Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer
Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer
Leopold Koss Lectureship Cellular Mechanisms in Hereditary Cancer
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Multiple Gene Mutations <strong>in</strong>Colorectal <strong>Cancer</strong>Normal Early adenoma Intermediate Late adenoma <strong>Cancer</strong>APC K-RAS SMAD2, 4 TP53Adapted from Ilyas et al. Eur. J. <strong>Cancer</strong> 1999; 35:335-351 and Kelloff et al. Oncology 1996; 10:1471-1484