tooth solution.”Dental professionals positively received the NobelGuide planning and surgical conceptlaunched last year at the company’s World Conference in Las Vegas. Canepa said,“NobelGuide is the most exciting new concept in implantology in the past 20 years. Theresponse was overwhelming as dentists realized they can now safely and quickly letpatients with lost teeth enjoy a normal life again.”Using the NobelGuide concept, dentists plan the entire implant treatment, including howmany, which length and which angle of insertion using the Procera® software. CT computerscanned data or a plaster model of the patient’s teeth and mouth are used as the foundationto map the shape and location of bone.Nobel Biocare or a dental laboratory creates a surgical template complete with guide holes,based on the planning data, for use during surgery. Canepa said, “The precision planningoffered by the Procera® software provides dentists with a way to accurately place implants.”NobelGuide’s surgical template offers dentists a less invasive method as an alternative tomajor surgery that requires cutting and pulling back the soft tissue around the patient’sjawbone. Instead, the surgical template is secured over the patient’s soft tissue and thedentist drills through the soft tissue into the bone using the pre-planned guide holes. “UsingNobelGuide, patients no longer need suffer from the bruising, pain and swelling normallyassociated with dental surgery. In most cases, patients can return to work the next day”,said Canepa.The advance planning capabilities of NobelGuide enable dentists to work closely withtheir dental laboratory and offer patients the option of a temporary or a final prostheticsolution fitted at the time of implant placement. Canepa said, “The most exciting news aboutNobelGuide is that on the day of surgery, the patient leaves the dentist’s office completewith implants and fully functioning, beautiful teeth.”Conventional methods for implant placement and teeth restoration can take more than 10patient visits. Using NobelGuide, the entire treatment, from examination to implantplacement can take as little as 4 patient visits.1 (4)

How NobelGuide Works:1. Patient receives a CT scan or a model of their mouth is created.2. With a complete view of the patient’s bone structure, the dentist uses the Procera®software system to plan the placement of the implants, along with length and optimalangle.3. A surgical template is created by Nobel Biocare using CT data scans or by the dentallaboratory using a plaster model.4. The dental laboratory prepares a temporary or permanent crown or bridge, dependingon the dentist and patient needs.5. On the day of surgery, the dentist uses the surgical template to optimally place theimplants and installs the temporary or permanent prosthetic restoration.The U.S. Food and Drug Administration (FDA) has cleared NobelGuide.Reference: http://investor.nobelbiocare.com/phoenix.zhtml?c=139018&p=iroldownloadcenter2 (4)

