GABA - Molecular Devices

Summary and Conclusions• Electrophysiological assays for screening compounds against GABA Areceptors have been developed using two automated platforms andMillipore’s and cell lines.• These assays can detect agonists, antagonists and allosteric modulatorswith good resolution and reproducibility and can discriminate subtypeselective compounds• Despite the inability to resolve peak agonist responses, these datademonstrate that assays for improved throughput compound screeningagainst GABA Achannels can be developed on Ionworks• Using a similar approach, assays for other slowly gating LGICs are beingdeveloped, providing the opportunity for information-richelectrophysiological screening of compounds earlier in the screeningcascade