Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer
Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer
Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer
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Double Strand Breaks(DSBs) <strong>in</strong> DNAOccur spontaneously (approx. 50) per cell cycleAlso <strong>in</strong>ducible by IR, ROS, and some chemicalsIf not repaired cell diesRepair can lead to:Recomb<strong>in</strong>ation (with LOH)Deletion (with LOH)TranslocationGenomic <strong>in</strong>stability (via BFB cycle)
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