NOBEL BIOCARE HOLDING AGFor further information, please contact:Suha Demokan, Head of Investor RelationsGunilla Ekholtz, Investor Relations OfficerTel +41 43 211 53 30, +41 79 430 81 46 Tel +46 31 81 88 36, +46 708 81 88 36e-mail suha.demokan@nobelbiocare.come-mail gunilla.ekholtz@nobelbiocare.comDisclaimer:This release may contain forward-looking statements including, but not limited to, projections of futureperformance of materials and products, financial conditions, results of operations and cash flows,containing risks and uncertainties. These statements are subject to change based on unknown risksand other factors that could cause the actual results or performance to differ materially from thestatements made herein.Nobel Biocare is a medical devices group and the world leader in innovative esthetic dentalsolutions with its brands Brånemark System ® , NobelSpeedy, NobelReplace, NobelPerfect ® ,NobelDirect ® , Replace ® Select, (dental implants) and Procera ® (individualized dental prosthetics).Nobel Biocare is a one-stop shop for restorative esthetic dentistry, offering a wide range of innovativeCrown & Bridge & Implant products, as well as training and education and clinically documentedtreatment concepts. Nobel Biocare has some 1650 employees and recorded revenue of EUR 485million in 2005. The company is domiciled in Zurich, Switzerland with headquarters in Zurich and inGothenburg, Sweden. Production takes place at four production sites located in Sweden and theUSA. Nobel Biocare has direct sales organizations in 33 countries. The shares of the parentcompany Nobel Biocare Holding AG are listed on the SWX Swiss Exchange and on the StockholmStock Exchange, Sweden.www.nobelbiocare.comReferences1van Steenberghe D, Naert I, Andersson M, Brajnovic I, Van Cleynenbreugel J, Suetens P. A customtemplate and definite prosthesis allowing immediate implant loading in the maxilla: A clinical report. Int JOral Maxillofac Implants 2002; 17: 663-670.2Parel SM, Triplett RG. Interactive imaging for implant planning, placement, and prosthesis construction. JOral Maxillofac Surg 2004; 62 (suppl 2): 41-47.3van Steenberghe D, Ericsson I, Van Cleynenbreugel J, Schutyser F, Brajnovic I, Andersson M. Highprecision planning for oral implants based on 3-D CT scanning. A new surgical technique for immediateand delayed loading. Appl Osseointegration Res 2004; 4: 27-31.4Wendelhag I, van Steenberghe D, Blombäck U, Glauser R. Immediate function in edentulous maxillae withflapless surgery including a 3-D CT-scan based treatment planning procedure. Clin Oral Implant Res2004; 15: 1xxiii. Abstract.5Marchack CB. An immediately loaded CAD/CAM-guided definitive prosthesis: A clinical report. J Prosth Dent2005; 93: 8-12.6Yildirim M, Liebe J, Charrat A, Spiekermann H. Sofortversorgung des zahnlosen Kiefers:”Teeth in an Hour”Implantologie 2004; 12: 341-358.7van Steenberghe D, Glauser R, Blombäck U, Andersson M, Schutyser F, Pettersson A, Wendelhag I. Acomputed tomographic scan-derived customized surgical template and fixed prosthesis for flaplesssurgery and immediate loading of implants in fully edentulous maxillae. A prospective multicenter study.Clin Implant Dent Rel Res 2005; 7 (Suppl 1): 111-120.8Hahn J. Single-stage, immediate loading, and flapless surgery. J Oral Implantology 2000; 26: 193-198.3 (4)

References1234567van Steenberghe D, Naert I, Andersson M, Brajnovic I, Van Cleynenbreugel J, Suetens P. A customtemplate and definite prosthesis allowing immediate implant loading in the maxilla: A clinical report. Int JOral Maxillofac Implants 2002; 17: 663-670.Parel SM, Triplett RG. Interactive imaging for implant planning, placement, and prosthesis construction. JOral Maxillofac Surg 2004; 62 (suppl 2): 41-47.van Steenberghe D, Ericsson I, Van Cleynenbreugel J, Schutyser F, Brajnovic I, Andersson M. Highprecision planning for oral implants based on 3-D CT scanning. A new surgical technique for immediateand delayed loading. Appl Osseointegration Res 2004; 4: 27-31.Wendelhag I, van Steenberghe D, Blombäck U, Glauser R. Immediate function in edentulous maxillae withflapless surgery including a 3-D CT-scan based treatment planning procedure. Clin Oral Implant Res2004; 15: 1xxiii. Abstract.Marchack CB. An immediately loaded CAD/CAM-guided definitive prosthesis: A clinical report. J ProsthDent 2005; 93: 8-12.Yildirim M, Liebe J, Charrat A, Spiekermann H. Sofortversorgung des zahnlosen Kiefers:”Teeth in anHour” Implantologie 2004; 12: 341-358.van Steenberghe D, Glauser R, Blombäck U, Andersson M, Schutyser F, Pettersson A, Wendelhag I. Acomputed tomographic scan-derived customized surgical template and fixed prosthesis for flaplesssurgery and immediate loading of implants in fully edentulous maxillae. A prospective multicenter study.Clin Implant Dent Rel Res 2005; 7 (Suppl 1): 111-120.4 (4)