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GENERAL ARTICLE4. COMBINATION OF PROSTAGLANDINAND DOPAMINE AGONISTSimultaneous administration of prostaglandinand dopamine agonist is found to be highly effective.Therapy begins 28 days after first breeding.Cloprostenol is administered subcutaneously onalternative days at a dose rate of 1 µg/kg and the drughas to be administered three times. Oral cabergolinehas to be given at a dose rate of 5µg/kg body weightfor 9 days. This regimen reduces the adverse effectsof prostaglandin therapy alone and increases theefficacy of prolactin antagonists. When the bitcheswere treated for approximately 9 days, 100 percentshowed resorption and there was generally no sideeffects except sanguinous vaginal discharge (Onclinet.al, 1995).5. ANTI PROGESTERONE THERAPYAnti-progestins are synthetic steroids thatbind with great affinity to progesterone receptors,preventing progesterone from exerting its biologicaleffects. After administration of the drug peripheralprogesterone concentration remains unaltered but itsaction is blocked. In dogs, the anti-progestinsmifepristone and aglepristone have been used forexperimental and clinical purposes, includingpregnancy termination and management ofpyometra.a. Mifepristone: -Mifepristone is a progesterone andglucocorticoid antagonist. It is more potent as ananti-progestin than as an anti-corticoid. In pregnantwomen, mifepristone is able to interrupt earlypregnancy in 80 percent of cases without any majorside effects. To improve its efficacy, mifepristone iscurrently used in combination with low doses ofprostaglandin analogs such as misoprostol. Theefficacy of combined treatment (mifepristone plusmisoprostol) is 96 percent in humans. The drug act asa progesterone receptor antagonist at the level of theuterus independent of any additional effects on lutealfunction. Premature cessation of luteal function mayhave occurred secondary to the termination ofpregnancy or may represent a luteolytic effect oftreatment independent of pregnancy status.Mifepristone has been demonstrated to induce directluteolysis and has an anticorticoid activity.This drug is orally active and has beenshown to be safe and effective in terminatingpregnancy after 30 days of gestation. The treatmentprotocol involved oral administration of drug at therate of 2.5 mg/kg twice daily for 4-5 days or untilabortion or resorption occurred (Concanoon et.al,1990). It is a competitive antagonist of progesteroneon the receptor level thus having most clinical effectsin the presence of progesterone. Preparation Tab.MTPILL 200mg, MEFIPIL 200mg, UNWANTED200mgB. Aglepristone: - This is a relatively newantiprogesterone drug developed for animal use.Aglepristone can be used any time up to day 45 forsafe effective termination of pregnancy (Fieni et. al,2001). Aglepristone does not modify plasmaconcentrations of progesterone, prostaglandins,oxytocin or cortisol within 24 hours after itsadministration but induces an increase inconcentrations of prolactin within 12 hours in bitchestreated in mid pregnancy (Galac, et. al, 2000). Thiscan explain the mammary gland congestion typicallyobserved after mid pregnancy termination.Shortening of the inter-oestrous interval andprolactin release seems to prove a direct or indirectaction of aglepristone on hypothalamic-pituitaryaxis. As an abortifacient, aglepristone acts like aprogesterone antagonist, at the uterus level and doesnot have direct and immediate luteolysis properties.Termination of pregnancy occurs in the presence ofhigh plasma progesterone concentrations (Baanet.al, 2005)..The early administration of aglepristone at 0to 25 days after mating always resulted in preventionof pregnancy. The later administration ofaglepristone at day 26 to 45 after mating inducedresorbtion or abortion within seven days in 96percent of cases. There were no untoward sideeffects. The drug can be administered at a dosage ofJIVA Vol. 10 Issue 1 April 201263