Nutritional Pathology Topics Nutritional ... - มหาวิทยาลัยนเรศวร

9/7/2012Neurohumoral mechanism• เปนกลไกการควบคุมการเผาผลาญพลังงาน• Afferent (humoral) signals : leptin(adiposetissue), insulin, ghrelin(stomach)• Hypothalamus (central melanocortin system)• Efferent : feeding behavior + energyexpenditure (TRH and autonomic pathway)Food–derived energy > energy expenditureStorage as triglycerides in adipose tissue (insulin effect)- Daily requirement : 2000 – 3000 kcal/d.- Daily energy expenditure = Basal energy expenditure (BEE)+Activities.BEE man = 66 + (13.7 x Wt.) + (5 x Ht.) – (6.8 x age)BEE woman = 655 + (9.5 x Wt.) + (1.8 x Ht.) – (4.7 x age)Wt (Kg), Ht (cm.), Age (yrs)Factors contributing toobesity :1. Genetic predisposition2. Decreased lipid utitization : aging,defective thermogenesis, inactivity,underexcercising3. Sociocultural environment : stress,emotional, disturbances4. Diseases : hypothalamic disorder.: hypothyroidism.: Cushing’s syndrome.: Polycystic ovary syndrome.21