Nutritional Pathology Topics Nutritional ... - มหาวิทยาลัยนเรศวร

9/7/2012Vitamin E (a-tocopheral)- serves as a scavenger of free radicals, theantioxidant effect- may reduce mutagenesis- Cause of deficiency : deficient diet is uncommon: occurs in association withmalabsorption syndromes, infants of low birthweight, developmental defects in the GI tract, orlipoprotein disorders.Vitamin E Deficiency: Poor nerve conduction,axon degenerationon the posterior columns of the spinalcord, loss of nerve cells in the dorsalroot ganglia, and degenerative changes inthe spinocerebellar tracts: The neurologic manifestations areataxia, dysarthria, absent tendonreflexes, and loss of position sense andpain sensation.Vitamin K- Clotting factor 2, 7, 9, 10- Anticoagulant protein C and S- May favor calcification of boneproteins and inhibit bone resorption prevent osteoporosisVitamin K Deficiency: ภาวะเลือดออกงาย (bleeding diathesis): Intracranial hemorrhage of thenewborn11