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GENERAL ARTICLEdogs. Among these aglepristone is the best drug ofchoice. Due to adverse side effects diethylstilbesterol and tamoxifen citrate are not preferred.During mid gestation from 28-30 days onwardssynthetic prostaglandins, anti prolactins andantiprogesterone therapy are found to be effective. Acombination of prostaglandin and antiprolactin(cabergoline) is found to be highly effective interminating pregnancy. This treatment has theadvantages of being free of side effects, it inducesabortions by resorption, and it works as early as day25. The embryo toxic agents such as phenyltriazoleisoindole and isoquinoline compounds are drugswhich can be tried for pregnancy termination but thetoxic side effects limits its use in dogs.REFERENCEBaan, M, Taverne, M.A.M, Kooistra,H.S, J. deGier, Dieleman, S.J and Okkens, A.C (2005)“Induction of parturition in the bitch with theprogesterone-receptor blocker aglépristone”Theriogenology Volume 63, Issue 7 , Pages1958-1972, 15 April 2005Bowen RA, Olson PN, Young S, Withrow SJ. 1988“Efficacy and toxicity of tamoxifen citrate forprevention and termination of pregnancy inbitches” Am. J. Vet. Res. Jan; 49 (1):27-31.Concannon PW, Yeager A, Frank D, Iyampillai A.1990 “Termination of pregnancy and inductionof premature luteolysis by the antiprogestagen,mifepristone, in dogs” J. Reprod. Fertil. Jan;88(1):99-104.Feldman EC, Davidson AP, Nelson RW, Nyland TG,Munro C 1993 Prostaglandin induction ofabortion in pregnant bitches after misalliance J.Am. Vet. Med. Assoc. Jun 1;202(11):1855-8.Fieni,F, J.F. Bruyas, I. Battut and D. Tainturier 2001“Clinical Use of Anti-Progestins in the Bitch”International Veterinary Information Service,Ithaca NY (www.ivis.org), A1219.0201Galac,S, H.S. Kooistra,J. Butinar, M.M. Bevers, S.J.Dieleman, G. Voorhout, A.C. Okkens 2000Termination of mid-gestation pregnancy inbitches with aglepristone, a progesteronereceptor antagonist. Theriogenology, Volume53, Issue 4 , Pages 941-950.Galliani, G, Lernerm, L.J, Caramel, C., Maraschin.R, Nani, S., Nava, A, Nava, A. 1982 “Pregnancytermination in dogs with novel non-hormonalcompounds. Studies of 2-(3-ethoxy-phenyl)-5,6-dihydro-s-triazole [5,1-a] isoquinoline (DL204-IT)” Arzneimittelforschung. 32 (2): 123-7.Gilian, M. Simpson. 1998 Basava Manual of SmallAnimal Reproduction and Neonatology.Published by British Small Animal VeterinaryAssociation, United Kingdom pp 121-124Keister DM, Gutheil RF, Kaiser LD, D'Ver AS 1989Efficacy of oral epostane administration toterminate pregnancy in mated laboratory bitchesJ. Reprod. Fertil. Suppl. 39:241-9.Onchn, K., L. D. M. Silva and J. P. Verstegen 1995Termination of unwanted Pregnancy in dogswith the dopamine agonist, cabergoline, incombination with a synthetic analog ofpcxzalpha, either cloprostenol or alphaprostol.Theriogenology 43:813-622.Reddy,R.C.K., Sadasiva Rao,K, Solomon Raju, K.G,K.B.Raghavender and A. Gopal Reddy 2010Ind. J. Anim. Reprod. 31(2) 19-22Renukaradhya, G.J, Krishnaswamy, A. andHonnappa,T.G (2008) Studies on thetermination of pregnancy in bitches usingnatural prostaglandins. National Symposium onRecent trends and Future Strategies forimproved Reproduction of Livestock,Companion and wild animals pp - 186Wanke, M.M, S. Romagnoli, J. Verstegen and P. W.Concannon 2002 Pharmacological Approachesto Pregnancy Termination in Dogs and CatsIncluding the Use of Prostaglandins, DopamineAgonists, and Dexamethasone InternationalVeterinary Information Service (www.ivis.org),Ithaca, New York, USAJIVA Vol. 10 Issue 1 April 201265