2012 Jiva April Cover 220 GSM Art Card Glossy ... - Jivaonline.net

GENERAL ARTICLEJ. Ind. Vet. Assoc., Kerala. 10 (1)10mg/kg body weight (0.33ml/kg/day)subcutaneously twice at 24 hour interval. Efficacy oftreatment for termination of pregnancy is reported tobe 95 percent. No side effects were observed exceptmammary development and lactation. PreparationALIZIN 10 ml vial 30 mg/ml.6. OGESTERONE SYNTHESIS INHIBITORSProgesterone production can be blocked bythe hydroxyl steroid dehydrogenase isomeraseenzyme inhibitors, which prevent the conversion ofprognenelone to progesterone. Prognenelone isbiologically inactive, and therefore progesteronesupport for the pregnancy is lost, resulting inresorption or abortion (Simpson, 1998). Epostane isone such enzyme inhibitor that has no intrinsicoestrogenic, androgenic or progestogenic activity.When administered subcutaneously at the onset ofmetoestrus (dioestrus), epostane will prevent orterminate pregnancy. It can be given at a dose rate of5mg/kg body weight orally for 7 days (Keister et. al,1989).7. TAMOXIFEN CITRATEIt acts as an antiestrogen in premenopausalwomen but has estrogenic activity in dogs. It mayinterfere with zygote transport and/or implantation.Relatively high doses of drug are given twice dailyduring proestrus, oestrus, and early metoestrus. Thedrug was effective in preventing or terminatingpregnancy if administration began during proestrusor estrus or on day 2 of estrus. Efficacy was muchpoor in if the treatment commenced on day 15onwards. It can be given at a dose rate of 1mg/kgorally twice a day for 10 days. A high incidence ofpathological changes in the bitch's reproductive tractis induced by tamoxifen, including ovarian cysts andendometritis, and the compound is of little value forpotential breeding animals (Bowen et.al, 1988).Preparation TAMOFEN Tab 10 mg, TAMOXIFENTab 10, 20 and 40 mg.8. EMBRYOTOXIC AGENTSSeveral novel embryotoxic agents such asphenyltriazole isoindole and isoquinolinecompounds have been evaluated in the bitch. Theyare most effective when given around the time ofimplantation and often only a single administration isrequired. A single sub cutaneous or intra muscularinjection of 2-(3-ethoxy-phenyl)-5, 6-dihydro-striazole[5,1-a]isoquinoline(DL 204-IT) dissolved orsuspended in an oily vehicle is sufficient. Theoptimal time of treatment was found to be day 20 ofgestation, at which time the smallest effective dosewas 6.25 ng/kg (Galliani et. al, 1982). Howevermany of these agents have toxic side effectsincluding vomiting, diarrhoea, weight loss, pyrexia,lethargy and immunosuppression.9. DEXAMETHAZONEDexamethasone administered beginning atmid-gestation can terminate pregnancy in dogs,presumably by activating endogenous mechanismssimilar to those involved in parturition. It can resultin the production of oestrogen and prostaglandin bythe fetoplacental unit. Single dose of glucocorticoidsare not efficacious in the bitch. It can be given at adose rate of 200µg/kg body weight for 7 days andthen at a tapering dose of 10-20 µg/kg for next 3 days(Wanke et. al, 2002). Advantages of such a therapyfor pregnancy termination include the fact that itinvolves only oral administration of a relativelyinexpensive drug; however repeated administrationand high doses make the method impractical.Preparation: - DEXONA Tab 0.5mg, WYMESONETab 0.5 mgCONCLUSIONBefore deciding treatment for misalliance,vaginal cytology should be performed to make surethat mating had taken place. Aglepristone,oestrogens and tamoxifen citrate are the drugs whichcan be preferred for the treatment of misalliance in64