2010 Hong Kong Reference Framework for Hypertension Care for ...
2010 Hong Kong Reference Framework for Hypertension Care for ... 2010 Hong Kong Reference Framework for Hypertension Care for ...
Module 7Drug Treatment for People with HypertensionIt has also shown that the lower the blood pressure the better, and that this shouldbe the primary objective of any treatment strategy. 1Therefore it is important totreat in order to reach the target blood pressure levels whichever drug(s) is/areused 1 , i.e. treating SBP and DBP to targets
Module 7Drug Treatment for People with HypertensionWith reference to the UK and US guidelines, 5,12 the rationales on selectingdifferent classes of drugs for uncomplicated hypertensive patients are introducedbelow.Thiazide-type diureticsThiazide-type diuretics have been widely studied and shown to be the drug mostlikely to confer benefit as first-line treatment for most patients. 11,27,29 In thesetrials, including ALLHAT 7 thiazide-type diuretics had significantly preventthe cardiovascular complications of hypertension. Thiazide-type diuretics aregenerally well tolerated and have good blood pressure lowing effect in particularolder patients. Thiazide-type diuretics are also more affordable than otherantihypertensive agents and are recommended as the initial therapy for mostpatients with hypertension by US guideline. 5Angiotensin-converting enzyme inhibitors (ACEI)/ Angiotensin II ReceptorAntagonists (ARB)It was demonstrated that younger patients and Caucasians tend to have higherserum renin levels than those older patients and the black population, and thusshould have better response to ACEI/ ARB which inhibit the renin-angiotensinsystem. 12,16,17,18ACEI/ ARB is recommended by the UK guideline 12 as theinitial drug choice for people aged
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Module 7Drug Treatment <strong>for</strong> People with <strong>Hypertension</strong>It has also shown that the lower the blood pressure the better, and that this shouldbe the primary objective of any treatment strategy. 1There<strong>for</strong>e it is important totreat in order to reach the target blood pressure levels whichever drug(s) is/areused 1 , i.e. treating SBP and DBP to targets
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