The Production of Therapeutic Proteins in Plants: Apo AI and Insulin
The Production of Therapeutic Proteins in Plants: Apo AI and Insulin The Production of Therapeutic Proteins in Plants: Apo AI and Insulin
Apo AINext Generation Therapy in AtherosclerosisStatins (LDL therapy)Halts plaque build-upApo AI (HDL therapy)Reverses plaque build-up
Apo AI Milano (SBS-2000)• FTO – SBS has the patents for expression of Apo AIin plants• Volume/Dosing – likely 50-100 mg/kg which meansseveral grams are required for each dose in eachperson• Manufacturing – bacteria free system avoids theinteraction of Apo AI with bacterial endotoxin•Unmet need – no drug on the market is able toreverse plaque buildup in blood vessels
- Page 1 and 2: The Production of Therapeutic Prote
- Page 3 and 4: SemBioSys OverviewLocation: Calgary
- Page 5 and 6: SemBioSys’ TechnologyProof-of-Con
- Page 7 and 8: Field Grown GMO SafflowerPlanting s
- Page 9 and 10: Purification of OilbodiesThe Proces
- Page 11 and 12: Plant Impurity AssaysPhytate (IP 6
- Page 13 and 14: Product Impurity Assays - Fusion Pa
- Page 15 and 16: Viral Load/Viral ClearanceRegulator
- Page 17 and 18: InsulinPositioned to Meet the Growi
- Page 19 and 20: Economics of Plant-Produced Insulin
- Page 21 and 22: Insulin - Equivalence DataV8 Protea
- Page 23 and 24: Insulin - Equivalence DataIGF-1 Rec
- Page 25: Insulin Characterization: Clinical
- Page 29 and 30: Functional Characterization of Puri
- Page 31 and 32: Cholesterol Mobilization in vivoSBS
- Page 33: Non-Pharma ProductsProducts and Com
<strong>Apo</strong> <strong>AI</strong> Milano (SBS-2000)• FTO – SBS has the patents for expression <strong>of</strong> <strong>Apo</strong> <strong>AI</strong><strong>in</strong> plants• Volume/Dos<strong>in</strong>g – likely 50-100 mg/kg which meansseveral grams are required for each dose <strong>in</strong> eachperson• Manufactur<strong>in</strong>g – bacteria free system avoids the<strong>in</strong>teraction <strong>of</strong> <strong>Apo</strong> <strong>AI</strong> with bacterial endotox<strong>in</strong>•Unmet need – no drug on the market is able toreverse plaque buildup <strong>in</strong> blood vessels
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