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GENERAL ARTICLEJ. Ind. Vet. Assoc., Kerala. 10 (1)approximately 5-7 days (Feldman et.al, 1993 andRenukaradhya et.al, 2008). This protocol resulted inthe least side effects. After administration of drug,the dog should be observed for 30 minutes for anyside effects. The dog should be fed 1-2 hours afterprostaglandin injection so as to avoid vomiting. It hasbeen observed that plasma progesterone less than 2.0ng / ml result in pregnancy termination and pretreatment concentration of plasma progesterone ismore than 6ng/ml (Feldman et.al, 1993). Most of theanimals treated will exhibit some of the followingside effects like panting, respiratory distress, excesssalivation, vomiting, defecation, stranguria andurination. Normally these side effects start within 30seconds to 3 minutes and usually persist for 5-20minutes. Side effects are usually severe during thefirst few injections and side effects will bediminishing after each subsequent injection.Preparation - LUTALYSE 5ml &10ml vials areavailable. Concentration 5mg/mlb. Prostaglandin analogs:- It has greater luteolyticeffectiveness at relatively low doses and decreasesthe occurrence of myometrial contractions andseverity of side effects compared to naturalprostaglandins. It has much greater affinity for theprostaglandin receptors and has a longer half life thannatural prostaglandin. It can be given at the dose rateof 2.5µg/Kg body weight subcutaneously every 48hours for 3 to 4 times (Reddy et.al, 2010). In order toreduce the side effects atropine sulphate can be givenat the rate of 0.04 mg/kg body weight subcutaneously10-15 minutes prior to the administration of drug.Preparation Inj.Clostenol 2ml, Inj.Pragma2ml,Inj.Cyclix 2ml, Inj. Estropur 2ml Concentration-250µg/ml3. DOPAMINE AGONISTSDopaminergic agonists are ergotinederivativealkaloid compounds that exert an antiprolactinergiceffect. The ability of dopamineagonists to inhibit prolactin secretion makes themoptimal for milk suppression, either during overtpseudopregnancy episodes or in the post-partumperiod. It is well known that prolactin is a requiredluteotropic hormone during the second half of canineluteal phase. Therefore, anti-prolactins can also beused to suppress luteal function in progesteronedependent conditions such as pyometra, unwantedpregnancy and mammary tumors. Two of the mostwidely used dopamine agonists in dogs arebromocriptine and cabergoline, which have a directaction on D2-dopamine receptors of the lactotrophiccells of the anterior pituitary gland.a. Bromocriptine: - It has been reported to be aneffective abortifacient after 35 days of gestation butnot prior to day 30. Two different treatment protocolshave been adopted. In one protocol 0.1mg/kg bodyweight daily or BID for 6 consecutive daysbeginning on day 30 of gestation. In the secondprotocol, 0.03 mg/kg twice daily for 4 daysbeginning after day 30 of gestation. Bromocriptinecommonly causes inappetence, anorexia, vomitingand depression. Also the drug is not 100% effectivein terminating pregnancy. Emesis is presumably dueto interaction with dopaminergic elements in theemesis centre of the brain and the ability of the drugto cross the blood brain barrier. The emetic effectmay reduce the absorption of the total doseadministered, and thus compromise efficacy.Because of above reasons the drug has not been usedextensively. Preparation ENCRIPT 2.5 mg tab,PROCTINAL 1.25 & 2.5 mg tabs.b. Cabergoline: - It is a long acting dopaminereceptor agonist and prolactin inhibitor. It is highlyeffective orally and parenterally. A dose of 5µg/kgonce daily cause a sharp decline in serum prolactinconcentration and result in abortion without muchside effects (Reddy et.al, 2010).. The side effects ofcabergoline are milder (compared to those ofbromocriptine) presumably due to the fact that itappears to be a more specific D-2 dopamine receptoragonist and is less able to cross the blood-brainbarrier and have CNS effects.Preparation CABGOLIN Tab 0.25 & 0.5mg, CAMFORTE Tab 0.5 & 1mg62