The Production of Therapeutic Proteins in Plants: Apo AI and Insulin

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Plant Impurity AssaysCarbohydrate – simple and complex, some unique to plants.Detected using an HPLC method involving TFA hydrolysisof the protein to release monosaccharides.Limit of Detection =
Product Impurity Assays – Fusion PartnerFusion partner - usually a single chain antibody (scFv) thatinteracts with oleosin on the oilbody surface.Solubility issues are usually a problem with this once it iscleaved.Product is cleaved from the fusion partner using enzymes.Limit of Detection =
Page 1 and 2: The Production of Therapeutic Prote
Page 3 and 4: SemBioSys OverviewLocation: Calgary
Page 5 and 6: SemBioSys’ TechnologyProof-of-Con
Page 7 and 8: Field Grown GMO SafflowerPlanting s
Page 9 and 10: Purification of OilbodiesThe Proces
Page 11: Plant Impurity AssaysPhytate (IP 6
Page 15 and 16: Viral Load/Viral ClearanceRegulator
Page 17 and 18: InsulinPositioned to Meet the Growi
Page 19 and 20: Economics of Plant-Produced Insulin
Page 21 and 22: Insulin - Equivalence DataV8 Protea
Page 23 and 24: Insulin - Equivalence DataIGF-1 Rec
Page 25 and 26: Insulin Characterization: Clinical
Page 27 and 28: Apo AI Milano (SBS-2000)• FTO - S
Page 29 and 30: Functional Characterization of Puri
Page 31 and 32: Cholesterol Mobilization in vivoSBS
Page 33: Non-Pharma ProductsProducts and Com

The Production of Therapeutic Proteins in Plants: Apo AI and Insulin

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