GABA - Molecular Devices
GABA - Molecular Devices
GABA - Molecular Devices
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Ionworks assays – robustness and resolution65Frequency Count432N.B. Experiments carried outas blinded, mock screens100.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0No <strong>GABA</strong> EC20EC80 EC100Current (nA)POSITIVE MODULATOR ASSAYEC 20 to 30 M Zolpidem = ~0.3 - 0.5EC 20 to EC 100 = ~ 0.5Z’ VALUES:-ANTAGONIST ASSAYEC 80 to 100 M Bicuculline = 0.6 - 0.7
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