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09. SAFETY METHODS IN PHARMACEUTICAL INDUSTRY:(a) Mechanical, chemical and fire hazards problems.(b) Inflammable gases and dusts.Note: STUDY TOUR:A visit to the pharmaceutical industries will be anintegral part of the syllabi and will prepare and submit a report aboutoperations in Pharmaceutical industry that will be evaluated in practicalexamination.PHARM 625 PHARMACEUTICS-X (Industrial Pharmacy-II) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities,e.g. Manufacture of Tablets by Wet Granulation Method, by Slugging andby Direct Compression. Coating of Tablets (Sugar Coating, Filmcoatingand Enteric Coating). Clarification of liquids by various processes.Size Reduction. Homogenization. Ampoule filling, sealing andsterilization clarity and leakage tests in injectables. Capsule filling bysemi automatic machines. Manufacture of sustained action drugs. TabletsTests like Disintegration. Dissolution. Friability. Hardness and thicknesstests. Determination of weight variation in tablets. Density of powder.Particle size analysis.(Note: A minimum of 10 practical will be conducted)Recommended Books:1. Lachman, Theory and Practice of Industrial Pharmacy, 3 rd Ed,VerghesePublishing House, Bombay, 2009.2. Cooper and Gunn’s, Tutorial Pharmacy, 6 th Ed, CBS Publishers &Distributors, New Delhi, 2004.4. Bentley’s Pharmaceutical Text Book, CBS Publishers & Distributors, NewDelhi, 1986.5. Remington’s Pharmaceutical Sciences, 21 st Ed, Mack PublishingCompany, USA, 2005.6. John Sharp, Good Pharmaceutical Manufacturing Practice, 6 thEd,Rational and Compliance. 2009.PHARM 626 PHARMACEUTICS-XI (Biopharmaceutics-II) [Th.]Cr. Hr.: 03 Marks: 1001. MULTIPLE DOSAGE REGIMENa. Introduction, principles of superposition76 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
. Factors: persistent, accumulation and loss factorsc. Repetitive Intravenous injections – One Compartment Open Modeld. Repetitive Extravascular dosing – One Compartment Open modele. Multiple Dose Regimen – Two Compartment Open Model2. ELIMINATION OF DRUGS:a) Hepatic Elimination. Percent of Drug Metabolized, DrugBiotransformation reactions, (Phase-I reactions and phase-II reactions),First pass effect, Hepatic clearance of protein bound drugs and Biliaryexcretion of drugs.b) Renal Excretion of Drugs: Renal clearance, Tubular Secretion andTubular Reabsorption.c) Elimination of Drugs through other organs: Pulmonary excretion,Salivary excretion, Mammilary excretion, Skin excretion and Genitalexcretion.6. PROTEIN BINDING: Introduction, types, kinetics, determination andclinical significance of drug-protein binding.4. PHARMACOKINETICS VARIATIONS IN DISEASE STATES.Determination of pharmacokinetics variations in renal and hepatic diseases,general approaches for dose adjustment in renal diseaseand hepatic diseases.5. PHARMACOKINETICS OF INTRAVENOUS INFUSIONS.6. BIOPHARMACEUTICAL ASPECTS INDEVELOPING A DOSAGEFORMDrug considerations, drug product considerations, patient considerations,manufacturing considerations, pharmacodynamic considerationspharmacokinetic considerations7. IN-VITRO-IN-VIVO CORRELATION (IVIVC)Introduction, levels and determination of in-vitro/in-vivo correlationPHARM 627 PHARMACEUTICS-XI (Biopharmaceutics-II) [Lab.]Cr. Hr.: 01 Marks: 50NOTE:- Practical of the subject shall be designed from time to time on the basis ofthe above mentioned theoretical topics and availability of the facilities,e.g. Blood Sampling Techniques (In Laboratory Animals like dog,rabbits, mice etc. in human beings), In-vitro dissolution studies, Optionaldose determination, Measurement of rate of Bioavailability,Determination of relative and absolute bioavailability. Plasma level-timecurve (Determination of Pharmacokinetic parameters). Determination ofplasma protein binding. Urinary sampling techniques. In Laboratoryanimals. In humans. Renal excretion of drugs or drug disposition.Recommended Books:77 | Pakistan Pharmacist Federation; www.pharmacistfed.pk,www.pharmafed.wordpress.com, www.pharmarev.com, info@pharmacistfed.pk,
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NATIONAL CURRICULUM REVISIONCOMMITT
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The aims and objectives of Doctor o
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14. To prepare pharmacy graduates f
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and its Applications in Pharmacy)[L
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DETAILS OF COURSES ( SEMESTER SYSTE
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PHARM 311 PHARMACEUTICS-I (Physical
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9. Naser-ud-Din, Introduction to St
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Expression of Genetic Information,
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2. STRUCTURE OF CELL: Cell Membrane
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Communications SkillsObjectives: En
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Experiments to demonstrate some of
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Objectives• Develop vision of his
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2 To enhance understanding of the s
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1) Basic Concepts of Islam & Scienc
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Chondroma, Fibroma, Leomyoma, Neofi
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Note:(a)(b)(c)(d)Pollution and its
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14. Pharmacology by Ran & Dell, 6 t
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(e) Phenolic volatile oils: Clove,
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their identification. Isolation and
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6. ROLE OF PHARMACIST: As Public He
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d. I.R. Spectroscopye. Mass Spectro
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F O U R T H P R O F E S S I O N A L
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16. NUCLEAR PHARMACY.17. THE PHYSIC
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I. Ensure continuity of pharmaceuti
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1. MASS TRANSFER.2. HEAT TRANSFER.3
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Delhi, 1986.4. Remington’s Pharma
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14. IN-VITRO-IN-VIVO CORRELATION (I
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5. QUALITY CONTROL OF STERILE PRODU
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F I N A L P R O F E S S I O N A LPH
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3. Tyagi, Textbook of Synthetic Dru
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Horwood Publishing limited, West Su
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NOTE:- Practical of the subject sha
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3. The Pharmacy Act 1967.4. The Poi
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5. Application of Computers in Hosp
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